# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA processing	49	4.508637e-37	1.210799067e-34	2.103836	361	0.02723501	152	4.739941057894737e-10	1.419725	180	252	0.01905367	
GO Biological Process	rRNA metabolic process	53	4.396614e-35	1.091604596716981e-32	2.049252	363	0.02738589	162	3.323957714012346e-9	1.396703	182	259	0.01926538	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	68	1.278654e-30	2.474383527352941e-28	2.621597	189	0.01425877	241	0.0000030814708768464733	1.482289	88	118	0.009315126	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	71	8.43681e-29	1.5636617294366198e-26	2.359915	216	0.01629574	287	0.000018774802698257838	1.45993	83	113	0.008785858	
GO Biological Process	nuclear-transcribed mRNA catabolic process	72	1.886101e-28	3.447111535972222e-26	2.039321	295	0.02225575	177	1.703202081638418e-8	1.4355	143	198	0.01513708	
GO Biological Process	translational initiation	81	1.593095e-25	2.5880910006172843e-23	2.205879	219	0.01652207	220	7.64353674e-7	1.459438	105	143	0.01111464	
GO Biological Process	regulation of DNA-templated transcription in response to stress	83	4.931394e-25	7.818338993493976e-23	2.163531	224	0.01689928	331	0.00008424240729909366	1.419725	85	119	0.008997565	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	89	1.458959e-24	2.1571282562921346e-22	2.636604	148	0.0111656	280	0.000016017435577142855	1.512316	70	92	0.00740976	
GO Biological Process	viral gene expression	90	1.478699e-24	2.1620222378888893e-22	2.336605	186	0.01403244	202	2.775906033019802e-7	1.502449	96	127	0.01016196	
GO Biological Process	cotranslational protein targeting to membrane	94	1.367997e-23	1.9150502684042553e-21	2.536063	152	0.01146737	274	0.000012999511959489053	1.500852	74	98	0.007833175	
GO Biological Process	protein targeting to ER	103	2.691781e-22	3.438946230970874e-20	2.438768	154	0.01161826	369	0.00019431185641192411	1.436593	73	101	0.007727321	
GO Biological Process	multi-organism metabolic process	113	5.781965e-21	6.733174994247788e-19	2.038991	213	0.01606941	190	6.274566493000001e-8	1.487331	110	147	0.01164391	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	115	8.891542e-21	1.017424358069565e-18	2.276408	164	0.01237269	313	0.00004988677799680511	1.457584	77	105	0.008150736	
GO Biological Process	protein localization to endoplasmic reticulum	116	1.048671e-20	1.1896087662931035e-18	2.146261	186	0.01403244	279	0.000015744304866666668	1.442624	90	124	0.009526834	
GO Biological Process	viral transcription	117	1.524155e-20	1.7142184311965812e-18	2.250468	166	0.01252358	237	0.0000026811379215189875	1.495109	85	113	0.008997565	
GO Biological Process	translational elongation	126	1.455669e-19	1.5202498707142856e-17	2.233445	160	0.01207092	264	0.000010683936649621212	1.472965	83	112	0.008785858	
GO Biological Process	mitochondrial transmembrane transport	127	3.954412e-19	4.09733129984252e-17	2.328322	143	0.01078838	646	0.010650739788235294	1.364989	57	83	0.006033661	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	152	1.097587e-16	9.50207061381579e-15	2.198913	139	0.01048661	648	0.010847946563580247	1.376041	54	78	0.0057161	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	159	3.166537e-16	2.6206578857232704e-14	3.207548	69	0.005205583	518	0.003911385732625483	1.739163	21	24	0.002222928	
GO Biological Process	retrograde transport, endosome to Golgi	165	9.32993e-16	7.440760537575758e-14	2.087639	147	0.01109015	900	0.04978299721	1.316472	51	77	0.005398539	
GO Cellular Component	ribosomal subunit	31	4.148746e-31	2.3125913187096773e-29	2.244581	260	0.01961524	40	1.2600480959999998e-9	1.47191	137	185	0.01450196	
GO Cellular Component	large ribosomal subunit	39	1.17023e-21	5.185019076923076e-20	2.333014	163	0.01229725	52	2.195117612307692e-7	1.520958	88	115	0.009315126	
GO Cellular Component	mitochondrial ribosome	46	4.418993e-18	1.6600043269565215e-16	2.59726	109	0.008223312	99	0.0019758458181818182	1.403022	60	85	0.006351223	
GO Cellular Component	mitochondrial large ribosomal subunit	71	2.342049e-12	5.700085453521127e-11	2.685994	67	0.005054696	123	0.005038897170731707	1.480968	38	51	0.004022441	
GO Cellular Component	small ribosomal subunit	76	1.17038e-11	2.6610745263157895e-10	2.126062	100	0.007544323	144	0.0091162056	1.380288	50	72	0.005292686	
GO Cellular Component	cytosolic large ribosomal subunit	79	2.249477e-11	4.920375007594936e-10	2.146995	95	0.007167107	83	0.0003392055672289156	1.531441	47	61	0.004975124	
GO Cellular Component	spliceosomal snRNP complex	83	6.299659e-11	1.3115434640963854e-9	2.233443	83	0.006261788	97	0.0018582413195876288	1.474682	46	62	0.004869271	
GO Cellular Component	mitochondrial nucleoid	99	4.142653e-9	7.230812509090909e-8	2.263011	65	0.00490381	178	0.04287314588764045	1.419725	30	42	0.003175611	
GO Cellular Component	MLL1 complex	112	3.1737e-8	4.896565714285715e-7	2.473422	48	0.003621275	116	0.004547120275862069	1.644923	24	29	0.002540489	
GO Cellular Component	cytosolic small ribosomal subunit	127	3.838187e-7	0.000005222352075590551	2.002313	64	0.004828367	160	0.022260117599999997	1.445538	32	44	0.003387319	
GO Cellular Component	spliceosomal tri-snRNP complex	146	0.000001643942	0.00001945706695890411	2.336201	40	0.003017729	179	0.043014003486033514	1.507846	22	29	0.002328782	
GO Cellular Component	INO80-type complex	157	0.000003171379	0.00003490536886624204	2.690328	29	0.002187854	114	0.004090172968421052	1.728361	20	23	0.002117074	
GO Cellular Component	methylosome	172	0.00001575988	0.00015833181767441862	3.317753	18	0.001357978	172	0.03387939906976744	1.821981	11	12	0.001164391	
GO Cellular Component	Ino80 complex	199	0.00005862639	0.0005090773965829145	2.79727	20	0.001508865	115	0.004234399387826088	1.863389	15	16	0.001587806	
GO Cellular Component	U2 snRNP	295	0.001456625	0.008532366101694916	2.073191	22	0.001659751	165	0.0250691328	1.673781	16	19	0.001693659	
GO Molecular Function	structural constituent of ribosome	8	1.056461e-26	5.5754729275e-24	2.192022	233	0.01757827	25	9.086161133599999e-10	1.521384	124	162	0.01312586	
GO Molecular Function	unfolded protein binding	10	1.666761e-17	7.0370649420000005e-15	2.223588	143	0.01078838	137	0.02312397104379562	1.312576	70	106	0.00740976	
GO Molecular Function	rRNA binding	13	2.158809e-15	7.011147383076923e-13	2.893028	76	0.005733685	115	0.008480683673043478	1.457584	44	60	0.004657563	
GO Molecular Function	snRNA binding	17	2.679501e-13	6.654619542352941e-11	3.098972	58	0.004375707	118	0.009594945823728815	1.56917	30	38	0.003175611	
Human Phenotype	Laryngomalacia	1	9.311089e-14	6.2132896897e-10	3.394316	53	0.003998491	123	0.003594874762357724	1.987615	14	14	0.001481952	
Human Phenotype	Aplasia/Hypoplasia involving the carpal bones	252	0.0002157169	0.005712217752777778	2.082725	30	0.002263297	238	0.027581098744117648	1.845643	13	14	0.001376098	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	1	3.572787e-23	3.2716010559e-19	2.693018	134	0.01010939	230	0.009196781193043478	1.457584	44	60	0.004657563	
Mouse Phenotype Single KO	early cellular replicative senescence	2	3.990751e-20	1.82716534535e-16	2.666503	117	0.008826858	380	0.04372792814473685	1.414265	37	52	0.003916587	
Mouse Phenotype Single KO	increased squamous cell carcinoma incidence	7	1.9117e-15	2.5007767e-12	2.949686	74	0.005582799	360	0.034910299416666665	1.605381	21	26	0.002222928	
Mouse Phenotype Single KO	small superior cervical ganglion	28	1.479773e-10	4.839386200357143e-8	2.360241	71	0.005356469	244	0.011285859890983605	1.614937	26	32	0.002752196	
Mouse Phenotype Single KO	absent ductus venosus valve	104	3.398166e-7	0.000029920198136538458	2.048688	61	0.004602037	270	0.015948645155555555	1.716577	19	22	0.00201122	
Mouse Phenotype Single KO	abnormal DNA replication	112	6.550673e-7	0.00005355760059017857	2.290108	45	0.003394945	366	0.03558327636885245	1.641943	19	23	0.00201122	
Mouse Phenotype Single KO	abnormal hepatic vein morphology	160	0.000003126357	0.00017892531905625	2.748927	28	0.00211241	277	0.017233011191335742	1.987615	11	11	0.001164391	
Mouse Phenotype Single KO	increased circulating fructosamine level	266	0.00005118885	0.001762166539285714	2.344184	28	0.00211241	277	0.017233011191335742	1.987615	11	11	0.001164391	
Mouse Phenotype	abnormal cellular replicative senescence	1	1.289289e-31	1.2326892129e-27	2.610258	197	0.01486232	148	0.00001939573530608108	1.538036	65	84	0.006880491	
Mouse Phenotype	early cellular replicative senescence	2	1.728262e-31	8.261956491e-28	2.725537	182	0.01373067	164	0.00005513227056585366	1.551973	57	73	0.006033661	
Mouse Phenotype	subcutaneous edema	32	5.490771e-12	1.64053942284375e-9	2.458228	76	0.005733685	654	0.04206486213761468	1.523838	23	30	0.002434635	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	40	1.97243e-11	4.7146008075e-9	2.574546	66	0.004979253	601	0.03550921992179701	1.590092	20	25	0.002117074	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	45	3.124367e-11	6.638238419333333e-9	3.229247	45	0.003394945	617	0.037093487834683955	1.673781	16	19	0.001693659	
Mouse Phenotype	increased adrenal gland tumor incidence	72	8.933682e-9	0.0000011863185222500001	2.874592	40	0.003017729	527	0.02304630972865275	1.753778	15	17	0.001587806	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	131	3.219502e-7	0.00002349744932977099	2.216861	51	0.003847605	481	0.015824057283367984	1.590092	24	30	0.002540489	
Mouse Phenotype	absent ductus venosus valve	133	3.398166e-7	0.000024428470019548873	2.048688	61	0.004602037	437	0.010288598663615561	1.716577	19	22	0.00201122	
Mouse Phenotype	absent subcutaneous adipose tissue	134	3.400297e-7	0.00002426137284850746	2.139662	55	0.004149378	544	0.024631754729779413	1.689473	17	20	0.001799513	
Mouse Phenotype	increased cellular sensitivity to alkylating agents	140	4.337837e-7	0.000029624328255	2.156768	53	0.003998491	374	0.0056524938770053474	1.788854	18	20	0.001905367	
Mouse Phenotype	increased kidney tumor incidence	161	9.219917e-7	0.00005475256300434782	2.569006	35	0.002640513	605	0.035522781366942154	1.739163	14	16	0.001481952	
Mouse Phenotype	increased cellular sensitivity to DNA damaging agents	162	9.419374e-7	0.00005559174988518518	2.06759	55	0.004149378	298	0.002157616111409396	1.806923	20	22	0.002117074	
Mouse Phenotype	abnormal DNA replication	185	0.000001871242	0.00009670780952432433	2.049559	53	0.003998491	355	0.004675716826478873	1.693154	23	27	0.002434635	
Mouse Phenotype	abnormal hepatic vein morphology	208	0.000003126357	0.0001437072080625	2.748927	28	0.00211241	446	0.011175222645739911	1.987615	11	11	0.001164391	
Mouse Phenotype	absent stapedial artery	238	0.000006851481	0.0002752395371470588	2.04936	47	0.003545832	617	0.037093487834683955	1.673781	16	19	0.001693659	
Mouse Phenotype	abnormal cervical rib	245	0.000007433715	0.0002900969351632653	2.26816	37	0.002791399	672	0.04797936020089285	1.821981	11	12	0.001164391	
Mouse Phenotype	increased circulating fructosamine level	351	0.00005118885	0.001394349273076923	2.344184	28	0.00211241	446	0.011175222645739911	1.987615	11	11	0.001164391	
Mouse Phenotype	absent uterus	363	0.00006589608	0.0017356265038016528	2.234495	30	0.002263297	591	0.033350515187817266	1.987615	9	9	0.0009526834