# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of fatty acid transport 93 2.546712e-9 3.60346056e-7 3.370563 34 0.004809733 735 0.017144218367891154 2.69862 7 7 0.001006036 GO Biological Process transdifferentiation 272 0.00001775831 0.0008591235341544117 3.286024 18 0.002546329 881 0.03861951415323496 2.69862 6 6 0.0008623168 GO Biological Process negative regulation of organic acid transport 278 0.00001833105 0.000867691679676259 2.018721 44 0.00622436 767 0.01884850896349413 2.063651 13 17 0.001868353 GO Biological Process urea transport 473 0.0004339749 0.012073310167230445 3.090929 13 0.001839015 881 0.03861951415323496 2.69862 6 6 0.0008623168 GO Biological Process negative regulation of mRNA splicing, via spliceosome 543 0.0007839426 0.018997975457458564 2.06136 25 0.003536568 902 0.041415676664079824 1.889034 14 20 0.002012072 GO Molecular Function dynein light intermediate chain binding 23 3.806021e-7 0.00006986530722608696 2.242834 49 0.006931674 43 0.0004034852486046511 2.140285 23 29 0.003305548 Mouse Phenotype Single KO abnormal tectorial membrane morphology 30 4.112661e-48 1.2553212259e-45 4.708663 138 0.01952186 794 0.019947302028967256 1.717304 21 33 0.003018109 Mouse Phenotype Single KO decreased cochlear outer hair cell number 35 1.466246e-43 3.836118463428571e-41 3.800216 158 0.02235111 1046 0.04579487485277246 1.653993 19 31 0.00273067 Mouse Phenotype Single KO absent startle reflex 36 1.073735e-42 2.731164276388889e-40 4.015037 145 0.0205121 779 0.01910853137869063 1.660689 24 39 0.003449267 Mouse Phenotype Single KO abnormal outer hair cell stereociliary bundle morphology 43 4.334643e-36 9.230773476976745e-34 3.225337 161 0.0227755 873 0.02870647125085911 1.521041 31 55 0.004455303 Mouse Phenotype Single KO abnormal cochlear outer hair cell number 44 9.16333e-36 1.9070139275e-33 2.917781 185 0.0261706 369 0.0007048544914634147 1.818635 31 46 0.004455303 Mouse Phenotype Single KO cochlear ganglion degeneration 45 4.808747e-34 9.785265839777777e-32 3.0787 162 0.02291696 766 0.018391523687989558 1.529218 34 60 0.004886462 Mouse Phenotype Single KO abnormal stria vascularis morphology 46 5.107884e-34 1.016802038869565e-31 3.326616 145 0.0205121 771 0.018702311433203632 1.6455 25 41 0.003592986 Mouse Phenotype Single KO cochlear degeneration 61 2.102524e-29 3.1561987324590164e-27 2.799341 161 0.0227755 1053 0.045737432298195636 1.463658 32 59 0.004599023 Mouse Phenotype Single KO cochlear hair cell degeneration 66 1.786747e-27 2.4789761028787875e-25 2.314562 212 0.0299901 313 0.00024179778187539933 1.625305 53 88 0.007617131 Mouse Phenotype Single KO head bobbing 69 3.053354e-27 4.0521105185507245e-25 2.738676 154 0.02178526 867 0.02794534738638985 1.619172 24 40 0.003449267 Mouse Phenotype Single KO abnormal cochlear hair cell number 70 1.241251e-26 1.6237336295714285e-24 2.39255 192 0.02716084 589 0.006443177688455008 1.600876 35 59 0.005030181 Mouse Phenotype Single KO abnormal cochlear ganglion morphology 78 1.643388e-22 1.929295373846154e-20 2.256007 181 0.02560475 1007 0.04349258551539226 1.379976 45 88 0.006467376 Mouse Phenotype Single KO impaired limb coordination 79 1.662719e-22 1.9272807446835442e-20 2.359475 165 0.02334135 963 0.03781396937798546 1.493879 31 56 0.004455303 Mouse Phenotype Single KO abnormal pinna reflex 91 1.029453e-17 1.035901222087912e-15 2.058018 172 0.02433159 991 0.042728899760847636 1.424272 38 72 0.005461339 Mouse Phenotype Single KO abnormal white fat cell number 128 3.599545e-12 2.575080747265625e-10 3.341999 47 0.006648748 866 0.0276129335 1.949004 13 18 0.001868353 Mouse Phenotype Single KO increased bone trabecula number 153 2.632297e-10 1.5754211522222223e-8 2.410944 66 0.00933654 691 0.012527983239797397 1.686638 25 40 0.003592986 Mouse Phenotype Single KO abnormal ureter development 155 3.795309e-10 2.2421706137419356e-8 2.633891 55 0.00778045 919 0.032073254393906424 2.207962 9 11 0.001293475 Mouse Phenotype Single KO decreased kidney apoptosis 174 8.630751e-9 4.542056718793103e-7 3.346622 32 0.004526807 1024 0.046307360349609375 2.361293 7 8 0.001006036 Mouse Phenotype Single KO ectopic kidney 189 4.113531e-8 0.000001992994887142857 2.889651 36 0.005092658 1024 0.046307360349609375 2.361293 7 8 0.001006036 Mouse Phenotype Single KO increased susceptibility to induced arthritis 217 4.722084e-7 0.000019926324049769584 2.26922 47 0.006648748 1046 0.04579487485277246 1.653993 19 31 0.00273067 Mouse Phenotype unidirectional circling 13 1.789143e-75 1.3158458633076923e-72 9.03958 128 0.01810723 1082 0.012506813024029576 2.24885 10 12 0.001437195 Mouse Phenotype abnormal tectorial membrane morphology 26 1.277711e-48 4.698536488846154e-46 4.627956 142 0.02008771 1016 0.009132459229429133 1.724119 23 36 0.003305548 Mouse Phenotype abnormal otolithic membrane morphology 29 1.368991e-43 4.513421707241379e-41 4.333258 136 0.01923893 1609 0.04502320060720945 1.574195 21 36 0.003018109 Mouse Phenotype absent startle reflex 32 2.343488e-40 7.001902739999999e-38 3.677223 152 0.02150233 815 0.0035994572385276073 1.717304 28 44 0.004024145 Mouse Phenotype decreased cochlear outer hair cell number 40 1.077615e-35 2.57576925375e-33 3.118848 167 0.02362428 1011 0.009089158502967359 1.704392 24 38 0.003449267 Mouse Phenotype abnormal stria vascularis morphology 47 1.912976e-32 3.891481603404255e-30 3.210179 145 0.0205121 1357 0.02773341021665439 1.568965 25 43 0.003592986 Mouse Phenotype abnormal outer hair cell stereociliary bundle morphology 49 5.053276e-32 9.860075884897958e-30 2.915934 165 0.02334135 1521 0.039468996053254435 1.433642 34 64 0.004886462 Mouse Phenotype abnormal cochlear outer hair cell number 50 6.555619e-32 1.25356546518e-29 2.629295 195 0.02758523 487 0.00018555048405954826 1.79908 36 54 0.005173901 Mouse Phenotype cochlear ganglion degeneration 57 2.733457e-30 4.585014452105263e-28 2.770039 169 0.0239072 916 0.006034079659716158 1.56014 37 64 0.00531762 Mouse Phenotype cochlear degeneration 59 2.375777e-29 3.84996676220339e-27 2.785523 162 0.02291696 1546 0.041915819798188876 1.436362 33 62 0.004742742 Mouse Phenotype cochlear hair cell degeneration 65 4.124072e-26 6.0661926756923075e-24 2.22622 218 0.03083887 420 0.00006219787899285714 1.630416 58 96 0.008335729 Mouse Phenotype absent pinna reflex 67 9.254294e-26 1.3206015661791045e-23 2.544525 165 0.02334135 1642 0.04973092428562728 1.411586 34 65 0.004886462 Mouse Phenotype abnormal cochlear hair cell stereociliary bundle morphology 68 2.087119e-25 2.934550699852941e-23 2.321518 194 0.02744377 1629 0.04737992580478821 1.34931 45 90 0.006467376 Mouse Phenotype decreased startle reflex 71 2.089376e-24 2.8135949205633805e-22 2.060433 242 0.03423398 1425 0.0334558914568421 1.307793 63 130 0.009054326 Mouse Phenotype decreased cochlear hair cell number 72 3.199365e-24 4.24849010625e-22 2.355955 179 0.02532183 1516 0.03839251714313984 1.471975 30 55 0.004311584 Mouse Phenotype head bobbing 73 3.966172e-24 5.194598697534246e-22 2.491453 160 0.02263404 1193 0.017460894460184413 1.574195 28 48 0.004024145 Mouse Phenotype abnormal cochlear hair cell number 75 2.472388e-21 3.1518002224e-19 2.071654 207 0.02928278 801 0.0034825614250936325 1.552631 42 73 0.006036217 Mouse Phenotype abnormal vestibular saccule morphology 78 7.383015e-20 9.049872617307692e-18 2.224483 163 0.02305842 1047 0.010497786232091692 1.570106 32 55 0.004599023 Mouse Phenotype impaired swimming 80 1.820045e-19 2.175181280625e-17 2.128617 176 0.02489744 1539 0.040707016727095514 1.383043 41 80 0.005892498 Mouse Phenotype abnormal cochlear ganglion morphology 85 6.78659e-19 7.633716116470589e-17 2.012288 195 0.02758523 1131 0.014499751034482759 1.404384 51 98 0.007329692