# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 65 1.012694e-28 2.0501600532307692e-26 3.237993 126 0.01753409 449 0.0023178209846770603 1.495363 61 114 0.009078732 GO Biological Process regulation of gene expression, epigenetic 75 5.131112e-26 9.002707041066668e-24 2.14418 236 0.03284164 333 0.0006348391604804805 1.3635 121 248 0.01800863 GO Biological Process regulation of megakaryocyte differentiation 80 7.628313e-24 1.2547621345875e-21 3.02726 114 0.01586418 431 0.002081354144988399 1.617933 44 76 0.006548594 GO Biological Process chromatin silencing 85 1.466717e-21 2.2706504709411765e-19 3.391344 87 0.01210687 539 0.0059254977 1.498143 52 97 0.007739247 GO Biological Process platelet activation 91 6.119139e-21 8.848543967142857e-19 2.080136 201 0.02797105 386 0.001186814300880829 1.466676 74 141 0.01101354 GO Biological Process gene silencing 104 1.606152e-17 2.032245593076923e-15 2.14642 154 0.02143056 569 0.008022854975043937 1.350729 87 180 0.01294836 GO Biological Process response to dexamethasone 336 1.729256e-8 6.772404673809524e-7 2.080204 72 0.01001948 889 0.04783601421709786 1.579563 26 46 0.003869623 GO Biological Process regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 339 1.952424e-8 7.578745550442477e-7 2.571403 46 0.006401336 895 0.049081761451396644 1.712827 19 31 0.002827802 GO Biological Process negative regulation of interleukin-4 production 359 3.406677e-8 0.0000012487036947910865 3.926577 24 0.003339827 824 0.0334767674842233 2.794612 6 6 0.00089299 GO Biological Process definitive hemopoiesis 407 1.346041e-7 0.000004351978751597052 2.623858 39 0.00542722 666 0.014781903816816816 2.137056 13 17 0.001934812 GO Biological Process mammary gland epithelial cell proliferation 500 6.879424e-7 0.0000181052680832 2.421273 40 0.005566379 710 0.019136929828169016 2.328844 10 12 0.001488317 GO Biological Process positive regulation of metanephros development 501 6.881542e-7 0.0000180746928499002 2.523006 37 0.005148901 512 0.004605264482421875 2.395382 12 14 0.00178598 GO Biological Process bone cell development 517 9.507216e-7 0.00002419834726189555 2.255751 45 0.006262176 601 0.010116253844925125 2.032445 16 22 0.002381307 GO Biological Process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 552 0.000001719113 0.00004098153617210145 2.226983 44 0.006123017 803 0.03177061109090909 1.769921 19 30 0.002827802 GO Biological Process negative regulation of protein kinase activity by regulation of protein phosphorylation 568 0.000002356033 0.00005458281381514084 2.853357 27 0.003757306 549 0.006425623591621129 2.794612 8 8 0.001190653 GO Biological Process megakaryocyte development 611 0.000004474716 0.00009637117486743045 2.459016 33 0.004592263 770 0.027703300907792206 2.095959 12 16 0.00178598 GO Biological Process regulation of interleukin-4 production 643 0.000006863955 0.0001404708924494557 2.065857 46 0.006401336 818 0.032584338321515895 1.827246 17 26 0.002530138 GO Biological Process regulation of immunoglobulin mediated immune response 675 0.00001056905 0.0002060416725185185 2.066875 44 0.006123017 734 0.021200475656675752 1.630191 28 48 0.004167287 GO Biological Process determination of left/right asymmetry in lateral mesoderm 704 0.00001384633 0.0002588122961221591 3.220872 19 0.00264403 824 0.0334767674842233 2.794612 6 6 0.00089299 GO Biological Process negative regulation of receptor biosynthetic process 844 0.00004930715 0.0007687592261255925 4.510839 11 0.001530754 824 0.0334767674842233 2.794612 6 6 0.00089299 GO Cellular Component nucleosome 26 2.148628e-19 1.4280112246153848e-17 3.256648 82 0.01141108 71 0.01743903441126761 1.437229 54 105 0.00803691 GO Cellular Component DNA packaging complex 31 3.295944e-16 1.837222978064516e-14 2.773084 86 0.01196772 73 0.017155754432876712 1.422258 57 112 0.008483405 GO Cellular Component clathrin vesicle coat 105 0.000003878038 0.00006382142537142856 2.277164 39 0.00542722 79 0.022975837974683545 1.900336 17 25 0.002530138 GO Cellular Component granular component 163 0.0003730037 0.003954296893251534 4.732147 8 0.001113276 89 0.04070067128089888 2.794612 6 6 0.00089299 GO Cellular Component HFE-transferrin receptor complex 221 0.00219457 0.017159352760180994 2.573304 13 0.001809073 58 0.007986941131034483 2.794612 8 8 0.001190653 GO Molecular Function nucleosome binding 55 2.350469e-7 0.00001804305476 2.017464 65 0.009045366 70 0.036182467622857144 1.566677 37 66 0.005506772 GO Molecular Function NF-kappaB binding 168 0.0003340215 0.008394278410714287 2.117503 27 0.003757306 55 0.010153495476363636 1.996152 20 28 0.002976633 Mouse Phenotype Single KO abnormal erythropoiesis 37 4.329404e-22 1.0714689845405405e-19 2.180639 191 0.02657946 251 0.0015723419032270915 1.524334 60 110 0.0089299 Mouse Phenotype Single KO decreased erythroid progenitor cell number 43 1.478514e-20 3.1485471390697677e-18 2.595834 125 0.01739493 341 0.006380850021700879 1.698686 31 51 0.004613782 Mouse Phenotype Single KO abnormal platelet activation 55 1.26286e-17 2.1025470945454547e-15 2.394122 123 0.01711662 534 0.031010369127340825 1.446623 44 85 0.006548594 Mouse Phenotype Single KO abnormal platelet aggregation 57 2.753668e-17 4.423743487017544e-15 2.408494 119 0.01655998 440 0.01709430008681818 1.504791 42 78 0.00625093 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 60 5.89817e-17 9.001590448333333e-15 2.403177 117 0.01628166 519 0.027546390868978806 1.581856 30 53 0.00446495 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 64 1.723262e-16 2.4656109584375e-14 2.042551 162 0.02254384 274 0.002587735114489051 1.578134 48 85 0.00714392 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 73 4.284651e-15 5.374595781780821e-13 3.123804 66 0.009184525 646 0.04968145942414861 1.734587 18 29 0.00267897 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 77 1.869274e-14 2.2229794828571427e-12 2.910294 70 0.009741163 464 0.019754707911637935 1.756613 22 35 0.003274297 Mouse Phenotype Single KO increased body temperature 110 2.352148e-12 1.958056294181818e-10 2.928774 58 0.00807125 272 0.0025617545769485296 1.94776 23 33 0.003423128 Mouse Phenotype Single KO abnormal T cell subpopulation ratio 135 4.690096e-11 3.181274746074074e-9 2.893252 52 0.007236293 538 0.031844318522304835 1.746633 20 32 0.002976633 Mouse Phenotype Single KO abnormal erythrocyte osmotic lysis 227 4.220491e-8 0.0000017025126029515418 2.791498 38 0.00528806 646 0.04968145942414861 1.734587 18 29 0.00267897 Mouse Phenotype Single KO decreased spleen iron level 263 1.66404e-7 0.000005793769688212928 3.056514 30 0.004174784 353 0.006807635462322945 2.270622 13 16 0.001934812 Mouse Phenotype Single KO interstitial pneumonia 286 3.38961e-7 0.00001085267789160839 3.451921 24 0.003339827 616 0.04507341488149351 2.149702 10 13 0.001488317 Mouse Phenotype Single KO increased activated T cell number 287 3.424359e-7 0.000010925733575958189 2.399422 43 0.005983858 551 0.033777447504537206 1.863075 16 24 0.002381307 Mouse Phenotype Single KO decreased fetal cardiomyocyte proliferation 302 5.523836e-7 0.00001674892922251656 3.16884 26 0.003618146 525 0.028707421744761905 2.4841 8 9 0.001190653 Mouse Phenotype Single KO abnormal coronary circulation 327 0.000001131679 0.00003169047279204892 3.218292 24 0.003339827 417 0.01427592330239808 2.515151 9 10 0.001339485 Mouse Phenotype Single KO decreased inguinal fat pad weight 432 0.00001347206 0.0002855640125462963 2.177747 38 0.00528806 355 0.006903307533802817 1.966579 19 27 0.002827802 Mouse Phenotype Single KO abnormal liver iron level 459 0.00002400241 0.0004788454648583878 2.257909 33 0.004592263 545 0.03257428851009174 1.769921 19 30 0.002827802 Mouse Phenotype Single KO abnormal brown adipose tissue physiology 522 0.00006484896 0.0011375898979310345 2.396923 26 0.003618146 638 0.049546976912225704 2.049382 11 15 0.001637148 Mouse Phenotype Single KO abnormal cellular hemoglobin content 591 0.0001592003 0.002466661839424704 3.100164 15 0.002087392 566 0.03932237444699647 2.286501 9 11 0.001339485 Mouse Phenotype abnormal erythropoiesis 51 3.216448e-22 6.029893985882353e-20 2.045475 223 0.03103256 266 0.0000931848487556391 1.519219 81 149 0.01205537 Mouse Phenotype decreased erythroid progenitor cell number 72 7.177209e-18 9.53073545125e-16 2.234156 144 0.02003896 495 0.0032691183666666668 1.581162 43 76 0.006399762 Mouse Phenotype abnormal platelet aggregation 78 2.128996e-17 2.6096577892307694e-15 2.339398 127 0.01767325 816 0.019606869242647058 1.427036 48 94 0.00714392 Mouse Phenotype abnormal platelet physiology 92 4.283348e-16 4.451422850869566e-14 2.010675 164 0.02282215 726 0.01315586093429752 1.376135 65 132 0.009674059 Mouse Phenotype abnormal embryonic hematopoiesis 108 1.005319e-14 8.899865702777778e-13 2.18531 122 0.01697746 899 0.027497127580645164 1.511839 33 61 0.004911445 Mouse Phenotype decreased cytotoxic T cell cytolysis 109 1.2362e-14 1.0843402018348622e-12 2.767349 77 0.01071528 680 0.010484669931617648 1.664875 28 47 0.004167287 Mouse Phenotype abnormal proerythroblast morphology 119 4.984424e-14 4.004712425546218e-12 2.083424 129 0.01795157 489 0.00306588422392638 1.576448 44 78 0.006548594 Mouse Phenotype abnormal embryonic erythrocyte morphology 128 1.194404e-13 8.921638003125e-12 2.683229 75 0.01043696 554 0.0050835560870036095 1.791418 25 39 0.003720792 Mouse Phenotype abnormal embryonic erythropoiesis 134 4.885915e-13 3.486136814552239e-11 2.781653 67 0.009323685 946 0.03373902052959831 1.712827 19 31 0.002827802 Mouse Phenotype increased body temperature 142 1.266843e-12 8.529778819014085e-11 2.770788 65 0.009045366 343 0.0005257125606122449 1.996152 25 35 0.003720792 Mouse Phenotype abnormal splenic cell ratio 154 3.488023e-12 2.1655186950000003e-10 2.210328 96 0.01335931 899 0.027497127580645164 1.511839 33 61 0.004911445 Mouse Phenotype abnormal T cell subpopulation ratio 179 3.096402e-11 1.653893828044693e-9 2.239111 85 0.01182856 622 0.007682704658681673 1.610455 34 59 0.005060277 Mouse Phenotype abnormal cytotoxic T cell physiology 202 1.50159e-10 7.1072782128712866e-9 2.01467 101 0.01405511 1071 0.046025663084033615 1.397306 42 84 0.00625093 Mouse Phenotype increased erythroblast number 244 2.193782e-9 8.596208894262295e-8 2.478669 56 0.007792931 847 0.02248670441086187 1.796536 18 28 0.00267897 Mouse Phenotype abnormal thymus corticomedullary boundary morphology 255 3.619127e-9 1.3569597351764704e-7 2.596324 50 0.006957974 735 0.013721309800000003 1.802976 20 31 0.002976633 Mouse Phenotype abnormal erythrocyte osmotic lysis 263 5.358735e-9 1.948093738973384e-7 2.839095 42 0.005844698 1065 0.04594117955774648 1.64389 20 34 0.002976633 Mouse Phenotype abnormal erythrocyte physiology 291 2.388239e-8 7.84671927113402e-7 2.250984 59 0.008210409 951 0.03393746822712934 1.524334 30 55 0.00446495 Mouse Phenotype decreased spleen iron level 318 8.287296e-8 0.0000024916615426415096 3.090302 31 0.004313944 453 0.0023846526993377484 2.301445 14 17 0.002083643 Mouse Phenotype interstitial pneumonia 329 1.409907e-7 0.000004097301163221884 2.699601 37 0.005148901 318 0.00038580920018867925 2.286501 18 22 0.00267897 Mouse Phenotype abnormal brown adipose tissue physiology 342 2.19463e-7 0.000006135338429824562 2.609883 38 0.00528806 707 0.011700914080056577 2.059188 14 19 0.002083643