# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 51 4.861147e-48 1.254271242607843e-45 2.170185 439 0.03323995 428 0.011973435590654205 1.214701 151 248 0.01604335 GO Biological Process viral gene expression 71 6.166908e-43 1.1429625686197184e-40 2.887244 229 0.01733929 170 0.000046852046696470595 1.429493 91 127 0.009668508 GO Biological Process multi-organism metabolic process 84 4.753931e-41 7.447259289166665e-39 2.565207 267 0.02021655 174 0.0000502846606408046 1.397862 103 147 0.01094348 GO Biological Process chromatin assembly or disassembly 86 6.990702e-41 1.0696586932325582e-38 2.274625 336 0.02544105 340 0.004533852173823529 1.277701 114 178 0.0121122 GO Biological Process viral transcription 89 9.586598e-41 1.4174162144044942e-38 2.91175 214 0.01620353 198 0.00016067710552525254 1.430049 81 113 0.008606035 GO Biological Process nucleosome organization 94 1.082738e-39 1.515718015106383e-37 2.298044 319 0.02415386 371 0.007622788792183289 1.271671 109 171 0.01158096 GO Biological Process chromatin assembly 120 8.451321e-34 9.267577753250001e-32 2.221529 290 0.02195805 587 0.03719105528449744 1.237409 98 158 0.01041224 GO Biological Process nucleosome assembly 124 1.343333e-33 1.4255579795967743e-31 2.298821 268 0.02029227 464 0.015005672802586207 1.27849 91 142 0.009668508 GO Biological Process gene silencing 142 2.296118e-31 2.1277899128169014e-29 2.161334 285 0.02157947 548 0.02756282218978102 1.230254 111 180 0.01179346 GO Biological Process intracellular protein transmembrane transport 168 3.958567e-28 3.100641854345238e-26 3.020376 137 0.01037329 526 0.02415418257319392 1.425005 40 56 0.004249894 GO Biological Process protein transmembrane transport 179 2.377929e-27 1.7481099279888269e-25 2.857443 145 0.01097903 448 0.013877786876785715 1.425005 45 63 0.00478113 GO Biological Process DNA replication-independent nucleosome assembly 254 8.244399e-22 4.2711829307480313e-20 2.934897 109 0.008253199 437 0.012678127380778033 1.468024 39 53 0.004143646 GO Biological Process DNA replication-independent nucleosome organization 256 9.581302e-22 4.925013789765625e-20 2.911865 110 0.008328916 401 0.009230411724688279 1.477782 40 54 0.004249894 GO Biological Process cotranslational protein targeting to membrane 265 2.562583e-21 1.2724916866792454e-19 2.444809 146 0.01105474 125 6.081063398e-7 1.567505 77 98 0.008181045 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 298 2.174682e-19 9.602899475838926e-18 2.413751 135 0.01022185 149 0.000007587324847986577 1.539624 71 92 0.007543561 GO Biological Process mitochondrial translational termination 315 2.120085e-18 8.856570957142857e-17 2.469204 122 0.009237526 479 0.016966868455114824 1.352935 59 87 0.006268593 GO Biological Process mitochondrial translation 330 1.057565e-17 4.217120556060606e-16 2.22202 145 0.01097903 382 0.008141304506544503 1.342434 72 107 0.007649809 GO Biological Process mitochondrial translational elongation 342 2.480596e-17 9.54449203625731e-16 2.427841 118 0.008934656 551 0.027657184981851178 1.337828 57 85 0.006056099 GO Biological Process protein targeting to ER 358 7.645713e-17 2.8103334460055865e-15 2.209226 139 0.01052472 169 0.000046169612895266275 1.48144 75 101 0.007968551 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 372 2.208438e-16 7.812052591935484e-15 2.102116 151 0.01143333 411 0.010167306152554744 1.318733 78 118 0.008287293 GO Cellular Component ribosomal subunit 37 3.687365e-33 1.7220991135135134e-31 2.29606 265 0.02006512 33 0.0000052090167272727275 1.380329 128 185 0.01359966 GO Cellular Component large ribosomal subunit 64 2.516203e-20 6.7937481e-19 2.284033 159 0.01203907 71 0.00926650952112676 1.318439 76 115 0.008074798 GO Cellular Component mitochondrial ribosome 66 1.788458e-19 4.682508218181818e-18 2.678443 112 0.008480351 87 0.047198333793103446 1.314357 56 85 0.005949851 GO Cellular Component small ribosomal subunit 76 4.440091e-16 1.0095364799999999e-14 2.389844 112 0.008480351 47 0.00050037696 1.496255 54 72 0.005737357 GO Cellular Component cytosolic large ribosomal subunit 109 1.863255e-11 2.9538574678899083e-10 2.154798 95 0.007193155 80 0.02118444408 1.406316 43 61 0.004568636 GO Cellular Component cytosolic small ribosomal subunit 143 1.684726e-8 2.0358087608391606e-7 2.135189 68 0.005148785 75 0.015173876736 1.496255 33 44 0.003506162 GO Molecular Function protein transporter activity 17 7.525258e-24 1.8689199574117645e-21 2.261348 193 0.01461346 70 0.021557176145714285 1.350786 65 96 0.006906077 GO Molecular Function structural constituent of ribosome 18 1.643488e-23 3.854892408888889e-21 2.105569 223 0.01688499 36 0.0003767509909444444 1.354634 110 162 0.01168721 GO Molecular Function ribosomal small subunit binding 211 0.00001821815 0.000364535683886256 2.259553 34 0.002574392 82 0.04841847266341463 1.852506 13 14 0.001381215 Mouse Phenotype Single KO abnormal pre-B cell morphology 2 1.406411e-80 6.4392527635000004e-77 3.129308 386 0.02922693 218 0.008408961309633027 1.394101 58 83 0.006162346 Mouse Phenotype Single KO abnormal platelet activation 30 2.172707e-39 6.631825999666667e-37 2.6159 247 0.0187022 436 0.04990785524082569 1.314357 56 85 0.005949851 Mouse Phenotype Single KO abnormal platelet aggregation 31 1.465829e-38 4.3298697267741936e-36 2.631962 239 0.01809646 430 0.048558676595348835 1.330004 52 78 0.005524862 Mouse Phenotype Single KO decreased pre-B cell number 49 2.850243e-31 5.326464316530612e-29 2.443568 220 0.01665783 315 0.023609815775238095 1.420174 42 59 0.004462388 Mouse Phenotype Single KO abnormal single-positive T cell number 87 6.37794e-22 6.712965124137931e-20 2.159888 195 0.0147649 186 0.005050784582795699 1.459035 49 67 0.00520612 Mouse Phenotype Single KO abnormal splenocyte morphology 151 2.047078e-15 1.2413969037086094e-13 2.20887 126 0.009540395 146 0.0020360997174657535 1.57938 38 48 0.004037399 Mouse Phenotype Single KO increased thymus tumor incidence 165 1.491288e-14 8.276196494545453e-13 2.110819 131 0.009918982 350 0.028562043468571427 1.454692 35 48 0.003718657 Mouse Phenotype Single KO increased T cell derived lymphoma incidence 179 1.23582e-13 6.322013262569832e-12 2.06675 128 0.00969183 388 0.0380491050386598 1.443196 34 47 0.00361241 Mouse Phenotype Single KO aberrant origin of the right subclavian artery 185 2.483275e-13 1.2291540094594594e-11 2.139128 115 0.008707504 182 0.00471555613967033 1.710005 24 28 0.002549936 Mouse Phenotype Single KO abnormal splenocyte number 217 8.1818e-12 3.452568783410138e-10 2.041112 112 0.008480351 160 0.0031864465645625 1.586937 35 44 0.003718657 Mouse Phenotype Single KO decreased splenocyte number 222 1.231118e-11 5.078084471171171e-10 2.339345 81 0.006133111 176 0.004233587547329546 1.755606 22 25 0.002337442 Mouse Phenotype Single KO decreased fetal cardiomyocyte proliferation 380 1.955616e-7 0.000004712519924210526 2.586275 39 0.002952979 409 0.04463775551589242 1.995006 9 9 0.0009562261 Mouse Phenotype Single KO abnormal thymocyte activation 416 8.28242e-7 0.000018231278831730768 2.182551 49 0.003710154 429 0.048623371170163174 1.680005 16 19 0.001699958 Mouse Phenotype decreased pre-B cell number 3 2.407912e-91 7.674015544e-88 2.95475 477 0.03611721 263 0.0021166974297718633 1.381158 72 104 0.007649809 Mouse Phenotype abnormal pre-B cell morphology 4 1.313738e-83 3.1401622545e-80 2.642857 523 0.03960021 308 0.003991636790259739 1.320004 88 133 0.009349766 Mouse Phenotype abnormal pro-B cell morphology 12 2.906434e-61 2.3157012895e-58 2.370954 467 0.03536004 648 0.04594476580555555 1.264692 71 112 0.007543561 Mouse Phenotype abnormal platelet aggregation 49 2.853236e-40 5.567303958367347e-38 2.585849 258 0.0195351 451 0.014146307203104213 1.337079 63 94 0.006693583 Mouse Phenotype abnormal cerebellum fissure morphology 176 3.988223e-18 2.1665568240340905e-16 2.837285 94 0.007117438 453 0.014279513905298013 1.773339 16 18 0.001699958 Mouse Phenotype increased B cell derived lymphoma incidence 187 4.60535e-17 2.3546391096256686e-15 2.015816 175 0.01325055 594 0.036702779676767674 1.330004 52 78 0.005524862 Mouse Phenotype increased single-positive T cell number 192 1.30931e-16 6.519954640625001e-15 2.086885 156 0.01181192 289 0.003049543476955017 1.514727 41 54 0.004356141 Mouse Phenotype abnormal Bergmann glial cell morphology 196 1.964747e-16 9.584156156632654e-15 3.144907 72 0.005451654 489 0.01838658899631902 1.852506 13 14 0.001381215 Mouse Phenotype abnormal cerebellar granule cell precursor proliferation 210 3.73386e-15 1.6999731171428575e-13 2.794379 79 0.005981676 489 0.01838658899631902 1.852506 13 14 0.001381215 Mouse Phenotype abnormal third pharyngeal arch artery morphology 227 4.293923e-14 1.808554969295154e-12 2.410244 95 0.007193155 466 0.015788280368240343 1.710005 18 21 0.001912452 Mouse Phenotype abnormal third pharyngeal arch morphology 281 1.423188e-11 4.842384508185053e-10 2.075361 105 0.007950329 568 0.03241335544542254 1.567505 22 28 0.002337442 Mouse Phenotype decreased splenocyte number 296 7.478229e-11 2.4155184955743243e-9 2.156773 89 0.006738851 647 0.045913281523956725 1.482005 26 35 0.002762431