# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	22	5.946276e-69	3.556683903818182e-66	2.671478	426	0.01844715	386	0.0006053416134455959	1.289646	92	113	0.007761093	
GO Biological Process	regulation of DNA-templated transcription in response to stress	24	6.821973e-65	3.740430946125e-62	2.500294	451	0.01952973	330	0.00014127669878181818	1.304489	98	119	0.008267252	
GO Biological Process	endoplasmic reticulum unfolded protein response	60	8.96471e-42	1.9661103148333332e-39	2.27735	345	0.01493959	472	0.002372991185614407	1.264439	91	114	0.007676734	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	64	4.515136e-40	9.28354291e-38	2.497039	275	0.01190837	733	0.02479823423738063	1.259095	62	78	0.005230302	
GO Biological Process	cellular response to topologically incorrect protein	76	1.273919e-37	2.205723700131579e-35	2.060835	388	0.01680163	423	0.0010225473151536644	1.253543	110	139	0.009279568	
GO Biological Process	cellular response to unfolded protein	90	6.297608e-35	9.207802630222221e-33	2.075254	353	0.01528602	528	0.004793282885037878	1.243654	95	121	0.008014172	
GO Biological Process	liver regeneration	169	2.955798e-26	2.301499756331361e-24	2.552162	169	0.007318235	829	0.04768126347647768	1.357733	30	35	0.002530791	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	182	3.517888e-25	2.54351034021978e-23	2.670723	149	0.006452172	815	0.0411796131398773	1.446281	21	23	0.001771554	
GO Biological Process	mitochondrial translation	209	4.453699e-23	2.804125604832536e-21	2.050783	234	0.01013294	531	0.004912552078531074	1.258335	85	107	0.007170575	
GO Biological Process	cotranslational protein targeting to membrane	246	3.237695e-21	1.7319035977642274e-19	2.049414	214	0.009266877	266	0.000029905766721052634	1.357733	84	98	0.007086216	
GO Biological Process	protein-lipid complex subunit organization	248	3.869977e-21	2.053428521895161e-19	2.274031	168	0.007274932	664	0.016092866430421685	1.348104	40	47	0.003374388	
GO Biological Process	triglyceride homeostasis	261	2.131142e-20	1.0744711715708812e-18	2.719529	115	0.004979864	609	0.010214501969950739	1.43552	29	32	0.002446432	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	294	6.622612e-19	2.9641820172789114e-17	2.014414	197	0.008530724	334	0.00015096075716766464	1.342975	78	92	0.006580057	
GO Biological Process	negative regulation of response to endoplasmic reticulum stress	306	1.535557e-18	6.603396916013072e-17	2.183974	159	0.006885203	794	0.03525193347103275	1.346419	34	40	0.00286823	
GO Biological Process	cholesterol efflux	417	5.71802e-15	1.8043986853717024e-13	2.622285	87	0.003767375	757	0.03031418144121532	1.45202	22	24	0.001855914	
GO Biological Process	plasma lipoprotein particle organization	502	1.35152e-13	3.542759298804781e-12	2.022303	135	0.005845927	633	0.012430403008530806	1.368019	38	44	0.003205669	
GO Biological Process	protein import into mitochondrial matrix	619	9.859404e-12	2.0959595676252019e-10	3.069459	51	0.002208461	594	0.008864538196801346	1.584022	17	17	0.001434115	
GO Biological Process	ER-associated misfolded protein catabolic process	869	3.181738e-9	4.818008094591484e-8	3.148857	37	0.001602217	809	0.0410509725512979	1.584022	13	13	0.001096676	
GO Biological Process	2-oxoglutarate metabolic process	956	1.31554e-8	1.8107940230125521e-7	2.041523	77	0.003334344	594	0.008864538196801346	1.584022	17	17	0.001434115	
GO Biological Process	histone mRNA metabolic process	1135	1.679672e-7	0.000001947383598942731	2.12448	59	0.002554887	757	0.03031418144121532	1.45202	22	24	0.001855914	
GO Cellular Component	endopeptidase complex	74	1.263563e-16	2.9505903567567566e-15	2.023502	169	0.007318235	101	0.0019463199683168316	1.331497	58	69	0.004892863	
GO Cellular Component	proteasome complex	78	2.458561e-16	5.446658215384615e-15	2.012665	168	0.007274932	104	0.0025377840000000004	1.327783	57	68	0.004808503	
GO Cellular Component	U1 snRNP	168	1.204121e-8	1.238524457142857e-7	2.319504	58	0.002511584	149	0.022379154040268457	1.500653	18	19	0.001518475	
GO Cellular Component	U2 snRNP	264	0.000001845582	0.000012080173090909091	2.271775	42	0.001818733	149	0.022379154040268457	1.500653	18	19	0.001518475	
GO Molecular Function	unfolded protein binding	20	2.115967e-23	4.4668063369999996e-21	2.070645	232	0.01004633	89	0.0007686891035955056	1.300094	87	106	0.007339295	
GO Molecular Function	rRNA binding	34	1.38292e-19	1.7172612470588235e-17	2.600072	119	0.005153077	124	0.01767645509516129	1.320019	50	60	0.004217985	
Human Phenotype	Increased serum lactate	9	1.27808e-30	9.476253155555555e-28	2.190915	271	0.01173516	56	5.594321466071429e-7	1.40978	89	100	0.007508014	
Human Phenotype	Abnormal CSF metabolite level	21	1.639892e-20	5.210952055238095e-18	2.312138	157	0.006798597	214	0.002024818013130841	1.357733	54	63	0.004555424	
Human Phenotype	Exercise intolerance	29	5.081068e-19	1.169171267724138e-16	2.181192	164	0.007101719	315	0.014847558459999998	1.289847	57	70	0.004808503	
Human Phenotype	Increased CSF lactate	30	6.160699e-18	1.3703448142333335e-15	2.276671	140	0.006062443	273	0.007414966714652014	1.338226	49	58	0.004133626	
Human Phenotype	Glycosuria	74	9.125239e-12	8.228745925270269e-10	2.146981	99	0.004287013	268	0.006219285798507462	1.474779	27	29	0.002277712	
Human Phenotype	Prolonged neonatal jaundice	263	6.162102e-7	0.000015634869447148286	2.082728	56	0.002424977	409	0.04748554114669927	1.496021	17	18	0.001434115	
Mouse Phenotype	dry eyes	175	4.853312e-20	2.6515723446857144e-18	2.649641	118	0.005109774	432	0.014035145198611113	1.584022	16	16	0.001349755	
Mouse Phenotype	spleen atrophy	235	9.323752e-17	3.793378420085107e-15	2.267184	131	0.005672715	457	0.016902433725164114	1.462174	24	26	0.002024633	
Mouse Phenotype	abnormal transitional stage T1 B cell morphology	402	1.802903e-11	4.28794915e-10	2.001328	114	0.004936561	414	0.012647156853623187	1.466687	25	27	0.002108993	
Mouse Phenotype	increased liver adenoma incidence	419	5.565396e-11	1.2699463283054894e-9	2.171524	89	0.003853982	574	0.03373965299477352	1.414306	25	28	0.002108993	
Mouse Phenotype	abnormal nucleotide metabolism	491	7.986756e-10	1.5552214687576376e-8	2.726539	50	0.002165158	544	0.027990882022058825	1.584022	14	14	0.001181036