# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	negative regulation of stem cell differentiation	407	6.816822e-17	2.2039941203439802e-15	2.4376	114	0.005656445	809	0.034613976876390604	1.52641	17	18	0.001463247	
GO Biological Process	regulation of vascular endothelial growth factor receptor signaling pathway	468	4.434667e-15	1.2469184413034185e-13	2.095614	139	0.006896894	868	0.04284402122465438	1.429715	23	26	0.001979687	
GO Biological Process	negative regulation of actin filament depolymerization	635	3.394945e-12	7.035288386614174e-11	2.176384	100	0.004961794	779	0.03226230375224647	1.385313	30	35	0.0025822	
GO Biological Process	membrane protein proteolysis	638	3.574541e-12	7.372630880721003e-11	2.146371	103	0.005110648	722	0.02476352477839335	1.391727	31	36	0.002668273	
GO Biological Process	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	1143	1.124147e-7	0.0000012941951332458444	2.13526	60	0.002977077	705	0.02242892754468085	1.616199	14	14	0.001205027	
GO Biological Process	cellular biogenic amine biosynthetic process	1145	1.151862e-7	0.0000013237862059388646	2.076276	64	0.003175548	843	0.04114511788374852	1.469272	20	22	0.001721467	
GO Biological Process	negative regulation of receptor binding	1354	0.000001232307	0.000011976313008124076	2.235535	45	0.002232807	892	0.04634244270964126	1.616199	12	12	0.00103288	
GO Biological Process	purine nucleobase biosynthetic process	2266	0.000302877	0.0017588519165931155	2.068745	29	0.00143892	892	0.04634244270964126	1.616199	12	12	0.00103288	
GO Cellular Component	intrinsic component of mitochondrial membrane	58	6.043489e-24	1.8005429296551724e-22	2.333709	182	0.009030465	122	0.046285117377049184	1.268095	51	65	0.00438974	
GO Cellular Component	Sin3 complex	271	0.00001463084	0.00009329185062730628	2.022076	45	0.002232807	104	0.032282363076923073	1.616199	13	13	0.001118953	
Human Phenotype	Laryngomalacia	80	2.908173e-8	0.000002425779803625	2.316634	55	0.002728987	170	0.047167943488235296	1.616199	14	14	0.001205027	
Mouse Phenotype Single KO	increased integument system tumor incidence	167	5.500948e-22	3.0162982536526944e-20	2.102126	209	0.01037015	491	0.020528744470468433	1.275947	60	76	0.0051644	
Mouse Phenotype Single KO	increased circulating interferon-gamma level	208	1.842873e-18	8.113071183173078e-17	2.445087	125	0.006202243	294	0.0035437247391156466	1.428269	38	43	0.003270787	
Mouse Phenotype Single KO	decreased cytotoxic T cell cytolysis	308	3.320061e-14	9.870713823701297e-13	2.21018	115	0.005706063	603	0.040605873691542296	1.378523	29	34	0.002496127	
Mouse Phenotype Single KO	abnormal circulating interleukin-12b level	386	2.663075e-12	6.317559009067358e-11	2.72714	65	0.003225166	502	0.02167952583864542	1.481516	22	24	0.001893613	
Mouse Phenotype Single KO	osteosclerosis	773	2.686837e-7	0.0000031828417087968953	2.000328	66	0.003274784	634	0.045371678440063096	1.616199	12	12	0.00103288	
Mouse Phenotype	increased circulating interferon-gamma level	187	1.472432e-22	7.528300722994652e-21	2.518849	147	0.007293837	620	0.015043781665645161	1.336472	43	52	0.003701153	
Mouse Phenotype	microcytic anemia	336	4.151316e-15	1.1812717939285713e-13	2.458484	99	0.004912176	877	0.04338376247890536	1.393275	25	29	0.002151833	
Mouse Phenotype	decreased spleen iron level	380	6.593045e-14	1.6588448222368421e-12	2.701337	76	0.003770964	833	0.03748175989195678	1.521128	16	17	0.001377173	
Mouse Phenotype	abnormal circulating interleukin-12b level	412	4.909397e-13	1.1392899203155337e-11	2.502293	81	0.004019053	614	0.014284165143322477	1.449006	26	29	0.002237907