# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of anoikis 2 6.853542e-58 4.5092879589e-54 11.84026 82 0.02911932 384 0.039411513414062495 3.131936 9 23 0.003836317 GO Biological Process negative regulation of cell death 3 3.494545e-56 1.5328239218333332e-52 2.038126 538 0.1910511 37 0.000006375482152702703 1.498554 173 924 0.07374254 GO Biological Process negative regulation of anoikis 4 4.815758e-56 1.58426398805e-52 12.47069 77 0.02734375 280 0.013975887221785716 4.001918 8 16 0.00341006 GO Biological Process negative regulation of apoptotic process 5 4.209951e-55 1.1079749041799998e-51 2.096647 498 0.1768466 64 0.000056149000659374994 1.477927 154 834 0.06564365 GO Biological Process negative regulation of programmed cell death 6 7.794748e-55 1.7095181488666665e-51 2.084098 502 0.178267 57 0.00003474250722982456 1.485346 157 846 0.06692242 GO Biological Process regulation of metanephros development 19 4.526035e-37 3.134636556052631e-34 6.825323 75 0.02663352 338 0.0306249290204142 3.274297 9 22 0.003836317 GO Biological Process positive regulation of kidney development 25 6.689994e-34 3.5213452418400002e-31 5.034799 89 0.03160511 339 0.030871184795280233 2.601247 13 40 0.005541347 GO Biological Process in utero embryonic development 32 2.388685e-33 9.8227205984375e-31 2.370654 240 0.08522727 180 0.003085043478611111 1.636567 64 313 0.02728048 GO Biological Process regulation of kidney development 53 6.110335e-29 1.5170924200943396e-26 3.831887 101 0.03586648 197 0.00384836224142132 2.667945 18 54 0.007672634 GO Biological Process transforming growth factor beta receptor signaling pathway 57 2.104297e-28 4.857972670701754e-26 3.680266 104 0.03693182 146 0.0015116112833561642 2.323694 27 93 0.01150895 GO Biological Process cellular response to transforming growth factor beta stimulus 64 1.557686e-27 3.2027484490625e-25 2.738926 153 0.05433239 124 0.0008885801522903225 2.085507 37 142 0.01577153 GO Biological Process negative regulation of MAPK cascade 74 6.825417e-26 1.2137251662567566e-23 2.872495 133 0.04723011 315 0.022413073016190478 1.77863 34 153 0.01449275 GO Biological Process response to transforming growth factor beta 77 1.124412e-25 1.9215762997402598e-23 2.612512 154 0.0546875 125 0.000970502673272 2.055039 38 148 0.01619778 GO Biological Process actin filament bundle assembly 89 8.101665e-25 1.197863030730337e-22 4.961239 65 0.02308239 309 0.022047346626537217 2.501199 15 48 0.006393862 GO Biological Process cell differentiation involved in embryonic placenta development 97 3.183256e-24 4.318398526185567e-22 5.551757 57 0.02024148 262 0.010854823942366414 3.260822 11 27 0.004688832 GO Biological Process actin filament bundle organization 102 8.454682e-24 1.0907368670392157e-21 4.672032 66 0.0234375 283 0.015071528130035334 2.511007 16 51 0.006820119 GO Biological Process ERK1 and ERK2 cascade 115 3.205045e-23 3.667407578695652e-21 5.095553 59 0.0209517 358 0.037411037 2.964384 10 27 0.004262575 GO Biological Process formation of primary germ layer 121 4.820647e-23 5.242553212644628e-21 2.738406 127 0.04509943 286 0.01584926092797203 1.94876 28 115 0.01193521 GO Biological Process actomyosin structure organization 124 5.310734e-23 5.635802315e-21 3.489647 89 0.03160511 318 0.024359493890566034 2.000959 24 96 0.01023018 GO Biological Process gastrulation 166 8.087437e-21 6.410999005e-19 2.38379 146 0.05184659 266 0.01109653452368421 1.823659 36 158 0.01534527 GO Cellular Component focal adhesion 28 4.630148e-27 2.857462765714285e-25 2.211487 223 0.07919034 13 0.0000016078056369230768 1.812574 89 393 0.03793691 GO Cellular Component cell-substrate junction 29 6.216285e-27 3.7040484413793103e-25 2.187831 227 0.0806108 14 0.000001950284982857143 1.796372 90 401 0.03836317 GO Cellular Component cell-substrate adherens junction 30 7.09805e-27 4.0884768000000006e-25 2.204078 223 0.07919034 15 0.000002040846336 1.798842 89 396 0.03793691 GO Cellular Component stress fiber 48 5.603966e-16 2.01742776e-14 3.681696 56 0.01988636 47 0.048077813106382976 2.308799 15 52 0.006393862 GO Cellular Component actomyosin 51 1.123883e-14 3.8079800470588236e-13 3.176992 62 0.02201705 31 0.011635649651612904 2.376139 19 64 0.008098892 GO Cellular Component ruffle 72 6.113579e-11 1.4672589599999999e-9 2.100544 94 0.03338068 34 0.01903953091764706 1.77863 36 162 0.01534527 GO Cellular Component platelet dense tubular network 134 0.000007185185 0.00009265671402985074 5.075521 12 0.004261364 40 0.04303496304 4.365729 6 11 0.002557545 GO Molecular Function cadherin binding 11 3.494862e-27 1.3413915785454547e-24 2.437261 185 0.06569602 13 0.01028021924923077 1.65869 63 304 0.02685422 GO Molecular Function oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 20 1.93611e-22 4.08712821e-20 6.155315 48 0.01704545 25 0.030072833136 2.972853 13 35 0.005541347 GO Molecular Function retinal dehydrogenase activity 27 1.581314e-20 2.4727065585185184e-18 11.57187 28 0.009943182 11 0.009076655185454545 6.860431 6 7 0.002557545 GO Molecular Function organic hydroxy compound transmembrane transporter activity 247 0.00001511945 0.0002584385340080971 2.617582 26 0.009232955 34 0.04679397820588235 2.667945 14 42 0.005967604 Mouse Phenotype Single KO abnormal T cell proliferation 10 3.887576e-40 3.5598533432e-37 2.995231 196 0.06960227 177 0.01144091617683616 1.6253 53 261 0.02259165 Mouse Phenotype Single KO abnormal T cell activation 13 1.115552e-38 7.857776664615384e-36 2.854293 203 0.07208807 223 0.021149692948430495 1.550916 56 289 0.02387042 Mouse Phenotype Single KO abnormal T cell physiology 16 7.247026e-38 4.147563567625e-35 2.290738 291 0.1033381 213 0.019335280639906104 1.402577 92 525 0.03921569 Mouse Phenotype Single KO neoplasm 35 5.020772e-32 1.3135774058285714e-29 2.009972 326 0.115767 115 0.002672620147043478 1.451611 109 601 0.04646206 Mouse Phenotype Single KO abnormal tumor incidence 38 2.052961e-31 4.9470957571052636e-29 2.076316 297 0.1054688 133 0.0037707445060902256 1.476436 95 515 0.04049446 Mouse Phenotype Single KO abnormal artery development 43 5.155333e-31 1.0978461460697674e-28 2.950604 154 0.0546875 71 0.0005265775410704225 2.257492 33 117 0.0140665 Mouse Phenotype Single KO altered tumor susceptibility 45 2.018265e-30 4.106945023333333e-28 2.044233 298 0.1058239 138 0.004685541348695652 1.463559 96 525 0.04092072 Mouse Phenotype Single KO abnormal response to injury 55 9.939109e-29 1.6547712929636361e-26 2.106684 263 0.09339489 90 0.0010924931815555555 1.552983 91 469 0.03878943 Mouse Phenotype Single KO weight loss 64 9.148085e-28 1.3088908491406249e-25 2.417327 192 0.06818182 191 0.012230458356544504 1.600767 55 275 0.02344416 Mouse Phenotype Single KO abnormal angiogenesis 69 1.670452e-27 2.216859270144928e-25 2.076333 260 0.09232955 29 0.000034237865120689656 1.839391 74 322 0.03154305 Mouse Phenotype Single KO decreased T cell proliferation 87 8.13882e-26 8.56634192413793e-24 3.034635 122 0.04332386 203 0.016497945868965518 1.814203 34 150 0.01449275 Mouse Phenotype Single KO abnormal placenta morphology 101 2.485113e-24 2.253087103069307e-22 2.185474 205 0.0727983 273 0.035274239853479855 1.489673 59 317 0.02514919 Mouse Phenotype Single KO abnormal vascular endothelial cell physiology 109 8.819901e-24 7.409526005229358e-22 4.738968 65 0.02308239 294 0.04133145878911565 2.477378 13 42 0.005541347 Mouse Phenotype Single KO reduced female fertility 112 1.313334e-23 1.0737678069642858e-21 2.158955 204 0.07244318 198 0.014825238496969697 1.626796 50 246 0.02131287 Mouse Phenotype Single KO abnormal blood vessel physiology 142 6.426541e-22 4.1442137983802816e-20 2.055283 211 0.07492898 159 0.008046733906918239 1.550601 68 351 0.02898551 Mouse Phenotype Single KO abnormal pregnancy 152 1.71226e-21 1.0315240013157895e-19 2.574899 131 0.04651989 131 0.003812803543129771 1.946879 36 148 0.01534527 Mouse Phenotype Single KO abnormal dorsal aorta morphology 156 3.368567e-21 1.9773056422435896e-19 2.95571 103 0.0365767 117 0.003301472606495726 2.390756 23 77 0.009803922 Mouse Phenotype Single KO abnormal exocrine gland physiology 161 8.037146e-21 4.571189187701863e-19 2.630797 122 0.04332386 119 0.003606288998067227 1.903351 39 164 0.01662404 Mouse Phenotype Single KO abnormal kidney epithelium morphology 165 2.601072e-20 1.4435161396363637e-18 4.047973 65 0.02308239 238 0.02544951530042017 2.371507 16 54 0.006820119 Mouse Phenotype Single KO abnormal right subclavian artery morphology 169 4.738364e-20 2.5674082336094673e-18 4.294643 60 0.02130682 170 0.00959180667882353 2.972853 13 35 0.005541347 Mouse Phenotype abnormal liver lobule morphology 1 1.740917e-55 1.6644907437e-51 3.702312 205 0.0727983 482 0.03533707911410788 1.540487 46 239 0.01960784 Mouse Phenotype abnormal liver parenchyma morphology 3 5.849046e-54 1.8640909602e-50 3.494798 214 0.07599432 441 0.02659156919047619 1.544047 49 254 0.02088662 Mouse Phenotype abnormal T cell proliferation 23 1.971858e-39 8.196927973043479e-37 2.623697 237 0.08416193 103 0.00014591431966019417 1.696465 78 368 0.03324808 Mouse Phenotype abnormal response to injury 24 3.404353e-39 1.3562091263749999e-36 2.138815 346 0.1228693 81 0.0000742347555888889 1.562393 114 584 0.04859335 Mouse Phenotype abnormal liver vasculature morphology 26 6.311845e-38 2.3210596171153845e-35 3.778258 136 0.04829545 561 0.049813508754010694 1.77076 25 113 0.01065644 Mouse Phenotype abnormal T cell activation 29 1.014321e-36 3.3441114072413797e-34 2.437624 251 0.08913352 110 0.00020997711747272726 1.64382 84 409 0.03580563 Mouse Phenotype abnormal T cell physiology 32 6.481368e-36 1.93651123275e-33 2.043689 351 0.1246449 99 0.00012224356584848486 1.494969 130 696 0.05541347 Mouse Phenotype absent type I pneumocytes 47 8.468001e-33 1.722607607680851e-30 14.28161 41 0.01455966 167 0.0013539017216766468 6.860431 6 7 0.002557545 Mouse Phenotype reduced female fertility 53 1.036241e-31 1.8693396605660378e-29 2.253173 252 0.08948864 166 0.0013471644827710845 1.682162 62 295 0.02642796 Mouse Phenotype abnormal hepatoblast physiology 59 3.707173e-31 6.007505263220339e-29 18.62554 34 0.01207386 299 0.007774397644816054 8.003836 4 4 0.00170503 Mouse Phenotype abnormal exocrine gland physiology 67 3.606983e-30 5.1472185765671635e-28 2.64664 178 0.06321023 261 0.005271825503448275 1.70991 47 220 0.0200341 Mouse Phenotype abnormal hepatoblast migration 69 4.374051e-30 6.060913276956522e-28 19.59307 32 0.01136364 498 0.037401864048192776 8.003836 3 3 0.001278772 Mouse Phenotype pale kidney 90 3.346527e-28 3.555127183e-26 5.211798 71 0.02521307 297 0.007567357663636363 2.667945 15 45 0.006393862 Mouse Phenotype decreased type I pneumocyte number 103 3.581535e-27 3.324568556796117e-25 7.373442 51 0.0181108 132 0.0005867500954772727 5.145323 9 14 0.003836317 Mouse Phenotype abnormal keratinocyte physiology 118 4.147328e-26 3.360390085423729e-24 3.510931 101 0.03586648 240 0.004060218081250001 2.054082 29 113 0.01236147 Mouse Phenotype abnormal trophoblast layer morphology 144 8.782638e-24 5.83130568875e-22 2.781606 128 0.04545455 419 0.02510184644391408 1.711512 34 159 0.01449275 Mouse Phenotype altered tumor pathology 147 1.099917e-23 7.153949957142856e-22 2.277307 183 0.0649858 266 0.005589044296240601 1.600767 59 295 0.02514919 Mouse Phenotype thin epidermis 153 2.408583e-23 1.5051282394117647e-21 3.97833 77 0.02734375 301 0.007981837264784053 2.561228 16 50 0.006820119 Mouse Phenotype abnormal type I pneumocyte morphology 154 2.82551e-23 1.754201370779221e-21 5.74213 53 0.01882102 160 0.0012701459840625 4.001918 11 22 0.004688832 Mouse Phenotype short nasal bone 159 4.221882e-23 2.5387052705660378e-21 4.030835 75 0.02663352 370 0.015641677133513512 2.667945 13 39 0.005541347