# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process DNA replication-dependent nucleosome assembly 1 4.779853e-29 6.289808562700001e-25 35.8441 24 0.01431981 100 0.0017988642498 3.731975 13 32 0.006360078 GO Biological Process regulation of hematopoietic progenitor cell differentiation 2 5.516807e-25 3.62978316565e-21 5.970586 55 0.03281623 174 0.012278972968390806 2.113685 26 113 0.01272016 GO Biological Process regulation of hematopoietic stem cell differentiation 3 3.64439e-24 1.5985509336666666e-20 6.262516 51 0.03042959 185 0.016557215724864866 2.14052 24 103 0.01174168 GO Biological Process chromatin silencing at rDNA 4 2.854108e-23 9.389301793e-20 17.03603 26 0.01551313 90 0.0017043814601111111 3.572489 14 36 0.006849315 GO Biological Process negative regulation of gene expression, epigenetic 6 3.768949e-22 8.265933315166667e-19 5.619384 51 0.03042959 33 0.00003656632091424243 2.659221 33 114 0.01614481 GO Biological Process regulation of megakaryocyte differentiation 11 1.056082e-19 1.2633620943636366e-16 5.351259 47 0.02804296 14 0.0000022460138372857142 3.384463 28 76 0.01369863 GO Biological Process chromatin silencing 15 1.405465e-18 1.2329675956666668e-15 6.351105 38 0.02267303 44 0.0000761233495659091 2.746449 29 97 0.01418787 GO Biological Process DNA conformation change 19 3.714483e-17 2.5725727261578947e-14 2.784772 89 0.05310263 148 0.007965635273378378 1.699974 52 281 0.02544031 GO Biological Process protein heterotetramerization 20 4.510161e-17 2.96746042995e-14 8.013998 29 0.0173031 124 0.0038259007204838706 3.131727 15 44 0.007338552 GO Biological Process regulation of gene expression, epigenetic 21 1.100464e-16 6.895717036190477e-14 2.99953 77 0.04594272 58 0.00024282075820689656 1.963222 53 248 0.02592955 GO Biological Process hemostasis 26 7.060061e-16 3.5732054884230767e-13 2.41272 105 0.06264916 79 0.0012047850708607594 1.772296 60 311 0.02935421 GO Biological Process gene silencing 28 1.787741e-15 8.401744221071429e-13 3.466052 58 0.03460621 39 0.00006065357625384616 2.245564 44 180 0.02152642 GO Biological Process blood coagulation 29 2.685155e-15 1.218412229137931e-12 2.386111 103 0.06145585 105 0.002210280886095238 1.741213 58 306 0.02837573 GO Biological Process coagulation 30 2.861746e-15 1.2552571871333334e-12 2.383664 103 0.06145585 106 0.0026698071645283017 1.729906 58 308 0.02837573 GO Biological Process protein-DNA complex subunit organization 36 2.571136e-14 9.398216284444444e-12 2.655866 79 0.04713604 78 0.001168384404602564 1.874025 51 250 0.02495108 GO Biological Process protein-DNA complex assembly 41 6.752223e-14 2.1671342062682926e-11 2.753239 72 0.04295943 61 0.0003452986316393443 2.013457 48 219 0.02348337 GO Biological Process nucleosome assembly 42 1.080957e-13 3.3867412292857144e-11 3.447233 51 0.03042959 55 0.0002157607061090909 2.328946 36 142 0.01761252 GO Biological Process myeloid leukocyte mediated immunity 45 2.425971e-13 7.094078308666667e-11 2.105754 115 0.06861575 207 0.033401604126086955 1.438184 80 511 0.03913894 GO Biological Process leukocyte degranulation 48 5.202852e-13 1.4263401972499998e-10 2.104674 112 0.06682578 225 0.037545796856888886 1.43595 78 499 0.03816047 GO Biological Process nucleosome organization 51 5.641877e-13 1.4557148910392156e-10 3.122199 55 0.03281623 98 0.0018081003102040816 2.041422 38 171 0.018591 GO Cellular Component nuclear nucleosome 13 2.378522e-21 3.1616046276923077e-19 15.32174 25 0.01491647 34 0.01044173985882353 2.98558 13 40 0.006360078 GO Cellular Component nucleosome 17 1.129774e-19 1.1483820423529411e-17 6.641021 39 0.02326969 1 2.40352704e-7 3.149623 36 105 0.01761252 GO Cellular Component DNA packaging complex 20 1.847536e-17 1.596271104e-15 5.53016 40 0.02386635 2 2.260606752e-7 3.034793 37 112 0.01810176 GO Cellular Component nuclear chromosome, telomeric region 29 5.462557e-15 3.254930515862069e-13 4.156582 45 0.02684964 36 0.018966220800000003 1.94863 28 132 0.01369863 GO Cellular Component chromosome, telomeric region 30 4.611425e-14 2.6561807999999998e-12 3.582672 50 0.02983294 45 0.0396567936 1.760268 32 167 0.01565558 GO Cellular Component nuclear chromatin 33 1.449727e-12 7.591297745454546e-11 2.177192 100 0.05966587 3 1.6947619200000004e-7 2.122175 73 316 0.03571429 GO Cellular Component protein-DNA complex 39 5.774078e-12 2.558360713846154e-10 2.83708 58 0.03460621 8 0.000001323350568 2.319338 51 202 0.02495108 GO Cellular Component uropod 60 1.078207e-7 0.00000310523616 8.648053 11 0.006563246 50 0.04970975615999999 4.239877 6 13 0.002935421 GO Cellular Component ruffle membrane 96 0.00008634227 0.00155416086 2.190824 30 0.01789976 46 0.03914385808695652 2.087818 20 88 0.009784736 GO Cellular Component melanosome 102 0.0001485383 0.0025164135529411767 2.09204 31 0.01849642 41 0.033241991180487804 2.012259 23 105 0.01125245 GO Cellular Component cortical cytoskeleton 112 0.0002194324 0.003385528457142857 2.135169 28 0.01670644 35 0.013975106194285715 2.243191 21 86 0.01027397 GO Cellular Component cortical actin cytoskeleton 146 0.00100817 0.011932313424657535 2.224345 20 0.01193317 39 0.02277379495384615 2.449706 16 60 0.007827789 GO Molecular Function cadherin binding 14 7.141512e-10 2.1536759760000002e-7 2.014328 91 0.05429594 21 0.005765531032380953 1.72245 57 304 0.0278865 GO Molecular Function chromatin DNA binding 31 0.000001622425 0.00022096381774193546 2.529815 34 0.0202864 28 0.040991820199999994 2.119938 24 104 0.01174168 Mouse Phenotype Single KO abnormal platelet morphology 25 6.417339e-12 2.35054292892e-9 2.225071 90 0.05369928 77 0.035840557461038966 1.657696 48 266 0.02348337 Mouse Phenotype Single KO decreased myeloid cell number 33 1.180626e-11 3.276058267272727e-9 2.044589 106 0.06324582 67 0.029594521967164177 1.626444 54 305 0.02641879 Mouse Phenotype Single KO decreased erythrocyte cell number 42 7.471836e-11 1.6290381488571428e-8 2.356594 72 0.04295943 51 0.022099539709803925 1.889774 36 175 0.01761252 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 72 3.665673e-9 4.6620232862499994e-7 3.170411 36 0.02147971 49 0.01991197125102041 2.773253 16 53 0.007827789 Mouse Phenotype Single KO abnormal erythrocyte physiology 75 5.657586e-9 6.907535333599999e-7 4.485112 23 0.01372315 64 0.0285292773515625 2.857991 14 45 0.006849315 Mouse Phenotype Single KO abnormal erythropoiesis 78 7.099213e-9 8.334294030897435e-7 2.496512 51 0.03042959 74 0.032607470658108116 2.087818 25 110 0.01223092 Mouse Phenotype Single KO abnormal megakaryocyte progenitor cell morphology 97 4.049133e-8 0.0000038224650392783504 2.620679 42 0.02505967 86 0.04216853867906977 2.192209 21 88 0.01027397 Mouse Phenotype Single KO abnormal iron level 102 7.27918e-8 0.000006534848162745097 2.71631 38 0.02267303 84 0.042282600116666666 2.007112 26 119 0.01272016 Mouse Phenotype Single KO increased kidney iron level 142 5.708696e-7 0.00003681304878309859 8.322522 10 0.005966587 79 0.03564108404050633 4.5932 7 14 0.003424658 Mouse Phenotype Single KO thin ventricular wall 143 5.727672e-7 0.00003667712762517482 2.338876 43 0.02565632 35 0.006427554696 2.392291 25 96 0.01223092 Mouse Phenotype Single KO abnormal enterocyte proliferation 394 0.0002866433 0.006661910401269035 2.924576 15 0.008949881 89 0.04265867673483146 3.594678 9 23 0.004403131 Mouse Phenotype abnormal megakaryocyte progenitor cell morphology 66 8.084707e-11 1.1711800549545454e-8 2.730575 55 0.03281623 79 0.013660696287341772 2.091213 28 123 0.01369863 Mouse Phenotype extramedullary hematopoiesis 77 2.656892e-10 3.299031741818182e-8 2.448484 63 0.0375895 84 0.014009551185714286 1.889774 36 175 0.01761252 Mouse Phenotype abnormal granulocyte physiology 107 6.062636e-9 5.41727689682243e-7 2.081354 75 0.0447494 97 0.015531686792783503 1.682491 50 273 0.02446184 Mouse Phenotype decreased erythrocyte cell number 109 6.394479e-9 5.60895538706422e-7 2.033631 79 0.04713604 116 0.02524711453189655 1.710022 43 231 0.02103718 Mouse Phenotype abnormal erythropoiesis 110 6.540613e-9 5.684981899363636e-7 2.320355 59 0.03520286 114 0.023951512705263158 1.911264 31 149 0.01516634 Mouse Phenotype abnormal embryonic hematopoiesis 114 1.192624e-8 0.0000010002349178947369 2.918435 38 0.02267303 102 0.01830686850882353 2.560144 17 61 0.008317025 Mouse Phenotype abnormal erythrocyte physiology 129 3.182669e-8 0.0000023588758379069765 3.925951 24 0.01431981 142 0.039584681125352114 2.505382 15 55 0.007338552 Mouse Phenotype abnormal liver iron level 131 3.494494e-8 0.000002550447109465649 4.401036 21 0.01252983 121 0.027963996996694218 2.843409 13 42 0.006360078 Mouse Phenotype abnormal iron level 133 3.597957e-8 0.0000025864711937593982 2.632248 42 0.02505967 112 0.021412636331250002 1.973375 29 135 0.01418787 Mouse Phenotype increased liver iron level 134 3.947302e-8 0.000002816429434477612 4.813649 19 0.01133652 104 0.018662391698076923 3.149623 12 35 0.005870841 Mouse Phenotype abnormal iron homeostasis 154 1.971995e-7 0.00001224301571103896 2.467723 42 0.02505967 131 0.034745053520610684 1.902897 29 140 0.01418787 Mouse Phenotype abnormal reticulocyte cell number 174 4.626941e-7 0.000025424243046551725 2.516688 38 0.02267303 141 0.03844327565106383 2.022693 24 109 0.01174168 Mouse Phenotype abnormal spleen red pulp morphology 199 0.000001362663 0.00006546945197487438 2.092155 51 0.03042959 135 0.03687803763555556 1.84921 31 154 0.01516634 Mouse Phenotype abnormal reticulocyte morphology 202 0.000001431887 0.00006777362181683168 2.366262 39 0.02326969 138 0.03729738478913043 1.997043 25 115 0.01223092 Mouse Phenotype abnormal neutrophil physiology 214 0.000002103791 0.00009399226986448599 2.042985 52 0.03102625 130 0.03498296353846153 1.768505 36 187 0.01761252 Mouse Phenotype abnormal spleen iron level 225 0.000002928721 0.00012445111769333333 4.155529 16 0.009546539 122 0.02843988414590164 3.157825 11 32 0.005381605 Mouse Phenotype abnormal erythrocyte osmotic lysis 229 0.000003470267 0.00014488743575109171 4.347454 15 0.008949881 149 0.042057831565771815 2.97207 11 34 0.005381605 Mouse Phenotype increased intestinal iron level 546 0.001302869 0.02281452474175824 5.1369 6 0.003579952 74 0.010729916231756757 7.655333 5 6 0.002446184 Mouse Phenotype abnormal intestinal iron level 550 0.001345648 0.023392255505454547 5.103957 6 0.003579952 113 0.022373484573451327 6.561714 5 7 0.002446184