# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	3	5.691084e-30	2.4962991452e-26	5.711035	70	0.01093921	382	0.027015485560994763	2.468768	11	16	0.002103653	
GO Biological Process	mitochondrial transport	19	3.933288e-21	2.724112462736842e-18	2.073845	204	0.03187998	89	0.000004460149902022472	1.592632	106	239	0.02027156	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	22	1.777419e-20	1.0631389373181818e-17	2.320167	154	0.02406626	231	0.003115569842640693	1.529043	66	155	0.01262192	
GO Biological Process	cellular response to epidermal growth factor stimulus	23	2.194401e-20	1.2554835982173914e-17	3.191949	89	0.01390842	422	0.033489873277251184	1.889966	20	38	0.003824823	
GO Biological Process	regulation of DNA-templated transcription in response to stress	29	6.330714e-19	2.87261605262069e-16	2.480872	124	0.01937803	362	0.021807112975414364	1.508796	50	119	0.009562058	
GO Biological Process	liver regeneration	32	1.538742e-18	6.327595618125001e-16	3.651443	67	0.01047039	396	0.02889030869267677	1.949365	19	35	0.003633582	
GO Biological Process	mRNA catabolic process	33	1.633114e-18	6.512165795757575e-16	2.136552	165	0.02578528	226	0.0028899038866371683	1.449861	86	213	0.01644674	
GO Biological Process	nuclear-transcribed mRNA catabolic process	41	8.152956e-17	2.616701170829268e-14	2.133622	149	0.02328489	223	0.0027893999731838565	1.469019	81	198	0.01549053	
GO Biological Process	negative regulation of endoplasmic reticulum unfolded protein response	43	1.383285e-16	4.233173794186046e-14	7.058081	31	0.004844507	305	0.010530988066229508	3.191942	8	9	0.001529929	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	46	2.607707e-16	7.459742698478262e-14	2.844752	83	0.01297078	424	0.034132335594339626	1.958692	18	33	0.003442341	
GO Biological Process	mitochondrial membrane organization	69	1.23906e-14	2.3630131217391307e-12	2.146421	126	0.01969058	154	0.0004480817231948052	1.679631	58	124	0.01109199	
GO Biological Process	protein refolding	85	1.05083e-13	1.6268084670588235e-11	7.079942	25	0.00390686	428	0.03503946544859813	2.22296	13	21	0.002486135	
GO Biological Process	regulation of plasma lipoprotein particle levels	113	1.709838e-12	1.9911290479646015e-10	2.481766	78	0.0121894	346	0.018522018907225435	1.67249	34	73	0.006502199	
GO Biological Process	regulation of mitochondrial membrane permeability	114	1.773138e-12	2.046730082631579e-10	2.386601	84	0.01312705	242	0.004305315944132231	1.770872	36	73	0.006884682	
GO Biological Process	dicarboxylic acid metabolic process	115	1.862394e-12	2.1310645779130436e-10	2.088127	112	0.01750273	137	0.00025775647492700727	1.795468	49	98	0.009370817	
GO Biological Process	cellular protein complex disassembly	120	2.296978e-12	2.518827791833333e-10	2.17587	101	0.01578372	299	0.008985282072240804	1.538972	54	126	0.01032702	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	124	2.482414e-12	2.6343617601612903e-10	2.384789	83	0.01297078	258	0.005778045494573644	1.582446	52	118	0.00994454	
GO Biological Process	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	133	6.782293e-12	6.710390495263158e-10	3.138756	50	0.007813721	451	0.0406006210421286	1.969223	17	31	0.0032511	
GO Biological Process	regulation of membrane permeability	144	1.501019e-11	1.3716603486805558e-9	2.223778	89	0.01390842	296	0.008619291705067568	1.684636	38	81	0.007267164	
GO Biological Process	translational elongation	178	1.38551e-10	1.0242655106741574e-8	2.255368	78	0.0121894	338	0.01742070955739645	1.538972	48	112	0.009179575	
GO Cellular Component	ribosomal subunit	29	1.379268e-17	8.218534841379309e-16	2.324732	130	0.02031567	42	0.00009395679085714284	1.572247	81	185	0.01549053	
GO Cellular Component	large ribosomal subunit	31	2.261688e-16	1.2607086658064516e-14	2.69798	91	0.01422097	39	0.000027280020184615382	1.779855	57	115	0.01090075	
GO Cellular Component	azurophil granule lumen	39	6.870966e-13	3.044366473846154e-11	2.417427	85	0.01328333	74	0.034267104	1.538972	39	91	0.007458405	
GO Cellular Component	mitochondrial large ribosomal subunit	44	3.671371e-12	1.44184752e-10	3.570806	43	0.0067198	59	0.011414552949152543	1.830673	26	51	0.00497227	
GO Cellular Component	mitochondrial ribosome	46	5.599267e-12	2.1033768208695652e-10	2.862757	58	0.009063916	73	0.03233585095890411	1.563113	37	85	0.007075923	
GO Cellular Component	cytosolic large ribosomal subunit	84	2.00614e-7	0.000004126916571428571	2.293882	49	0.007657446	57	0.00979233347368421	1.766034	30	61	0.005737235	
GO Cellular Component	very-low-density lipoprotein particle	151	0.00001810928	0.00020723732344370865	2.950983	21	0.003281763	92	0.04856983513043479	2.154561	12	20	0.002294894	
GO Cellular Component	DNA-directed RNA polymerase I complex	210	0.0002990373	0.0024606497828571425	3.217415	13	0.002031567	69	0.02190727846956522	2.564954	10	14	0.001912412	
GO Molecular Function	structural constituent of ribosome	9	6.527207e-17	3.061985328222222e-14	2.35799	121	0.0189092	33	0.0011477881862424243	1.573805	71	162	0.01357812	
Human Phenotype	Central apnea	24	1.167993e-19	3.24750720375e-17	9.148212	31	0.004844507	52	0.004623579257115385	3.590935	8	8	0.001529929	
Human Phenotype	Abnormality of brainstem morphology	37	2.260149e-14	4.0762092640540535e-12	2.517623	89	0.01390842	63	0.011683723923809524	1.795468	33	66	0.006310958	
Human Phenotype	Abnormality of cells of the monocyte/macrophage lineage	41	1.019286e-13	1.658950116585366e-11	4.832397	35	0.005469605	78	0.02879624499871795	2.209806	16	26	0.003059858	
Human Phenotype	Severe short stature	62	3.264351e-11	3.5133893908064514e-9	2.997971	50	0.007813721	91	0.049457276816483514	2.019901	18	32	0.003442341	
Human Phenotype	Mildly elevated creatine phosphokinase	266	0.00002742744	0.0006880575455639098	2.866291	21	0.003281763	88	0.04416561448181818	2.334108	13	20	0.002486135	
Mouse Phenotype Single KO	absent hypoglossal nerve	60	1.99016e-14	3.0373158533333338e-12	5.639644	32	0.005000781	137	0.02190921866642336	2.633352	11	15	0.002103653	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	69	1.086687e-13	1.4421438926086957e-11	2.306614	100	0.01562744	176	0.04326370329545454	1.761591	26	53	0.00497227	
Mouse Phenotype Single KO	increased incidence of corneal inflammation	128	2.728297e-11	1.951798096015625e-9	4.03603	34	0.00531333	171	0.04199623502280701	2.468768	11	16	0.002103653	
Mouse Phenotype Single KO	decreased bone ossification	301	4.933326e-7	0.000015008128299667776	2.242901	48	0.007501172	156	0.03599052605320513	2.127962	16	27	0.003059858	
Mouse Phenotype Single KO	absent hypoglossal canal	357	0.000002386831	0.00006122188085994398	5.195604	13	0.002031567	170	0.04222106866764706	3.142068	7	8	0.001338688	
Mouse Phenotype	extramedullary hematopoiesis	2	1.399187e-37	6.6888134535e-34	2.524471	248	0.03875606	180	0.009614307886666666	1.456894	71	175	0.01357812	
Mouse Phenotype	absent hypoglossal nerve	69	1.99016e-14	2.7576695304347826e-12	5.639644	32	0.005000781	214	0.014644811555607477	2.633352	11	15	0.002103653	
Mouse Phenotype	abnormal embryonic hematopoiesis	102	2.170937e-12	2.0349341820588234e-10	2.132231	106	0.01656509	271	0.028852346125461253	1.707166	29	61	0.005545993	
Mouse Phenotype	increased incidence of corneal inflammation	190	8.843102e-10	4.449942011684211e-8	3.370184	36	0.005625879	308	0.03537781087012987	2.22296	13	21	0.002486135	
Mouse Phenotype	abnormal vertebral transverse process morphology	197	1.606309e-9	7.79589865431472e-8	3.597782	32	0.005000781	208	0.0142564071	2.938038	9	11	0.00172117	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	251	2.52118e-8	9.603586446215139e-7	3.061363	34	0.00531333	276	0.029336033620652176	2.034863	17	30	0.0032511	
Mouse Phenotype	abnormal cellular replicative senescence	273	5.763687e-8	0.000002018557194395604	2.003585	73	0.01140803	295	0.034018426922033905	1.581721	37	84	0.007075923	
Mouse Phenotype	absent hypoglossal canal	387	0.000002386831	0.00005896767749612403	5.195604	13	0.002031567	269	0.027859669946096656	3.142068	7	8	0.001338688	
Mouse Phenotype	absent amnion	457	0.00001008352	0.00021095959457330418	2.111581	42	0.006563526	298	0.034084900832214764	2.051963	16	28	0.003059858	
Mouse Phenotype	increased liver copper level	637	0.0001571511	0.002358746730141287	5.391888	8	0.001250195	237	0.018776311354430378	3.590935	6	6	0.001147447	
Mouse Phenotype	abnormal copper level	718	0.000384659	0.0051221792465181055	3.316982	12	0.001875293	284	0.03138180097605634	2.693201	9	12	0.00172117	
Mouse Phenotype	corneal scarring	799	0.001051619	0.012583891438047558	2.801669	13	0.002031567	237	0.018776311354430378	3.590935	6	6	0.001147447