# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular response to insulin stimulus	43	2.043438e-68	6.253395498139534e-66	2.058738	720	0.02763385	331	0.00032794406589728095	1.279172	115	148	0.01008241	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	57	6.584119e-64	1.5200074021228069e-61	2.490057	448	0.0171944	650	0.016664604162615382	1.238321	85	113	0.007452218	
GO Biological Process	cellular response to epidermal growth factor stimulus	58	7.27753e-64	1.6511209874137934e-61	2.950746	335	0.01285742	720	0.029355974466666667	1.386306	32	38	0.002805541	
GO Biological Process	response to epidermal growth factor	68	3.289953e-60	6.366542871617647e-58	2.799595	343	0.01316446	706	0.026396804889518417	1.371866	35	42	0.00306856	
GO Biological Process	liver regeneration	69	1.436199e-59	2.7389771943478256e-57	3.39973	254	0.009748609	552	0.006975814752173913	1.458097	31	35	0.002717868	
GO Biological Process	regulation of DNA-templated transcription in response to stress	84	7.988293e-57	1.2514041379404763e-54	2.294672	467	0.01792362	585	0.009603307734700854	1.245055	90	119	0.007890584	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	89	1.481126e-56	2.1899030375280897e-54	2.097987	567	0.02176166	664	0.01947786262003012	1.200161	113	155	0.009907066	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	171	2.105717e-42	1.620416959239766e-40	2.483187	295	0.0113222	367	0.0006164948473297002	1.546467	31	33	0.002717868	
GO Biological Process	triglyceride homeostasis	193	1.232733e-39	8.40493966165803e-38	3.437391	164	0.006294377	660	0.01831020618969697	1.440459	28	32	0.002454848	
GO Biological Process	regulation of mitochondrial membrane permeability	246	8.048255e-34	4.305162095325203e-32	2.163133	310	0.01189791	448	0.0019424002837276784	1.353073	60	73	0.005260389	
GO Biological Process	regulation of membrane permeability	303	5.609298e-30	2.436064435049505e-28	2.006643	327	0.01255037	427	0.0015203252190866513	1.34138	66	81	0.005786428	
GO Biological Process	regulation of extracellular matrix organization	363	1.966513e-26	7.128745059779615e-25	2.23959	221	0.008482057	699	0.02512798588412017	1.433821	27	31	0.002367175	
GO Biological Process	negative regulation of cyclin-dependent protein kinase activity	425	1.632857e-23	5.055709473647058e-22	2.612067	144	0.00552677	768	0.03425159194140625	1.456288	23	26	0.002016483	
GO Biological Process	drug transport	493	7.704354e-22	2.0564217907910752e-20	2.548659	139	0.005334869	822	0.044586293916058395	1.419171	25	29	0.002191829	
GO Biological Process	heart valve formation	647	5.18256e-18	1.0540542046367851e-16	2.4425	122	0.004682403	714	0.0281806619789916	1.646239	13	13	0.001139751	
GO Biological Process	negative regulation of Notch signaling pathway	654	6.851456e-18	1.3785674236085628e-16	2.152951	158	0.006064095	617	0.013424807534521879	1.446695	29	33	0.002542521	
GO Biological Process	virion assembly	799	1.292219e-15	2.1281989763454315e-14	2.323917	115	0.00441374	652	0.017678159848773006	1.417595	31	36	0.002717868	
GO Biological Process	fatty-acyl-CoA biosynthetic process	906	4.419726e-14	6.419334926490066e-13	2.159914	120	0.004605642	445	0.0018925220572584272	1.53649	28	30	0.002454848	
GO Biological Process	release of cytochrome c from mitochondria	935	8.629917e-14	1.2145569818502673e-12	2.334891	99	0.003799655	826	0.04611413833171912	1.489454	19	21	0.00166579	
GO Biological Process	vacuolar acidification	1588	1.868325e-8	1.5481919820528967e-7	2.219538	62	0.002379582	755	0.03344927168476821	1.496581	20	22	0.001753463	
GO Cellular Component	cleavage furrow	52	8.40439e-31	2.7928434461538466e-29	2.281136	250	0.009595087	63	0.0002709877028571429	1.456288	46	52	0.004032965	
GO Cellular Component	cell division site part	63	3.966618e-27	1.0879866514285714e-25	2.070688	272	0.01043945	70	0.0006829394194285714	1.403351	52	61	0.004559004	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	110	3.570046e-37	2.971901020181818e-35	2.024275	401	0.01539052	428	0.02283659523130841	1.256806	71	93	0.006224794	
Mouse Phenotype Single KO	abnormal osteoblast differentiation	145	3.9907e-33	2.5201958551724135e-31	2.116392	319	0.01224333	486	0.03191713801440329	1.353574	37	45	0.003243907	
Mouse Phenotype Single KO	increased respiratory quotient	265	7.97661e-24	2.7562950101886793e-22	2.193289	207	0.007944732	358	0.011836432839385473	1.377465	41	49	0.003594599	
Mouse Phenotype	extramedullary hematopoiesis	20	5.463333e-93	2.61174634065e-90	2.169998	868	0.03331414	775	0.04046983781032258	1.166478	124	175	0.01087147	
Mouse Phenotype	thick epidermis	49	5.370754e-68	1.047954673346939e-65	2.174535	630	0.02417962	402	0.0035762896716417915	1.266338	90	117	0.007890584	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	137	3.968384e-43	2.769468571094891e-41	2.834925	238	0.009134523	403	0.0036096404858560797	1.52865	26	28	0.002279502	
Mouse Phenotype	dry eyes	193	1.775971e-34	8.797957891709844e-33	3.164401	159	0.006102476	803	0.046263107174346195	1.543349	15	16	0.001315097	
Mouse Phenotype	decreased fibroblast cell migration	237	1.143724e-30	4.6139853012658225e-29	2.028342	326	0.01251199	593	0.0163924554232715	1.378246	36	43	0.003156234	
Mouse Phenotype	increased follicular B cell number	321	1.33708e-25	3.9824990280373836e-24	2.309782	200	0.00767607	579	0.015164882091191711	1.440459	28	32	0.002454848	
Mouse Phenotype	increased respiratory quotient	328	2.564018e-25	7.473956127439025e-24	2.130904	236	0.009057762	511	0.00911778122818004	1.352268	46	56	0.004032965	
Mouse Phenotype	abnormal lymph organ development	449	6.875313e-21	1.4640282314699332e-19	2.047666	211	0.008098254	807	0.047346249713754646	1.411062	24	28	0.002104156	
Mouse Phenotype	dry skin	529	3.75066e-18	6.778839368620038e-17	2.122208	166	0.006371138	732	0.03544957570491803	1.358147	33	40	0.002893214	
Mouse Phenotype	abnormal preputial gland morphology	555	1.441417e-17	2.483132961621622e-16	2.209902	146	0.005603531	838	0.04960983841288783	1.481615	18	20	0.001578117	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	945	1.526985e-10	1.5449210142857142e-9	2.078667	94	0.003607753	492	0.008004107747560977	1.481615	27	30	0.002367175	
Mouse Phenotype	abnormal hematopoietic stem cell proliferation	1065	2.249609e-9	2.0195785585915495e-8	3.027024	40	0.001535214	648	0.02256081726388889	1.646239	13	13	0.001139751