# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process glycolytic process 56 2.648118e-7 0.00006222604421785714 5.017627 16 0.008830022 372 0.017052390826075268 2.571689 14 38 0.005204461 GO Biological Process glucose catabolic process 59 2.865811e-7 0.00006391729991355931 5.768467 14 0.007726269 346 0.013341476537572252 2.888399 12 29 0.004460967 GO Biological Process ATP generation from ADP 63 4.42169e-7 0.00009235717255555556 4.823577 16 0.008830022 402 0.02140205619726368 2.505748 14 39 0.005204461 GO Biological Process canonical glycolysis 66 7.034479e-7 0.00014025258963787878 5.804514 13 0.007174393 336 0.012748866084226191 3.071331 11 25 0.004089219 GO Biological Process ADP metabolic process 67 7.098805e-7 0.00013942264924626864 4.386792 17 0.009381898 427 0.024458306636299765 2.379647 15 44 0.005576208 GO Biological Process glycolytic process through glucose-6-phosphate 70 8.325432e-7 0.00015650622812571428 5.715818 13 0.007174393 376 0.01720468205398936 2.953203 11 26 0.004089219 GO Biological Process peptidyl-tyrosine autophosphorylation 92 0.000002538764 0.0003631260377826087 2.900327 26 0.01434879 288 0.007327182500347222 2.524788 17 47 0.006319703 GO Biological Process purine ribonucleoside diphosphate metabolic process 118 0.000006615324 0.0007377207501355932 3.054331 22 0.01214128 374 0.01719460141631016 2.210428 19 60 0.007063197 GO Biological Process ribonucleoside diphosphate metabolic process 125 0.000009294067 0.0009784050212239999 2.986827 22 0.01214128 424 0.023898584397877357 2.139123 19 62 0.007063197 GO Biological Process gap junction assembly 186 0.00004781046 0.0033824615222580643 5.576488 9 0.004966887 300 0.008138573933666666 5.235223 6 8 0.002230483 GO Biological Process posttranscriptional gene silencing 330 0.0006922945 0.027605767653030307 2.497287 17 0.009381898 396 0.021005067041919193 2.28202 17 52 0.006319703 GO Biological Process lysosome localization 349 0.0008612272 0.03247246052951289 2.622785 15 0.008278146 402 0.02140205619726368 2.505748 14 39 0.005204461 GO Biological Process organelle transport along microtubule 386 0.001137487 0.03877769801295337 2.153749 21 0.0115894 406 0.021533922386945813 2.115242 20 66 0.007434944 GO Biological Process negative regulation of heart contraction 424 0.001483825 0.04605106880896226 2.479391 15 0.008278146 280 0.00611709274 3.338403 11 23 0.004089219 GO Biological Process posttranscriptional gene silencing by RNA 434 0.001580508 0.047921439566820274 2.380879 16 0.008830022 500 0.039069018363999994 2.189897 16 51 0.005947955 GO Biological Process positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway 451 0.001705685 0.04976742553215077 5.977384 5 0.002759382 526 0.046568074887832704 5.584238 4 5 0.001486989 GO Cellular Component cytoplasmic side of membrane 25 1.792652e-10 1.2390810624000001e-8 2.343512 70 0.03863135 59 0.012384906955932203 1.644573 45 191 0.01672862 GO Cellular Component cytoplasmic side of plasma membrane 26 2.723747e-10 1.81024416e-8 2.390049 66 0.03642384 65 0.015384477046153845 1.663908 41 172 0.01524164 GO Cellular Component extrinsic component of cytoplasmic side of plasma membrane 34 6.535207e-9 3.321422851764706e-7 2.621779 47 0.02593819 51 0.008050870588235295 1.921183 30 109 0.01115242 GO Cellular Component extrinsic component of plasma membrane 38 1.544427e-7 0.000007023078568421052 2.145811 57 0.03145695 68 0.01750991294117647 1.699151 37 152 0.01375465 GO Cellular Component ruffle membrane 51 0.00000198626 0.00006729916235294118 2.43167 36 0.01986755 60 0.013023838079999999 1.983039 25 88 0.00929368 GO Molecular Function non-membrane spanning protein tyrosine kinase activity 32 0.00000502688 0.00066323398 2.788829 26 0.01434879 62 0.0333757544 2.326766 17 51 0.006319703 GO Molecular Function protein phosphorylated amino acid binding 78 0.0005047997 0.027323901710256414 2.300746 21 0.0115894 44 0.0059018666318181815 2.696933 17 44 0.006319703 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 17 0.000002280275 0.0012282634220588235 3.385605 21 0.0115894 222 0.01444672254009009 2.641194 14 37 0.005204461 Mouse Phenotype Single KO decreased single-positive T cell number 32 0.00001079924 0.0030902700212499996 3.050373 21 0.0115894 52 0.00009693839690769231 3.315641 19 40 0.007063197 Mouse Phenotype Single KO abnormal response to stress-induced hyperthermia 89 0.0002787164 0.028676472750561798 4.941521 8 0.004415011 312 0.031508503266025646 4.188178 6 10 0.002230483 Mouse Phenotype Single KO increased circulating luteinizing hormone level 90 0.0002882197 0.029324753254444443 2.536446 19 0.01048565 137 0.003140499424671533 3.240852 13 28 0.004832714 Mouse Phenotype Single KO increased luteinizing hormone level 94 0.0003050316 0.029714620863829786 2.524582 19 0.01048565 167 0.006226606469461078 3.024796 13 30 0.004832714 Mouse Phenotype Single KO abnormal single-positive T cell number 111 0.0004643624 0.03830780627747748 2.099017 26 0.01434879 92 0.0009332183363260869 2.500405 24 67 0.008921933 Mouse Phenotype Single KO decreased response to stress-induced hyperthermia 113 0.000500061 0.04052264227433628 6.196497 6 0.003311258 239 0.01610754230669456 6.980297 4 4 0.001486989 Mouse Phenotype decreased single-positive T cell number 12 4.510048e-9 0.0000035933807440000002 2.884783 41 0.02262693 52 0.0000020548556359615384 2.775299 33 83 0.01226766 Mouse Phenotype abnormal single-positive T cell number 40 0.000001066126 0.00025483076715 2.149299 49 0.02704194 71 0.000009507889318309858 2.308445 42 127 0.01561338 Mouse Phenotype enlarged liver sinusoidal spaces 54 0.000003038055 0.0005379045158333334 3.113515 23 0.01269316 278 0.0030089020712589926 2.724018 16 41 0.005947955 Mouse Phenotype abnormal peripheral B cell anergy 96 0.00005400899 0.0053789578478125 42.89848 3 0.001655629 689 0.04076122119013063 6.980297 3 3 0.001115242 Mouse Phenotype abnormal vas deferens morphology 100 0.00006469656 0.0061856381016 2.960207 18 0.009933775 672 0.03859925090625 2.47688 11 31 0.004089219 Mouse Phenotype disorganized retinal ganglion layer 110 0.0001102475 0.00958251225 3.807581 12 0.006622517 330 0.005375712811818182 5.235223 6 8 0.002230483 Mouse Phenotype abnormal liver sinusoid morphology 115 0.0001254198 0.010427293111304348 2.176817 29 0.01600442 668 0.03712957098502994 1.879311 21 78 0.007806691 Mouse Phenotype abnormal copulation 119 0.0001561488 0.012545703166386554 2.967595 16 0.008830022 230 0.001523963955521739 3.490149 12 24 0.004460967 Mouse Phenotype abnormal response to stress-induced hyperthermia 135 0.0002787164 0.01973931481777778 4.941521 8 0.004415011 529 0.01940335366162571 4.188178 6 10 0.002230483 Mouse Phenotype decreased circulating follicle stimulating hormone level 137 0.0003017655 0.02105970763138686 2.33966 22 0.01214128 278 0.0030089020712589926 2.724018 16 41 0.005947955 Mouse Phenotype abnormal cardiac muscle relaxation 138 0.0003937907 0.027282846976086957 2.471439 19 0.01048565 660 0.03565787987727272 2.393245 12 35 0.004460967 Mouse Phenotype decreased response to stress-induced hyperthermia 153 0.000500061 0.031248909941176472 6.196497 6 0.003311258 404 0.009949377759653464 6.980297 4 4 0.001486989 Mouse Phenotype increased luteinizing hormone level 185 0.0008661725 0.044764731202702704 2.114744 23 0.01269316 263 0.0022359979882129277 2.696933 17 44 0.006319703