# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of interleukin-1 production 337 0.00003058047 0.0011940902217507418 2.141744 36 0.008763389 364 0.018045189757692308 1.917639 22 42 0.004289335 GO Biological Process positive regulation of interleukin-1 beta production 459 0.0001941861 0.005567091263398693 2.03804 32 0.007789679 367 0.018770628658310626 1.978891 20 37 0.003899396 GO Biological Process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 592 0.0007435635 0.016527959622466216 2.104137 24 0.005842259 458 0.04046280447379913 2.019833 16 29 0.003119516 GO Biological Process miRNA mediated inhibition of translation 609 0.0008467722 0.01829667550049261 3.02521 12 0.00292113 409 0.025685821048899753 2.745711 9 12 0.001754728 GO Cellular Component ribonucleoprotein granule 30 3.913536e-12 2.254196736e-10 2.013685 118 0.02872444 33 0.0022124683636363636 1.483153 79 195 0.01540261 GO Cellular Component cytoplasmic ribonucleoprotein granule 36 2.217333e-11 1.06431984e-9 2.00396 111 0.02702045 40 0.00758836512 1.452441 73 184 0.01423279 GO Cellular Component SWI/SNF superfamily-type complex 42 2.379922e-9 9.791679085714286e-8 2.445703 57 0.01387537 55 0.04136524101818182 1.627088 32 72 0.006239033 GO Cellular Component P-body 57 4.303541e-7 0.000013046524294736842 2.117926 55 0.01338851 53 0.03817693222641509 1.587881 36 83 0.007018912 GO Cellular Component cytoplasmic microtubule 65 0.000006222567 0.0001654245504 2.283194 37 0.009006816 56 0.04397473028571428 1.757255 24 50 0.004679275 GO Cellular Component aminoacyl-tRNA synthetase multienzyme complex 172 0.002535966 0.025477611906976744 3.191953 9 0.002190847 48 0.028740636 2.745711 9 12 0.001754728 GO Molecular Function mitogen-activated protein kinase binding 49 0.000002991646 0.000257769988 2.953907 25 0.006085686 82 0.02492471086829268 2.16945 16 27 0.003119516 Mouse Phenotype Single KO increased sensitivity to induced cell death 17 4.524397e-9 0.000002437053137 2.014208 84 0.02044791 274 0.04459933559854015 1.429274 57 146 0.01111328 Mouse Phenotype Single KO decreased adipocyte glucose uptake 18 6.716096e-9 0.0000034166272817777776 4.283722 24 0.005842259 308 0.04980453650324675 2.440632 10 15 0.001949698 Mouse Phenotype Single KO abnormal adipocyte glucose uptake 44 2.795159e-7 0.00005817107037045454 2.580682 38 0.009250243 249 0.031562204177108436 1.99688 18 33 0.003509456 Mouse Phenotype Single KO increased cellular sensitivity to hydrogen peroxide 142 0.0001010264 0.006514779892957747 3.23364 15 0.003651412 263 0.03997897455513308 2.312177 12 19 0.002339637 Mouse Phenotype Single KO decreased mitotic index 236 0.000640873 0.024866415512711865 3.125977 12 0.00292113 107 0.0026417825188785045 3.660948 8 8 0.001559758 Mouse Phenotype increased fibroblast apoptosis 17 5.674601e-10 3.191462362411765e-7 3.069032 42 0.01022395 432 0.04051192674305555 1.754204 23 48 0.004484305 Mouse Phenotype abnormal fibroblast apoptosis 28 4.803934e-9 0.0000016403718919285713 2.375123 58 0.01411879 172 0.0024863541702906974 1.830474 35 70 0.006823942 Mouse Phenotype decreased adipocyte glucose uptake 29 5.557815e-9 0.0000018323541108620688 4.028393 26 0.006329114 303 0.017761299305940594 2.440632 12 18 0.002339637 Mouse Phenotype increased adrenal gland tumor incidence 39 3.325208e-8 0.000008151875304615383 4.637624 20 0.004868549 401 0.03331460113466334 2.368848 11 17 0.002144668 Mouse Phenotype abnormal adipocyte glucose uptake 55 2.015258e-7 0.00003503251225090909 2.508406 41 0.009980526 312 0.019637662728846154 1.921997 21 40 0.004094365 Mouse Phenotype increased pulmonary respiratory rate 63 4.207214e-7 0.00006384948103809524 2.614267 36 0.008763389 133 0.0008264823137593985 2.301167 22 35 0.004289335 Mouse Phenotype decreased classified tumor incidence 70 6.71028e-7 0.0000916528386857143 2.98001 28 0.006815969 345 0.023395426129565217 2.09197 16 28 0.003119516 Mouse Phenotype tachypnea 92 0.000002162094 0.00022469326884782607 3.680403 19 0.004625122 203 0.004395887345172414 2.644018 13 18 0.002534607 Mouse Phenotype decreased B cell apoptosis 93 0.000002553075 0.0002624725814516129 2.838221 27 0.006572541 161 0.001913903758322981 2.614963 15 21 0.002924547 Mouse Phenotype decreased sebaceous gland number 157 0.00003552064 0.002163139102165605 4.304641 12 0.00292113 409 0.03549742158190709 3.660948 5 5 0.0009748489 Mouse Phenotype increased cellular sensitivity to oxidative stress 175 0.00005728572 0.0031297643938285715 2.325492 28 0.006815969 432 0.04051192674305555 1.754204 23 48 0.004484305 Mouse Phenotype abnormal lung endothelial cell proliferation 365 0.001536356 0.040244108810958905 3.182714 10 0.002434275 212 0.005101758619811321 3.660948 7 7 0.001364788 Mouse Phenotype abnormal cerebellar granule cell precursor proliferation 391 0.001864723 0.04559748491815857 2.160656 19 0.004625122 206 0.004477235290776699 2.876459 11 14 0.002144668 Mouse Phenotype increased lung endothelial cell proliferation 396 0.001991675 0.048086880492424246 4.070968 7 0.001703992 409 0.03549742158190709 3.660948 5 5 0.0009748489