# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 14 4.36686e-42 4.104536481428571e-39 2.301156 336 0.03524599 248 0.00204250283766129 1.32887 125 248 0.01755125 GO Biological Process regulation of megakaryocyte differentiation 37 2.726049e-25 9.69515643e-23 2.782386 139 0.01458093 434 0.02194041911981567 1.491692 43 76 0.00603763 GO Biological Process rRNA metabolic process 44 1.818567e-24 5.438755262045454e-22 2.017307 257 0.02695898 326 0.006466865418404908 1.292791 127 259 0.01783207 GO Biological Process rRNA processing 45 4.487979e-24 1.3123847924666668e-21 2.025792 250 0.02622469 349 0.009648668963323783 1.286853 123 252 0.01727043 GO Biological Process nuclear-transcribed mRNA catabolic process 79 1.323736e-20 2.2049420283544304e-18 2.028132 211 0.02213364 304 0.004918682698355263 1.34487 101 198 0.01418141 GO Biological Process positive regulation of mRNA catabolic process 83 3.815357e-20 6.048949730481928e-18 3.420624 80 0.008391902 226 0.0012439057135840707 2.109183 20 25 0.0028082 GO Biological Process positive regulation of mRNA metabolic process 96 6.402633e-18 8.7762757965625e-16 2.664461 103 0.01080457 264 0.0027054256018939397 1.723851 34 52 0.00477394 GO Biological Process regulation of mRNA catabolic process 110 1.065978e-16 1.2752004092727272e-14 2.79262 88 0.009231092 250 0.0023262980241999997 1.956097 23 31 0.00322943 GO Biological Process platelet aggregation 131 3.912314e-15 3.929934345496183e-13 2.768709 80 0.008391902 225 0.0011966022605333334 1.864826 29 41 0.00407189 GO Biological Process platelet formation 143 2.435467e-14 2.2411405771328672e-12 3.620393 51 0.005349837 519 0.04269545306743738 1.942668 14 19 0.00196574 GO Biological Process gene silencing by miRNA 144 2.866362e-14 2.6193373304166667e-12 2.663186 80 0.008391902 184 0.00020636973634782609 1.917439 32 44 0.00449312 GO Biological Process erythrocyte homeostasis 156 6.802365e-14 5.737969297115384e-12 2.06971 130 0.01363684 239 0.0017801401600418408 1.609279 47 77 0.00659927 GO Biological Process regulation of membrane permeability 163 8.6275e-14 6.964986042944785e-12 2.096496 125 0.01311235 211 0.0007324885630331754 1.627456 50 81 0.0070205 GO Biological Process endoplasmic reticulum unfolded protein response 167 1.062578e-13 8.372732875449102e-12 2.062772 129 0.01353194 530 0.044403158549056604 1.364493 59 114 0.00828419 GO Biological Process erythrocyte differentiation 185 4.77374e-13 3.3955483599999995e-11 2.084542 119 0.01248295 287 0.0042084160116376305 1.604813 42 69 0.00589722 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 215 9.378621e-12 5.740152266930232e-10 2.957284 54 0.005664534 399 0.016875721623057643 2.142139 13 16 0.00182533 GO Biological Process regulation of mitochondrial membrane permeability 217 1.085104e-11 6.580130661751152e-10 2.059714 108 0.01132907 241 0.001819725895020747 1.625226 45 73 0.00631845 GO Biological Process response to arsenic-containing substance 230 2.569919e-11 1.470328874826087e-9 2.811703 56 0.005874331 332 0.006786496618975903 1.909174 21 29 0.00294861 GO Biological Process posttranscriptional gene silencing by RNA 234 3.174727e-11 1.7853090851709403e-9 2.291031 81 0.008496801 290 0.004305994613275863 1.705957 33 51 0.00463353 GO Biological Process posttranscriptional gene silencing 238 5.768122e-11 3.1891898066386556e-9 2.26169 81 0.008496801 330 0.006597244712121212 1.67315 33 52 0.00463353 GO Cellular Component sex chromatin 87 1.930483e-9 3.834338648275862e-8 5.858381 19 0.001993077 117 0.04391819815384615 2.636479 6 6 0.00084246 GO Cellular Component nuclear pore outer ring 302 0.001599896 0.009154371814569535 2.803604 12 0.001258785 77 0.0013775467885714285 2.636479 10 10 0.0014041 GO Cellular Component granular component 313 0.002219594 0.012253860805111821 3.567104 8 0.0008391902 117 0.04391819815384615 2.636479 6 6 0.00084246 GO Cellular Component Bcl-2 family protein complex 356 0.00499733 0.024256702921348315 2.427017 12 0.001258785 110 0.017708685381818183 2.636479 7 7 0.00098287 GO Molecular Function mitogen-activated protein kinase binding 53 1.104512e-7 0.000008798584271698114 2.39307 47 0.004930242 91 0.029379209200000006 1.8553 19 27 0.00266779 GO Molecular Function polyubiquitin binding 58 1.691867e-7 0.000012315624955172414 2.170859 56 0.005874331 98 0.03497475935306122 1.640476 28 45 0.00393148 GO Molecular Function acylglycerol O-acyltransferase activity 79 7.869942e-7 0.000042059360916455696 2.166239 50 0.005244939 72 0.019429485675 1.883199 20 28 0.0028082 GO Molecular Function 1-acylglycerol-3-phosphate O-acyltransferase activity 125 0.000009634819 0.00032542564654400004 2.116919 42 0.004405748 39 0.0005257484472307693 2.358954 17 19 0.00238697 GO Molecular Function lysophosphatidic acid acyltransferase activity 130 0.00001176111 0.00038196466476923076 2.098587 42 0.004405748 44 0.0019992801227272728 2.241007 17 20 0.00238697 Human Phenotype Gastrointestinal hemorrhage 29 6.617665e-10 1.5227475360344828e-7 2.739863 50 0.005244939 47 0.041348662387234045 1.926657 19 26 0.00266779 Human Phenotype Hematochezia 180 0.00001777584 0.0006589898906666666 3.052904 20 0.002097975 41 0.026360628585365854 2.636479 9 9 0.00126369 Mouse Phenotype Single KO abnormal erythropoiesis 10 1.405159e-28 1.2867040962999999e-25 2.177351 253 0.02653939 40 3.024950851e-7 1.749663 73 110 0.01024993 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 16 2.884076e-26 1.65059274575e-23 3.3847 108 0.01132907 115 0.00020883478087826087 2.033855 27 35 0.00379107 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 19 2.41467e-23 1.1637438521052632e-20 3.389386 95 0.009965383 220 0.0071267474204545446 1.909174 21 29 0.00294861 Mouse Phenotype Single KO decreased erythroid progenitor cell number 29 1.330204e-19 4.200233802758621e-17 2.316787 148 0.01552502 111 0.0001831291930900901 1.861044 36 51 0.00505476 Mouse Phenotype Single KO abnormal iron level 35 2.898218e-18 7.582566350285714e-16 2.111297 168 0.01762299 244 0.01150474971967213 1.417938 64 119 0.00898624 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 36 4.158543e-18 1.0577716180833334e-15 2.245047 145 0.01521032 144 0.0005764955320625001 1.790816 36 53 0.00505476 Mouse Phenotype Single KO abnormal iron homeostasis 42 1.012427e-16 2.207331914047619e-14 2.013865 171 0.01793769 268 0.01791147126380597 1.393261 65 123 0.00912665 Mouse Phenotype Single KO extramedullary hematopoiesis 44 3.23407e-16 6.730540679545455e-14 2.005763 167 0.0175181 172 0.0013989478977906977 1.503255 65 114 0.00912665 Mouse Phenotype Single KO decreased mean corpuscular volume 49 9.494382e-15 1.7742868566122448e-12 2.06991 139 0.01458093 301 0.031608108262458474 1.435416 49 90 0.00688009 Mouse Phenotype Single KO pale liver 65 6.117197e-14 8.617718912153845e-12 2.144647 120 0.01258785 212 0.005356978899528302 1.548931 47 80 0.00659927 Mouse Phenotype Single KO decreased circulating total protein level 76 3.355574e-13 4.043025147105263e-11 2.254394 101 0.01059478 256 0.0156537913453125 1.590978 35 58 0.00491435 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 79 4.731329e-13 5.484149323164556e-11 2.147733 111 0.01164376 313 0.037697789198083066 1.490184 39 69 0.00547599 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 99 1.049214e-11 9.704699593939393e-10 2.390233 78 0.008182104 232 0.009645541737931033 1.781404 25 37 0.00351025 Mouse Phenotype Single KO abnormal platelet volume 140 6.485939e-10 4.242267387357143e-8 2.050708 90 0.00944089 331 0.04767319553172205 1.526382 33 57 0.00463353 Mouse Phenotype Single KO increased respiratory quotient 148 1.573015e-9 9.732498888513514e-8 2.171942 75 0.007867408 288 0.025028227171875 1.614171 30 49 0.0042123 Mouse Phenotype Single KO decreased prostaglandin level 253 8.392549e-7 0.000030375719839130438 3.182552 25 0.002622469 286 0.02479350920874126 2.230866 11 13 0.00154451 Mouse Phenotype Single KO abnormal leukotriene level 299 0.000002331798 0.0000714122885819398 4.243808 16 0.00167838 303 0.03225155842244225 2.372831 9 10 0.00126369 Mouse Phenotype Single KO abnormal thymus development 306 0.00000290907 0.00008705344441176471 2.400412 36 0.003776356 195 0.0029834398220512817 2.306919 14 16 0.00196574 Mouse Phenotype Single KO delayed hepatic development 649 0.0007923454 0.011179517454237288 2.095837 24 0.002517571 332 0.04812050388253012 2.197065 10 12 0.0014041 Mouse Phenotype abnormal erythropoiesis 13 6.68427e-34 4.916023497692308e-31 2.150341 311 0.03262352 57 2.471317215789474e-9 1.716365 97 149 0.01361977 Mouse Phenotype abnormal embryonic erythrocyte morphology 26 8.128195e-25 2.9889873998076926e-22 3.101358 115 0.01206336 145 0.00000905627151310345 2.095662 31 39 0.00435271 Mouse Phenotype decreased erythroid progenitor cell number 30 3.363028e-24 1.0717970236e-21 2.268874 194 0.02035036 122 0.0000014048635598360655 1.838597 53 76 0.00744173 Mouse Phenotype abnormal megakaryocyte progenitor cell morphology 31 1.065327e-23 3.2856746603225806e-21 2.059908 236 0.02475611 110 7.330236171818182e-7 1.671913 78 123 0.01095198 Mouse Phenotype abnormal bone marrow hematopoietic cell morphology 35 4.040357e-22 1.1037100936285715e-19 2.016577 231 0.02423162 84 5.726316233928571e-8 1.735682 79 120 0.01109239 Mouse Phenotype abnormal embryonic erythropoiesis 36 4.606767e-22 1.2234805357500002e-19 3.129577 100 0.01048988 300 0.0014085249265 1.956097 23 31 0.00322943 Mouse Phenotype abnormal megakaryocyte morphology 38 7.783332e-22 1.9583272961052634e-19 2.06865 214 0.02244834 87 8.179735517586207e-8 1.757652 74 111 0.01039034 Mouse Phenotype abnormal iron level 39 9.452742e-22 2.317376058e-19 2.148605 195 0.02045526 371 0.004841430114016173 1.406122 72 135 0.01010952 Mouse Phenotype abnormal iron homeostasis 40 2.000763e-21 4.78232376075e-19 2.096947 203 0.02129445 383 0.00555441676762402 1.393567 74 140 0.01039034 Mouse Phenotype microcytic anemia 42 3.70125e-21 8.425631249999999e-19 3.832541 73 0.00765761 363 0.004509802541322314 1.909174 21 29 0.00294861 Mouse Phenotype increased red blood cell distribution width 47 3.404788e-20 6.926208099574468e-18 2.198138 171 0.01793769 182 0.00004611768837857143 1.677759 56 88 0.00786296 Mouse Phenotype decreased mean corpuscular volume 52 1.452882e-19 2.6713470773076924e-17 2.137332 176 0.01846218 254 0.0005080941250393701 1.542091 62 106 0.00870542 Mouse Phenotype poikilocytosis 55 4.775306e-19 8.301218302909091e-17 3.537076 72 0.007552712 481 0.01623977194864865 1.69005 25 39 0.00351025 Mouse Phenotype abnormal red blood cell distribution width 56 4.800036e-19 8.195204320714285e-17 2.090543 180 0.01888178 183 0.00004606365977213115 1.634617 62 100 0.00870542 Mouse Phenotype abnormal reticulocyte cell number 57 8.005658e-19 1.3428437918947368e-16 2.084218 179 0.01877688 380 0.005118393288157895 1.451273 60 109 0.0084246 Mouse Phenotype reticulocytosis 59 1.409593e-18 2.28425740220339e-16 2.174243 160 0.0167838 518 0.021913535137065638 1.41337 52 97 0.00730132 Mouse Phenotype abnormal proerythroblast morphology 71 2.329562e-17 3.137034124225352e-15 2.057464 169 0.01772789 232 0.0002932030658793103 1.656249 49 78 0.00688009 Mouse Phenotype abnormal embryonic hematopoiesis 75 5.482569e-17 6.9891789612e-15 2.106374 156 0.01636421 186 0.00004796272051774193 1.81528 42 61 0.00589722 Mouse Phenotype decreased mean corpuscular hemoglobin 85 1.763714e-15 1.9838670063529414e-13 2.137548 136 0.01426623 379 0.005122884707651715 1.540799 45 77 0.00631845 Mouse Phenotype abnormal megakaryocyte differentiation 91 5.55243e-15 5.833712442857143e-13 2.770821 79 0.008287003 376 0.004913199560106383 1.871049 22 31 0.00308902