# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process neuron fate commitment 20 1.37301e-8 0.000009033719295 2.717544 42 0.03671329 72 0.009362440253194444 3.374514 14 69 0.01240035 GO Biological Process lung alveolus development 21 1.730571e-8 0.000010844087518571429 3.560722 28 0.02447552 18 0.000700452765838889 5.39401 12 37 0.01062888 GO Biological Process negative regulation of auditory receptor cell differentiation 36 1.654539e-7 0.00006047799639166666 14.01056 8 0.006993007 108 0.02641903187777778 16.63153 3 3 0.002657219 GO Biological Process lung saccule development 57 4.17273e-7 0.00009633149836842106 7.520317 11 0.009615385 126 0.041034231882539685 9.503733 4 7 0.003542958 GO Biological Process loop of Henle development 63 7.560929e-7 0.0001579274043031746 4.927197 15 0.01311189 132 0.043072178365151516 6.929805 5 12 0.004428698 GO Biological Process embryonic digestive tract development 79 0.00000133256 0.00022196401316455696 2.92589 27 0.0236014 33 0.0015422340024848487 5.227053 11 35 0.009743136 GO Biological Process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 164 0.00001302173 0.001044835030914634 3.875581 15 0.01311189 102 0.022640923865686276 4.751866 8 28 0.007085917 GO Biological Process foregut morphogenesis 226 0.00004481609 0.0026094465854424776 4.547207 11 0.009615385 98 0.02043169732142857 8.315766 5 10 0.004428698 GO Biological Process response to estradiol 239 0.00005663952 0.0031184913961506276 2.040865 37 0.03234266 83 0.013725160426024096 2.578532 20 129 0.01771479 GO Biological Process lung epithelium development 323 0.0001437425 0.005856060549535603 2.768232 18 0.01573427 75 0.010542613575333334 4.828509 9 31 0.007971656 GO Biological Process digestive tract morphogenesis 335 0.0001650471 0.006483148623582089 2.245464 26 0.02272727 94 0.01739775188191489 3.733609 11 49 0.009743136 GO Biological Process mammary gland epithelium development 578 0.001215978 0.027683485297577852 2.095115 22 0.01923077 118 0.03455441883050847 3.387905 11 54 0.009743136 GO Molecular Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 14 0.000001006685 0.00030358743357142856 2.125587 50 0.04370629 20 0.028142163199999997 2.500982 20 133 0.01771479 Mouse Phenotype Single KO no spontaneous movement 17 3.921206e-10 2.1121460789411766e-7 4.942982 24 0.02097902 27 0.033316835582962966 5.117395 8 26 0.007085917 Mouse Phenotype Single KO abnormal notochord morphology 34 1.627322e-8 0.000004382761045294118 3.30463 31 0.0270979 11 0.007940868819454546 3.880691 14 60 0.01240035 Mouse Phenotype Single KO abnormal small intestinal villus morphology 38 2.108957e-8 0.00000508203138131579 3.742719 26 0.02272727 36 0.04677443928611111 3.867798 10 43 0.008857396 Mouse Phenotype Single KO kinked tail 77 3.785114e-7 0.0000450133622051948 2.460329 40 0.03496503 28 0.03354202559285714 2.799367 17 101 0.01505757 Mouse Phenotype Single KO decreased circulating glucagon level 85 6.070816e-7 0.00006540054366117647 4.200563 18 0.01573427 29 0.03411462453103448 5.821036 7 20 0.006200177 Mouse Phenotype Single KO decreased caudal vertebrae number 143 0.00001054006 0.0006749323735664336 2.726747 25 0.02185315 15 0.013224808005333332 3.285241 16 81 0.01417183 Mouse Phenotype Single KO abnormal mast cell physiology 172 0.0000229104 0.0012197124 3.208086 18 0.01573427 35 0.044387798777142856 3.382685 12 59 0.01062888 Mouse Phenotype Single KO decreased body temperature 305 0.0002452658 0.007363603051147542 2.56592 19 0.01660839 19 0.01748778798736842 3.475246 14 67 0.01240035 Mouse Phenotype Single KO decreased hair follicle number 337 0.0003385772 0.009199855846884273 2.661251 17 0.01486014 23 0.02375118772173913 4.376719 10 38 0.008857396 Mouse Phenotype kinked tail 3 4.063046e-14 1.2948927602e-10 3.084395 61 0.05332168 60 0.02681758516 2.527993 19 125 0.01682905 Mouse Phenotype abnormal utricle morphology 21 1.121393e-10 5.105542129999999e-8 3.61404 36 0.03146853 55 0.02620923901090909 3.658937 11 50 0.009743136 Mouse Phenotype abnormal vestibular saccule morphology 37 3.098747e-9 8.007329747837838e-7 3.120148 37 0.03234266 42 0.018904651152857145 3.628698 12 55 0.01062888 Mouse Phenotype no spontaneous movement 41 4.473351e-9 0.0000010431636319756097 4.353199 24 0.02097902 97 0.037372007229896906 4.292008 8 31 0.007085917 Mouse Phenotype abnormal notochord morphology 49 1.117758e-8 0.000002180996783265306 2.915879 38 0.03321678 27 0.01230519822 3.167911 16 84 0.01417183 Mouse Phenotype abnormal respiratory system development 66 4.363586e-8 0.000006321249355454546 2.014779 71 0.06206294 6 0.0048735301235 2.551928 29 189 0.02568645 Mouse Phenotype abnormal semicircular canal morphology 95 2.187486e-7 0.000022015319627368418 2.419143 43 0.03758741 121 0.04609270391652893 2.978782 12 67 0.01062888 Mouse Phenotype abnormal otolith organ morphology 97 2.326732e-7 0.000022933901703092783 2.621688 37 0.03234266 96 0.03756437225 3.118412 12 64 0.01062888 Mouse Phenotype decreased circulating glucagon level 136 0.000001061781 0.00007464476574264706 4.035732 18 0.01573427 73 0.02799614037945206 5.291851 7 22 0.006200177 Mouse Phenotype abnormal lens development 139 0.00000116876 0.00008039218964028777 2.379504 39 0.03409091 43 0.018880317931395347 3.079913 15 81 0.01328609 Mouse Phenotype abnormal caudal vertebrae morphology 181 0.000003795419 0.00020048619369613258 2.138745 44 0.03846154 44 0.020637218588181818 2.49473 21 140 0.01860053 Mouse Phenotype abnormal posterior semicircular canal morphology 191 0.000004940902 0.00024732965456544505 3.209253 21 0.01835664 98 0.038068555649999995 4.850864 7 24 0.006200177 Mouse Phenotype abnormal superior semicircular canal morphology 193 0.000004971334 0.00024627421955440416 3.454798 19 0.01660839 123 0.04987760715121951 5.252063 6 19 0.005314438 Mouse Phenotype abnormal incisor morphology 247 0.00001368412 0.0005296917867206477 2.067811 42 0.03671329 124 0.04965726640887097 2.486958 16 107 0.01417183 Mouse Phenotype decreased caudal vertebrae number 277 0.00002345176 0.0008094667052707581 2.595866 25 0.02185315 47 0.022192850802127663 2.89244 16 92 0.01417183 Mouse Phenotype abnormal mast cell physiology 284 0.00002667059 0.0008978785598239437 3.05346 19 0.01660839 89 0.034555162088764045 3.002916 13 72 0.01151461 Mouse Phenotype abnormal pancreas development 290 0.00002895984 0.0009547759663448276 2.409475 28 0.02447552 29 0.01237872560689655 3.913302 12 51 0.01062888 Mouse Phenotype abnormal metacarpal bone morphology 292 0.00002973089 0.0009734830112671233 2.683537 23 0.0201049 76 0.028341772942105263 3.779894 10 44 0.008857396 Mouse Phenotype abnormal vertebral transverse process morphology 310 0.00004237787 0.001307015532483871 5.659962 9 0.007867133 80 0.031688572057499996 7.559787 5 11 0.004428698 Mouse Phenotype abnormal optic vesicle formation 327 0.0000523911 0.0015318388596330275 2.650433 22 0.01923077 83 0.030819975654216868 4.045508 9 37 0.007971656