# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process RNA catabolic process 7 1.433825e-24 2.695386167857143e-21 2.055587 246 0.02896162 249 0.000014411467278313255 1.396215 137 241 0.01792021 GO Biological Process nuclear-transcribed mRNA catabolic process 8 3.077092e-24 5.0614317035e-21 2.21149 205 0.02413468 259 0.000027858964626254826 1.426532 115 198 0.01504251 GO Biological Process mRNA catabolic process 10 5.510648e-24 7.2514617032e-21 2.136356 219 0.02578291 225 0.000004693093601955555 1.441382 125 213 0.01635056 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 24 8.592934e-20 4.711434104416667e-17 2.597484 120 0.01412762 469 0.0041557637108742005 1.415388 68 118 0.008894702 GO Biological Process regulation of gene silencing 25 2.218507e-19 1.16773334452e-16 2.265497 153 0.01801271 176 5.7668121227272737e-8 1.649909 88 131 0.01151079 GO Biological Process viral transcription 32 4.884615e-17 2.00864527453125e-14 2.432933 115 0.01353897 721 0.02928508985991678 1.347603 62 113 0.008109876 GO Biological Process protein targeting to ER 37 3.046377e-16 1.0834398633243243e-13 2.520678 102 0.01200848 747 0.03374827250870147 1.361806 56 101 0.007325049 GO Biological Process cotranslational protein targeting to membrane 41 1.417531e-15 4.549583031463414e-13 2.525548 97 0.01141983 797 0.04528916684441656 1.35337 54 98 0.00706344 GO Biological Process multi-organism metabolic process 44 3.432344e-15 1.0265048794545454e-12 2.091372 140 0.01648222 794 0.04475604608060453 1.286536 77 147 0.01007194 GO Biological Process negative regulation of gene expression, epigenetic 55 2.305154e-14 5.515185724727272e-12 2.30455 106 0.0124794 765 0.03671075458300654 1.335782 62 114 0.008109876 GO Biological Process regulation of posttranscriptional gene silencing 56 2.972078e-14 6.983852571785714e-12 2.159566 121 0.01424535 221 0.000004511453590904977 1.622388 72 109 0.00941792 GO Biological Process regulation of gene silencing by RNA 56 2.972078e-14 6.983852571785714e-12 2.159566 121 0.01424535 221 0.000004511453590904977 1.622388 72 109 0.00941792 GO Biological Process protein localization to endoplasmic reticulum 59 7.982242e-14 1.7803105504745763e-11 2.142812 119 0.01400989 654 0.02013339072477064 1.346902 68 124 0.008894702 GO Biological Process establishment of protein localization to endoplasmic reticulum 62 1.551191e-13 3.2922778014516136e-11 2.252719 104 0.01224394 731 0.032555528012311895 1.356711 58 105 0.007586658 GO Biological Process regulation of gene silencing by miRNA 65 6.345772e-13 1.2846771345846153e-10 2.104314 115 0.01353897 230 0.0000066543003330434784 1.621963 70 106 0.009156311 GO Biological Process gene silencing by miRNA 80 1.095101e-10 1.801304257375e-8 2.465884 66 0.007770191 497 0.00554470483501006 1.674624 30 44 0.003924133 GO Biological Process midbrain-hindbrain boundary development 91 8.789606e-10 1.2710156632307693e-7 3.520855 34 0.004002826 537 0.0075127181465549355 2.456115 9 9 0.00117724 GO Biological Process posttranscriptional gene silencing by RNA 94 9.502195e-10 1.3302062128191492e-7 2.253833 71 0.008358842 575 0.010450676410086956 1.589251 33 51 0.004316547 GO Biological Process posttranscriptional gene silencing 101 1.595304e-9 2.0784757758415844e-7 2.224968 71 0.008358842 627 0.01602719608325359 1.558688 33 52 0.004316547 GO Biological Process rostrocaudal neural tube patterning 128 4.115718e-8 0.00000423115102828125 2.75152 39 0.004591476 553 0.009087129486799276 2.251439 11 12 0.001438849 GO Cellular Component cytoplasmic stress granule 31 6.852007e-11 3.819441321290323e-9 2.475047 67 0.007887921 92 0.019771437913043477 1.599331 28 43 0.003662525 GO Cellular Component nuclear transcriptional repressor complex 60 7.549257e-7 0.00002174186016 2.230667 47 0.005533318 83 0.011313519961445783 1.778566 21 29 0.002746893 GO Cellular Component telomerase holoenzyme complex 65 0.00000233962 0.00006219789784615384 2.999679 25 0.002943254 103 0.0399557387184466 1.786266 16 22 0.002092871 GO Cellular Component NuRD complex 68 0.0000033197 0.00008435943529411766 2.582641 31 0.003649635 93 0.021178442322580645 1.995594 13 16 0.001700458 GO Molecular Function miRNA binding 23 0.000003294337 0.0006047256875652173 2.266642 40 0.004709206 104 0.02804161058653846 1.842086 18 24 0.00235448 Human Phenotype Neoplasm of striated muscle 80 0.0002313952 0.01930125212 2.045305 31 0.003649635 50 0.03599502949 2.046763 15 18 0.001962067 Human Phenotype Upper limb muscle weakness 89 0.0002767807 0.020752332708988762 2.719514 17 0.002001413 16 0.008609784031875 2.456115 12 12 0.001569653 Mouse Phenotype Single KO fused somites 10 7.120524e-8 0.00006520263826800001 3.261536 29 0.003414175 459 0.017249479797603485 2.232832 10 11 0.001308044 Mouse Phenotype Single KO decreased neurotransmitter release 58 0.00001039193 0.0016406707415517242 2.109675 42 0.004944667 299 0.0030096596716387963 2.009549 18 22 0.00235448 Mouse Phenotype Single KO fused dorsal root ganglion 138 0.0002165073 0.014366357580434782 2.144182 28 0.003296445 242 0.001202701569752066 2.292374 14 15 0.001831262 Mouse Phenotype Single KO abnormal cervical rib 140 0.0002260876 0.01478774395142857 2.396847 22 0.002590064 459 0.017249479797603485 2.232832 10 11 0.001308044 Mouse Phenotype rib bifurcation 7 1.023013e-8 0.000013972896132857142 2.435793 53 0.006239699 758 0.017158538912928758 1.66149 23 34 0.003008502 Mouse Phenotype fused somites 43 0.000002924283 0.0006502109247209302 2.278337 40 0.004709206 304 0.000186438304875 2.311638 16 17 0.002092871 Mouse Phenotype abnormal mesendoderm development 60 0.000008293153 0.0013215139305500002 2.201526 39 0.004591476 846 0.02241784396099291 1.842086 15 20 0.001962067 Mouse Phenotype embryonic lethality before implantation, incomplete penetrance 117 0.00006875842 0.005618797039487179 2.343597 27 0.003178714 1027 0.04537971782570594 1.708602 16 23 0.002092871 Mouse Phenotype distended cecum 158 0.0001910792 0.011562710324050632 3.047222 15 0.001765952 569 0.005151569299297013 2.456115 9 9 0.00117724 Mouse Phenotype abnormal serotonergic neuron morphology 198 0.0003537603 0.017082334486363634 2.077444 28 0.003296445 434 0.0011179547323271891 2.456115 11 11 0.001438849 Mouse Phenotype abnormal atrium myocardium morphology 208 0.0004050522 0.018618769635576925 2.293769 22 0.002590064 981 0.042187079201834864 2.183213 8 9 0.001046436 Mouse Phenotype abnormal cervical rib 275 0.001208742 0.04202466277090909 2.104564 22 0.002590064 941 0.033310412234856535 2.046763 10 12 0.001308044