# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of cellular amide metabolic process 52 1.438761e-16 3.640895384423077e-14 3.042886 75 0.0397667 189 0.00036310429379894177 2.111798 38 154 0.01731996 GO Biological Process negative regulation of translation 53 1.774805e-16 4.406539433018868e-14 3.116562 72 0.03817603 191 0.00038683243608376967 2.154547 36 143 0.01640839 GO Biological Process posttranscriptional regulation of gene expression 56 3.004799e-15 7.060741078749999e-13 2.003771 150 0.0795334 372 0.019814503837096775 1.398221 91 557 0.04147675 GO Biological Process regulation of gene expression, epigenetic 58 6.279217e-15 1.4246244224655172e-12 2.734777 79 0.04188759 318 0.01194461051226415 1.656453 48 248 0.02187785 GO Biological Process regulation of translation 69 2.874718e-13 5.482378864057972e-11 2.037278 124 0.06574761 366 0.01886425343169399 1.463136 73 427 0.03327256 GO Biological Process histone modification 74 8.728681e-13 1.5521718010675677e-10 2.009772 123 0.06521739 109 1.0497332691743118e-8 2.042331 84 352 0.03828624 GO Biological Process gene silencing by miRNA 86 4.478143e-11 6.852079504302326e-9 4.71148 28 0.01484624 327 0.012984085903975534 2.723108 14 44 0.006381039 GO Biological Process regulation of mRNA stability 89 4.916016e-10 7.268522982471911e-8 2.597425 55 0.02916225 375 0.020113138484533333 1.813688 32 151 0.01458523 GO Biological Process mRNA stabilization 91 7.677984e-10 1.1102702357802198e-7 4.140565 28 0.01484624 411 0.02941099893722628 2.702634 12 38 0.005469462 GO Biological Process posttranscriptional gene silencing by RNA 92 1.587049e-9 2.2699975859782606e-7 4.003058 28 0.01484624 466 0.04670114980901288 2.349348 14 51 0.006381039 GO Biological Process heterochromatin organization 93 1.885778e-9 2.6682744840860215e-7 7.89489 15 0.00795334 306 0.011448497712745098 4.608337 7 13 0.00319052 GO Biological Process RNA stabilization 95 2.438115e-9 3.3771742405263157e-7 3.704468 30 0.01590668 385 0.024072032133766238 2.64901 13 42 0.005925251 GO Biological Process regulation of RNA stability 96 3.996028e-9 5.477472130416666e-7 2.442878 55 0.02916225 458 0.04566379866375546 1.711668 32 160 0.01458523 GO Biological Process regulation of chromatin organization 104 1.791078e-8 0.0000022662303271153845 2.204011 62 0.03287381 213 0.0012920482313615025 2.016934 37 157 0.01686418 GO Biological Process negative regulation of hyaluronan biosynthetic process 127 6.089561e-7 0.00006309648283385827 32.71464 5 0.002651113 460 0.04557971510217391 8.558341 3 3 0.001367366 GO Biological Process regulation of histone modification 132 0.000001440617 0.0001436142356287879 2.089793 51 0.02704136 344 0.016130409308139537 1.909168 29 130 0.01321787 GO Biological Process histone deacetylation 133 0.000001447669 0.0001432321531654135 2.735574 30 0.01590668 164 0.00011955753878048782 3.046189 21 59 0.009571559 GO Biological Process protein deacetylation 135 0.00000176554 0.00017209437674074073 2.708023 30 0.01590668 171 0.00021334640528070177 2.946314 21 61 0.009571559 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 139 0.000001957867 0.0001853494377913669 2.595026 32 0.01696713 341 0.01569848247595308 2.094062 23 94 0.01048314 GO Biological Process regulation of protein deacetylation 145 0.000002791291 0.00025331447082068965 3.130426 23 0.01219512 411 0.02941099893722628 2.702634 12 38 0.005469462 GO Cellular Component nuclear transcriptional repressor complex 18 6.55097e-12 6.2889312e-10 5.557516 26 0.01378579 22 0.000012072821236363636 4.426728 15 29 0.006836828 GO Cellular Component transcriptional repressor complex 22 2.447275e-10 1.922223272727273e-8 2.841365 49 0.02598091 13 7.314116233846154e-9 3.402714 33 83 0.01504102 GO Cellular Component stress fiber 35 3.306062e-7 0.000016322500388571426 2.94491 30 0.01590668 34 0.0006570725082352942 2.962503 18 52 0.008204193 GO Cellular Component actin filament bundle 38 7.384175e-7 0.00003357856421052631 2.720651 32 0.01696713 36 0.0008869199999999999 2.803594 19 58 0.008659982 GO Cellular Component actomyosin 43 0.000002417965 0.00009716845395348838 2.524813 33 0.01749735 33 0.0003462527127272727 2.808206 21 64 0.009571559 GO Cellular Component P-body 44 0.000002699728 0.00010602568145454545 2.600151 31 0.0164369 60 0.0333455616 2.062251 20 83 0.00911577 GO Cellular Component transcription factor AP-1 complex 45 0.000003099187 0.0001190087808 11.75952 7 0.003711559 37 0.0010130820324324324 8.558341 5 5 0.002278943 GO Cellular Component NuRD complex 48 0.000004586917 0.000165129012 4.877713 13 0.006892895 27 0.00012226176 5.348963 10 16 0.004557885 GO Cellular Component SWI/SNF superfamily-type complex 49 0.000007132958 0.00025154594742857146 2.616831 28 0.01484624 53 0.015029707109433962 2.258451 19 72 0.008659982 GO Cellular Component PcG protein complex 50 0.000007157523 0.00024736399488 2.95073 23 0.01219512 47 0.005376602144680851 2.790763 15 46 0.006836828 GO Cellular Component histone deacetylase complex 52 0.000007946855 0.00026408010461538464 2.280584 36 0.01908802 19 3.3456862989473685e-7 3.565975 25 60 0.01139471 GO Cellular Component heterochromatin 53 0.000009295127 0.00030305621615094345 2.528581 29 0.01537646 61 0.04285476826229508 2.110276 18 73 0.008204193 GO Cellular Component protein serine/threonine phosphatase complex 81 0.0004023116 0.008582647466666668 2.241339 23 0.01219512 58 0.03219925406896552 2.44524 14 49 0.006381039 GO Molecular Function cadherin binding 23 4.226619e-11 7.758602355652173e-9 2.026089 103 0.05461294 35 0.000048574001434285714 1.858061 66 304 0.03008204 GO Molecular Function mRNA 3'-UTR binding 25 2.390985e-9 4.0378954679999995e-7 3.052398 39 0.02067869 59 0.0096333374 2.463765 19 66 0.008659982 GO Molecular Function histone deacetylase activity 39 0.000002256747 0.0002443073290769231 3.274146 22 0.0116649 41 0.0004174686826341463 3.306632 17 44 0.007748405 GO Molecular Function protein deacetylase activity 41 0.000002689942 0.00027699841765853664 3.237713 22 0.0116649 44 0.0005574029291363637 3.233151 17 45 0.007748405 GO Molecular Function deacetylase activity 54 0.00004697333 0.003672618504814815 2.608573 23 0.01219512 52 0.005561153446153846 2.656037 18 58 0.008204193 GO Molecular Function histone methyltransferase activity 56 0.00007112153 0.005362055351071428 2.376338 26 0.01378579 65 0.019163891833846154 2.465963 17 59 0.007748405 GO Molecular Function 14-3-3 protein binding 86 0.0005878819 0.028860899788372096 2.624035 16 0.008483563 50 0.0042471014788 3.76567 11 25 0.005013674 Human Phenotype Renal malrotation 4 4.903409e-8 0.0000818011206425 8.231324 12 0.006362672 53 0.04676447213396226 6.113101 5 7 0.002278943 Human Phenotype Abnormality of adipose tissue 43 0.00004857563 0.007538259976511628 2.670364 22 0.0116649 38 0.032741056939473684 2.552488 17 57 0.007748405 Human Phenotype Distal lower limb amyotrophy 79 0.0002905579 0.024542947679746838 6.874937 6 0.003181336 31 0.03337819531935484 5.705561 6 9 0.002734731 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 10 5.299548e-9 0.0000048527961035999995 4.027234 26 0.01378579 246 0.026144943562195124 2.775678 12 37 0.005469462 Mouse Phenotype Single KO abnormal vitelline vein morphology 13 2.222659e-8 0.00001565606804846154 4.00594 24 0.01272534 131 0.003515817567862595 3.76567 11 25 0.005013674 Mouse Phenotype Single KO persistent right dorsal aorta 16 6.562108e-8 0.0000375557643475 4.433862 20 0.01060445 133 0.003696046794962406 4.890481 8 14 0.003646308 Mouse Phenotype Single KO absent hypoglossal canal 19 9.028899e-8 0.000043514541127894735 12.2041 9 0.004772004 262 0.031273849674427485 5.348963 5 8 0.002278943 Mouse Phenotype Single KO small thyroid gland 21 1.160323e-7 0.000050595608147619055 4.728135 18 0.009544008 250 0.0288533443828 3.603512 8 19 0.003646308 Mouse Phenotype Single KO vertebral transformation 23 1.249962e-7 0.00004976479145217391 2.701292 37 0.01961824 97 0.0011594414036082475 2.418662 26 92 0.0118505 Mouse Phenotype Single KO cervical vertebral transformation 26 1.467851e-7 0.000051696583103846154 4.033012 21 0.01113468 269 0.03127012696505576 2.702634 12 38 0.005469462 Mouse Phenotype Single KO rib bifurcation 29 1.737426e-7 0.000054860723731034486 4.866045 17 0.009013786 285 0.036578198771929825 2.951152 10 29 0.004557885 Mouse Phenotype Single KO abnormal liver lobule morphology 30 1.887558e-7 0.00005761456202 2.116741 58 0.03075292 205 0.014888558373658538 1.778981 37 178 0.01686418 Mouse Phenotype Single KO thoracic vertebral transformation 33 4.589252e-7 0.00012734478958787877 3.616323 22 0.0116649 260 0.03041483462307692 2.496183 14 48 0.006381039 Mouse Phenotype Single KO abnormal liver parenchyma morphology 36 5.737444e-7 0.00014593826307777777 2.014985 60 0.03181336 228 0.022264719374122808 1.720725 38 189 0.01731996 Mouse Phenotype Single KO rib fractures 37 5.994732e-7 0.0001483615160108108 20.92688 6 0.003181336 178 0.009565890916292135 8.558341 4 4 0.001823154 Mouse Phenotype Single KO double ureter 40 8.667389e-7 0.00019841820268249997 5.247048 14 0.007423118 84 0.0004454121777142858 6.224248 8 11 0.003646308 Mouse Phenotype Single KO fusion of atlas and occipital bones 41 8.863595e-7 0.00019796082784146344 6.964635 11 0.00583245 206 0.01552206626116505 5.135005 6 10 0.002734731 Mouse Phenotype Single KO abnormal eye muscle morphology 42 9.099301e-7 0.00019838642680238095 3.466632 22 0.0116649 198 0.013428310398484848 3.020591 12 34 0.005469462 Mouse Phenotype Single KO pale yolk sac 43 0.000001664316 0.00035442189795348837 2.19675 45 0.02386002 53 0.00002413075100566038 2.85278 28 84 0.01276208 Mouse Phenotype Single KO absent subcutaneous adipose tissue 48 0.000001956494 0.00037324199079166666 4.887477 14 0.007423118 162 0.00695059258765432 4.053951 9 19 0.004102097 Mouse Phenotype Single KO abnormal cervical vertebrae morphology 50 0.000002499737 0.00045780183417999995 2.032082 52 0.02757158 120 0.003011184827666666 2.105624 31 126 0.01412944 Mouse Phenotype Single KO abnormal brain vasculature morphology 61 0.000006158704 0.0009245123365245902 2.308215 36 0.01908802 288 0.038409735993055555 2.204421 17 66 0.007748405 Mouse Phenotype Single KO abnormal sublingual gland morphology 73 0.00001059071 0.0013284812530136988 6.781765 9 0.004772004 262 0.031273849674427485 5.348963 5 8 0.002278943 Mouse Phenotype enlarged liver sinusoidal spaces 3 1.838007e-10 5.857728309e-7 4.031822 31 0.0164369 317 0.004183495476340694 2.92236 14 41 0.006381039 Mouse Phenotype fusion of atlas and occipital bones 4 3.237996e-10 7.739619938999999e-7 9.008336 15 0.00795334 271 0.0018939561302214023 4.890481 8 14 0.003646308 Mouse Phenotype persistent right dorsal aorta 5 5.175941e-10 9.8974343802e-7 4.692742 25 0.01325557 181 0.00021929326175138122 5.034318 10 17 0.004557885 Mouse Phenotype abnormal liver lobule morphology 11 2.048249e-9 0.0000017803007899090907 2.103317 78 0.04135737 248 0.0010841626555645164 1.790448 50 239 0.02278943 Mouse Phenotype bicuspid aortic valve 21 9.396468e-9 0.000004278077645142858 5.005307 20 0.01060445 396 0.011524484141666668 3.501139 9 22 0.004102097 Mouse Phenotype abnormal vitelline vein morphology 26 2.222659e-8 0.000008173401038076923 4.00594 24 0.01272534 269 0.001787703340037175 3.76567 11 25 0.005013674 Mouse Phenotype abnormal liver sinusoid morphology 33 5.958911e-8 0.000017264590324545454 2.740463 38 0.02014846 402 0.011810094440298508 2.194446 20 78 0.00911577 Mouse Phenotype absent hypoglossal canal 38 9.028899e-8 0.000022717185089210525 12.2041 9 0.004772004 455 0.018802748754065936 5.348963 5 8 0.002278943 Mouse Phenotype abnormal sublingual gland morphology 44 1.61624e-7 0.000035120160545454544 6.055381 14 0.007423118 316 0.0041354350632911395 4.992366 7 12 0.00319052 Mouse Phenotype thoracic vertebral transformation 45 1.6464e-7 0.000034980512 3.473286 25 0.01325557 325 0.0054849809566153845 2.552488 17 57 0.007748405 Mouse Phenotype abnormal aorta tunica media morphology 48 2.523387e-7 0.00005026271480625 3.207316 27 0.01431601 589 0.044291535407470294 2.317884 13 48 0.005925251 Mouse Phenotype abnormal aortic valve cusp morphology 49 4.025392e-7 0.00007854443451428572 3.30561 25 0.01325557 460 0.01909300107130435 2.702634 12 38 0.005469462 Mouse Phenotype absent ductus venosus valve 51 5.335529e-7 0.00010002547601764704 4.248704 18 0.009544008 573 0.0403238095026178 3.112124 8 22 0.003646308 Mouse Phenotype ectopic parathyroid gland 54 5.808596e-7 0.00010284441917777778 9.7429 9 0.004772004 377 0.009419606251193634 6.113101 5 7 0.002278943 Mouse Phenotype abnormal eye muscle morphology 55 7.520281e-7 0.00013072983025636363 3.026737 27 0.01431601 185 0.00023578351091351352 3.423336 16 40 0.007292616 Mouse Phenotype abnormal intestine development 61 8.286024e-7 0.00012987323846557378 3.616134 21 0.01113468 386 0.010390694167616581 3.29167 10 26 0.004557885 Mouse Phenotype decreased fibroblast proliferation 62 0.000001001198 0.00015439442061290323 2.289755 43 0.02279958 462 0.019501447531168833 1.843335 28 130 0.01276208 Mouse Phenotype abnormal liver vasculature morphology 63 0.000001024089 0.00015541769728571428 2.115504 51 0.02704136 291 0.002626971488969072 2.120651 28 113 0.01276208 Mouse Phenotype abnormal myelopoiesis 66 0.000001192656 0.0001727724850909091 2.008776 57 0.03022269 427 0.015642104997189696 1.776259 33 159 0.01504102 Mouse Phenotype absent stapedial artery 74 0.000001792895 0.0002316468796621622 4.596737 15 0.00795334 439 0.01715622573143508 3.603512 8 19 0.003646308