# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	22	5.73424e-64	3.429857461818182e-61	2.741607	377	0.01893141	401	0.0009716707327930175	1.335833	84	113	0.008039047	
GO Biological Process	regulation of DNA-templated transcription in response to stress	27	2.270415e-60	1.1065329994444444e-57	2.565129	399	0.02003616	330	0.0001846966136909091	1.359086	90	119	0.008613264	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	50	6.009962e-49	1.5817017991600002e-46	2.173695	449	0.02254695	459	0.0034168533257080604	1.263707	109	155	0.01043162	
GO Biological Process	cellular response to insulin stimulus	52	5.969767e-48	1.5106954606346152e-45	2.001497	535	0.02686552	250	0.0000063792673924	1.372045	113	148	0.01081443	
GO Biological Process	mRNA catabolic process	68	7.580394e-44	1.466917715382353e-41	2.009696	483	0.02425429	308	0.000065987471737013	1.282376	152	213	0.01454685	
GO Biological Process	endoplasmic reticulum unfolded protein response	77	1.808719e-42	3.091030301428571e-40	2.4036	314	0.0157678	273	0.000022256689146520145	1.402932	89	114	0.008517561	
GO Biological Process	nuclear-transcribed mRNA catabolic process	78	2.318733e-42	3.911821480384615e-40	2.047599	445	0.02234609	316	0.00008931979403797467	1.288768	142	198	0.01358982	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	79	9.818855e-42	1.635522948670886e-39	2.548206	276	0.0138596	248	0.000005986527868548387	1.416291	93	118	0.008900373	
GO Biological Process	IRE1-mediated unfolded protein response	91	6.10975e-39	8.83496706043956e-37	3.158288	181	0.009089083	469	0.004001722043923241	1.425218	46	58	0.004402335	
GO Biological Process	viral gene expression	98	2.632097e-37	3.534261675816326e-35	2.366356	283	0.01421111	153	3.0068512815032684e-8	1.471571	104	127	0.009953106	
GO Biological Process	cellular response to topologically incorrect protein	100	9.008667e-37	1.18545049053e-34	2.137287	347	0.01742493	332	0.00019609628998192773	1.3316	103	139	0.009857403	
GO Biological Process	multi-organism metabolic process	104	8.683718e-36	1.0987408188653845e-33	2.140899	336	0.01687255	167	6.934125594431138e-8	1.430277	117	147	0.01119724	
GO Biological Process	cotranslational protein targeting to membrane	107	1.306611e-35	1.60688730364486e-33	2.565368	231	0.01159988	231	0.0000028625370836363632	1.46695	80	98	0.007656235	
GO Biological Process	cellular response to unfolded protein	108	1.400536e-35	1.7064493725925925e-33	2.181567	320	0.0160691	295	0.00004131693598677967	1.381176	93	121	0.008900373	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	109	1.444283e-35	1.7436073391743117e-33	2.516589	239	0.01200161	638	0.023250715476489027	1.313203	57	78	0.005455067	
GO Biological Process	viral transcription	111	2.329353e-35	2.7614374889189192e-33	2.382265	264	0.01325701	158	3.87564781221519e-8	1.494861	94	113	0.008996076	
GO Biological Process	cellular response to epidermal growth factor stimulus	124	1.027126e-33	1.0899960511290322e-31	2.546899	221	0.01109772	343	0.00027647162583965015	1.607855	34	38	0.0032539	
GO Biological Process	protein targeting to ER	127	1.267193e-33	1.3129915501574803e-31	2.466533	234	0.01175053	187	2.8285734935294116e-7	1.494546	84	101	0.008039047	
GO Biological Process	response to epidermal growth factor	138	1.974251e-32	1.8825484716666666e-30	2.445509	229	0.01149945	340	0.00025125140520294116	1.583084	37	42	0.003541009	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	148	7.197848e-31	6.399762285945946e-29	2.49014	210	0.01054534	227	0.0000023188540532599117	1.48449	76	92	0.007273423	
GO Cellular Component	ribosomal subunit	40	1.056771e-35	4.56525072e-34	2.074389	361	0.01812795	52	5.306588307692308e-8	1.37933	142	185	0.01358982	
GO Cellular Component	mitochondrial ribosome	50	2.221461e-26	7.677369216e-25	2.601081	164	0.008235412	96	0.0009523859400000001	1.374187	65	85	0.006220691	
GO Cellular Component	large ribosomal subunit	62	1.395124e-22	3.8883456e-21	2.086388	219	0.01099729	67	0.000023915313671641792	1.390733	89	115	0.008517561	
GO Cellular Component	catalytic step 2 spliceosome	73	7.272819e-21	1.721565922191781e-19	2.004328	222	0.01114794	80	0.00021256477919999998	1.385198	74	96	0.007082017	
GO Cellular Component	endopeptidase complex	78	1.293625e-18	2.8658769230769226e-17	2.193794	158	0.007934117	98	0.001317158831020408	1.406359	54	69	0.005167959	
GO Cellular Component	proteasome complex	79	2.728781e-18	5.968776668354431e-17	2.181141	157	0.007883901	105	0.0017463447771428572	1.400614	53	68	0.005072256	
GO Cellular Component	mitochondrial large ribosomal subunit	86	1.935934e-17	3.8898766883720927e-16	2.668403	100	0.005021593	108	0.0030308416	1.444658	41	51	0.00392382	
GO Cellular Component	host cell	95	5.412501e-16	9.845054450526316e-15	2.002907	166	0.008335844	124	0.010468860851612903	1.347761	51	68	0.00488085	
GO Cellular Component	PcG protein complex	96	6.102769e-16	1.09849842e-14	2.00479	165	0.008285628	90	0.000509452224	1.523555	39	46	0.003732415	
GO Cellular Component	small ribosomal subunit	97	6.260771e-16	1.1153208544329896e-14	2.094396	148	0.007431957	110	0.0032558551854545456	1.372719	55	72	0.005263662	
GO Cellular Component	spliceosomal snRNP complex	115	1.291137e-13	1.940073683478261e-12	2.1314	119	0.005975695	125	0.0110913739776	1.362253	47	62	0.004498038	
GO Cellular Component	platelet dense tubular network	214	5.66435e-8	4.5738302803738317e-7	2.571829	43	0.002159285	141	0.019375095829787237	1.797014	11	11	0.001052732	
GO Cellular Component	U1 snRNP	284	0.000006866201	0.000041777448338028165	2.086899	45	0.002259717	145	0.021575367062068966	1.607855	17	19	0.00162695	
GO Molecular Function	rRNA binding	19	5.031738e-27	1.1181051492631579e-24	3.141825	124	0.006226775	81	0.010923940251851852	1.407661	47	60	0.004498038	
GO Molecular Function	protein transporter activity	22	5.383175e-24	1.0330802204545454e-21	2.004821	258	0.01295571	49	0.0008479294196734695	1.385198	74	96	0.007082017	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	32	7.218871e-35	2.06572505459375e-32	2.14655	325	0.01632018	221	0.006836566478733032	1.333269	69	93	0.006603503	
Mouse Phenotype Single KO	decreased fatty acid level	33	1.677562e-34	4.6549803739393935e-32	2.011036	376	0.01888119	395	0.03798159005822785	1.242935	83	120	0.007943344	
Mouse Phenotype Single KO	abnormal osteoblast differentiation	63	1.702307e-27	2.474289714126984e-25	2.161411	249	0.01250377	294	0.017469914592176873	1.437611	36	45	0.003445306	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	67	1.181372e-26	1.6146005080597013e-24	2.608317	165	0.008285628	301	0.01799051452458472	1.581372	22	25	0.002105465	
Mouse Phenotype Single KO	decreased epididymal fat pad weight	109	2.863426e-22	2.4055405396330277e-20	2.159668	199	0.00999297	336	0.02305747044077381	1.401671	39	50	0.003732415	
Mouse Phenotype Single KO	absent hypoglossal nerve	131	1.714754e-20	1.1986261357251908e-18	3.907549	69	0.003464899	411	0.043720397277372265	1.677213	14	15	0.001339841	
Mouse Phenotype Single KO	renal glomerulus hypertrophy	140	7.357809e-20	4.812532643785714e-18	2.540165	126	0.006327207	353	0.028811449909348443	1.617313	18	20	0.001722653	
Mouse Phenotype Single KO	increased hepatocyte proliferation	212	4.466042e-16	1.9290352166981134e-14	3.012109	75	0.003766195	339	0.02375299868672566	1.797014	12	12	0.001148435	
Mouse Phenotype Single KO	increased hepatocyte apoptosis	233	2.475073e-15	9.727143116309014e-14	2.052124	149	0.007482173	292	0.01665566102808219	1.454726	34	42	0.0032539	
Mouse Phenotype Single KO	increased respiratory quotient	248	6.43153e-15	2.374738718145161e-13	2.037865	147	0.007381741	204	0.005372003425980392	1.46695	40	49	0.003828118	
Mouse Phenotype	extramedullary hematopoiesis	6	2.470473e-63	3.9366987255e-60	2.090129	639	0.03208798	492	0.03035642762804878	1.201432	117	175	0.01119724	
Mouse Phenotype	decreased circulating free fatty acid level	33	6.755715e-42	1.9573148822727274e-39	2.081138	423	0.02124134	167	0.0002651775983353294	1.359086	90	119	0.008613264	
Mouse Phenotype	abnormal vitelline vein morphology	89	1.181372e-26	1.2691121002247189e-24	2.608317	165	0.008285628	405	0.013960634614074072	1.581372	22	25	0.002105465	
Mouse Phenotype	decreased epididymal fat pad weight	151	2.991503e-21	1.8941563035099337e-19	2.009421	225	0.01129858	424	0.018092104413679245	1.362253	47	62	0.004498038	
Mouse Phenotype	absent hypoglossal nerve	163	1.714754e-20	1.0058136806134968e-18	3.907549	69	0.003464899	523	0.035873548399617594	1.677213	14	15	0.001339841	
Mouse Phenotype	spontaneous skin ulceration	167	2.471737e-20	1.4151064345508983e-18	2.368071	148	0.007431957	460	0.023769311113043475	1.437611	32	40	0.003062494	
Mouse Phenotype	increased hepatocyte proliferation	354	2.332832e-13	6.300623376271187e-12	2.011798	134	0.006728934	543	0.041317236425414364	1.437611	28	35	0.002679682