# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	14	9.871025e-50	9.278058426785715e-47	2.722107	294	0.01879675	270	0.00011191768489629629	1.404238	84	113	0.008450704	
GO Biological Process	regulation of DNA-templated transcription in response to stress	19	2.120329e-44	1.4684952268947368e-41	2.496492	305	0.01950003	264	0.00009639231676893939	1.396933	88	119	0.008853119	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	20	2.744851e-44	1.80597471545e-41	2.268266	368	0.02352791	447	0.00673072252147651	1.267481	104	155	0.01046278	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	29	9.731408e-40	4.4157102714482766e-37	2.552169	261	0.01668691	558	0.02324812557043011	1.306247	65	94	0.006539235	
GO Biological Process	DNA-templated transcription, elongation	42	9.447298e-34	2.959928437666667e-31	2.55244	220	0.0140656	391	0.0029305759363682862	1.339497	78	110	0.007847082	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	48	8.855737e-32	2.4277633996458333e-29	2.627631	196	0.01253117	278	0.00015627415394604314	1.477322	61	78	0.006136821	
GO Biological Process	endoplasmic reticulum unfolded protein response	60	1.711651e-30	3.7539359181666668e-28	2.319548	238	0.01521642	414	0.003994509805072464	1.325638	80	114	0.00804829	
GO Biological Process	transcription elongation from RNA polymerase II promoter	72	8.9862e-29	1.6423528583333332e-26	2.536845	188	0.01201969	474	0.009587067182489452	1.332266	67	95	0.006740443	
GO Biological Process	cellular response to topologically incorrect protein	76	4.186572e-28	7.248829072105262e-26	2.1095	269	0.01719839	381	0.0025908820722309713	1.304657	96	139	0.009657948	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	78	6.381919e-28	1.0766624630897437e-25	2.384612	205	0.01310658	382	0.0026732911537434554	1.337369	80	113	0.00804829	
GO Biological Process	regulation of cellular amino acid metabolic process	80	3.018921e-27	4.965747679874999e-25	3.12444	126	0.008055751	483	0.010001553800828155	1.416776	45	60	0.004527163	
GO Biological Process	cellular response to epidermal growth factor stimulus	82	1.227485e-26	1.9698140384146342e-24	2.538397	173	0.01106067	693	0.04967759855699856	1.441631	29	38	0.002917505	
GO Biological Process	cellular response to unfolded protein	89	1.560346e-25	2.3070329229213483e-23	2.109205	243	0.01553609	424	0.004851785370754717	1.311396	84	121	0.008450704	
GO Biological Process	response to epidermal growth factor	92	3.890653e-25	5.564902481195652e-23	2.42018	178	0.01138035	624	0.03494431496794871	1.439264	32	42	0.003219316	
GO Biological Process	cellular protein complex disassembly	107	9.170568e-24	1.1278084515140187e-21	2.071224	235	0.01502461	188	0.0000013533373550000001	1.454256	97	126	0.009758551	
GO Biological Process	translational elongation	108	1.498541e-23	1.8258612054629628e-21	2.259455	191	0.0122115	169	3.5108640251479293e-7	1.501108	89	112	0.008953722	
GO Biological Process	mitochondrial translational termination	112	2.683212e-23	3.1525345275e-21	2.546379	149	0.009526245	248	0.00004999760458185484	1.476487	68	87	0.006841046	
GO Biological Process	regulation of hematopoietic stem cell differentiation	113	2.826762e-23	3.2918018723893804e-21	2.328957	177	0.01131641	525	0.016965199393142855	1.30215	71	103	0.007142857	
GO Biological Process	anaphase-promoting complex-dependent catabolic process	114	3.230431e-23	3.728880835877193e-21	2.358852	172	0.01099674	255	0.00007596860992941176	1.487614	63	80	0.006338028	
GO Biological Process	mitochondrial translational elongation	116	4.018518e-23	4.558592962241379e-21	2.553849	147	0.009398376	238	0.000035513232750420164	1.489003	67	85	0.006740443	
GO Cellular Component	proteasome core complex	30	5.533958e-40	3.187559808e-38	7.018654	80	0.005114762	114	0.005869793178947368	1.652905	21	24	0.002112676	
GO Cellular Component	mitochondrial ribosome	35	1.038994e-32	5.129661805714286e-31	3.109745	154	0.009845918	59	0.0000188120448	1.489003	67	85	0.006740443	
GO Cellular Component	ribosomal subunit	42	2.604105e-27	1.0714032000000001e-25	2.048496	280	0.01790167	49	2.2801450187755103e-7	1.388695	136	185	0.01368209	
GO Cellular Component	mitochondrial large ribosomal subunit	46	1.895628e-23	7.120967791304348e-22	3.329443	98	0.006265584	89	0.0008235807208988765	1.518635	41	51	0.004124748	
GO Cellular Component	ficolin-1-rich granule lumen	47	4.957106e-23	1.8225274825531915e-21	2.060898	230	0.01470494	62	0.000024726863380645162	1.401542	92	124	0.009255533	
GO Cellular Component	endopeptidase complex	49	1.464579e-22	5.1648826775510206e-21	2.54563	144	0.009206572	87	0.0007207056993103447	1.450997	53	69	0.005331992	
GO Cellular Component	proteasome complex	50	9.156198e-22	3.1643820288e-20	2.511692	142	0.009078703	90	0.0010211422079999999	1.444556	52	68	0.005231388	
GO Cellular Component	large ribosomal subunit	51	3.83352e-21	1.2988867764705882e-19	2.19545	181	0.01157215	80	0.000391591152	1.36339	83	115	0.008350101	
GO Cellular Component	peptidase complex	56	2.002732e-19	6.179858742857143e-18	2.178146	168	0.010741	99	0.0019372101818181818	1.373843	64	88	0.006438632	
GO Cellular Component	methyltransferase complex	57	3.892731e-19	1.1801121347368421e-17	2.066101	187	0.01195576	110	0.003695519650909091	1.34931	65	91	0.006539235	
GO Cellular Component	spliceosomal snRNP complex	102	3.138269e-11	5.316596894117647e-10	2.143581	94	0.006009846	142	0.014827554253521124	1.371073	45	62	0.004527163	
GO Cellular Component	endoribonuclease complex	127	3.638008e-9	4.949982538582677e-8	2.401424	58	0.003708203	160	0.0333100944	1.4982	23	29	0.002313883	
GO Cellular Component	endoplasmic reticulum chaperone complex	142	3.135323e-8	3.815378974647887e-7	3.947012	24	0.001534429	134	0.011767097122388059	1.889034	11	11	0.00110664	
GO Cellular Component	transcription factor TFTC complex	162	1.741848e-7	0.0000018579712	2.677986	37	0.002365578	148	0.02124158010810811	1.754103	13	14	0.001307847	
GO Cellular Component	proteasome regulatory particle	187	0.000001942935	0.000017953966203208555	2.31996	40	0.002557381	112	0.0045001872	1.709126	19	21	0.001911469	
GO Cellular Component	INO80-type complex	228	0.00001023244	0.00007755112421052631	2.437161	31	0.00198197	161	0.03311800009937888	1.560507	19	23	0.001911469	
GO Cellular Component	Ino80 complex	268	0.00007107192	0.000458254767761194	2.607608	22	0.00140656	174	0.04144702344827587	1.652905	14	16	0.001408451	
GO Cellular Component	U2-type prespliceosome	274	0.00009260609	0.0005840267281751824	2.301412	27	0.001726232	120	0.00830258064	1.77097	15	16	0.001509054	
GO Molecular Function	5S rRNA binding	193	0.000001208439	0.000026435385792746114	3.307013	23	0.001470494	108	0.03567178745925926	1.889034	11	11	0.00110664	
Human Phenotype	Increased serum lactate	15	3.975873e-18	1.7687333686e-15	2.076927	174	0.01112461	95	0.002125174894736842	1.378995	73	100	0.007344064	
Human Phenotype	External ophthalmoplegia	74	1.154303e-10	1.0409005295945947e-8	2.229726	81	0.005178697	150	0.008800681601333333	1.593873	27	32	0.002716298	
Human Phenotype	Abnormality of glycolysis	325	0.00002739504	0.0005624833905230769	2.479533	27	0.001726232	213	0.028587219720187795	1.889034	11	11	0.00110664	
Human Phenotype	Increased serum pyruvate	452	0.0002016522	0.0029770467491150444	2.363874	23	0.001470494	249	0.0462165816184739	1.889034	10	10	0.001006036	
Mouse Phenotype Single KO	abnormal osteoblast differentiation	68	2.907665e-17	3.915513000735294e-15	2.000372	181	0.01157215	200	0.023463333644499998	1.469249	35	45	0.003521127	
Mouse Phenotype Single KO	absent hypoglossal nerve	91	9.583532e-16	9.643560716923079e-14	3.821423	53	0.00338853	223	0.042137927044843045	1.763099	14	15	0.001408451	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	116	6.923206e-15	5.465154943275862e-13	2.924365	72	0.004603286	165	0.009368776436363635	1.717304	20	22	0.002012072	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	176	2.438163e-12	1.2685374199431816e-10	2.133419	106	0.00677706	175	0.012095653974857143	1.66235	22	25	0.00221328	
Mouse Phenotype Single KO	thin hypoglossal nerve	208	3.779928e-11	1.6640769565384615e-9	2.951371	51	0.003260661	223	0.042137927044843045	1.763099	14	15	0.001408451	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	211	4.361243e-11	1.892696784407583e-9	2.396126	73	0.004667221	188	0.018861632436702126	1.652905	21	24	0.002112676	
Mouse Phenotype Single KO	abnormal pharyngeal muscle morphology	425	0.00000161564	0.00003481038936470588	2.67967	31	0.00198197	220	0.037980522198181814	1.889034	11	11	0.00110664	
Mouse Phenotype	extramedullary hematopoiesis	1	4.075166e-60	3.8962662125999996e-56	2.211367	531	0.03394924	266	0.024558043135714285	1.230571	114	175	0.01146881	
Mouse Phenotype	abnormal pancreatic islet cell apoptosis	13	2.4016e-39	1.7662844307692307e-36	5.884999	91	0.005818042	204	0.008445451577941177	1.784088	17	18	0.001710262	
Mouse Phenotype	dry skin	58	1.845963e-20	3.0429745246551724e-18	2.619459	123	0.007863947	290	0.03941436530689655	1.464002	31	40	0.003118712	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	72	1.51668e-18	2.0140246499999998e-16	2.460441	124	0.007927882	293	0.04178280999317406	1.551707	23	28	0.002313883	
Mouse Phenotype	decreased circulating total protein level	80	1.725005e-17	2.0615966006250003e-15	2.127505	158	0.01010166	298	0.043522762852348996	1.376754	43	59	0.004325956	
Mouse Phenotype	absent hypoglossal nerve	104	9.583532e-16	8.810398985769231e-14	3.821423	53	0.00338853	284	0.034546956559859156	1.763099	14	15	0.001408451	
Mouse Phenotype	absent segment of posterior cerebral artery	129	6.923206e-15	5.131222679534884e-13	2.924365	72	0.004603286	200	0.008070248879999999	1.717304	20	22	0.002012072	
Mouse Phenotype	abnormal vitelline vein morphology	202	2.438163e-12	1.1540235862871287e-10	2.133419	106	0.00677706	219	0.010091910542465754	1.66235	22	25	0.00221328	
Mouse Phenotype	thin hypoglossal nerve	239	3.779928e-11	1.5121293559832638e-9	2.951371	51	0.003260661	284	0.034546956559859156	1.763099	14	15	0.001408451	
Mouse Phenotype	abnormal cerebral artery morphology	240	4.361243e-11	1.7374101801249999e-9	2.396126	73	0.004667221	236	0.015688276234322035	1.652905	21	24	0.002112676	
Mouse Phenotype	abnormal vertebral transverse process morphology	352	2.526922e-8	6.863608307386363e-7	2.391861	52	0.003324596	280	0.03115843851	1.889034	11	11	0.00110664	
Mouse Phenotype	abnormal pharyngeal muscle morphology	533	0.000004413887	0.00007917668594183864	2.502972	32	0.002045905	250	0.0184640731704	1.889034	12	12	0.001207243