# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	14	9.702471e-37	9.119629706357142e-34	2.793083	205	0.01928686	301	0.00034344740809634554	1.507442	69	113	0.009071785	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	17	6.039514e-33	4.6749391015294124e-30	5.043485	87	0.008185154	558	0.015138637130107529	1.851532	18	24	0.002366553	
GO Biological Process	regulation of DNA-templated transcription in response to stress	18	2.6475e-32	1.9354695833333334e-29	2.541469	211	0.01985135	270	0.00016603246407407405	1.514418	73	119	0.009597686	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	21	5.943141e-30	3.724085353285714e-27	2.249417	248	0.02333239	359	0.0010863007416713091	1.40159	88	155	0.01156981	
GO Biological Process	mRNA catabolic process	34	2.768442e-25	1.0714684787647057e-22	2.03465	261	0.02455546	257	0.00010236427061867704	1.390822	120	213	0.01577702	
GO Biological Process	nuclear-transcribed mRNA catabolic process	35	2.935943e-25	1.1038306839142855e-22	2.094871	243	0.02286198	269	0.00016310409286245353	1.396441	112	198	0.01472522	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	46	7.786027e-24	2.227311506369565e-21	2.577376	149	0.01401825	180	0.0000011761426473333334	1.631858	78	118	0.01025506	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	71	7.888794e-21	1.4620935245915493e-18	2.564625	130	0.01223069	436	0.004194642518348625	1.519205	48	78	0.006310807	
GO Biological Process	protein targeting to ER	74	1.884118e-20	3.350420102972973e-18	2.547574	129	0.01213661	193	0.0000029922856913989635	1.662101	68	101	0.00894031	
GO Biological Process	mitochondrial translation	78	5.210353e-20	8.790132708589743e-18	2.494382	131	0.01232477	373	0.0014623702536461127	1.476611	64	107	0.00841441	
GO Biological Process	mitochondrial translational termination	87	2.846942e-19	4.3060815836781615e-17	2.716018	108	0.01016088	415	0.0029694897459277107	1.503926	53	87	0.006968183	
GO Biological Process	cellular protein complex disassembly	90	3.77268e-19	5.5160773466666667e-17	2.165946	167	0.01571173	289	0.0002430974536193772	1.489063	76	126	0.009992111	
GO Biological Process	mitochondrial translational elongation	121	1.408396e-17	1.5316597490909094e-15	2.633221	103	0.009690469	539	0.011783337632467533	1.452182	50	85	0.006573758	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	127	3.466197e-17	3.591471364015748e-15	2.284901	132	0.01241885	197	0.0000034398487680710656	1.645806	70	105	0.009203261	
GO Biological Process	cotranslational protein targeting to membrane	134	6.584095e-17	6.465679560074628e-15	2.41358	116	0.01091354	234	0.000033266924866239315	1.612218	64	98	0.00841441	
GO Biological Process	translational termination	139	8.95646e-17	8.478996916546763e-15	2.413429	115	0.01081946	417	0.0029871434901678658	1.481225	57	95	0.007494084	
GO Biological Process	translational elongation	143	1.216604e-16	1.1195309116083916e-14	2.263007	130	0.01223069	429	0.0039800576435897435	1.432733	65	112	0.008545885	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	146	1.797027e-16	1.619662896780822e-14	2.443786	110	0.01034905	230	0.0000280655037573913	1.636861	61	92	0.008019984	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	159	6.794393e-16	5.623108018050315e-14	2.35229	114	0.01072537	680	0.04121441373235295	1.645806	22	33	0.002892453	
GO Biological Process	positive regulation of gene expression, epigenetic	161	8.847181e-16	7.231059303043478e-14	2.505784	100	0.009408223	640	0.0319256050453125	1.419508	46	80	0.006047857	
GO Cellular Component	ribosomal subunit	39	4.757493e-19	2.10793536e-17	2.045515	190	0.01787562	59	0.00015868244501694915	1.401159	105	185	0.01380489	
GO Cellular Component	mitochondrial ribosome	40	3.526653e-18	1.5235140959999999e-16	2.822928	95	0.008937812	122	0.029585158819672133	1.394094	48	85	0.006310807	
GO Cellular Component	catalytic step 2 spliceosome	41	2.194201e-15	9.247754458536584e-14	2.182085	129	0.01213661	55	0.0001317810816	1.568659	61	96	0.008019984	
GO Cellular Component	large ribosomal subunit	49	6.777844e-13	2.390227435102041e-11	2.088349	117	0.01100762	108	0.011384016	1.37389	64	115	0.00841441	
GO Cellular Component	endopeptidase complex	50	8.842948e-13	3.0561228288e-11	2.341248	90	0.008467401	103	0.00833288742524272	1.502692	42	69	0.005521956	
GO Cellular Component	methyltransferase complex	54	1.402815e-12	4.489008000000001e-11	2.016061	124	0.0116662	41	0.000003686049904390244	1.681978	62	91	0.008151459	
GO Cellular Component	proteasome complex	57	4.778858e-12	1.448748530526316e-10	2.290514	88	0.008279236	109	0.01203959586055046	1.488486	41	68	0.005390481	
GO Cellular Component	peptidase complex	60	2.25514e-11	6.4948032e-10	2.041425	107	0.0100668	100	0.005559523776	1.458783	52	88	0.006836708	
GO Cellular Component	spliceosomal snRNP complex	66	4.013588e-11	1.050830312727273e-9	2.41611	72	0.00677392	99	0.005251549090909091	1.552898	39	62	0.005127531	
GO Cellular Component	methylosome	76	2.909212e-10	6.6146293894736835e-9	5.286725	23	0.002163891	65	0.0005161169132307693	2.468709	12	12	0.001577702	
GO Cellular Component	PcG protein complex	77	3.265855e-10	7.329087584415584e-9	2.071535	91	0.008561483	105	0.01004477513142857	1.610028	30	46	0.003944255	
GO Cellular Component	U5 snRNP	79	3.919853e-10	8.574058207594937e-9	3.480361	36	0.00338696	123	0.03140691980487805	1.795425	16	22	0.002103602	
GO Cellular Component	small nuclear ribonucleoprotein complex	98	6.757103e-9	1.191456528979592e-7	2.096186	75	0.007056167	114	0.017343360000000002	1.466914	41	69	0.005390481	
GO Cellular Component	axon cytoplasm	106	5.135688e-8	8.372140437735849e-7	2.124008	64	0.006021263	94	0.0027959113531914894	1.728096	28	40	0.003681304	
GO Cellular Component	Cul4-RING E3 ubiquitin ligase complex	117	2.322672e-7	0.000003430407876923077	2.355114	46	0.004327782	138	0.044769888	1.62009	21	32	0.002760978	
GO Cellular Component	ESCRT III complex	147	0.000004087826	0.00004805281175510204	3.267491	21	0.001975727	132	0.041019604363636365	2.057257	10	12	0.001314752	
GO Cellular Component	U1 snRNP	251	0.0003789272	0.0026087099665338645	2.172176	25	0.002352056	137	0.04428822376642336	1.819049	14	19	0.001840652	
GO Molecular Function	structural constituent of ribosome	14	7.20276e-17	2.1721466228571427e-14	2.017924	172	0.01618214	48	0.00009064246983333332	1.462939	96	162	0.01262161	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	26	2.368974e-11	3.8468493184615384e-9	2.704401	60	0.005644934	82	0.006070988858536585	1.872814	22	29	0.002892453	
GO Molecular Function	mismatch repair complex binding	142	0.000003315788	0.00009858631645070423	3.913861	17	0.001599398	105	0.02908159840952381	2.468709	8	8	0.001051801	
GO Molecular Function	RNA polymerase I activity	143	0.000003387424	0.00010001191697902098	3.430562	20	0.001881645	99	0.01544117604040404	2.262983	11	12	0.001446227	
GO Molecular Function	5S rRNA binding	231	0.0001243611	0.0022729548233766236	3.17374	15	0.001411233	108	0.03221107269814815	2.244281	10	11	0.001314752	
Human Phenotype	Increased serum lactate	9	3.321862e-16	2.462976125111111e-13	2.248299	128	0.01204253	78	0.005360345614871795	1.481225	60	100	0.007888509	
Human Phenotype	Abnormal CSF metabolite level	20	2.114763e-13	7.0559067495e-11	2.559717	80	0.007526578	63	0.002524606682063492	1.645806	42	63	0.005521956	
Human Phenotype	Increased CSF lactate	25	4.221005e-12	1.1266706546e-9	2.543857	72	0.00677392	89	0.007679573314606741	1.61743	38	58	0.004996056	
Human Phenotype	Abnormality of transition element cation homeostasis	28	1.742132e-11	4.15187387e-9	3.523872	41	0.003857371	131	0.025499697904580152	1.787686	21	29	0.002760978	
Human Phenotype	Abnormality of iron homeostasis	42	2.358952e-10	3.7479254038095237e-8	3.474953	37	0.003481042	136	0.03149780628088235	1.851532	18	24	0.002366553	
Human Phenotype	Tethered cord	264	0.00006879678	0.0017389428520454544	2.613127	22	0.002069809	72	0.004445804691111111	2.468709	11	11	0.001446227	
Human Phenotype	Basal cell carcinoma	265	0.00006965944	0.001754103558943396	2.133894	33	0.003104714	87	0.006961759118275861	2.019853	18	22	0.002366553	
Mouse Phenotype Single KO	pale liver	33	3.125728e-18	8.673421604848484e-16	2.276146	142	0.01335968	140	0.00918795066	1.512084	49	80	0.006442282	
Mouse Phenotype Single KO	increased skin tumor incidence	217	2.342811e-7	0.000009886230565437788	2.057977	62	0.005833098	148	0.011628461925675676	1.683211	30	44	0.003944255	
Mouse Phenotype Single KO	thymus cortex hypoplasia	257	0.000001549319	0.00005520277853307393	2.214423	45	0.0042337	169	0.02025151825147929	1.974967	16	20	0.002103602	
Mouse Phenotype Single KO	small thymus cortex	266	0.000001846359	0.00006356056151503759	2.199189	45	0.0042337	219	0.04087300540502284	1.880921	16	21	0.002103602	
Mouse Phenotype Single KO	accumulation of giant lysosomes in kidney/renal tubule cells	844	0.002937638	0.03187198005450237	2.390144	14	0.001317151	204	0.032464774438725495	2.468709	8	8	0.001051801	
Mouse Phenotype	pancytopenia	34	7.019866e-20	1.9740276125294117e-17	3.213606	86	0.008091072	354	0.049008416601694915	1.702558	20	29	0.002629503	
Mouse Phenotype	dry eyes	54	1.013614e-16	1.794659898888889e-14	3.317431	68	0.006397591	303	0.033961713297029704	2.005826	13	16	0.001709177	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	173	3.367345e-10	1.8609933841040465e-8	2.764559	51	0.004798194	155	0.003800432115096774	1.892677	23	30	0.003023928	
Mouse Phenotype	early eyelid opening	218	1.61424e-8	7.079701211009173e-7	2.260906	60	0.005644934	358	0.049706784385474864	2.221838	9	10	0.001183276	
Mouse Phenotype	absent Langerhans cell	232	2.976516e-8	0.0000012266581670689657	4.106077	23	0.002163891	349	0.048941252252149	2.468709	7	7	0.0009203261	
Mouse Phenotype	thymus cortex hypoplasia	324	0.000001549319	0.000045719256046296294	2.214423	45	0.0042337	230	0.015536978341304346	1.974967	16	20	0.002103602	
Mouse Phenotype	small thymus cortex	331	0.000001846359	0.000053332442293051356	2.199189	45	0.0042337	297	0.031468376835353536	1.880921	16	21	0.002103602	
Mouse Phenotype	abnormal tail position or orientation	511	0.00005492377	0.0010276441584540117	2.376688	27	0.00254022	349	0.048941252252149	2.468709	7	7	0.0009203261