# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	17	5.298987e-40	4.101727643117647e-37	2.750919	230	0.01899571	304	0.00011261948348026316	1.495372	74	113	0.008999149	
GO Biological Process	mitochondrial transport	19	5.4292e-39	3.760149621052632e-36	2.084576	388	0.03204493	113	1.0193245541238939e-10	1.519131	159	239	0.01933601	
GO Biological Process	endoplasmic reticulum unfolded protein response	23	4.352715e-36	2.4903207254347825e-33	2.694216	214	0.01767426	412	0.0016588165133495146	1.422163	71	114	0.008634318	
GO Biological Process	regulation of DNA-templated transcription in response to stress	24	5.589879e-36	3.064884073375e-33	2.527088	239	0.01973902	310	0.00013907165557096773	1.477541	77	119	0.009363979	
GO Biological Process	rRNA processing	25	8.971866e-35	4.7224313877600005e-32	2.118118	332	0.02741989	85	1.7671809384705885e-14	1.585745	175	252	0.02128177	
GO Biological Process	rRNA metabolic process	26	1.28712e-34	6.51431233846154e-32	2.095056	339	0.02799802	79	6.150008562658228e-15	1.58697	180	259	0.02188982	
GO Biological Process	cellular response to topologically incorrect protein	29	4.398701e-34	1.995948498586207e-31	2.441386	241	0.0199042	305	0.00011373021690163935	1.445652	88	139	0.01070169	
GO Biological Process	mRNA catabolic process	34	1.131971e-32	4.3810607026470595e-30	2.121441	310	0.02560291	133	1.120143549924812e-9	1.522315	142	213	0.01726864	
GO Biological Process	nuclear-transcribed mRNA catabolic process	36	6.025115e-32	2.2023468968055554e-29	2.171965	287	0.02370334	139	2.1308823111510795e-9	1.533848	133	198	0.01617415	
GO Biological Process	RNA catabolic process	37	8.282624e-32	2.945704032864865e-29	2.010642	343	0.02832838	109	1.6747809401834863e-11	1.534949	162	241	0.01970084	
GO Biological Process	cellular response to unfolded protein	41	1.930503e-31	6.195972921219512e-29	2.45555	219	0.01808722	405	0.001330030166691358	1.415376	75	121	0.009120759	
GO Biological Process	response to topologically incorrect protein	43	3.728797e-31	1.1410985982093024e-28	2.156797	284	0.02345557	318	0.0001696152478081761	1.38277	109	180	0.0132555	
GO Biological Process	response to unfolded protein	51	1.86581e-28	4.8141556450980387e-26	2.146502	261	0.021556	411	0.001591441135571776	1.355812	95	160	0.01155296	
GO Biological Process	activation of signaling protein activity involved in unfolded protein response	55	1.045379e-27	2.5011167747272727e-25	6.606763	57	0.004707631	638	0.027848589703761754	2.283473	8	8	0.0009728809	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	58	1.967456e-27	4.463750604137931e-25	2.596615	171	0.01412289	175	3.309217800571429e-8	1.644875	85	118	0.01033686	
GO Biological Process	positive regulation of nuclease activity	60	2.493594e-27	5.468867240999999e-25	5.572726	65	0.005368352	579	0.018274698749050085	1.97901	13	15	0.001580932	
GO Biological Process	translational elongation	62	6.970197e-27	1.4793681019838711e-24	2.582553	169	0.01395771	316	0.0001638736909493671	1.488335	73	112	0.008877539	
GO Biological Process	mitochondrial membrane organization	63	1.160754e-26	2.4245018866666667e-24	2.160704	240	0.01982161	182	5.5179179196153847e-8	1.620529	88	124	0.01070169	
GO Biological Process	multi-organism metabolic process	74	2.101695e-23	3.737324933108108e-21	2.169269	207	0.01709613	131	9.46272429183206e-10	1.631052	105	147	0.01276906	
GO Biological Process	mitochondrial transmembrane transport	76	2.508487e-23	4.343313214868421e-21	2.584535	145	0.01197555	387	0.0010019952852454782	1.513145	55	83	0.006688556	
GO Cellular Component	ribosomal subunit	37	2.748928e-26	1.2838236713513514e-24	2.183138	231	0.0190783	58	3.885732744827586e-7	1.468829	119	185	0.0144716	
GO Cellular Component	mitochondrial ribosome	43	2.738434e-21	1.1004683609302326e-19	2.869385	110	0.009084903	132	0.01201986458181818	1.396948	52	85	0.006323726	
GO Cellular Component	large ribosomal subunit	46	1.682761e-18	6.321328278260869e-17	2.271983	145	0.01197555	76	0.0003620767073684211	1.449509	73	115	0.008877539	
GO Cellular Component	PcG protein complex	47	7.734152e-17	2.8435350331914896e-15	2.378033	119	0.009828213	73	0.00019939418038356164	1.737425	35	46	0.004256354	
GO Cellular Component	endopeptidase complex	54	4.710645e-16	1.5074064e-14	2.443479	107	0.008837132	97	0.0018554622680412372	1.522315	46	69	0.005594065	
GO Cellular Component	proteasome complex	56	6.680077e-15	2.061280902857143e-13	2.376313	104	0.008589362	105	0.0026457391542857142	1.511122	45	68	0.005472455	
GO Cellular Component	intrinsic component of mitochondrial membrane	60	3.250743e-14	9.36213984e-13	2.283747	107	0.008837132	136	0.016957740705882355	1.440345	41	65	0.004986015	
GO Cellular Component	integral component of mitochondrial membrane	61	4.941452e-14	1.3998080419672133e-12	2.278178	106	0.008754542	144	0.023492688	1.427171	40	64	0.004864405	
GO Cellular Component	catalytic step 2 spliceosome	64	2.262806e-13	6.1095762e-12	2.004637	135	0.01114965	92	0.0013900486539130436	1.450957	61	96	0.007418217	
GO Cellular Component	peptidase complex	73	9.248406e-13	2.189211721643836e-11	2.043288	122	0.01007598	111	0.004784515978378379	1.427171	55	88	0.006688556	
GO Cellular Component	small ribosomal subunit	82	5.190874e-11	1.0938817404878048e-9	2.141268	92	0.007598282	93	0.0013771255122580644	1.522315	48	72	0.005837286	
GO Cellular Component	proteasome accessory complex	90	1.174547e-9	2.25513024e-8	3.046877	41	0.003386191	118	0.00653603113220339	1.80775	19	24	0.002310592	
GO Cellular Component	spliceosomal snRNP complex	106	1.8279e-8	2.979821886792453e-7	2.091522	71	0.005863892	169	0.04200864113609467	1.399548	38	62	0.004621184	
GO Cellular Component	mitochondrial nucleoid	107	2.54714e-8	4.1135120747663547e-7	2.248706	59	0.004872811	130	0.011014279975384615	1.576684	29	42	0.003526693	
GO Cellular Component	Bcl-2 family protein complex	116	5.613649e-8	8.362401268965517e-7	3.82173	24	0.001982161	156	0.03416835323076923	2.283473	7	7	0.0008512708	
GO Cellular Component	ESCRT complex	136	3.938008e-7	0.0000050035866352941175	2.47899	40	0.003303601	129	0.010748339497674418	1.712605	21	28	0.002553812	
GO Cellular Component	proteasome regulatory particle	163	0.000004050365	0.00004293883877300614	2.472444	33	0.002725471	152	0.03011602736842105	1.739789	16	21	0.001945762	
GO Cellular Component	exon-exon junction complex	196	0.00002513058	0.00022155939918367347	2.322039	31	0.002560291	152	0.03011602736842105	1.739789	16	21	0.001945762	
GO Cellular Component	preribosome, large subunit precursor	247	0.0003076119	0.002152037907692308	2.010993	31	0.002560291	167	0.04212245231137724	1.644101	18	25	0.002188982	
GO Cellular Component	exosome (RNase complex)	272	0.0006091357	0.0038698032705882356	2.00455	28	0.002312521	162	0.035800330666666665	1.687785	17	23	0.002067372	
GO Molecular Function	unfolded protein binding	8	7.267962e-28	3.8356669455e-25	2.723614	160	0.0132144	73	0.005501943833424657	1.421785	66	106	0.008026268	
GO Molecular Function	structural constituent of ribosome	9	6.490477e-24	3.044754877111111e-21	2.173095	211	0.01742649	21	0.0000041979647571428574	1.494124	106	162	0.01289067	
GO Molecular Function	ribonucleoprotein complex binding	11	1.605785e-20	6.163294790909091e-18	2.212018	172	0.01420548	49	0.0002429013102857143	1.489222	75	115	0.009120759	
GO Molecular Function	protein transporter activity	12	1.502939e-18	5.287840381666666e-16	2.134315	167	0.01379253	23	0.000004059203351304347	1.641246	69	96	0.008391098	
GO Molecular Function	ribonuclease activity	15	8.549495e-17	2.4063978593333334e-14	2.151233	147	0.01214073	66	0.003398989547575758	1.453119	63	99	0.007661437	
GO Molecular Function	exonuclease activity	29	6.091046e-12	8.867722831724138e-10	2.036414	114	0.009415263	101	0.021512339879207917	1.442194	48	76	0.005837286	
GO Molecular Function	NF-kappaB binding	30	6.870144e-12	9.668582656000001e-10	2.792713	60	0.004955401	81	0.00981953802469136	1.794158	22	28	0.002675423	
GO Molecular Function	mRNA 5'-UTR binding	67	3.042352e-8	0.0000019171358423880597	2.630468	43	0.003551371	92	0.01383072589347826	1.868296	18	22	0.002188982	
GO Molecular Function	RNA polymerase I CORE element sequence-specific DNA binding	161	0.0000178288	0.00046753536397515534	3.59284	16	0.00132144	123	0.04634619835772358	2.283473	8	8	0.0009728809	
Human Phenotype	Increased serum lactate	5	7.108172e-17	9.4865663512e-14	2.189538	142	0.01172778	47	0.0001196090952638298	1.552762	68	100	0.008269488	
Human Phenotype	Abnormal CSF metabolite level	19	8.152709e-12	2.863317218789474e-9	2.33131	83	0.006854972	111	0.004526327762072071	1.558561	43	63	0.005229235	
Human Phenotype	Increased CSF lactate	20	1.503766e-11	5.0173152590000004e-9	2.388201	77	0.006359432	116	0.0053612998951724136	1.574809	40	58	0.004864405	
Mouse Phenotype	spleen atrophy	59	8.306706e-13	1.346108746881356e-10	2.541641	77	0.006359432	189	0.03110033444126984	1.756518	20	26	0.002432202	
Mouse Phenotype	abnormal sublingual gland morphology	218	9.193084e-7	0.0000403188422587156	2.492783	37	0.003055831	103	0.0045978468416504855	2.283473	12	12	0.001459321