# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	15	1.226567e-61	1.0760263435333335e-58	2.815386	347	0.01944087	284	0.000033671661577112676	1.387593	89	113	0.008350535	
GO Biological Process	regulation of DNA-templated transcription in response to stress	21	3.148145e-53	1.9726876216666665e-50	2.546299	355	0.01988907	286	0.00003617919356328672	1.37685	93	119	0.00872584	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	22	7.560404e-53	4.522152556181818e-50	2.306347	427	0.02392291	323	0.0001910010109628483	1.307124	115	155	0.01079002	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	28	2.180883e-46	1.0249371213214285e-43	2.579206	301	0.01686369	575	0.013999033943652173	1.293218	69	94	0.00647401	
GO Biological Process	endoplasmic reticulum unfolded protein response	31	2.730651e-45	1.1591173067419354e-42	2.553573	299	0.01675164	412	0.0018675188921359223	1.313604	85	114	0.00797523	
GO Biological Process	cellular response to topologically incorrect protein	43	1.323613e-41	4.050563596976744e-39	2.302092	335	0.01876856	508	0.007740582292716535	1.25479	99	139	0.009288797	
GO Biological Process	regulation of nuclease activity	47	1.13067e-39	3.1656354319148938e-37	4.297878	125	0.007003193	710	0.047485511798591555	1.490733	22	26	0.002064177	
GO Biological Process	cellular response to unfolded protein	50	7.373929e-38	1.94067063422e-35	2.304654	303	0.01697574	537	0.010021632200186219	1.266731	87	121	0.008162882	
GO Biological Process	nuclear-transcribed mRNA catabolic process	52	1.397268e-37	3.535894156153846e-35	2.038074	397	0.02224214	158	1.2052536312025317e-8	1.379167	155	198	0.01454307	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	60	7.622783e-36	1.671803358283333e-33	2.666394	217	0.01215754	695	0.04224826646618705	1.441452	27	33	0.002533308	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	61	1.018744e-35	2.197647917377049e-33	2.619774	223	0.0124937	365	0.000743607879589041	1.400385	62	78	0.005817226	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	77	7.236066e-32	1.2366154869350649e-29	2.400081	233	0.01305395	221	7.691524814479638e-7	1.433309	96	118	0.009007318	
GO Biological Process	mitochondrial translational termination	93	1.089869e-29	1.5421060398924731e-27	2.665677	178	0.009972547	240	0.0000032662288357916665	1.478271	73	87	0.006849315	
GO Biological Process	translational elongation	96	1.867786e-28	2.5602287472916668e-26	2.31167	223	0.0124937	199	1.84261707839196e-7	1.462903	93	112	0.00872584	
GO Biological Process	regulation of necrotic cell death	97	1.912059e-28	2.5938952970103095e-26	4.486875	84	0.004706146	665	0.03341335258796992	1.500771	23	27	0.002158003	
GO Biological Process	regulation of cellular amino acid metabolic process	98	5.390407e-28	7.23799650132653e-26	2.998689	138	0.007731526	715	0.04798264632447553	1.321331	45	60	0.004222181	
GO Biological Process	mitochondrial translational elongation	101	1.73648e-27	2.2624099326732674e-25	2.603303	171	0.009580369	272	0.000023728216880514704	1.450874	70	85	0.006567836	
GO Biological Process	DNA-templated transcription, elongation	102	2.203904e-27	2.8432522290196075e-25	2.267192	223	0.0124937	244	0.0000039031530098770495	1.425436	89	110	0.008350535	
GO Biological Process	cotranslational protein targeting to membrane	104	6.942222e-27	8.783913394038462e-25	2.403721	194	0.01086896	234	0.0000025213718089316235	1.456161	81	98	0.007599925	
GO Biological Process	cellular protein complex disassembly	115	1.567561e-25	1.7936987129565217e-23	2.038983	264	0.01479074	256	0.000011149882851953125	1.384252	99	126	0.009288797	
GO Cellular Component	ribosomal subunit	39	2.587784e-33	1.1465873723076924e-31	2.096406	327	0.01832035	43	2.410598980465116e-10	1.418943	149	185	0.01398011	
GO Cellular Component	mitochondrial ribosome	43	1.833717e-30	7.368983665116279e-29	2.866617	162	0.009076139	65	0.00001303891643076923	1.450874	70	85	0.006567836	
GO Cellular Component	large ribosomal subunit	46	3.724545e-26	1.3991334260869566e-24	2.263994	213	0.01193344	51	1.100718042352941e-7	1.45538	95	115	0.008913492	
GO Cellular Component	mitochondrial large ribosomal subunit	48	5.285895e-24	1.9029222e-22	3.185516	107	0.005994734	79	0.00013101700374683545	1.519963	44	51	0.004128354	
GO Cellular Component	endopeptidase complex	49	6.059066e-23	2.1367481730612245e-21	2.4476	158	0.008852037	108	0.0024364	1.378781	54	69	0.005066617	
GO Cellular Component	proteasome complex	50	8.516306e-22	2.9432353536000005e-20	2.402484	155	0.00868396	116	0.003160497103448276	1.373148	53	68	0.00497279	
GO Cellular Component	peptidase complex	53	1.178507e-20	3.842377539622641e-19	2.135926	188	0.0105328	91	0.0008758519912087911	1.361372	68	88	0.006380184	
GO Cellular Component	spliceosomal snRNP complex	75	1.719094e-12	3.960792576e-11	2.138191	107	0.005994734	97	0.0011499818622680413	1.420786	50	62	0.004691312	
GO Cellular Component	spliceosomal tri-snRNP complex	87	1.442351e-11	2.864807503448276e-10	2.689105	62	0.003473584	106	0.0022298421735849057	1.579523	26	29	0.002439482	
GO Cellular Component	outer mitochondrial membrane protein complex	147	9.075496e-8	0.000001066833815510204	2.955154	33	0.001848843	162	0.02702702933333333	1.644324	14	15	0.001313567	
GO Cellular Component	U4/U6 x U5 tri-snRNP complex	161	4.595958e-7	0.0000049328046111801244	2.251604	48	0.002689226	142	0.016256987492957748	1.541553	21	24	0.001970351	
GO Cellular Component	DNA-directed RNA polymerase I complex	178	9.566245e-7	0.000009286781662921348	2.750576	31	0.001736792	169	0.042865678011834316	1.635934	13	14	0.001219741	
GO Cellular Component	U2-type prespliceosome	311	0.0003212003	0.0017846756218649516	2.09141	28	0.001568715	149	0.017692586093959732	1.651664	15	16	0.001407394	
GO Molecular Function	structural constituent of ribosome	11	2.233704e-29	8.573362080000001e-27	2.067981	296	0.01658356	24	3.5248897474999998e-9	1.435521	132	162	0.01238506	
GO Molecular Function	rRNA binding	12	7.776161e-24	2.735912645166667e-21	3.10955	110	0.00616281	58	0.00020203543879310343	1.497509	51	60	0.004785138	
GO Molecular Function	unfolded protein binding	24	1.942957e-17	3.417985189166667e-15	2.032342	176	0.009860496	114	0.019198459871929825	1.27978	77	106	0.00722462	
GO Molecular Function	NF-kappaB binding	35	3.277774e-15	3.953931950857143e-13	2.683814	85	0.004762172	104	0.008829432063461538	1.573014	25	28	0.002345656	
GO Molecular Function	phosphate transmembrane transporter activity	141	1.497463e-7	0.000004483892756028369	2.087303	62	0.003473584	134	0.04209185914925373	1.541553	21	24	0.001970351	
Human Phenotype	Exercise intolerance	26	3.54052e-15	9.086880753846154e-13	2.185346	127	0.007115245	134	0.014873758450746268	1.359084	54	70	0.005066617	
Human Phenotype	Abnormal CSF metabolite level	43	1.258191e-13	1.9525368704651164e-11	2.172128	114	0.006386912	96	0.0031179696765625004	1.426199	51	63	0.004785138	
Human Phenotype	Laryngomalacia	168	1.327097e-7	0.000005271260881547619	2.330442	49	0.002745252	139	0.017234357100000004	1.761775	14	14	0.001313567	
Human Phenotype	Increased muscle lipid content	187	2.980753e-7	0.000010636665651871657	2.617946	37	0.002072945	135	0.01615080030296296	1.66905	18	19	0.001688872	
Human Phenotype	Increased intramyocellular lipid droplets	235	9.167458e-7	0.000026031679674042554	2.570183	35	0.001960894	175	0.03490696252171428	1.658141	16	17	0.00150122	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	207	3.204517e-10	1.4175730516425121e-8	2.38465	67	0.003753712	106	0.005911401558679245	1.681695	21	22	0.001970351	
Mouse Phenotype	extramedullary hematopoiesis	6	1.263869e-67	2.0139752515e-64	2.204214	604	0.03383943	183	0.007876973526229509	1.238276	123	175	0.01154063	
Mouse Phenotype	increased neural tube apoptosis	232	2.977893e-11	1.227225645387931e-9	2.011125	110	0.00616281	243	0.023459137150617284	1.434003	35	43	0.003283918	
Mouse Phenotype	absent segment of posterior cerebral artery	270	3.204517e-10	1.1347550754444445e-8	2.38465	67	0.003753712	160	0.004089087919125	1.681695	21	22	0.001970351	
Mouse Phenotype	abnormal antigen presentation via MHC class I	519	0.000002413177	0.000044455463	2.788325	28	0.001568715	298	0.04894641656375839	1.651664	15	16	0.001407394