# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	39	2.071728e-42	6.990222756923078e-40	2.029337	455	0.02449133	208	4.095818463173077e-7	1.324599	163	213	0.01502581	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	47	6.120503e-41	1.7136106165319148e-38	2.592903	262	0.0141027	286	0.00005250496212587412	1.364198	93	118	0.008573009	
GO Biological Process	nuclear-transcribed mRNA catabolic process	52	1.328862e-39	3.3627875111538463e-37	2.046881	415	0.02233825	203	3.704088016403941e-7	1.337528	153	198	0.01410398	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	72	2.337394e-36	4.271912173055556e-34	2.291768	294	0.01582517	733	0.02736964286493861	1.240747	81	113	0.007466814	
GO Biological Process	endoplasmic reticulum unfolded protein response	74	1.304264e-35	2.3192986454054056e-33	2.313882	282	0.01517924	699	0.02275356764091559	1.245046	82	114	0.007558997	
GO Biological Process	cellular response to topologically incorrect protein	81	3.418218e-33	5.553127242222222e-31	2.112724	320	0.01722467	709	0.023869275283497884	1.22036	98	139	0.009033923	
GO Biological Process	multi-organism metabolic process	83	5.030798e-33	7.975936250843374e-31	2.130939	312	0.01679406	204	3.756782906519608e-7	1.389444	118	147	0.01087758	
GO Biological Process	regulation of DNA-templated transcription in response to stress	84	5.272732e-33	8.25998576047619e-31	2.136277	310	0.0166864	560	0.008503726471071428	1.265461	87	119	0.008019912	
GO Biological Process	triglyceride homeostasis	90	1.41678e-31	2.07148978e-29	3.586221	122	0.006566907	708	0.023842825555084747	1.460462	27	32	0.002488938	
GO Biological Process	cellular response to unfolded protein	97	9.105668e-31	1.2352730434226804e-28	2.126528	291	0.01566369	656	0.017808995428810974	1.244544	87	121	0.008019912	
GO Biological Process	cotranslational protein targeting to membrane	106	1.682473e-29	2.0886473780188677e-27	2.452248	206	0.01108838	359	0.00042674746963788305	1.360007	77	98	0.007098083	
GO Biological Process	viral gene expression	117	5.118356e-28	5.756619367863248e-26	2.195934	245	0.01318764	265	0.000024486580036603772	1.362928	100	127	0.009218289	
GO Biological Process	protein targeting to ER	118	6.966059e-28	7.768336472966102e-26	2.36144	209	0.01124987	294	0.00006809200639455783	1.388162	81	101	0.007466814	
GO Biological Process	protein-lipid complex subunit organization	120	1.009479e-27	1.10697784675e-25	2.708909	161	0.008666164	631	0.015074378994928686	1.399466	38	47	0.00350295	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	135	4.716116e-25	4.5969904032592595e-23	2.36416	186	0.01001184	399	0.0009422539876942356	1.354632	72	92	0.006637168	
GO Biological Process	viral transcription	145	2.311255e-24	2.0975037617241379e-22	2.147329	222	0.01194962	328	0.0002200961903140244	1.347972	88	113	0.008112094	
GO Biological Process	regulation of mitochondrial membrane permeability	147	2.709376e-24	2.4253522982312926e-22	2.152962	220	0.01184196	453	0.0022618183025607066	1.37525	58	73	0.005346608	
GO Biological Process	mitochondrial transmembrane transport	153	9.534664e-24	8.200434220653596e-22	2.253666	194	0.01044246	502	0.004581169541633467	1.334684	64	83	0.005899705	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	156	1.483054e-23	1.250994076025641e-21	2.139147	216	0.01162666	257	0.00001988443177392996	1.401219	85	105	0.007835546	
GO Biological Process	RNA 3'-end processing	164	5.183694e-23	4.159282277195122e-21	2.150904	208	0.01119604	568	0.00921388778221831	1.277968	79	107	0.007282448	
GO Cellular Component	mitochondrial ribosome	85	1.79904e-14	3.6573424941176475e-13	2.142102	126	0.006782216	108	0.00908572	1.30328	64	85	0.005899705	
GO Cellular Component	nuclear ubiquitin ligase complex	148	5.066604e-10	5.915602508108108e-9	2.207203	77	0.004144687	112	0.012722376857142859	1.428007	33	40	0.003042035	
GO Cellular Component	nuclear pore outer ring	380	0.001046704	0.004759748715789474	2.277821	19	0.001022715	150	0.04763499263999999	1.730918	10	10	0.0009218289	
GO Molecular Function	ribonuclease activity	21	8.394622e-20	1.687718765904762e-17	2.002916	210	0.01130369	108	0.027156670214814813	1.276334	73	99	0.006729351	
GO Molecular Function	mRNA 5'-UTR binding	200	7.925175e-7	0.000016730044425	2.11307	53	0.002852837	85	0.004823826231764706	1.65224	21	22	0.001935841	
GO Molecular Function	mismatched DNA binding	476	0.0005354449	0.004749261276890756	2.158334	24	0.001291851	123	0.0473345582601626	1.730918	12	12	0.001106195	
Human Phenotype	Progressive external ophthalmoplegia	7	1.134513e-23	1.0815150355714286e-20	4.487587	69	0.00371407	93	0.01905083380322581	1.730918	15	15	0.001382743	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	39	3.859913e-26	9.06287777974359e-24	2.003566	283	0.01523307	249	0.005048905019277109	1.321454	71	93	0.006544985	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	67	1.575002e-20	2.1525810916417907e-18	3.145955	92	0.004952094	345	0.021236258811884057	1.573562	20	22	0.001843658	
Mouse Phenotype Single KO	decreased red blood cell distribution width	203	1.735435e-13	7.828265169950739e-12	3.252302	55	0.002960491	344	0.021197297065406975	1.730918	13	13	0.001198378	
Mouse Phenotype Single KO	decreased creatinine clearance	410	1.87984e-8	4.1984621658536586e-7	2.490993	49	0.002637528	381	0.028599185661417323	1.629099	16	17	0.001474926	
Mouse Phenotype	absent segment of posterior cerebral artery	101	1.575002e-20	1.490949913069307e-18	3.145955	92	0.004952094	478	0.01600365984790795	1.573562	20	22	0.001843658	
Mouse Phenotype	decreased red blood cell distribution width	248	1.735435e-13	6.690521788306452e-12	3.252302	55	0.002960491	477	0.015961387959119496	1.730918	13	13	0.001198378	
Mouse Phenotype	decreased creatinine clearance	507	1.87984e-8	3.545000047337278e-7	2.490993	49	0.002637528	532	0.021385387031954885	1.629099	16	17	0.001474926