# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of lipid storage 104 0.000006209991 0.0007857429958557693 4.142482 15 0.005510654 351 0.0016803829306837608 3.410956 11 17 0.003088153 GO Biological Process Fc-gamma receptor signaling pathway 121 0.00001195731 0.0013003821676859503 2.159679 39 0.0143277 428 0.004605831397429906 1.968018 28 75 0.007860752 GO Biological Process Fc receptor mediated stimulatory signaling pathway 134 0.00002056257 0.0020192750644029847 2.106238 39 0.0143277 388 0.002938317877731959 2.021936 28 73 0.007860752 GO Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis 137 0.00002143998 0.002059333553430657 2.125806 38 0.01396032 420 0.004272442188333333 2.004646 27 71 0.007580011 GO Biological Process positive regulation of pri-miRNA transcription from RNA polymerase II promoter 170 0.00004027328 0.0031173887736470588 3.202875 17 0.006245408 676 0.03307286898076923 2.635738 10 20 0.002807412 GO Biological Process regulation of transcription from RNA polymerase III promoter 215 0.0001760015 0.010772110411627907 2.729142 18 0.006612785 705 0.04021086156453901 2.342879 12 27 0.003368894 GO Biological Process entrainment of circadian clock 249 0.0003101381 0.0163899889875502 2.688816 17 0.006245408 724 0.04422865310359116 2.416093 11 24 0.003088153 GO Biological Process ascending aorta morphogenesis 250 0.0003162111 0.0166440874596 3.389144 12 0.004408523 640 0.026590144568749995 5.271477 4 4 0.001122965 GO Biological Process regulation of pri-miRNA transcription from RNA polymerase II promoter 284 0.0004761396 0.022061693649295774 2.215509 23 0.008449669 637 0.026604027494505494 2.363076 13 29 0.003649635 GO Biological Process adherens junction assembly 310 0.0006616043 0.02808403543129032 2.205203 22 0.008082292 561 0.016006745992335116 2.325651 15 34 0.004211117 GO Biological Process labyrinthine layer blood vessel development 341 0.001064963 0.0410963287888563 2.568306 15 0.005510654 548 0.014457769287226278 2.76125 11 21 0.003088153 Mouse Phenotype Single KO abnormal neural fold morphology 38 0.000008597125 0.002071680884868421 2.246316 37 0.01359295 286 0.0015624112039510489 2.355341 21 47 0.005895564 Mouse Phenotype Single KO extended life span 41 0.00001171852 0.0026172314058536582 3.921489 15 0.005510654 616 0.02481227396915584 3.012272 8 14 0.002245929 Mouse Phenotype Single KO decreased white adipose tissue amount 44 0.00001387095 0.0028867338443181816 2.001925 46 0.01689934 272 0.001204691890110294 2.108591 28 70 0.007860752 Mouse Phenotype Single KO persistent right dorsal aorta 47 0.00001592253 0.00310218313212766 3.072103 20 0.007347539 264 0.0009766304698863636 3.76534 10 14 0.002807412 Mouse Phenotype Single KO decreased susceptibility to induced choroidal neovascularization 85 0.0001055019 0.011365657627058823 5.020924 9 0.003306392 680 0.030946445086764703 3.514318 6 9 0.001684447 Mouse Phenotype Single KO increased skin papilloma incidence 104 0.0001683051 0.014818940391346154 3.233823 14 0.005143277 787 0.047830827386276996 2.396126 10 22 0.002807412 Mouse Phenotype Single KO enhanced wound healing 107 0.0001810622 0.01549520154579439 3.059388 15 0.005510654 787 0.047830827386276996 2.396126 10 22 0.002807412 Mouse Phenotype Single KO abnormal neural fold formation 124 0.0002614391 0.01930643418306452 2.268366 24 0.008817046 281 0.0014188869261565836 2.824005 15 28 0.004211117 Mouse Phenotype Single KO increased susceptibility to experimental autoimmune encephalomyelitis 136 0.0003263128 0.021970928747058825 2.117567 27 0.009919177 640 0.026309663475 1.916901 20 55 0.005614823 Mouse Phenotype Single KO absent middle ear ossicles 160 0.000505749 0.02894464745625 5.176904 7 0.002571639 581 0.02038237874698795 5.271477 4 4 0.001122965 Mouse Phenotype Single KO increased body temperature 182 0.0007764383 0.039065085236813187 2.399549 18 0.006612785 611 0.02439182012111293 2.236384 14 33 0.003930376 Mouse Phenotype increased body temperature 28 6.693454e-8 0.000022855754890714287 3.263526 29 0.01065393 616 0.004297380807467532 2.409818 16 35 0.004491859 Mouse Phenotype increased squamous cell carcinoma incidence 33 1.578732e-7 0.000045740171672727275 2.770231 35 0.01285819 763 0.0102767316982962 2.027491 20 52 0.005614823 Mouse Phenotype increased skin tumor incidence 49 0.000001009021 0.0001968826485918367 2.347655 41 0.01506245 459 0.0009805051294771241 1.954592 33 89 0.009264458 Mouse Phenotype abnormal inguinal fat pad morphology 57 0.000001847822 0.0003099478270526316 2.214652 44 0.01616458 395 0.00037938217435443036 2.223904 27 64 0.007580011 Mouse Phenotype increased skin papilloma incidence 60 0.000002551867 0.00040664000645 2.835379 27 0.009919177 351 0.0001519818739145299 2.635738 21 42 0.005895564 Mouse Phenotype abnormal vascular endothelial cell physiology 75 0.00000523611 0.0006674993028 2.123038 44 0.01616458 185 0.000001808192341135135 2.680412 30 59 0.008422235 Mouse Phenotype persistent right dorsal aorta 80 0.000005877244 0.00070240412355 2.991356 23 0.008449669 345 0.00014089807367826087 3.721042 12 17 0.003368894 Mouse Phenotype abnormal sebocyte morphology 92 0.00001170565 0.0012164969527173914 4.828798 12 0.004408523 903 0.01767297380398671 3.012272 8 14 0.002245929 Mouse Phenotype decreased mesenchymal cell proliferation involved in lung development 97 0.00001385899 0.0013660392102061857 3.4928 17 0.006245408 467 0.0010624478014561029 4.217181 8 10 0.002245929 Mouse Phenotype abnormal interventricular septum thickness 102 0.00001898097 0.0017791868055882353 2.029527 43 0.01579721 860 0.015442204566279072 1.833557 24 69 0.006737788 Mouse Phenotype abnormal adaptive thermogenesis 107 0.00002109913 0.0018853157189719627 2.059836 41 0.01506245 590 0.003782662183728814 1.949724 27 73 0.007580011 Mouse Phenotype polydipsia 110 0.00002277263 0.001979355594818182 2.55339 26 0.0095518 899 0.01746979751612903 2.108591 16 40 0.004491859 Mouse Phenotype abnormal thymus involution 116 0.0000286319 0.002359910309482758 3.293892 17 0.006245408 1241 0.04662166253424658 2.291946 10 23 0.002807412 Mouse Phenotype decreased neurotransmitter release 127 0.00004944911 0.003722700320551181 2.343846 28 0.01028655 1222 0.044586698548281505 1.994613 14 37 0.003930376 Mouse Phenotype abnormal mesenchymal cell proliferation involved in lung development 135 0.00005776757 0.004091227679777778 2.640932 22 0.008082292 345 0.00014089807367826087 3.721042 12 17 0.003368894 Mouse Phenotype decreased vascular endothelial cell proliferation 145 0.00006707572 0.004422834199448276 4.351569 11 0.004041146 581 0.003630076377624785 4.100037 7 9 0.001965188 Mouse Phenotype abnormal vascular endothelial cell migration 159 0.00008526334 0.005127061595849056 2.569194 22 0.008082292 575 0.003503068923652174 2.741168 13 25 0.003649635 Mouse Phenotype abnormal vascular endothelial cell proliferation 162 0.00009229452 0.0054470858377777785 3.635431 13 0.0047759 598 0.003986332642474917 3.388806 9 14 0.00252667 Mouse Phenotype axonal dystrophy 186 0.0001481131 0.007613491124193548 3.118089 15 0.005510654 1014 0.02542256699408284 2.510227 10 21 0.002807412 Mouse Phenotype decreased fetal cardiomyocyte proliferation 204 0.0002217719 0.010393927136764706 2.769918 17 0.006245408 916 0.018190846277292578 2.790782 9 17 0.00252667