# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 17 1.074692e-56 8.318748251764707e-54 2.052317 596 0.0314346 284 0.00038238733466549295 1.241208 172 248 0.01639344 GO Biological Process gene silencing 43 1.865143e-42 5.707771334186047e-40 2.134146 404 0.02130802 594 0.026154177095959595 1.203042 121 180 0.0115326 GO Biological Process endoplasmic reticulum unfolded protein response 97 1.823262e-33 2.473433469896907e-31 2.251183 280 0.01476793 321 0.001102611877071651 1.334388 85 114 0.008101411 GO Biological Process cellular response to topologically incorrect protein 104 5.478975e-33 6.932483848557693e-31 2.096035 324 0.01708861 274 0.0003035332741386861 1.326143 103 139 0.009817003 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 108 2.149509e-32 2.6190174936111112e-30 2.366113 244 0.0128692 337 0.0017458006252522257 1.319487 87 118 0.008292032 GO Biological Process cellular response to unfolded protein 118 2.254306e-30 2.513933275762712e-28 2.105164 294 0.01550633 281 0.00036230384359074735 1.345935 91 121 0.008673275 GO Biological Process multi-organism metabolic process 126 2.638043e-29 2.7550799870634925e-27 2.041159 305 0.0160865 280 0.00034811937115 1.314844 108 147 0.01029356 GO Biological Process viral gene expression 127 3.066608e-29 3.177440525354331e-27 2.213168 252 0.01329114 307 0.0007355178043648209 1.324622 94 127 0.008959207 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 150 2.140131e-27 1.8774655886e-25 2.077557 272 0.01434599 500 0.0101424203128 1.282846 81 113 0.007720168 GO Biological Process viral transcription 166 2.595702e-25 2.0576411215662652e-23 2.160932 228 0.01202532 378 0.0028962408967724866 1.314521 83 113 0.007910789 GO Biological Process mitochondrial transmembrane transport 170 6.358951e-25 4.9222021299411764e-23 2.276557 200 0.01054852 551 0.016442471413611614 1.315284 61 83 0.005813953 GO Biological Process cotranslational protein targeting to membrane 173 1.159039e-24 8.816066012138729e-23 2.286199 196 0.01033755 399 0.0034022050330827064 1.333106 73 98 0.006957682 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 178 1.806969e-24 1.3358373635393258e-22 2.328982 187 0.009862869 336 0.001729944801904762 1.36169 70 92 0.00667175 GO Biological Process Fc-gamma receptor signaling pathway 184 1.908082e-23 1.3645897303260868e-21 2.003433 252 0.01329114 536 0.014343054676119403 1.336271 56 75 0.0053374 GO Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis 185 2.149478e-23 1.5289178920000002e-21 2.007843 250 0.01318565 413 0.003939855579176755 1.386348 55 71 0.005242089 GO Biological Process regulation of mitochondrial membrane permeability 191 1.370152e-22 9.439701658638743e-21 2.090407 218 0.01149789 248 0.00009763712697580646 1.470945 60 73 0.005718643 GO Biological Process photoperiodism 201 4.474243e-22 2.929182270497512e-20 3.274849 94 0.004957806 512 0.011402625606054687 1.626954 20 22 0.001906214 GO Biological Process protein targeting to ER 206 1.66136e-21 1.061254186407767e-19 2.147795 194 0.01023207 462 0.0064585084067099565 1.311228 74 101 0.007052993 GO Biological Process positive regulation of mRNA metabolic process 240 3.450033e-19 1.891624343625e-17 2.1721 167 0.008808017 614 0.02840288709934853 1.376653 40 52 0.003812429 GO Biological Process gene silencing by miRNA 251 3.269296e-18 1.7139707595219122e-16 2.309839 138 0.007278481 575 0.020653048211478262 1.423585 35 44 0.003335875 GO Cellular Component ribosomal subunit 36 3.741966e-35 1.79614368e-33 2.09427 347 0.01830169 76 0.00044536153263157895 1.267265 131 185 0.0124857 GO Cellular Component ficolin-1-rich granule lumen 47 1.360361e-27 5.001497463829787e-26 2.062334 279 0.01471519 72 0.000180557904 1.342237 93 124 0.008863896 GO Cellular Component large ribosomal subunit 56 4.504483e-22 1.3899547542857143e-20 2.101312 210 0.01107595 87 0.0020859264 1.307222 84 115 0.0080061 GO Cellular Component PcG protein complex 68 1.71813e-20 4.366071529411765e-19 2.207756 173 0.009124473 115 0.0064315709217391305 1.4395 37 46 0.003526496 GO Cellular Component nuclear transcriptional repressor complex 75 6.434183e-18 1.4824357632e-16 2.487692 117 0.006170886 140 0.02738555382857143 1.481089 24 29 0.002287457 GO Cellular Component cytosolic large ribosomal subunit 96 6.442111e-15 1.1595799799999999e-13 2.117159 134 0.007067511 132 0.016292749090909095 1.349572 46 61 0.004384293 GO Cellular Component cytoplasmic stress granule 112 4.879216e-13 7.527933257142858e-12 2.052127 124 0.006540084 88 0.0020909428363636365 1.498311 36 43 0.003431186 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 15 6.679647e-38 4.0777018385999997e-35 3.157195 176 0.0092827 260 0.01847016206923077 1.542801 25 29 0.002382768 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 17 6.741044e-36 3.6310435239999995e-33 2.930898 186 0.009810127 284 0.023500250734859156 1.482852 29 35 0.002764011 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 39 2.620965e-26 6.153891411538461e-24 2.062978 265 0.01397679 96 0.0001341637855 1.55328 46 53 0.004384293 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 47 4.081003e-25 7.951009461914893e-23 2.526857 164 0.008649789 320 0.03398282885625 1.451067 30 37 0.002859321 Mouse Phenotype Single KO increased circulating interferon-gamma level 86 7.823894e-19 8.330627599767442e-17 2.515896 121 0.006381857 328 0.0363105201097561 1.415072 34 43 0.003240564 Mouse Phenotype Single KO absent segment of posterior cerebral artery 110 4.350934e-17 3.621954785272727e-15 2.881534 86 0.004535865 157 0.0029222792424840765 1.708302 21 22 0.002001525 Mouse Phenotype Single KO decreased spongiotrophoblast size 133 9.208563e-16 6.340061006842105e-14 2.943853 76 0.004008439 240 0.0162860221025 1.690224 17 18 0.001620282 Mouse Phenotype Single KO increased hemangioma incidence 157 8.647765e-15 5.043795165923567e-13 3.848898 49 0.002584388 283 0.023449297371024736 1.684376 16 17 0.001524971 Mouse Phenotype Single KO abnormal circulating interleukin-10 level 171 1.338732e-13 7.1688707157894735e-12 2.585982 80 0.004219409 269 0.02173084093754647 1.574891 22 25 0.002096836 Mouse Phenotype Single KO abnormal cerebral artery morphology 180 2.736592e-13 1.3921651635555556e-11 2.409922 89 0.004694093 135 0.0011503376114074075 1.715081 23 24 0.002192146 Mouse Phenotype Single KO increased interleukin-1 beta secretion 278 1.888205e-10 6.2195299226618705e-9 2.018075 100 0.005274262 346 0.04311830163583815 1.464258 27 33 0.002573389 Mouse Phenotype Single KO thin ventricle myocardium compact layer 305 7.28356e-10 2.1867396367213115e-8 2.228328 74 0.003902954 352 0.04302871698579546 1.789649 11 11 0.001048418 Mouse Phenotype Single KO hyperlipidemia 491 2.338765e-7 0.000004361725275967414 2.102285 59 0.003111814 240 0.0162860221025 1.690224 17 18 0.001620282 Mouse Phenotype abnormal embryonic erythrocyte morphology 36 8.826995e-33 2.344302755416667e-30 2.671232 197 0.0103903 520 0.033482052017307695 1.422542 31 39 0.002954632 Mouse Phenotype abnormal embryonic erythropoiesis 40 3.987414e-32 9.5309163135e-30 2.800896 178 0.009388186 442 0.020961919272624436 1.500996 26 31 0.002478079 Mouse Phenotype enlarged liver sinusoidal spaces 61 1.673037e-25 2.622279796229508e-23 2.393397 185 0.009757384 314 0.007377733470382166 1.484099 34 41 0.003240564 Mouse Phenotype increased circulating interferon-gamma level 73 7.412701e-23 9.708607433013699e-21 2.586402 142 0.007489451 490 0.025859207430612246 1.376653 40 52 0.003812429 Mouse Phenotype abnormal central nervous system regeneration 99 9.709508e-20 9.377030907878788e-18 4.078058 63 0.003322785 511 0.030947834377690806 1.789649 11 11 0.001048418 Mouse Phenotype absent segment of posterior cerebral artery 130 4.350934e-17 3.1999446133846153e-15 2.881534 86 0.004535865 238 0.0020127716769327733 1.708302 21 22 0.002001525 Mouse Phenotype absent hypoglossal nerve 141 2.715264e-16 1.8411800782978724e-14 3.568837 60 0.003164557 534 0.03704966279775281 1.670339 14 15 0.00133435 Mouse Phenotype decreased spongiotrophoblast size 142 2.747698e-16 1.8500521533802817e-14 2.963918 78 0.004113924 316 0.007585939450632911 1.695457 18 19 0.001715593 Mouse Phenotype abnormal circulating interleukin-10 level 182 6.770621e-14 3.5568080978571428e-12 2.278437 105 0.005537975 416 0.016751265012259615 1.482852 29 35 0.002764011 Mouse Phenotype pancytopenia 197 2.412521e-13 1.1708686944670051e-11 2.220517 106 0.005590717 383 0.013091680088772845 1.542801 25 29 0.002382768 Mouse Phenotype abnormal cerebral artery morphology 200 2.736592e-13 1.3082278056e-11 2.409922 89 0.004694093 202 0.0008027084278217822 1.715081 23 24 0.002192146 Mouse Phenotype hyperlipidemia 309 3.515325e-10 1.0877029878640777e-8 2.281988 73 0.003850211 559 0.04307989906797853 1.545606 19 22 0.001810904 Mouse Phenotype increased incidence of tumors by ionizing radiation induction 412 1.09772e-8 2.5474031359223304e-7 2.508419 50 0.002637131 526 0.03497061169961978 1.601265 17 19 0.001620282 Mouse Phenotype increased cellular sensitivity to ultraviolet irradiation 453 2.659293e-8 5.612693239072848e-7 2.096809 69 0.003639241 246 0.0023043004965853657 1.610684 27 30 0.002573389 Mouse Phenotype enhanced lipolysis 463 3.290956e-8 6.795859679481641e-7 2.349576 53 0.002795359 559 0.04307989906797853 1.545606 19 22 0.001810904