# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	20	1.791493e-69	1.1787128193499999e-66	2.198387	629	0.02280307	293	0.00006250340863822526	1.248689	131	155	0.01030766	
GO Biological Process	endoplasmic reticulum unfolded protein response	41	1.471344e-56	4.722296511219512e-54	2.381832	431	0.015625	585	0.006492900283589743	1.218254	94	114	0.007396333	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	47	1.087275e-54	3.0441386648936167e-52	2.315281	441	0.01598753	528	0.0037608297388257578	1.229035	94	113	0.007396333	
GO Biological Process	cellular response to topologically incorrect protein	59	2.578109e-51	5.7500570052542375e-49	2.152186	484	0.0175464	455	0.0013463276569230767	1.222356	115	139	0.009048706	
GO Biological Process	IRE1-mediated unfolded protein response	60	7.54779e-51	1.6553561434999998e-48	3.098914	246	0.008918213	725	0.019756686645517243	1.27367	50	58	0.00393422	
GO Biological Process	cellular response to unfolded protein	63	1.725311e-49	3.6037091188888893e-47	2.195102	446	0.01616879	604	0.007735274142052981	1.208828	99	121	0.007789755	
GO Biological Process	liver regeneration	72	1.12349e-47	2.0533340152777775e-45	3.021638	239	0.008664443	714	0.018462464029411763	1.350818	32	35	0.002517901	
GO Biological Process	regulation of DNA-templated transcription in response to stress	79	5.473904e-46	9.117861105822785e-44	2.10714	454	0.01645882	566	0.005500115588162545	1.216729	98	119	0.007711071	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	82	1.557738e-45	2.499789553902439e-43	2.21787	400	0.01450116	659	0.012722498597723824	1.225975	78	94	0.006137383	
GO Biological Process	response to epidermal growth factor	131	1.535997e-36	1.5429148490839695e-34	2.289768	297	0.01076711	823	0.03415814179343864	1.301569	37	42	0.002911323	
GO Biological Process	regulation of mitochondrial membrane permeability	137	1.251236e-35	1.2018258776642334e-33	2.161868	328	0.01189095	287	0.00004573172029094076	1.356022	67	73	0.005271855	
GO Biological Process	viral gene expression	145	4.44521e-34	4.034104716551724e-32	2.076602	344	0.012471	723	0.019314281504840942	1.186619	102	127	0.008025808	
GO Biological Process	regulation of membrane permeability	146	9.541224e-34	8.599518261369864e-32	2.04612	353	0.01279727	308	0.0000847724142012987	1.331535	73	81	0.005743961	
GO Biological Process	cotranslational protein targeting to membrane	186	2.159319e-30	1.5276601462903226e-28	2.18076	272	0.009860789	775	0.02485325897548387	1.206087	80	98	0.006294752	
GO Biological Process	regulation of plasma lipoprotein particle levels	203	2.311061e-29	1.4980912166995074e-27	2.103613	285	0.01033208	563	0.005359118446358792	1.275066	63	73	0.004957117	
GO Biological Process	regulation of cholesterol metabolic process	246	2.196619e-26	1.1750125780894308e-24	2.247283	219	0.007939385	745	0.022302102820134232	1.282321	46	53	0.003619482	
GO Biological Process	high-density lipoprotein particle remodeling	263	1.060787e-25	5.307565069581749e-24	3.913715	88	0.003190255	755	0.022804512141721852	1.477457	17	17	0.001337635	
GO Biological Process	plasma lipoprotein particle clearance	311	3.16745e-23	1.3402081848874599e-21	2.263668	188	0.006815545	681	0.014224351480616739	1.333315	37	41	0.002911323	
GO Biological Process	positive regulation of intrinsic apoptotic signaling pathway	319	8.740474e-23	3.6055140240125396e-21	2.134194	210	0.007613109	868	0.044358109711981564	1.258574	46	54	0.003619482	
GO Biological Process	regulation of cholesterol biosynthetic process	418	1.685097e-19	5.304830483971292e-18	2.135653	177	0.006416763	823	0.03415814179343864	1.301569	37	42	0.002911323	
GO Cellular Component	DNA-directed RNA polymerase I complex	284	0.000001035627	0.000006301279774647888	2.353978	41	0.001486369	160	0.0456258204	1.477457	14	14	0.001101582	
GO Molecular Function	unfolded protein binding	18	1.266764e-34	2.971265337777778e-32	2.226676	298	0.01080336	136	0.044311224897058826	1.198691	86	106	0.006766858	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	33	3.386066e-42	9.39582010969697e-40	3.684906	160	0.005800464	498	0.03927814244779116	1.4103	21	22	0.001652372	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	55	2.672125e-36	4.4488452045454545e-34	2.044058	382	0.01384861	207	0.0008134508146376812	1.365951	49	53	0.003855535	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	71	8.920952e-33	1.150551513577465e-30	3.015151	162	0.00587297	410	0.023646567782926824	1.415896	23	24	0.001809741	
Mouse Phenotype Single KO	pale liver	85	1.955376e-30	2.106515062588235e-28	2.019737	327	0.0118547	286	0.00384561021993007	1.274307	69	80	0.005429223	
Mouse Phenotype Single KO	abnormal hypoglossal nerve morphology	176	5.277662e-22	2.745883575795455e-20	2.149059	199	0.007214327	363	0.013570573096418733	1.357663	34	37	0.002675269	
Mouse Phenotype Single KO	abnormal transitional stage T2 B cell morphology	186	1.871986e-21	9.216008495698925e-20	2.957965	106	0.003842807	486	0.03643792630452675	1.477457	16	16	0.00125895	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	232	1.038556e-18	4.099162625862068e-17	2.82892	98	0.003552784	394	0.020573076058121826	1.477457	18	18	0.001416319	
Mouse Phenotype Single KO	abnormal stapedial artery morphology	249	5.933158e-18	2.181924811485944e-16	2.719704	100	0.00362529	437	0.027416791398169337	1.477457	17	17	0.001337635	
Mouse Phenotype Single KO	absent stapedial artery	275	6.106915e-17	2.033491660181818e-15	2.682884	96	0.003480278	486	0.03643792630452675	1.477457	16	16	0.00125895	
Mouse Phenotype Single KO	absent notochord	280	7.193544e-17	2.3525458002857143e-15	2.20711	140	0.005075406	437	0.027416791398169337	1.477457	17	17	0.001337635	
Mouse Phenotype	absent segment of posterior cerebral artery	48	3.386066e-42	6.74462021375e-40	3.684906	160	0.005800464	710	0.028765507390140846	1.4103	21	22	0.001652372	
Mouse Phenotype	abnormal cerebral artery morphology	97	8.920952e-33	8.793115677525773e-31	3.015151	162	0.00587297	611	0.016567648188216037	1.415896	23	24	0.001809741	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	124	3.544079e-30	2.7326563966935487e-28	2.574884	193	0.00699681	637	0.019437152773940345	1.375563	27	29	0.002124479	
Mouse Phenotype	increased body temperature	173	8.080993e-26	4.466033183410405e-24	2.287637	206	0.007468097	831	0.04783831968231047	1.308605	31	35	0.002439216	
Mouse Phenotype	absent heart	233	4.287585e-21	1.7593819821888415e-19	3.015985	101	0.003661543	767	0.03563078049934811	1.477457	15	15	0.001180266	
Mouse Phenotype	decreased transitional stage T2 B cell number	250	2.08518e-20	7.974562392e-19	2.328244	154	0.005582947	790	0.041247557893670884	1.363806	24	26	0.001888426	
Mouse Phenotype	abnormal hypoglossal nerve topology	292	1.038556e-18	3.400559560273972e-17	2.82892	98	0.003552784	579	0.014617294393264247	1.477457	18	18	0.001416319	
Mouse Phenotype	mammary gland hyperplasia	358	2.258742e-16	6.032355380446927e-15	2.273293	127	0.004604118	840	0.048711633207142856	1.403584	19	20	0.001495004	
Mouse Phenotype	abnormal stapedial artery morphology	414	5.971702e-15	1.3791169763768116e-13	2.299202	112	0.004060325	840	0.048711633207142856	1.403584	19	20	0.001495004	
Mouse Phenotype	common ventricle	598	2.34905e-11	3.7557302759197325e-10	2.109698	99	0.003589037	579	0.014617294393264247	1.477457	18	18	0.001416319