# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process anterograde axonal transport 95 3.160786e-8 0.000004378187681473685 2.446756 49 0.004356717 1252 0.04620854320607029 1.463361 24 31 0.002415945 GO Biological Process photoperiodism 136 2.335852e-7 0.000022601085638235292 2.466689 42 0.003734329 996 0.0139981372751004 1.632424 19 22 0.001912623 GO Biological Process negative regulation of viral transcription 142 2.741665e-7 0.00002540673925 2.316472 47 0.004178892 1105 0.02283695029321267 1.575146 20 24 0.002013288 GO Biological Process positive regulation of mRNA catabolic process 145 2.899529e-7 0.000026313725593793105 2.102017 58 0.005156931 1269 0.049887988090622545 1.51214 20 25 0.002013288 GO Biological Process entrainment of circadian clock by photoperiod 178 0.000001099072 0.00008125105869662922 2.473116 37 0.003289766 1046 0.018260553079349904 1.680156 16 18 0.00161063 GO Biological Process N-terminal protein amino acid modification 263 0.00001245772 0.000623312309809886 2.073157 43 0.003823242 1186 0.03446679396458684 1.52668 21 26 0.002113952 GO Biological Process histone H2A ubiquitination 285 0.00002085341 0.000962842183122807 2.06676 41 0.003645417 996 0.0139981372751004 1.632424 19 22 0.001912623 GO Biological Process regulation of intrinsic apoptotic signaling pathway by p53 class mediator 359 0.00006560468 0.002404713047688022 2.063319 36 0.003200854 1186 0.03446679396458684 1.52668 21 26 0.002113952 GO Biological Process regulation of ARF protein signal transduction 362 0.0000682648 0.002481482053038674 2.059094 36 0.003200854 1142 0.028347631715411558 1.667802 15 17 0.001509966 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 443 0.0002324098 0.006903567851467268 2.073066 30 0.002667378 1262 0.04850091458874802 1.591726 16 19 0.00161063 GO Molecular Function cyclin-dependent protein serine/threonine kinase inhibitor activity 24 0.000003845444 0.0006764776903333333 3.174203 22 0.001956077 139 0.014558585916546763 1.890175 12 12 0.001207973 Human Phenotype Flat acetabular roof 9 0.000001085601 0.0008049128303333334 2.787022 30 0.002667378 249 0.015321256238554216 1.772039 15 16 0.001509966 Human Phenotype Abnormality of metacarpal epiphyses 48 0.0001094098 0.015210241570833333 2.468273 23 0.00204499 317 0.03608398436908517 1.890175 10 10 0.001006644 Human Phenotype Abnormality of the phalanges of the hallux 54 0.0001305531 0.01613297845 2.146456 30 0.002667378 211 0.008015028851658768 1.890175 13 13 0.001308637 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 8 2.441987e-8 0.00002795159369875 2.018845 76 0.006757358 877 0.028922880460661344 1.458135 27 35 0.002717938 Mouse Phenotype Single KO absent segment of posterior cerebral artery 12 1.004788e-7 0.00007667369763333333 2.485305 44 0.003912154 372 0.00041476779193548385 1.804258 21 22 0.002113952 Mouse Phenotype Single KO abnormal pharyngeal muscle morphology 15 7.149267e-7 0.00043643891946000004 3.125509 26 0.002311728 714 0.01162517316302521 1.890175 11 11 0.001107308 Mouse Phenotype Single KO abnormal synaptic vesicle recycling 16 9.778787e-7 0.00055965220349375 2.746747 31 0.002756291 964 0.03935582660477179 1.653903 14 16 0.001409301 Mouse Phenotype Single KO abnormal infrahyoid muscle morphology 20 0.000002535046 0.0011606708111 3.0686 24 0.002133902 802 0.019571831552369075 1.890175 10 10 0.001006644 Mouse Phenotype Single KO abnormal infrahyoid muscle connection 21 0.000003435522 0.0014980511882857143 3.100284 23 0.00204499 930 0.03191613272580645 1.890175 9 9 0.0009059795 Mouse Phenotype Single KO abnormal cerebral artery morphology 23 0.000004649109 0.001850951787521739 2.099774 46 0.00408998 328 0.00014277622317682926 1.811418 23 24 0.002315281 Mouse Phenotype Single KO abnormal stapedial artery morphology 28 0.000007091857 0.002319290519607143 2.334588 35 0.003111941 589 0.004973611335314092 1.778988 16 17 0.00161063 Mouse Phenotype Single KO reduced sympathetic cervical ganglion size 34 0.000009106673 0.0024526413135588236 2.767341 25 0.002222815 918 0.03181808126361656 1.744777 12 13 0.001207973 Mouse Phenotype Single KO absent hypoglossal nerve 44 0.0000167175 0.003479139715909091 2.607057 26 0.002311728 731 0.012753897158686729 1.764163 14 15 0.001409301 Mouse Phenotype Single KO thin ventricle myocardium compact layer 48 0.00001786206 0.00340756007125 2.081292 41 0.003645417 714 0.01162517316302521 1.890175 11 11 0.001107308 Mouse Phenotype Single KO thin interventricular septum 52 0.00002246163 0.003955406652115385 2.08098 40 0.003556504 997 0.04272129925075226 1.591726 16 19 0.00161063 Mouse Phenotype Single KO absent stapedial artery 56 0.00002340891 0.00382777480125 2.261857 33 0.002934116 650 0.008054015400923077 1.772039 15 16 0.001509966 Mouse Phenotype Single KO abnormal transitional stage T2 B cell morphology 68 0.00005563883 0.007492423033970589 2.190068 32 0.002845203 964 0.03935582660477179 1.653903 14 16 0.001409301 Mouse Phenotype Single KO decreased transitional stage T2 B cell number 78 0.00007544596 0.008857162252820513 2.374845 26 0.002311728 1028 0.049927152916342414 1.732661 11 12 0.001107308 Mouse Phenotype Single KO testis degeneration 80 0.00007869713 0.009007870242625001 2.416233 25 0.002222815 918 0.03181808126361656 1.744777 12 13 0.001207973 Mouse Phenotype Single KO heterochrony 84 0.0000961452 0.010480971385714286 2.00086 37 0.003289766 385 0.0004709288122857143 1.890175 17 17 0.001711295 Mouse Phenotype abnormal transitional stage T2 B cell morphology 5 1.775221e-8 0.000033945775962 2.159558 66 0.005868232 1046 0.007318622839101338 1.564283 24 29 0.002415945 Mouse Phenotype decreased transitional stage T2 B cell number 7 2.804402e-8 0.000038304125031428575 2.224742 60 0.005334756 1338 0.022197797995515696 1.52668 21 26 0.002113952 Mouse Phenotype absent segment of posterior cerebral artery 8 1.004788e-7 0.00012008472585 2.485305 44 0.003912154 602 0.00026760953122923587 1.804258 21 22 0.002113952 Mouse Phenotype increased large intestine adenocarcinoma incidence 10 1.221931e-7 0.00011682882291 3.177293 29 0.002578465 1589 0.041685785507237255 1.638152 13 15 0.001308637 Mouse Phenotype absent heart 11 1.306379e-7 0.00011354808744545453 2.709755 37 0.003289766 1589 0.041685785507237255 1.638152 13 15 0.001308637 Mouse Phenotype increased leiomyosarcoma incidence 31 0.000002244766 0.0006923292814838709 4.032972 17 0.001511514 1354 0.0228888857127031 1.890175 9 9 0.0009059795 Mouse Phenotype increased adrenal gland tumor incidence 33 0.000002412577 0.0006989893544545455 2.625554 31 0.002756291 1277 0.018419270243539544 1.667802 15 17 0.001509966 Mouse Phenotype abnormal infrahyoid muscle morphology 35 0.000002535046 0.0006925021373142856 3.0686 24 0.002133902 1196 0.013703287261705685 1.890175 10 10 0.001006644 Mouse Phenotype abnormal infrahyoid muscle connection 38 0.000003435522 0.0008643954168947368 3.100284 23 0.00204499 1354 0.0228888857127031 1.890175 9 9 0.0009059795 Mouse Phenotype abnormal pharyngeal muscle morphology 41 0.000004203848 0.0009803168470243903 2.82818 26 0.002311728 1515 0.0353726329069307 1.732661 11 12 0.001107308 Mouse Phenotype abnormal cerebral artery morphology 42 0.000004649109 0.0010583364559285714 2.099774 46 0.00408998 518 0.00009439523618918919 1.811418 23 24 0.002315281 Mouse Phenotype reduced sympathetic cervical ganglion size 51 0.000009106673 0.0017072333441764706 2.767341 25 0.002222815 1347 0.02264118619153675 1.744777 12 13 0.001207973 Mouse Phenotype absent hypoglossal nerve 61 0.0000167175 0.002620262581967213 2.607057 26 0.002311728 1087 0.008955314608095677 1.764163 14 15 0.001409301 Mouse Phenotype abnormal stapedial artery morphology 69 0.00002141763 0.0029677385569565214 2.064256 41 0.003645417 695 0.0007578578238129496 1.795666 19 20 0.001912623 Mouse Phenotype increased kidney tumor incidence 75 0.00002939743 0.0037475843764 2.422134 28 0.002489553 1424 0.02781801820997191 1.653903 14 16 0.001409301 Mouse Phenotype absent hypoglossal canal 94 0.00005705018 0.005802731606170213 3.410824 15 0.001333689 1539 0.038077779001949315 1.890175 8 8 0.0008053151 Mouse Phenotype absent stapedial artery 96 0.00006154914 0.0061299096618749995 2.00414 39 0.003467591 760 0.0012489546880263159 1.790692 18 19 0.001811959 Mouse Phenotype heterochrony 104 0.0000961452 0.008838887088461537 2.00086 37 0.003289766 614 0.00030831717962540717 1.890175 17 17 0.001711295 Mouse Phenotype increased fibroma incidence 148 0.0002298844 0.014850842894594596 2.517801 20 0.001778252 1354 0.0228888857127031 1.890175 9 9 0.0009059795 Mouse Phenotype abnormal intestine placement 286 0.001447064 0.048375450713286715 2.406787 16 0.001422602 1196 0.013703287261705685 1.890175 10 10 0.001006644