# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process platelet activation 100 9.946165e-15 1.3088158523500002e-12 2.17835 122 0.02929172 40 0.000014385070086499999 1.888507 62 141 0.01418115 GO Biological Process platelet aggregation 107 2.213277e-14 2.721917013364486e-12 3.802271 48 0.01152461 277 0.014931683568953066 2.095039 20 41 0.004574565 GO Biological Process regulation of T cell differentiation 147 2.06656e-12 1.8499226557823128e-10 2.001181 123 0.02953181 323 0.022329788205572753 1.567954 46 126 0.0105215 GO Biological Process response to topologically incorrect protein 162 5.80063e-12 4.711758652469136e-10 2.163587 98 0.02352941 304 0.01851874727236842 1.479331 62 180 0.01418115 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell activation 199 6.247867e-11 4.131441299145728e-9 2.899871 51 0.0122449 287 0.015846989388501743 2.290576 16 30 0.003659652 GO Biological Process erythrocyte differentiation 224 2.654267e-10 1.5592633684375002e-8 2.485822 62 0.01488595 299 0.018344671433779262 1.805074 29 69 0.00663312 GO Biological Process erythrocyte homeostasis 225 2.692573e-10 1.5747363603111108e-8 2.405053 66 0.01584634 343 0.025136425383965016 1.729088 31 77 0.007090576 GO Biological Process regulation of CD4-positive, alpha-beta T cell activation 249 8.112458e-10 4.287222282008032e-8 2.454394 60 0.01440576 242 0.00871814744338843 2.05794 23 48 0.00526075 GO Biological Process regulation of proton transport 254 1.019761e-9 5.28308464527559e-8 4.73176 24 0.005762305 278 0.01514737696798561 2.779008 11 17 0.002516011 GO Biological Process homotypic cell-cell adhesion 273 2.106767e-9 1.0154925623809524e-7 2.526398 54 0.01296519 286 0.015756278329720277 1.944829 24 53 0.005489478 GO Biological Process response to unfolded protein 277 2.485843e-9 1.1809100374368231e-7 2.032203 85 0.02040816 268 0.01328994678022388 1.530033 57 160 0.01303751 GO Biological Process production of molecular mediator of immune response 287 3.240642e-9 1.48584000271777e-7 2.424005 57 0.01368547 355 0.028557773002816905 1.76846 28 68 0.006404392 GO Biological Process positive regulation of T cell differentiation 295 4.135298e-9 1.8446232671864408e-7 2.069759 79 0.01896759 398 0.04092161353517588 1.706166 29 73 0.00663312 GO Biological Process myeloid cell homeostasis 364 2.781038e-8 0.000001005375797857143 2.017096 75 0.0180072 309 0.019143768561488674 1.672724 37 95 0.008462946 GO Biological Process lipopolysaccharide-mediated signaling pathway 369 3.145851e-8 0.0000011218496831707317 3.029674 34 0.008163265 324 0.02277038233703704 2.216687 16 31 0.003659652 GO Biological Process negative regulation of immune effector process 406 8.550491e-8 0.0000027713278588423646 2.024265 69 0.01656663 267 0.013336276865168542 1.661208 41 106 0.009377859 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 418 1.294002e-7 0.000004073629741148325 2.624953 39 0.009363745 316 0.020051405195886076 1.908814 24 54 0.005489478 GO Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis 549 0.000001979691 0.000047451282092896165 2.010832 55 0.01320528 187 0.0029832262243315506 1.935698 32 71 0.007319305 GO Biological Process neurotrophin TRK receptor signaling pathway 560 0.000002538185 0.00005964281502678571 3.639035 19 0.004561825 305 0.018483420466557376 2.86322 10 15 0.002287283 GO Biological Process peptide catabolic process 705 0.00001468461 0.0002740918907659575 2.314056 33 0.007923169 201 0.0038377503355721395 2.415842 18 32 0.004117109 GO Cellular Component ficolin-1-rich granule lumen 37 1.397292e-14 6.525731286486486e-13 2.691957 80 0.01920768 39 0.007846462523076922 1.627879 47 124 0.01075023 GO Cellular Component melanosome 82 1.90253e-8 4.009233951219512e-7 2.036707 75 0.0180072 47 0.0350872128 1.595223 39 105 0.008920403 Mouse Phenotype Single KO abnormal erythropoiesis 27 4.876414e-30 1.653826777703704e-27 2.954703 150 0.03601441 48 5.57911972875e-7 2.108371 54 110 0.01235133 Mouse Phenotype Single KO abnormal platelet activation 29 2.34167e-29 7.394024893103447e-27 3.660495 109 0.02617047 126 0.0002744964093412698 1.970569 39 85 0.008920403 Mouse Phenotype Single KO abnormal T cell activation 30 5.41956e-29 1.6542303640000002e-26 2.243532 236 0.05666267 84 0.000018488702478571427 1.575267 106 289 0.0242452 Mouse Phenotype Single KO abnormal platelet aggregation 34 2.174898e-28 5.857512054705882e-26 3.666571 105 0.02521008 144 0.0004743380687638888 1.98223 36 78 0.008234218 Mouse Phenotype Single KO decreased myeloid cell number 37 2.961746e-27 7.329921114054054e-25 2.064623 266 0.06386555 36 5.2084634458333335e-8 1.689769 120 305 0.02744739 Mouse Phenotype Single KO decreased T cell proliferation 39 8.404145e-27 1.9732501478205127e-24 2.657182 158 0.03793517 147 0.00048029536431292515 1.6893 59 150 0.01349497 Mouse Phenotype Single KO abnormal platelet physiology 40 6.961241e-26 1.593602095925e-23 3.005568 125 0.030012 89 0.000025410510379775276 1.952196 50 110 0.01143641 Mouse Phenotype Single KO abnormal T cell proliferation 41 1.303426e-25 2.91109070292683e-23 2.211086 214 0.05138055 127 0.0002823232884251969 1.530342 93 261 0.02127173 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 47 1.548934e-22 3.0177848165957444e-20 2.478072 149 0.03577431 185 0.0012082329868108109 1.595223 65 175 0.01486734 Mouse Phenotype Single KO decreased erythrocyte cell number 51 1.767913e-21 3.1742704590196083e-19 2.252202 171 0.04105642 88 0.00002511641272386364 1.742474 71 175 0.01623971 Mouse Phenotype Single KO abnormal hemostasis 57 9.282832e-20 1.491278817964912e-17 2.092647 184 0.04417767 114 0.00015638155918421052 1.600801 82 220 0.01875572 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 59 1.405003e-19 2.1806122832203393e-17 2.12976 175 0.04201681 184 0.0012030073446195652 1.480976 90 261 0.02058554 Mouse Phenotype Single KO decreased erythroid progenitor cell number 60 2.081775e-19 3.1771356125e-17 3.117154 87 0.02088836 215 0.0022277609579534883 2.105309 25 51 0.005718207 Mouse Phenotype Single KO abnormal blood coagulation 64 2.955261e-19 4.22833202765625e-17 2.077801 182 0.04369748 132 0.0003564661933636364 1.576085 80 218 0.01829826 Mouse Phenotype Single KO decreased platelet aggregation 72 1.111499e-18 1.4136106031944442e-16 3.543921 70 0.01680672 316 0.013390226042088607 1.861093 26 60 0.005946935 Mouse Phenotype Single KO decreased susceptibility to autoimmune disorder 77 5.999207e-18 7.134381623246754e-16 2.440996 120 0.02881152 310 0.011504423534838711 1.511144 57 162 0.01303751 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 78 1.203541e-17 1.4129262739743589e-15 2.976812 84 0.02016807 247 0.004302103184210527 2.025864 25 53 0.005718207 Mouse Phenotype Single KO abnormal neutrophil cell number 82 2.870653e-17 3.2056792098780486e-15 2.016282 174 0.04177671 328 0.015880828760975612 1.378192 86 268 0.01967063 Mouse Phenotype Single KO decreased inflammatory response 94 1.582442e-15 1.5415341908510638e-13 2.054674 148 0.03553421 347 0.019225614975216136 1.385429 80 248 0.01829826 Mouse Phenotype Single KO thrombocytopenia 96 1.785531e-15 1.7031361840625e-13 2.154913 132 0.03169268 121 0.0002465344407438016 1.712318 61 153 0.01395242 Mouse Phenotype abnormal erythropoiesis 34 4.868168e-32 1.368957477882353e-29 2.785314 176 0.0422569 63 2.673425573333333e-8 2.017706 70 149 0.01601098 Mouse Phenotype abnormal T cell activation 36 2.580581e-30 6.8535930391666665e-28 2.028939 309 0.07418968 118 0.0000065014872922881365 1.491115 142 409 0.03247941 Mouse Phenotype abnormal platelet aggregation 38 1.43998e-28 3.6230654684210525e-26 3.527732 111 0.02665066 219 0.0004458709046575342 1.873277 41 94 0.009377859 Mouse Phenotype abnormal platelet activation 39 1.820794e-28 4.4637465215384614e-26 3.493223 112 0.02689076 254 0.000923064486496063 1.803829 42 100 0.009606587 Mouse Phenotype abnormal T cell proliferation 40 2.737046e-28 6.5422242015e-26 2.065818 276 0.06626651 251 0.0009176278311155378 1.400488 120 368 0.02744739 Mouse Phenotype decreased T cell proliferation 43 1.640219e-27 3.6470078741860467e-25 2.329667 207 0.04969988 208 0.0003368563236778846 1.572755 78 213 0.01784081 Mouse Phenotype abnormal platelet physiology 49 7.800791e-26 1.522109443897959e-23 2.855644 135 0.03241297 122 0.000009507818896721311 1.887123 58 132 0.01326624 Mouse Phenotype abnormal kidney afferent arteriole morphology 50 8.173348e-26 1.56290760456e-23 23.71782 25 0.006002401 651 0.04852780278801843 3.579026 5 6 0.001143641 Mouse Phenotype decreased inflammatory response 54 4.666517e-24 8.262327599444445e-22 2.245388 194 0.04657863 316 0.0028757545543670886 1.407908 99 302 0.0226441 Mouse Phenotype abnormal mean corpuscular hemoglobin 60 1.013919e-22 1.6156799265e-20 2.413396 158 0.03793517 191 0.00023348287374345552 1.633903 70 184 0.01601098 Mouse Phenotype decreased erythrocyte cell number 62 3.045034e-22 4.695737108709678e-20 2.113169 204 0.04897959 77 3.041561461948052e-7 1.74768 94 231 0.02150046 Mouse Phenotype decreased platelet aggregation 71 1.828254e-19 2.4619628864788733e-17 3.443745 76 0.0182473 342 0.004422384637719298 1.849163 31 72 0.007090576 Mouse Phenotype abnormal embryonic erythropoiesis 73 2.257699e-19 2.956967142328767e-17 4.226222 59 0.01416567 558 0.033182615639784946 2.078144 15 31 0.003430924 Mouse Phenotype decreased erythroid progenitor cell number 77 5.019448e-19 6.232589912727272e-17 2.757151 103 0.02472989 183 0.00018502677081967214 2.034394 36 76 0.008234218 Mouse Phenotype abnormal proerythroblast morphology 88 1.374123e-16 1.492953409431818e-14 2.647182 95 0.02280912 553 0.032547545826401444 1.651858 30 78 0.006861848 Mouse Phenotype decreased pre-B cell number 90 1.764786e-16 1.874790994e-14 2.337429 119 0.02857143 402 0.008704909962686566 1.651858 40 104 0.009149131 Mouse Phenotype decreased susceptibility to autoimmune disorder 92 2.886804e-16 3.0000796786956526e-14 2.216888 131 0.03145258 633 0.04551393971090048 1.368451 65 204 0.01486734 Mouse Phenotype abnormal pre-B cell morphology 102 6.437899e-16 6.034583562647058e-14 2.163191 135 0.03241297 436 0.012443474840366973 1.550014 48 133 0.01097896 Mouse Phenotype abnormal erythroid progenitor cell morphology 104 9.37482e-16 8.618524425e-14 2.229039 125 0.030012 220 0.0004499936800909091 1.76846 49 119 0.01120769 Mouse Phenotype abnormal embryonic hematopoiesis 113 2.954878e-15 2.5001405803539825e-13 2.65781 86 0.02064826 445 0.013508721860224717 1.830584 26 61 0.005946935