# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA processing	18	2.251582e-30	1.6460315298888886e-27	2.348291	229	0.03039958	109	3.90499361238532e-9	1.595092	136	252	0.02140721	
GO Biological Process	rRNA metabolic process	20	1.180845e-29	7.7693696775e-27	2.304562	232	0.03079782	112	3.927984998214286e-9	1.586216	139	259	0.02187943	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	22	3.223639e-29	1.9281757091363638e-26	2.902895	151	0.02004513	274	0.0009028711671167883	1.569351	60	113	0.009444357	
GO Biological Process	ribosome biogenesis	23	1.291642e-28	7.389876990434782e-26	2.067783	284	0.03770078	63	6.528027422698413e-12	1.601338	175	323	0.02754604	
GO Biological Process	regulation of DNA-templated transcription in response to stress	25	1.370603e-26	7.2143059508e-24	2.66825	157	0.02084163	260	0.0006736254056923076	1.564736	63	119	0.009916575	
GO Biological Process	RNA catabolic process	26	6.008806e-26	3.041149159769231e-23	2.16707	230	0.03053232	166	0.000001878562193072289	1.508466	123	241	0.01936093	
GO Biological Process	nucleic acid phosphodiester bond hydrolysis	27	1.782431e-25	8.687040566296296e-23	2.042375	259	0.03438205	162	9.829643034567902e-7	1.483141	139	277	0.02187943	
GO Biological Process	RNA phosphodiester bond hydrolysis	28	2.36526e-25	1.1115877264285716e-22	2.691962	147	0.01951414	190	0.000013038103418947369	1.644476	74	133	0.01164804	
GO Biological Process	mRNA catabolic process	29	2.962481e-25	1.3442512923793104e-22	2.254901	205	0.02721359	216	0.00006338763405555556	1.470868	106	213	0.01668503	
GO Biological Process	nuclear-transcribed mRNA catabolic process	30	4.743452e-25	2.0806361622666666e-22	2.323319	191	0.0253551	214	0.000053914150887383174	1.492733	100	198	0.01574059	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	35	1.739207e-23	6.538921403714285e-21	2.898288	120	0.01592991	352	0.003417335850880682	1.51704	58	113	0.009129545	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	38	6.599724e-23	2.2854149504210527e-20	2.880036	118	0.01566441	358	0.0036269243802513965	1.502853	60	118	0.009444357	
GO Biological Process	regulation of hematopoietic stem cell differentiation	40	8.067531e-23	2.654016010725e-20	3.005228	110	0.01460242	341	0.0029229438397360705	1.549544	54	103	0.008499921	
GO Biological Process	regulation of mRNA stability	42	2.878091e-22	9.017333206904763e-20	2.211035	187	0.02482411	189	0.000012130989677777778	1.605034	82	151	0.01290729	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	48	1.561212e-20	4.2799976474999995e-18	2.894931	104	0.01380592	349	0.0033339634859025787	1.629376	43	78	0.006768456	
GO Biological Process	endoplasmic reticulum unfolded protein response	50	1.652266e-20	4.3484336588e-18	2.569962	127	0.01685915	418	0.008122975145933013	1.477806	57	114	0.008972139	
GO Biological Process	regulation of RNA stability	53	3.253971e-20	8.079057431886792e-18	2.101719	189	0.02508961	213	0.00005178062793239437	1.551696	84	160	0.0132221	
GO Biological Process	response to unfolded protein	57	1.24529e-19	2.874872124561403e-17	2.194336	166	0.02203637	298	0.0014696677723489934	1.459333	79	160	0.01243507	
GO Biological Process	protein targeting to ER	63	3.578812e-19	7.475172556825396e-17	2.814381	101	0.01340767	268	0.0007779458407835821	1.609491	55	101	0.008657327	
GO Biological Process	response to topologically incorrect protein	64	3.720119e-19	7.64891342515625e-17	2.123951	174	0.02309837	407	0.007464302107125308	1.379285	84	180	0.0132221	
GO Cellular Component	ribosome	30	1.044248e-21	6.01486848e-20	2.124539	199	0.0264171	36	4.65195744e-8	1.565472	125	236	0.01967574	
GO Cellular Component	ribosomal subunit	32	3.902225e-21	2.1072015e-19	2.354536	155	0.02057613	41	0.0000011044061034146342	1.581652	99	185	0.01558319	
GO Cellular Component	endopeptidase complex	33	1.800231e-20	9.426664145454545e-19	3.230071	88	0.01168193	52	0.000011654306584615385	1.884738	44	69	0.006925862	
GO Cellular Component	proteasome complex	35	5.692879e-20	2.810655689142857e-18	3.19517	87	0.01154918	54	0.0000213988832	1.86899	43	68	0.006768456	
GO Cellular Component	large ribosomal subunit	39	6.485776e-19	2.873697673846154e-17	2.694793	107	0.01420417	48	0.0000064756548	1.696264	66	115	0.01038879	
GO Cellular Component	peptidase complex	41	9.409153e-18	3.965613752195122e-16	2.691995	100	0.01327492	51	0.0000118465344	1.780084	53	88	0.008342515	
GO Cellular Component	catalytic step 2 spliceosome	49	6.279599e-15	2.2145198106122446e-13	2.410615	101	0.01340767	67	0.0003439694901492537	1.631744	53	96	0.008342515	
GO Cellular Component	mitochondrial large ribosomal subunit	52	3.025361e-14	1.0053507323076922e-12	3.597594	51	0.006770211	77	0.001637330717922078	1.796548	31	51	0.004879584	
GO Cellular Component	mitochondrial ribosome	54	9.104082e-13	2.91330624e-11	2.767226	66	0.00876145	96	0.008731288799999999	1.529964	44	85	0.006925862	
GO Cellular Component	preribosome	56	3.135968e-12	9.676701257142857e-11	2.502741	75	0.009956193	80	0.0021316819680000003	1.633364	42	76	0.00661105	
GO Cellular Component	azurophil granule lumen	58	7.317665e-12	2.1801595034482757e-10	2.222626	92	0.01221293	115	0.0220409856	1.461566	45	91	0.007083268	
GO Cellular Component	proteasome accessory complex	87	7.144874e-8	0.0000014191198013793105	3.344519	28	0.003716979	133	0.04915125798496241	1.847257	15	24	0.002361089	
GO Cellular Component	endoplasmic reticulum exit site	96	1.552782e-7	0.0000027950076	2.779242	35	0.004646223	73	0.001296503250410959	2.709311	11	12	0.001731465	
GO Cellular Component	cytosolic large ribosomal subunit	99	1.699439e-7	0.000002966293527272728	2.187166	55	0.007301208	90	0.006845235839999999	1.64739	34	61	0.005351802	
GO Cellular Component	Golgi transport complex	186	0.0001514526	0.0014070435096774192	2.679038	19	0.002522235	100	0.013734729792	2.322266	11	14	0.001731465	
GO Cellular Component	eukaryotic translation initiation factor 2B complex	200	0.000245143	0.00211803552	5.855016	7	0.0009292447	116	0.022311206068965517	2.955612	6	6	0.0009444357	
GO Cellular Component	COPII vesicle coat	220	0.0004448514	0.0034941055418181814	2.699396	16	0.002123988	121	0.02669752859504132	2.273547	10	13	0.001574059	
GO Molecular Function	nuclease activity	8	2.470347e-19	1.30372562925e-16	2.00484	202	0.02681535	25	0.000065069767984	1.491747	107	212	0.01684244	
GO Molecular Function	ribonuclease activity	9	5.013512e-19	2.351894184888889e-16	2.634465	112	0.01486791	30	0.0001477514232	1.701716	57	99	0.008972139	
GO Molecular Function	structural constituent of ribosome	12	7.495728e-17	2.637246968e-14	2.234779	135	0.01792115	27	0.00011679465588148148	1.550784	85	162	0.01337951	
GO Molecular Function	exonuclease activity	13	5.563648e-16	1.8069016812307692e-13	2.641518	92	0.01221293	87	0.011667336855172414	1.594475	41	76	0.006453644	
GO Molecular Function	unfolded protein binding	15	2.23758e-14	6.29804184e-12	2.48984	91	0.01208018	64	0.002800358924375	1.561455	56	106	0.008814733	
GO Molecular Function	ribonucleoprotein complex binding	17	9.082371e-14	2.2556335507058825e-11	2.232485	108	0.01433692	100	0.028522983378	1.439254	56	115	0.008814733	
GO Molecular Function	proteasome binding	19	2.219882e-13	4.932811475789474e-11	4.837689	34	0.004513474	96	0.027297481733333333	2.46301	10	12	0.001574059	
GO Molecular Function	rRNA binding	21	7.073003e-13	1.4220104126666668e-10	3.349044	50	0.006637462	86	0.01144458521860465	1.674847	34	60	0.005351802	
GO Molecular Function	mRNA 5'-UTR binding	22	1.15431e-12	2.2152258272727274e-10	3.933045	40	0.005309969	62	0.0026017605132258063	2.283882	17	22	0.002675901	
GO Molecular Function	mRNA 3'-UTR binding	24	1.000196e-11	1.7595114633333335e-9	2.077094	106	0.01407142	71	0.003793335582816902	1.701716	38	66	0.005981426	
GO Molecular Function	3'-5' exonuclease activity	34	2.139466e-9	2.6567133682352937e-7	2.480749	56	0.007433957	108	0.040895542962962966	1.655142	28	50	0.004407367	
GO Molecular Function	endoribonuclease activity	46	4.723541e-8	0.000004335389152608695	2.298806	54	0.007168459	60	0.002403615561333333	1.794478	34	56	0.005351802	
GO Molecular Function	signal sequence binding	59	2.771562e-7	0.00001983310976949153	2.059868	61	0.008097703	103	0.03410024140194175	1.707687	26	45	0.004092555	
GO Molecular Function	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	103	0.000008513465	0.00034896940999999996	2.198576	39	0.00517722	68	0.003502917031470588	1.944481	25	38	0.003935149	
GO Molecular Function	endoribonuclease activity, producing 5'-phosphomonoesters	135	0.00003315458	0.0010368787908148149	2.19001	34	0.004513474	78	0.006375609723076923	2.038353	20	29	0.003148119	
Human Phenotype	Progressive external ophthalmoplegia	2	1.429448e-15	4.769353252e-12	5.613877	35	0.004646223	61	0.036370606714754096	2.364489	12	15	0.001888871	
Human Phenotype	Increased serum lactate	13	1.149166e-10	5.898757475384615e-8	2.156194	87	0.01154918	44	0.009117435160909092	1.566474	53	100	0.008342515	
Human Phenotype	Death in infancy	32	1.341259e-7	0.000027969441584375	2.204028	55	0.007301208	36	0.0063316463922222215	1.794478	34	56	0.005351802	
Mouse Phenotype	decreased type II pneumocyte number	194	0.00004699609	0.002316132043762887	2.497516	25	0.003318731	137	0.04331699681167883	2.46301	10	12	0.001574059