# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	4	3.887896e-37	1.2790205866e-33	3.295038	161	0.02275297	380	0.01145560207894737	1.51353	52	113	0.009108425	
GO Biological Process	regulation of DNA-templated transcription in response to stress	11	3.766897e-33	4.506236147545454e-30	2.985321	165	0.02331826	351	0.0073826563783475786	1.520134	55	119	0.009633911	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	24	5.557846e-25	3.0473206464166666e-22	3.230067	109	0.01540418	397	0.017139199746851387	1.602342	38	78	0.006656157	
GO Biological Process	mRNA catabolic process	25	2.347947e-24	1.2358653829200002e-21	2.271724	194	0.02741662	139	0.0000024662843939568347	1.590464	103	213	0.01804169	
GO Biological Process	nuclear-transcribed mRNA catabolic process	26	7.336896e-24	3.7133159409230765e-21	2.330924	180	0.0254381	162	0.000005282302837962963	1.594675	96	198	0.01681555	
GO Biological Process	tumor necrosis factor-mediated signaling pathway	33	4.241671e-23	1.6913984451212123e-20	2.668609	135	0.01907858	448	0.027591999746651785	1.438945	56	128	0.009809073	
GO Biological Process	RNA catabolic process	36	4.247457e-22	1.5525635184166665e-19	2.096387	209	0.02953646	136	0.0000022036593565441176	1.555801	114	241	0.01996847	
GO Biological Process	liver regeneration	39	5.239438e-22	1.767840119025641e-19	3.794938	77	0.01088185	368	0.009685553220652175	1.97341	21	35	0.003678403	
GO Biological Process	regulation of mRNA stability	41	7.337014e-22	2.354823590878049e-19	2.240548	178	0.02515546	270	0.0006010753398888889	1.546492	71	151	0.0124365	
GO Biological Process	regulation of cellular amino acid metabolic process	42	1.338778e-21	4.1945189766666665e-19	3.946489	72	0.01017524	459	0.032696015355119824	1.644509	30	60	0.005254861	
GO Biological Process	regulation of RNA stability	46	2.726501e-21	7.799571012826087e-19	2.178265	184	0.02600339	254	0.00042362447496062996	1.541727	75	160	0.01313715	
GO Biological Process	anaphase-promoting complex-dependent catabolic process	48	3.730118e-21	1.0225963075416668e-18	3.03144	100	0.01413228	302	0.0033354226232119207	1.685621	41	80	0.007181643	
GO Biological Process	rRNA metabolic process	53	2.679541e-20	6.6528452866037735e-18	2.072701	196	0.02769927	88	1.3760240691363637e-8	1.62546	128	259	0.02242074	
GO Biological Process	rRNA processing	57	9.404956e-20	2.171224842175439e-17	2.074198	190	0.02685133	90	1.639754686888889e-8	1.631457	125	252	0.02189525	
GO Biological Process	positive regulation of mRNA metabolic process	85	1.198247e-17	1.855027326235294e-15	2.962326	85	0.01201244	382	0.01227774314790576	1.771009	28	52	0.004904537	
GO Biological Process	positive regulation of ubiquitin protein ligase activity	87	3.074249e-17	4.649889952988507e-15	2.774079	92	0.0130017	475	0.03929839774105263	1.527044	39	84	0.006831319	
GO Biological Process	protein refolding	94	4.635388e-17	6.489050073617021e-15	7.683078	30	0.004239683	416	0.02069871159735577	2.192678	14	21	0.002452268	
GO Biological Process	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition	98	7.996185e-17	1.0736918205612243e-14	2.803805	88	0.0124364	470	0.03829456585744681	1.557956	36	76	0.006305833	
GO Biological Process	protein targeting to ER	104	2.243722e-16	2.8389555574999998e-14	2.699498	91	0.01286037	156	0.0000040016012884615385	1.856178	57	101	0.009984235	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	105	2.278315e-16	2.8552711509523813e-14	2.572357	99	0.01399096	193	0.000028304545366839374	1.728128	62	118	0.01086005	
GO Cellular Component	ribosomal subunit	36	1.306944e-18	6.273331200000001e-17	2.296371	142	0.02006783	36	5.3914272e-7	1.653398	93	185	0.01629007	
GO Cellular Component	proteasome complex	38	1.734726e-17	7.888438231578948e-16	3.088744	79	0.0111645	88	0.02507852290909091	1.596141	33	68	0.005780347	
GO Cellular Component	endopeptidase complex	39	1.788528e-17	7.92455483076923e-16	3.087	79	0.0111645	94	0.03201068527659574	1.573008	33	69	0.005780347	
GO Cellular Component	catalytic step 2 spliceosome	40	1.900606e-17	8.21061792e-16	2.617121	103	0.01455625	42	0.000014971276800000002	1.815812	53	96	0.009283587	
GO Cellular Component	mitochondrial ribosome	43	2.003994e-16	8.053259609302326e-15	3.169123	71	0.01003392	57	0.00036156732631578947	1.741244	45	85	0.007882291	
GO Cellular Component	peptidase complex	44	2.261121e-16	8.880038836363637e-15	2.665246	93	0.01314302	77	0.010505050597402598	1.569758	42	88	0.007356805	
GO Cellular Component	large ribosomal subunit	45	6.164964e-16	2.3673461760000003e-14	2.573907	96	0.01356699	39	0.000014721306092307691	1.744609	61	115	0.01068488	
GO Cellular Component	mitochondrial large ribosomal subunit	53	5.695697e-13	1.8570121539622642e-11	3.529555	47	0.006642171	59	0.0006972556149152543	1.934716	30	51	0.005254861	
GO Cellular Component	proton-transporting ATP synthase complex	68	1.873523e-9	4.760952564705882e-8	4.115849	27	0.003815715	74	0.006223718918918919	2.192678	16	24	0.002802592	
GO Cellular Component	PcG protein complex	71	3.360725e-9	8.179341971830986e-8	2.256833	66	0.009327304	72	0.0049176984	1.85901	26	46	0.004554213	
GO Cellular Component	mitochondrial proton-transporting ATP synthase complex	72	4.093531e-9	9.824474400000001e-8	4.0946	26	0.003674392	81	0.012667904	2.145011	15	23	0.00262743	
GO Cellular Component	exon-exon junction complex	107	0.000002417763	0.000039045742654205605	3.076122	24	0.003391747	101	0.04738283786138614	2.036058	13	21	0.002277106	
GO Cellular Component	cytosolic large ribosomal subunit	115	0.000006710132	0.00010082702692173915	2.032079	48	0.006783493	91	0.030345237098901103	1.61755	30	61	0.005254861	
GO Molecular Function	unfolded protein binding	7	3.109444e-17	1.8754389382857144e-14	2.738029	94	0.01328434	58	0.030964970562068966	1.520395	49	106	0.008582939	
GO Molecular Function	structural constituent of ribosome	11	1.353708e-14	5.1957774327272725e-12	2.167634	123	0.0173827	24	0.0001202822468	1.603904	79	162	0.0138378	
GO Molecular Function	ribonuclease activity	14	8.102268e-14	2.4434125354285715e-11	2.378911	95	0.01342566	36	0.0010509314441666665	1.694342	51	99	0.008933263	
GO Molecular Function	protein transporter activity	19	4.471343e-13	9.93579481368421e-11	2.230626	102	0.01441492	27	0.0004388079406666666	1.74729	51	96	0.008933263	
GO Molecular Function	heat shock protein binding	25	1.043406e-11	1.7621040527999997e-9	2.02162	113	0.01596947	42	0.003067565471904762	1.628847	52	105	0.009108425	
GO Molecular Function	endoribonuclease activity	26	5.120794e-11	8.31538164153846e-9	2.673873	59	0.008338044	47	0.007921972157446808	1.820706	31	56	0.005430023	
GO Molecular Function	mRNA 3'-UTR binding	27	1.315231e-10	2.056631585925926e-8	2.044356	98	0.01384963	56	0.020253446671428567	1.694342	34	66	0.005955509	
Human Phenotype	Increased serum lactate	12	2.861078e-11	1.5909977911666667e-8	2.242682	85	0.01201244	36	0.0009564351584444444	1.710289	52	100	0.009108425	
Human Phenotype	Abnormality of mitochondrial metabolism	43	1.33027e-8	0.0000020643934209302327	2.189627	65	0.009185981	82	0.02630375346707317	1.668342	35	69	0.006130671	
Human Phenotype	Abnormality of the mitochondrion	44	1.383557e-8	0.0000020982899684090906	2.172398	66	0.009327304	72	0.025007345541666663	1.667671	36	71	0.006305833	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	62	5.805195e-8	0.000006248075199193548	3.812757	24	0.003391747	59	0.011910083501694915	2.631214	12	15	0.002101944	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	63	1.102265e-7	0.000011675260865079366	3.56205	25	0.00353307	50	0.0052138791508	2.672327	13	16	0.002277106	
Human Phenotype	Delayed CNS myelination	113	0.000003202567	0.00018912150080530973	2.871603	26	0.003674392	75	0.024893430758666665	2.584228	11	14	0.001926782	
Human Phenotype	Abnormality of glycolysis	355	0.001770734	0.03328481121690141	2.638919	13	0.001837196	96	0.04468769774270833	2.691014	9	11	0.001576458	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	148	1.873003e-7	0.000011588573291216215	2.145859	57	0.008055399	92	0.04595428506086957	1.699326	31	60	0.005430023	
Mouse Phenotype	extramedullary hematopoiesis	1	2.597268e-33	2.4832479348e-29	2.338173	254	0.03589599	123	0.0426142087292683	1.390784	74	175	0.01296199	
Mouse Phenotype	expanded mesangial matrix	60	5.249105e-12	8.364448817499999e-10	2.283618	88	0.0124364	79	0.0109731597	1.879438	28	49	0.004904537	
Mouse Phenotype	abnormal mesangial matrix morphology	61	5.506234e-12	8.630344799016393e-10	2.257371	90	0.01271905	77	0.009565364534415585	1.870226	29	51	0.005079699	
Mouse Phenotype	decreased creatinine clearance	116	7.358598e-9	6.065134092931034e-7	3.737193	28	0.003957038	143	0.049931225993706294	2.321659	12	17	0.002101944	
Mouse Phenotype	increased lactate dehydrogenase level	183	4.287296e-7	0.00002239936451147541	2.437063	41	0.005794234	91	0.020516729261538462	2.083044	19	30	0.003328078	
Mouse Phenotype	pup cannibalization	313	0.0000231981	0.0007086167223642173	2.201105	35	0.004946297	67	0.007228133124179104	2.466763	15	20	0.00262743	
Mouse Phenotype	reticulocytopenia	452	0.0003769919	0.007974379548451328	2.359767	21	0.002967778	142	0.04922829624507043	2.530013	10	13	0.00175162	
Mouse Phenotype	decreased mitochondrial DNA content	466	0.0004753804	0.009753459236909871	2.265447	22	0.003109101	143	0.049931225993706294	2.321659	12	17	0.002101944