# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process activation of signaling protein activity involved in unfolded protein response 23 1.317856e-51 7.539855262608696e-49 10.04122 81 0.007154845 540 0.02516220116666667 2.361293 8 8 0.001006036 GO Biological Process placenta development 26 4.225874e-51 2.1387798448461538e-48 2.329726 401 0.0354209 252 0.0004768849275674603 1.423245 88 146 0.0110664 GO Biological Process embryonic placenta development 45 4.53886e-47 1.3272635275555555e-44 2.537411 313 0.02764773 260 0.0005790051100769231 1.53882 58 89 0.007293763 GO Biological Process liver development 61 3.825083e-42 8.251519212622951e-40 2.182333 378 0.03338928 585 0.03201391251452992 1.324628 69 123 0.008677062 GO Biological Process hepaticobiliary system development 71 6.968981e-41 1.291617196887324e-38 2.144515 381 0.03365427 543 0.025151623075506446 1.33057 71 126 0.008928571 GO Biological Process labyrinthine layer development 224 3.048029e-22 1.7905809647767855e-20 2.372186 162 0.01430969 603 0.03382956309950248 1.525002 31 48 0.00389839 GO Biological Process negative regulation of Notch signaling pathway 243 4.129903e-21 2.2364359496707815e-19 3.073332 98 0.008656479 437 0.011975256108009152 1.717304 24 33 0.003018109 GO Biological Process labyrinthine layer morphogenesis 285 1.596707e-18 7.372304355438596e-17 2.66323 107 0.009451462 618 0.036898623836569576 1.79908 16 21 0.002012072 GO Biological Process cell differentiation involved in embryonic placenta development 374 2.754869e-15 9.692866623262032e-14 2.446949 101 0.008921473 513 0.0214621853539961 1.749106 20 27 0.002515091 GO Biological Process pharyngeal system development 517 6.623116e-12 1.6857559660348163e-10 2.062902 110 0.009716456 485 0.018005101558144332 1.794582 19 25 0.002389336 GO Biological Process endoplasmic reticulum organization 536 1.3568e-11 3.330994626865672e-10 2.377821 78 0.006889851 557 0.027222545407540395 1.593873 27 40 0.003395372 GO Biological Process cytoplasmic translation 554 2.809829e-11 6.674104659025271e-10 2.805683 56 0.004946559 415 0.008051231097590362 1.647414 30 43 0.003772636 GO Biological Process regulation of transcription involved in cell fate commitment 569 4.842919e-11 1.119999492460457e-9 2.357095 75 0.006624856 621 0.037459710466988726 1.91855 13 16 0.001634809 GO Biological Process regulation of myotube differentiation 579 7.223509e-11 1.6416952492400691e-9 2.006524 106 0.00936313 390 0.005532897247948717 1.588506 37 55 0.004652918 GO Biological Process positive regulation of myotube differentiation 658 1.026658e-9 2.0531599729483283e-8 2.36609 64 0.005653211 396 0.006024811597222223 1.77097 24 32 0.003018109 GO Biological Process negative regulation of morphogenesis of an epithelium 663 1.25729e-9 2.495426713423831e-8 2.041045 88 0.007773165 675 0.047993309851851844 1.836561 14 18 0.001760563 GO Biological Process prostaglandin biosynthetic process 846 1.913142e-7 0.000002975772526950355 2.666698 37 0.003268263 675 0.047993309851851844 1.836561 14 18 0.001760563 GO Biological Process entrainment of circadian clock by photoperiod 966 0.000001275162 0.000017370452130434784 2.45695 37 0.003268263 675 0.047993309851851844 1.836561 14 18 0.001760563 GO Biological Process prostaglandin metabolic process 973 0.000001386045 0.000018745083406988694 2.20209 46 0.004063245 535 0.024963360887850467 1.709902 21 29 0.002640845 GO Biological Process lung lobe morphogenesis 1003 0.000002099914 0.000027550117972083747 2.166854 46 0.004063245 669 0.047982906789237674 2.361293 7 7 0.0008802817 GO Molecular Function proline-rich region binding 151 0.00001943122 0.0005433020585430463 2.014775 44 0.003886582 71 0.0268799635943662 1.967744 15 18 0.001886318 GO Molecular Function bile acid binding 341 0.002396915 0.029676759912023457 2.547011 13 0.001148308 69 0.02674154835362319 2.361293 9 9 0.001131791 Human Phenotype Glucose intolerance 18 7.615067e-11 2.823074560611111e-8 2.759222 55 0.004858228 42 0.041477032450000006 2.066131 14 16 0.001760563 Mouse Phenotype Single KO abnormal trophoblast layer morphology 24 5.025082e-33 1.9172781614166667e-30 2.064182 334 0.02950269 459 0.018710773408496733 1.313677 79 142 0.009934608 Mouse Phenotype Single KO decreased white adipose tissue amount 39 1.015772e-28 2.3849805651282055e-26 2.322984 222 0.01960958 254 0.0023957855662992125 1.551707 46 70 0.005784708 Mouse Phenotype Single KO decreased circulating free fatty acid level 133 4.688283e-18 3.2278652203759395e-16 2.056386 177 0.01563466 634 0.0443020281829653 1.345683 53 93 0.00666499 Mouse Phenotype Single KO abnormal large intestine crypts of Lieberkuhn morphology 255 3.365288e-12 1.2084683221960785e-10 2.042002 116 0.01024644 644 0.04552135233850931 1.53484 26 40 0.003269618 Mouse Phenotype Single KO absent segment of posterior cerebral artery 417 1.783433e-8 3.916282009832134e-7 2.581289 46 0.004063245 311 0.005316009490996784 1.931967 18 22 0.002263581 Mouse Phenotype Single KO absent hypoglossal nerve 560 8.112774e-7 0.000013265834199642858 2.888863 29 0.002561611 655 0.048041242859541984 1.889034 12 15 0.001509054 Mouse Phenotype Single KO abnormal circulating interleukin-1 level 594 0.000001673454 0.00002579767386868687 2.012275 56 0.004946559 515 0.027563654615533978 1.525002 31 48 0.00389839 Mouse Phenotype Single KO abnormal cerebral artery morphology 648 0.000005474446 0.0000773603426265432 2.086049 46 0.004063245 489 0.02261571141717791 1.77097 18 24 0.002263581 Mouse Phenotype Single KO decreased susceptibility to age related obesity 876 0.0001174825 0.0012280676398401828 2.192976 29 0.002561611 469 0.020160433880597017 2.361293 8 8 0.001006036 Mouse Phenotype Single KO abnormal leukotriene level 938 0.0002384132 0.0023274516763326226 3.126861 14 0.00123664 602 0.04115628860963456 2.125163 9 10 0.001131791 Mouse Phenotype abnormal trophoblast layer morphology 34 2.657509e-37 7.473071632058824e-35 2.059484 381 0.03365427 477 0.0039048126201257864 1.336581 90 159 0.01131791 Mouse Phenotype caudal vertebral fusion 43 1.649272e-35 3.6671371144186044e-33 3.581656 138 0.01218974 973 0.04512742868448099 1.805694 13 17 0.001634809 Mouse Phenotype decreased white adipose tissue amount 101 5.229056e-26 4.950000437227723e-24 2.087455 253 0.02234785 440 0.0024116666400000003 1.469249 56 90 0.007042254 Mouse Phenotype abnormal trophoblast giant cell morphology 144 8.708654e-22 5.782183395416666e-20 2.048938 219 0.01934458 689 0.015725499849056603 1.381607 55 94 0.006916499 Mouse Phenotype abnormal mural trophectoderm morphology 147 1.108268e-21 7.208265542857144e-20 2.040827 220 0.01943291 621 0.01231678966231884 1.39192 56 95 0.007042254 Mouse Phenotype abnormal Paneth cell morphology 162 3.715817e-21 2.193020144259259e-19 2.506256 138 0.01218974 522 0.0059127476879310345 1.677761 27 38 0.003395372 Mouse Phenotype impaired smooth muscle contractility 169 1.633483e-20 9.24126092485207e-19 2.150652 183 0.01616465 513 0.0053663060111111115 1.626668 31 45 0.00389839 Mouse Phenotype abnormal Paneth cell number 185 1.49172e-19 7.709370227027026e-18 2.805001 104 0.009186468 565 0.008467456817522125 1.847968 18 23 0.002263581 Mouse Phenotype conductive hearing impairment 340 2.274821e-13 6.396930465e-12 2.270773 101 0.008921473 973 0.04512742868448099 1.805694 13 17 0.001634809 Mouse Phenotype common ventricle 484 5.056203e-10 9.988090265082646e-9 2.699983 52 0.004593234 821 0.028669607612667476 1.836561 14 18 0.001760563 Mouse Phenotype ocular hypertension 506 1.251424e-9 2.3645977992094865e-8 2.197853 74 0.006536525 575 0.009038412367826086 2.046454 13 15 0.001634809 Mouse Phenotype absent mandibular angle 525 2.265958e-9 4.126633226285714e-8 2.455457 57 0.005034891 812 0.028723481179802956 2.361293 7 7 0.0008802817 Mouse Phenotype absent mandibular coronoid process 570 9.422712e-9 1.5805359549473686e-7 2.296701 60 0.005299885 584 0.0094127422880137 2.164518 11 12 0.0013833 Mouse Phenotype variable body spotting 589 1.722343e-8 2.795810088794567e-7 2.015745 78 0.006889851 907 0.03622416232524807 1.889034 12 15 0.001509054 Mouse Phenotype absent segment of posterior cerebral artery 591 1.783433e-8 2.88517815786802e-7 2.581289 46 0.004063245 473 0.0036495145541226215 1.931967 18 22 0.002263581 Mouse Phenotype absent hypoglossal nerve 762 8.112774e-7 0.000010179295566141733 2.888863 29 0.002561611 907 0.03622416232524807 1.889034 12 15 0.001509054 Mouse Phenotype increased transitional stage T1 B cell number 844 0.000003009633 0.0000340937216978673 2.397048 36 0.003179931 982 0.04514073290835031 1.967744 10 12 0.001257545 Mouse Phenotype abnormal cerebral artery morphology 879 0.000005474446 0.000059546277822525594 2.086049 46 0.004063245 695 0.016614390444604315 1.77097 18 24 0.002263581 Mouse Phenotype abnormal leukotriene level 1225 0.0002384132 0.001860790698122449 3.126861 14 0.00123664 838 0.030870152910501197 2.125163 9 10 0.001131791