# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process organelle transport along microtubule 306 3.446288e-30 1.4820164637908497e-28 2.078552 302 0.01118477 612 0.011332601755392156 1.296826 55 66 0.004558263 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 318 3.868535e-29 1.600819247327044e-27 2.049607 301 0.01114774 771 0.030576412833981843 1.200113 91 118 0.007541853 GO Biological Process gene silencing by miRNA 448 1.782582e-22 5.235936727232143e-21 2.221381 189 0.006999741 873 0.048328937206185564 1.308615 37 44 0.003066468 GO Biological Process positive regulation of mRNA catabolic process 522 5.555483e-20 1.4004712796360152e-18 2.309705 153 0.005666457 762 0.029214620557742783 1.431696 23 25 0.001906183 GO Cellular Component PcG protein complex 58 1.025788e-42 3.0561408e-41 2.544965 284 0.01051813 134 0.02333425432835821 1.319379 39 46 0.003232223 GO Cellular Component COPI vesicle coat 207 3.662549e-11 3.0574322086956524e-10 2.497436 68 0.002518425 151 0.03637016582781457 1.556191 13 13 0.001077408 GO Molecular Function snRNA binding 266 2.03402e-8 3.228433248120301e-7 2.019669 77 0.002851746 100 0.01840002486 1.392381 34 38 0.002817835 Mouse Phenotype Single KO decreased platelet aggregation 76 3.809809e-52 4.590318554342106e-50 2.608361 334 0.01236991 664 0.03507159960391566 1.270889 49 60 0.004060998 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 77 5.022972e-52 5.973422675844155e-50 2.306852 422 0.01562905 643 0.03175586363452566 1.291932 44 53 0.00364661 Mouse Phenotype Single KO abnormal iron level 109 5.374377e-42 4.5149697421100916e-40 2.023274 456 0.01688826 679 0.03814752255964654 1.190028 91 119 0.007541853 Mouse Phenotype Single KO abnormal circulating tumor necrosis factor level 128 2.032103e-37 1.453747435234375e-35 2.079637 378 0.01399948 376 0.0033895366111702124 1.259774 85 105 0.007044588 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 129 4.898899e-37 3.477458770775194e-35 2.21336 324 0.01199956 745 0.049306880530201345 1.240442 55 69 0.004558263 Mouse Phenotype Single KO abnormal platelet volume 210 1.403005e-27 6.117769897619048e-26 2.115762 263 0.00974038 521 0.01301872308253359 1.310477 48 57 0.00397812 Mouse Phenotype Single KO increased mean platelet volume 217 2.927555e-27 1.2353742458525347e-25 2.228134 231 0.008555239 449 0.007269287509131403 1.375239 38 43 0.003149345 Mouse Phenotype Single KO increased body temperature 222 6.95715e-27 2.8696676824324323e-25 2.472767 184 0.006814562 647 0.032505156282843894 1.367562 29 33 0.002403448 Mouse Phenotype Single KO increased circulating tumor necrosis factor level 224 9.376757e-27 3.833168028973214e-25 2.170634 240 0.00888856 483 0.010347774004968946 1.305192 52 62 0.00430963 Mouse Phenotype Single KO abnormal erythrocyte physiology 246 1.447698e-24 5.388849831707316e-23 2.311921 191 0.007073812 399 0.0042262446684210525 1.383281 40 45 0.0033151 Mouse Phenotype Single KO microcytic anemia 269 1.17154e-22 3.98802668401487e-21 2.757052 126 0.004666494 528 0.013590143030681817 1.485455 21 22 0.001740428 Mouse Phenotype Single KO increased skin tumor incidence 273 1.537947e-22 5.158600981318682e-21 2.299715 176 0.006518277 559 0.016204374629338103 1.343983 38 44 0.003149345 Mouse Phenotype Single KO abnormal circulating interleukin-1 beta level 340 2.189581e-19 5.897056828529412e-18 2.373386 140 0.005184993 658 0.03403118334802432 1.328456 35 41 0.002900713 Mouse Phenotype Single KO abnormal erythrocyte osmotic lysis 356 7.982016e-19 2.0531269806741574e-17 2.463381 126 0.004666494 310 0.0013490686128064516 1.502529 28 29 0.00232057 Mouse Phenotype Single KO hypochromic anemia 397 1.151158e-17 2.655202470025189e-16 2.707257 99 0.003666531 414 0.004935786675845411 1.556191 19 19 0.001574673 Mouse Phenotype Single KO abnormal circulating interleukin-1 level 407 2.106235e-17 4.738769998771499e-16 2.199668 146 0.005407207 694 0.04059250599711816 1.296826 40 48 0.0033151 Mouse Phenotype Single KO lymph node hyperplasia 457 2.769699e-16 5.54970103785558e-15 2.039649 162 0.005999778 750 0.049736904804000004 1.383281 24 27 0.00198906 Mouse Phenotype Single KO hemolysis 463 3.991404e-16 7.894014347300217e-15 2.255281 127 0.004703529 396 0.004128729433838384 1.455792 29 31 0.002403448 Mouse Phenotype Single KO abnormal thymus development 776 1.467404e-10 1.7315745396907217e-9 2.11873 90 0.00333321 537 0.01436243221452514 1.556191 16 16 0.00132604 Mouse Phenotype abnormal platelet physiology 76 8.678643e-59 1.0917961279342105e-56 2.045846 627 0.02322136 560 0.0035341416985714283 1.22609 104 132 0.008619261 Mouse Phenotype decreased platelet aggregation 79 2.011343e-58 2.4342342307594934e-56 2.614112 374 0.01385134 1047 0.04145296199140401 1.231985 57 72 0.004724018 Mouse Phenotype abnormal embryonic erythrocyte morphology 102 3.505724e-53 3.286100702352941e-51 2.827876 297 0.01099959 1033 0.04066804207260407 1.316777 33 39 0.002734958 Mouse Phenotype abnormal embryonic hematopoiesis 114 3.811278e-47 3.196458680526316e-45 2.140459 449 0.01662901 697 0.00986499453271162 1.301078 51 61 0.004226753 Mouse Phenotype increased circulating tumor necrosis factor level 161 1.127696e-38 6.696833202484472e-37 2.134316 368 0.01362912 596 0.004959852168120805 1.25448 79 98 0.006547323 Mouse Phenotype lymph node hyperplasia 221 8.390074e-32 3.629751018733032e-30 2.283846 258 0.009555202 959 0.03196563326277372 1.308615 37 44 0.003066468 Mouse Phenotype microcytic anemia 252 2.813652e-29 1.067512967142857e-27 2.873064 155 0.005740528 443 0.000985693992799097 1.502529 28 29 0.00232057 Mouse Phenotype abnormal lymph node cortex morphology 254 4.219782e-29 1.5883990433858268e-27 2.045715 302 0.01118477 983 0.03404531067955239 1.249668 53 66 0.004392508 Mouse Phenotype increased circulating interleukin-1 beta level 261 2.356947e-28 8.634011596551725e-27 2.564129 182 0.006740491 972 0.03229928103086419 1.340053 31 36 0.002569203 Mouse Phenotype abnormal circulating interleukin-1 beta level 268 3.74336e-28 1.335457647761194e-26 2.311841 221 0.008184882 747 0.012545058495582326 1.306089 47 56 0.003895243 Mouse Phenotype increased body temperature 293 1.521224e-26 4.963966779522184e-25 2.325687 205 0.007592311 772 0.014766048031088084 1.378341 31 35 0.002569203 Mouse Phenotype abnormal circulating interleukin-1 level 304 2.46766e-25 7.760953046052631e-24 2.151564 231 0.008555239 766 0.014642184712793731 1.284475 52 63 0.00430963 Mouse Phenotype ruffled hair 314 9.967643e-25 3.035052061242038e-23 2.459308 170 0.006296063 1041 0.04086037086455331 1.333878 30 35 0.002486325 Mouse Phenotype hypochromic microcytic anemia 359 3.133646e-22 8.345623789972145e-21 3.615855 83 0.00307396 784 0.015991613965561226 1.556191 15 15 0.001243163 Mouse Phenotype abnormal erythrocyte physiology 378 1.996511e-21 5.049905203968254e-20 2.091679 206 0.007629347 988 0.03421176437550607 1.273247 45 55 0.003729488 Mouse Phenotype poikilocytosis 381 2.17222e-21 5.451074913385827e-20 2.480263 143 0.0052961 1033 0.04066804207260407 1.316777 33 39 0.002734958 Mouse Phenotype hypochromic anemia 383 3.477888e-21 8.682007093472584e-20 2.475807 142 0.005259064 675 0.007866902699111111 1.445034 26 28 0.002154815 Mouse Phenotype abnormal lymph node germinal center morphology 400 3.083907e-20 7.37130870675e-19 2.250001 164 0.006073849 948 0.03198412687341772 1.361667 28 32 0.00232057 Mouse Phenotype small intestinal inflammation 421 2.599704e-19 5.903983359619952e-18 2.013647 202 0.007481204 1024 0.03963708625195313 1.302858 36 43 0.00298359 Mouse Phenotype increased circulating iron level 424 3.187246e-19 7.187089388207547e-18 2.005777 203 0.00751824 613 0.005559398640783034 1.375239 38 43 0.003149345