# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 39 1.706178e-51 5.7568195646153844e-49 2.184268 465 0.03345564 428 0.0037836583072429902 1.226354 157 248 0.01619726 GO Biological Process regulation of intrinsic apoptotic signaling pathway 75 6.429144e-31 1.12801474528e-28 2.094759 302 0.02172818 362 0.0011654355591988951 1.312277 105 155 0.01083256 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 112 1.848195e-25 2.1714641075892857e-23 2.26682 206 0.01482121 405 0.0025551808289876543 1.38075 67 94 0.006912205 GO Biological Process viral gene expression 203 1.293968e-18 8.387844784236454e-17 2.096557 175 0.01259083 580 0.014275443591896553 1.281279 84 127 0.008666048 GO Biological Process viral transcription 229 1.149422e-16 6.604910086462882e-15 2.068621 160 0.01151162 745 0.0343644723852349 1.26859 74 113 0.007634375 GO Biological Process regulation of nucleobase-containing compound transport 291 4.483685e-14 2.0275192754295533e-12 3.677284 49 0.003525433 681 0.025950069722466957 1.798802 13 14 0.001341174 GO Biological Process coronary artery morphogenesis 380 7.793242e-12 2.6987176704736846e-10 2.756768 61 0.004388805 795 0.043009372166037736 1.937171 9 9 0.0009285051 GO Biological Process liver regeneration 393 1.348535e-11 4.5153618486005085e-10 2.233101 89 0.006403338 721 0.03164025884327323 1.494389 27 35 0.002785515 GO Biological Process cytoplasmic translation 492 3.902912e-10 1.0438703050406505e-8 2.489325 61 0.004388805 738 0.03360664171951219 1.441616 32 43 0.003301351 GO Biological Process regulation of podosome assembly 752 1.031004e-7 0.0000018041198984042554 2.546392 42 0.0030218 681 0.025950069722466957 1.798802 13 14 0.001341174 GO Biological Process miRNA mediated inhibition of translation 1163 0.0000113806 0.00012876811298366295 2.384356 32 0.002302324 518 0.009066627210424711 1.937171 12 12 0.001238007 GO Biological Process Notch signaling involved in heart development 1437 0.00007487195 0.0006856228184064022 2.026964 37 0.002662062 795 0.043009372166037736 1.937171 9 9 0.0009285051 GO Biological Process dorsal aorta development 1461 0.00009169303 0.0008258648745859002 2.392389 25 0.001798691 795 0.043009372166037736 1.937171 9 9 0.0009285051 GO Cellular Component spliceosomal tri-snRNP complex 181 8.927421e-7 0.00000852297430276243 2.339353 42 0.0030218 118 0.029358075661016954 1.536377 23 29 0.002372846 GO Molecular Function ankyrin binding 81 2.057326e-9 1.0723494286419752e-7 2.341216 63 0.0045327 67 0.00411725722119403 1.835215 18 19 0.00185701 GO Molecular Function microtubule plus-end binding 263 0.00005263875 0.0008450220627376426 2.138706 34 0.002446219 80 0.018835661375 1.937171 12 12 0.001238007 Human Phenotype Aplasia/Hypoplasia involving the carpal bones 134 0.000003414922 0.00017005801870149253 2.383468 36 0.002590114 61 0.010391194506065574 1.937171 14 14 0.001444341 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 71 5.394643e-23 6.957569852253522e-21 2.166375 204 0.01467731 337 0.008614280641543027 1.462016 40 53 0.004126689 Mouse Phenotype Single KO abnormal vascular branching morphogenesis 213 1.063119e-12 4.570413466197183e-11 2.026222 124 0.008921505 372 0.012340610743817206 1.603176 24 29 0.002476014 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 245 4.673556e-12 1.7467653996734695e-10 2.143837 102 0.007338657 560 0.03875399377142857 1.465967 28 37 0.002888683 Mouse Phenotype Single KO decreased spleen iron level 314 3.15047e-10 9.187533054140127e-9 2.739127 52 0.003741276 596 0.04726804989765101 1.695025 14 16 0.001444341 Mouse Phenotype Single KO impaired macrophage chemotaxis 323 4.085587e-10 1.1582575900619193e-8 2.002597 98 0.007050867 269 0.0026406469815241636 1.589474 32 39 0.003301351 Mouse Phenotype Single KO increased T-helper 17 cell number 606 0.000001429389 0.00002159886975742574 2.350156 40 0.002877905 349 0.009364409985673353 1.937171 12 12 0.001238007 Mouse Phenotype Single KO fusion of vertebral bodies 627 0.000002014176 0.000029415964325358852 2.879812 27 0.001942586 393 0.01611832382188295 1.937171 11 11 0.00113484 Mouse Phenotype Single KO abnormal T-helper 17 cell number 628 0.000002025055 0.000029527752603503186 2.191747 45 0.003237643 516 0.03164501259496123 1.709269 15 17 0.001547509 Mouse Phenotype Single KO abnormal T-helper 17 cell morphology 629 0.000002066325 0.000030081618481717015 2.128705 48 0.003453486 435 0.021618182409195403 1.72193 16 18 0.001650676 Mouse Phenotype Single KO abnormal bone trabecular spacing 830 0.00005753837 0.0006347938001084337 2.011063 39 0.002805957 565 0.03938654219823009 1.788158 12 13 0.001238007 Mouse Phenotype increased respiratory quotient 71 7.416239e-26 9.986853673098592e-24 2.640486 156 0.01122383 608 0.01238168370394737 1.418286 41 56 0.004229857 Mouse Phenotype decreased circulating alanine transaminase level 100 3.661035e-22 3.5003155635e-20 2.008424 235 0.01690769 311 0.00037215008903536975 1.441616 64 86 0.006602703 Mouse Phenotype abnormal embryonic hematopoiesis 122 2.62453e-20 2.056814043442623e-18 2.000371 216 0.01554069 532 0.005968040898496241 1.429061 45 61 0.004642526 Mouse Phenotype decreased susceptibility to hepatic steatosis 152 9.281751e-18 5.838343507302632e-16 2.015632 183 0.01316641 182 0.000006823023784615385 1.5598 62 77 0.006396369 Mouse Phenotype increased body temperature 183 3.186855e-16 1.6650011286885246e-14 2.4243 110 0.007914238 713 0.02324696136605891 1.494389 27 35 0.002785515 Mouse Phenotype increased keratinocyte apoptosis 210 4.84382e-15 2.2053220485714286e-13 4.126813 46 0.003309591 772 0.0300974087642487 1.788158 12 13 0.001238007 Mouse Phenotype abnormal keratinocyte apoptosis 216 9.00236e-15 3.984794627777778e-13 3.369848 58 0.004172962 853 0.03830675737280187 1.584958 18 22 0.00185701 Mouse Phenotype enlarged liver sinusoidal spaces 225 3.151846e-14 1.3393244269333335e-12 2.153067 122 0.00877761 550 0.007807775092909091 1.511938 32 41 0.003301351 Mouse Phenotype ruffled hair 227 3.642053e-14 1.5339942173127751e-12 2.501211 89 0.006403338 713 0.02324696136605891 1.494389 27 35 0.002785515 Mouse Phenotype abnormal thymus corticomedullary boundary morphology 375 1.589258e-10 4.0519721967999996e-9 2.201438 82 0.005899705 613 0.012593209541598696 1.562235 25 31 0.002579181 Mouse Phenotype abnormal thrombopoiesis 410 8.058231e-10 1.8791401607560975e-8 2.530145 57 0.004101014 717 0.023778580372384936 1.709269 15 17 0.001547509 Mouse Phenotype decreased abdominal adipose tissue amount 416 1.084446e-9 2.4924010110576927e-8 2.583827 54 0.003885172 607 0.012364009553377265 1.627224 21 25 0.002166512 Mouse Phenotype abnormal spongiotrophoblast size 536 6.367968e-8 0.0000011358981725373136 2.09785 65 0.004676595 836 0.03572849632535885 1.522063 22 28 0.002269679 Mouse Phenotype decreased circulating ketone body level 603 2.999279e-7 0.00000475557322039801 3.277906 26 0.001870638 679 0.018910207656848307 1.798802 13 14 0.001341174 Mouse Phenotype fusion of vertebral bodies 687 0.000002014176 0.00002803134896069869 2.879812 27 0.001942586 598 0.011060158404682274 1.937171 11 11 0.00113484 Mouse Phenotype abnormal spinal cord central canal morphology 1025 0.0002088065 0.0019477062892682927 2.117237 29 0.002086481 676 0.018962730146449707 1.937171 10 10 0.001031672