# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 49 8.510675e-96 2.285550455612245e-93 2.200393 867 0.03370262 401 0.0017322661832668328 1.186434 185 248 0.01567 GO Biological Process regulation of DNA-templated transcription in response to stress 97 1.825386e-56 2.476314883917526e-54 2.299225 462 0.01795918 745 0.036435734311409396 1.202871 90 119 0.007623242 GO Biological Process multi-organism metabolic process 144 2.566181e-44 2.345026095763889e-42 2.12094 430 0.01671526 242 0.00001080555091322314 1.309156 121 147 0.01024903 GO Biological Process viral gene expression 171 4.368843e-40 3.361965206842105e-38 2.23314 345 0.01341108 247 0.000014966785551012147 1.327473 106 127 0.008978486 GO Biological Process viral transcription 231 6.666248e-34 3.797452702683983e-32 2.165464 310 0.01205053 281 0.00008412469090391459 1.32304 94 113 0.007962053 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 233 1.613441e-33 9.112133098283263e-32 2.172712 304 0.0118173 299 0.00015866440044481604 1.307414 97 118 0.008216161 GO Biological Process regulation of megakaryocyte differentiation 255 1.066959e-30 5.505926855294118e-29 2.136334 288 0.01119534 526 0.007936705750760456 1.297483 62 76 0.005251567 GO Biological Process nuclear envelope organization 275 5.358411e-29 2.5640483763272726e-27 2.042296 302 0.01173955 463 0.004287989466306695 1.294562 70 86 0.005929189 GO Biological Process cotranslational protein targeting to membrane 301 3.219884e-26 1.4076562643189368e-24 2.123429 247 0.009601555 440 0.003266440625909091 1.282108 79 98 0.006691513 GO Biological Process organelle transport along microtubule 312 8.714019e-26 3.675249231442308e-24 2.008276 278 0.01080661 590 0.014941373167966102 1.301287 54 66 0.004573945 GO Biological Process transport of virus 354 1.263402e-23 4.696357886440677e-22 2.127058 220 0.008551992 681 0.025940272933920705 1.281865 54 67 0.004573945 GO Biological Process positive regulation of mRNA metabolic process 357 1.613089e-23 5.945837017086835e-22 2.11855 221 0.008590865 707 0.029064024586987272 1.31519 43 52 0.003642216 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 395 5.766032e-22 1.9208915212151897e-20 2.046974 223 0.00866861 487 0.0055388933053388085 1.279285 74 92 0.006267999 GO Biological Process positive regulation of histone methylation 436 1.016344e-20 3.06744740733945e-19 2.15083 186 0.007230321 689 0.02672197557039187 1.397679 29 33 0.002456378 GO Biological Process positive regulation of mRNA catabolic process 446 2.511473e-20 7.409971571076233e-19 2.360891 149 0.005792031 656 0.021986462400914637 1.463225 23 25 0.001948162 GO Biological Process tRNA transport 478 1.778796e-19 4.8968988627615065e-18 2.423323 135 0.005247813 795 0.04540639574339623 1.363254 30 35 0.002541081 GO Biological Process multi-organism intracellular transport 482 2.383553e-19 6.507297495228216e-18 2.023107 200 0.007774538 756 0.03915637992063493 1.27237 52 65 0.00440454 GO Biological Process intracellular transport of virus 483 2.795744e-19 7.616810620289854e-18 2.032139 197 0.00765792 808 0.04719227804455446 1.2674 51 64 0.004319837 GO Biological Process cytoplasmic translation 503 1.287316e-18 3.3677517383697814e-17 2.557632 116 0.004509232 318 0.00025279175572955975 1.4795 40 43 0.003388108 GO Biological Process macrophage differentiation 702 3.115744e-14 5.840466566381766e-13 2.258764 110 0.004275996 617 0.016666790577795788 1.514726 20 21 0.001694054 GO Cellular Component PcG protein complex 67 1.806029e-30 4.657937480597015e-29 2.294974 244 0.009484937 144 0.036465828 1.31386 38 46 0.003218702 GO Cellular Component methyltransferase complex 70 3.565083e-29 8.800662034285716e-28 2.042173 304 0.0118173 118 0.02064450386440678 1.24091 71 91 0.006013891 GO Cellular Component histone methyltransferase complex 74 1.081767e-26 2.52607212972973e-25 2.081419 264 0.01026239 128 0.026715352499999998 1.26776 55 69 0.004658648 GO Cellular Component small ribosomal subunit 108 1.104918e-19 1.7678688e-18 2.081392 190 0.007385811 103 0.01541814878446602 1.281206 58 72 0.004912756 GO Cellular Component clathrin adaptor complex 140 9.439007e-16 1.1650431497142857e-14 2.197013 131 0.005092323 158 0.042454236759493676 1.378401 26 30 0.00220227 GO Cellular Component TOR complex 161 3.888569e-13 4.1735697093167705e-12 2.548933 79 0.003070943 105 0.01556209645714286 1.590462 15 15 0.00127054 GO Cellular Component TORC2 complex 197 8.868068e-11 7.778691118781725e-10 2.614856 60 0.002332362 155 0.04246479731612903 1.590462 12 12 0.001016432 GO Cellular Component methylosome 296 7.069436e-7 0.000004127022097297297 2.849162 30 0.001166181 155 0.04246479731612903 1.590462 12 12 0.001016432 Mouse Phenotype Single KO extramedullary hematopoiesis 28 3.264762e-60 1.0676937726428571e-57 2.265453 509 0.0197862 711 0.03757296118706048 1.199823 86 114 0.007284432 Mouse Phenotype Single KO abnormal platelet activation 49 4.098843e-46 7.659817418571428e-44 2.212928 407 0.01582119 676 0.03468710882988166 1.234947 66 85 0.005590378 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 63 3.757424e-42 5.4613859631746036e-40 2.186033 381 0.0148105 558 0.019200358215053764 1.320384 44 53 0.003726919 Mouse Phenotype Single KO increased respiratory quotient 87 2.625093e-36 2.7629858162068966e-34 2.554101 238 0.009251701 568 0.020352109602112676 1.330795 41 49 0.00347281 Mouse Phenotype Single KO increased body temperature 124 6.062581e-31 4.477020501370968e-29 2.651842 188 0.007308066 582 0.022013805608247426 1.397679 29 33 0.002456378 Mouse Phenotype Single KO absent hypoglossal nerve 167 6.918499e-26 3.793574571437126e-24 3.901651 89 0.00345967 527 0.016430707437381405 1.590462 15 15 0.00127054 Mouse Phenotype Single KO increased circulating tumor necrosis factor level 199 5.090173e-23 2.3422469427638192e-21 2.097935 221 0.008590865 401 0.0057118420231920194 1.333936 52 62 0.00440454 Mouse Phenotype Single KO decreased inguinal fat pad weight 204 1.155333e-22 5.185972686764706e-21 2.465337 154 0.005986395 681 0.03590674842437592 1.413744 24 27 0.002032865 Mouse Phenotype Single KO decreased circulating total protein level 208 1.727144e-22 7.603585388461539e-21 2.001695 242 0.009407191 653 0.030988830526799387 1.288823 47 58 0.003981027 Mouse Phenotype Single KO microcytic anemia 225 1.192437e-21 4.852953604e-20 2.756006 120 0.004664723 467 0.01005319578608137 1.518169 21 22 0.001778757 Mouse Phenotype Single KO increased circulating interleukin-1 beta level 236 3.378952e-21 1.3110620111864406e-19 3.026281 101 0.003926142 608 0.024314997779605264 1.457924 22 24 0.001863459 Mouse Phenotype Single KO spherocytosis 309 7.161065e-18 2.1221317865695792e-16 3.632746 65 0.002526725 663 0.033065056877828056 1.590462 13 13 0.001101135 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 313 1.105129e-17 3.233120208626198e-16 2.032698 179 0.006958212 588 0.022224085719387755 1.375535 32 37 0.002710486 Mouse Phenotype Single KO abnormal erythrocyte physiology 382 1.131466e-15 2.7122602518324608e-14 2.020046 159 0.006180758 789 0.04691125297084918 1.307714 37 45 0.003134 Mouse Phenotype Single KO decreased white fat cell number 422 1.341411e-14 2.9107347220379145e-13 2.861115 73 0.002837707 772 0.04518069730699482 1.590462 12 12 0.001016432 Mouse Phenotype Single KO abnormal white fat cell number 548 6.408498e-12 1.070850660328467e-10 2.090715 107 0.004159378 687 0.03642274724454148 1.502103 17 18 0.001439946 Mouse Phenotype Single KO hyperlipidemia 704 9.691357e-10 1.2605647166051138e-8 2.127196 81 0.003148688 687 0.03642274724454148 1.502103 17 18 0.001439946 Mouse Phenotype Single KO decreased circulating ketone body level 744 2.519425e-9 3.100856817876344e-8 3.119881 38 0.001477162 772 0.04518069730699482 1.590462 12 12 0.001016432 Mouse Phenotype extramedullary hematopoiesis 28 8.274755e-78 2.825533305535714e-75 2.063635 815 0.03168124 463 0.0014627985143196543 1.21784 134 175 0.01135016 Mouse Phenotype decreased platelet aggregation 45 4.379882e-62 9.305789289333332e-60 2.721767 371 0.01442177 1042 0.04559036226391555 1.237026 56 72 0.004743351 Mouse Phenotype abnormal platelet activation 51 3.822187e-58 7.165476452352941e-56 2.332974 462 0.01795918 821 0.02077912742630938 1.224656 77 100 0.006522107 Mouse Phenotype abnormal platelet physiology 52 6.668756e-58 1.226153386846154e-55 2.065129 603 0.02344023 656 0.008110134282164633 1.216945 101 132 0.008554972 Mouse Phenotype abnormal platelet aggregation 56 2.589159e-57 4.420526642678572e-55 2.336082 454 0.0176482 677 0.009898453870901033 1.252066 74 94 0.006267999 Mouse Phenotype increased respiratory quotient 101 5.93303e-39 5.616405923762375e-37 2.478317 271 0.0105345 513 0.0027021566578947368 1.363254 48 56 0.004065729 Mouse Phenotype abnormal embryonic hematopoiesis 118 2.156278e-36 1.7471333862711864e-34 2.006455 401 0.01558795 592 0.005437124285472974 1.329731 51 61 0.004319837 Mouse Phenotype abnormal lymph node secondary follicle morphology 120 3.648708e-36 2.907108099e-34 2.79183 203 0.007891156 971 0.03723129218434603 1.356571 29 34 0.002456378 Mouse Phenotype microcytic anemia 153 1.740954e-30 1.087925568235294e-28 2.976662 153 0.005947522 386 0.0006359149901036269 1.535619 28 29 0.002371675 Mouse Phenotype increased body temperature 158 2.92916e-30 1.7725125797468355e-28 2.476767 208 0.00808552 675 0.009858491577333333 1.408695 31 35 0.002625783 Mouse Phenotype absent hypoglossal nerve 212 6.918499e-26 3.120177780141509e-24 3.901651 89 0.00345967 720 0.012556959268750001 1.590462 15 15 0.00127054 Mouse Phenotype increased spleen white pulp amount 213 6.967475e-26 3.127513073943662e-24 2.515709 171 0.00664723 971 0.03723129218434603 1.356571 29 34 0.002456378 Mouse Phenotype poikilocytosis 220 2.262331e-25 9.831884859545455e-24 2.694312 148 0.005753158 889 0.028273242857142857 1.345776 33 39 0.002795189 Mouse Phenotype hypochromic anemia 232 1.02445e-24 4.221882090517242e-23 2.671811 146 0.005675413 827 0.0215514766904474 1.420056 25 28 0.002117567 Mouse Phenotype lymph node hyperplasia 244 3.313303e-24 1.298298769795082e-22 2.118393 228 0.008862974 506 0.0024669704116600786 1.409728 39 44 0.003303405 Mouse Phenotype microcytosis 248 8.694419e-24 3.351908873346774e-22 3.12621 109 0.004237123 804 0.019198702052238805 1.457924 22 24 0.001863459 Mouse Phenotype enlarged liver sinusoidal spaces 256 3.026179e-23 1.1302069304296874e-21 2.10726 221 0.008590865 599 0.005913286960767947 1.396504 36 41 0.003049297 Mouse Phenotype abnormal lymph node germinal center morphology 276 3.255749e-22 1.1278339198913045e-20 2.361605 164 0.006375121 839 0.022489637184743744 1.391655 28 32 0.002371675 Mouse Phenotype hypochromic microcytic anemia 313 1.17347e-20 3.584519702875399e-19 3.56658 78 0.00303207 720 0.012556959268750001 1.590462 15 15 0.00127054 Mouse Phenotype increased circulating interleukin-1 beta level 326 2.699867e-20 7.918229566564418e-19 2.30684 156 0.00606414 843 0.022482708512455516 1.369565 31 36 0.002625783