# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	14	2.239644e-34	2.1051053854285713e-31	2.049717	347	0.06255634	136	0.0000064545881925	1.364777	214	555	0.0403393	
GO Biological Process	ncRNA processing	18	6.795367e-29	4.96779079738889e-26	2.165545	256	0.04615107	145	0.000009094674959310344	1.430097	160	396	0.03016023	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	19	2.385996e-28	1.652490598105263e-25	3.237322	124	0.02235443	614	0.03325257868403909	1.472178	47	113	0.008859566	
GO Biological Process	regulation of DNA-templated transcription in response to stress	20	1.069346e-26	7.035762007e-24	3.000406	130	0.02343609	543	0.020743331418232043	1.487181	50	119	0.009425071	
GO Biological Process	nuclear-transcribed mRNA catabolic process	22	2.520924e-26	1.5078563143636365e-23	2.62653	159	0.02866414	115	0.0000017132743377391304	1.662488	93	198	0.01753063	
GO Biological Process	rRNA processing	24	3.939745e-26	2.1601293522916665e-23	2.464901	177	0.03190914	147	0.000009594880374149661	1.545016	110	252	0.02073516	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	26	1.805901e-25	9.139942791923077e-23	2.641777	152	0.0274022	254	0.0005509652577165353	1.575644	69	155	0.0130066	
GO Biological Process	rRNA metabolic process	27	1.896997e-25	9.245401304814815e-23	2.414701	179	0.0322697	152	0.000012942023673026315	1.530591	112	259	0.02111216	
GO Biological Process	ribosome biogenesis	33	7.544871e-24	3.0085744693636366e-21	2.135749	216	0.03893997	144	0.000009034592906388889	1.479354	135	323	0.02544769	
GO Biological Process	mRNA catabolic process	34	1.191802e-23	4.61262427e-21	2.434844	163	0.02938525	131	0.00000508529856351145	1.611881	97	213	0.01828464	
GO Biological Process	RNA catabolic process	47	7.407799e-21	2.0740261072553193e-18	2.21361	173	0.03118803	183	0.00006528079230054644	1.512729	103	241	0.01941565	
GO Biological Process	cellular response to decreased oxygen levels	53	1.93908e-20	4.814406362264151e-18	2.093225	192	0.0346133	322	0.0020970027107453416	1.471683	79	190	0.01489161	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	55	2.799052e-20	6.696859139636363e-18	3.08254	93	0.01676582	219	0.00017553799557534249	1.709754	57	118	0.01074458	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	57	3.010701e-20	6.950493764736843e-18	3.250972	86	0.01550388	697	0.0499199975035868	1.542855	34	78	0.006409048	
GO Biological Process	cellular response to oxygen levels	65	1.648603e-19	3.3375333656923074e-17	2.019884	199	0.03587525	307	0.0016288874579478826	1.46047	85	206	0.01602262	
GO Biological Process	cellular response to hypoxia	81	1.749423e-18	2.8420564514814816e-16	2.041064	183	0.03299081	386	0.0046398020367875645	1.450611	75	183	0.01413761	
GO Biological Process	multi-organism metabolic process	88	8.211614e-18	1.2279162343863636e-15	2.539102	111	0.02001082	234	0.000302787746474359	1.613237	67	147	0.01262959	
GO Biological Process	protein targeting to ER	89	9.906981e-18	1.4647861008876405e-15	3.065183	81	0.01460249	201	0.00012111131153731343	1.787268	51	101	0.009613572	
GO Biological Process	viral transcription	96	2.87584e-17	3.941997766666667e-15	2.850815	88	0.01586443	192	0.00008781754601041668	1.754084	56	113	0.01055608	
GO Biological Process	viral gene expression	98	3.747558e-17	5.032052624693878e-15	2.761734	92	0.01658554	229	0.00023140779562008735	1.6722	60	127	0.01131008	
GO Cellular Component	ribosomal subunit	28	3.10018e-21	1.913253942857143e-19	2.619915	127	0.02289526	33	0.000010787060945454546	1.626253	85	185	0.01602262	
GO Cellular Component	ribosome	35	2.88081e-16	1.4222970514285716e-14	2.116773	146	0.02632053	42	0.000303969312	1.469789	98	236	0.01847314	
GO Cellular Component	large ribosomal subunit	37	8.148004e-16	3.8053380843243244e-14	2.804563	82	0.01478277	78	0.014611126153846153	1.508131	49	115	0.009236569	
GO Cellular Component	PcG protein complex	43	2.878459e-11	1.1567388725581396e-9	2.660817	61	0.01099694	90	0.0279258048	1.769746	23	46	0.004335533	
GO Cellular Component	methyltransferase complex	49	1.551743e-10	5.472269191836734e-9	2.305409	74	0.01334054	74	0.010579892497297298	1.594716	41	91	0.007728558	
GO Cellular Component	cytosolic ribosome	51	4.715858e-10	1.597843651764706e-8	2.15568	81	0.01460249	55	0.0022002111883636364	1.611733	51	112	0.009613572	
GO Cellular Component	mitochondrial ribosome	52	5.256675e-10	1.7468335384615386e-8	2.790015	49	0.008833604	95	0.032948539957894735	1.54072	37	85	0.006974552	
GO Cellular Component	proteasome complex	58	1.818448e-9	5.417720937931034e-8	2.593509	52	0.009374437	93	0.03155987612903226	1.613592	31	68	0.005843544	
GO Cellular Component	endopeptidase complex	60	1.852294e-9	5.3346067199999995e-8	2.592045	52	0.009374437	98	0.03984785632653061	1.590206	31	69	0.005843544	
GO Cellular Component	catalytic step 2 spliceosome	61	2.090245e-9	5.92121862295082e-8	2.236482	69	0.01243916	57	0.0023711643284210528	1.659136	45	96	0.008482564	
GO Cellular Component	histone methyltransferase complex	77	4.278643e-8	9.601941693506495e-7	2.193836	60	0.01081666	98	0.03984785632653061	1.590206	31	69	0.005843544	
GO Cellular Component	small ribosomal subunit	93	2.780577e-7	0.0000051664914580645165	2.336982	46	0.008292771	46	0.0010579131547826088	1.818905	37	72	0.006974552	
GO Cellular Component	cytosolic small ribosomal subunit	101	0.000001600825	0.00002738837227722772	2.541865	34	0.006129439	54	0.0021079552	2.011074	25	44	0.004712535	
GO Cellular Component	spliceosomal snRNP complex	126	0.00001475578	0.00020236498285714286	2.250538	35	0.006309717	63	0.006433088914285715	1.769746	31	62	0.005843544	
GO Cellular Component	spliceosomal tri-snRNP complex	131	0.00001993324	0.00026293617343511454	2.930833	21	0.00378583	76	0.013529371452631578	2.074874	17	29	0.003204524	
GO Cellular Component	U4 snRNP	145	0.00004542921	0.0005413908612413794	5.011006	10	0.001802776	86	0.020549918511627904	2.831593	8	10	0.001508011	
GO Cellular Component	U2 snRNP	150	0.00006316547	0.0007276662144	3.377766	15	0.002704164	69	0.008024656695652175	2.421757	13	19	0.002450518	
GO Cellular Component	Bcl-2 family protein complex	176	0.0002048192	0.0020109521454545454	3.823453	11	0.001983054	104	0.04474752369230769	3.033849	6	7	0.001131008	
GO Cellular Component	U7 snRNP	179	0.0002215385	0.0021386509944134077	5.12113	8	0.001442221	104	0.04474752369230769	3.033849	6	7	0.001131008	
GO Cellular Component	Lsm1-7-Pat1 complex	193	0.0004829412	0.004323950225906736	7.964275	5	0.0009013881	94	0.03304640068085107	3.539491	5	5	0.0009425071	
GO Molecular Function	cadherin binding	6	6.065201e-31	4.267879770333333e-28	2.059944	308	0.05552551	6	7.11729983e-9	1.641672	141	304	0.0265787	
GO Molecular Function	structural constituent of ribosome	9	4.273762e-16	2.0048692404444446e-13	2.42792	108	0.01946998	21	0.00032410283523809526	1.616805	74	162	0.0139491	
GO Molecular Function	fatty acid binding	20	3.694022e-12	7.798080442e-10	4.755875	31	0.005588606	78	0.03954993142051282	2.097476	16	27	0.003016023	
Mouse Phenotype Single KO	abnormal osteoblast differentiation	54	1.097151e-11	1.8604836494444445e-9	2.399546	77	0.01388138	113	0.008799325959292035	1.966384	25	45	0.004712535	
Mouse Phenotype Single KO	increased trabecular bone mass	151	6.822746e-8	0.000004137475835894039	3.050775	32	0.005768884	153	0.021172785475163398	2.498464	12	17	0.002262017	
Mouse Phenotype Single KO	abnormal B cell apoptosis	176	2.39371e-7	0.000012454092312499998	2.161337	55	0.00991527	134	0.014151958993283581	1.996636	22	39	0.004147031	
Mouse Phenotype Single KO	decreased core body temperature	266	0.0000055067	0.00018956711240601505	4.189385	15	0.002704164	152	0.021072184789473685	2.895947	9	11	0.001696513	
Mouse Phenotype Single KO	increased B cell apoptosis	403	0.00008229846	0.001869992551414392	2.08636	34	0.006129439	140	0.016057721740714286	2.308364	15	23	0.002827521	
Mouse Phenotype Single KO	abnormal sublingual gland morphology	703	0.002353399	0.030654444726884778	2.81823	11	0.001983054	194	0.04074085710979381	3.097055	7	8	0.00131951	
Mouse Phenotype	extramedullary hematopoiesis	2	8.618846e-29	4.1202393303e-25	2.407279	205	0.03695691	360	0.023657709185833334	1.395571	69	175	0.0130066	
Mouse Phenotype	abnormal lymph node secondary follicle morphology	33	2.249051e-15	6.516114124545453e-13	3.571727	56	0.01009555	319	0.019604213081191226	1.977951	19	34	0.003581527	
Mouse Phenotype	thick epidermis	51	7.414826e-14	1.390061791882353e-11	2.075242	128	0.02307554	154	0.0017011260247402598	1.633611	54	117	0.01017908	
Mouse Phenotype	abnormal lymph node B cell domain morphology	61	7.379418e-13	1.1566330409508197e-10	2.639472	72	0.01297999	430	0.03675926563953488	1.676601	27	57	0.005089538	
Mouse Phenotype	abnormal follicular B cell morphology	65	1.141201e-12	1.6786188863076925e-10	2.145729	107	0.01928971	387	0.028045723527131784	1.512016	44	103	0.008294062	
Mouse Phenotype	thymus atrophy	70	2.426179e-12	3.313813917e-10	2.244691	94	0.0169461	239	0.01093867209288703	1.697016	35	73	0.006597549	
Mouse Phenotype	dry eyes	74	5.135629e-12	6.635371468783783e-10	3.739274	40	0.007211105	364	0.02355903946153846	2.4334	11	16	0.002073516	
Mouse Phenotype	early cellular replicative senescence	94	9.498347e-11	9.661031453936171e-9	2.433387	68	0.01225888	239	0.01093867209288703	1.697016	35	73	0.006597549	
Mouse Phenotype	abnormal cellular replicative senescence	126	1.004532e-9	7.622484485714287e-8	2.248004	71	0.01279971	318	0.01965438835	1.601198	38	84	0.007163054	
Mouse Phenotype	increased B cell proliferation	139	2.250229e-9	1.547801400647482e-7	2.137573	76	0.0137011	311	0.01874442043118971	1.616805	37	81	0.006974552	
Mouse Phenotype	absent incisors	155	7.783248e-9	4.801008653419355e-7	2.175665	68	0.01225888	346	0.022505007868786127	1.990964	18	32	0.003393025	
Mouse Phenotype	increased bone resorption	204	9.96808e-8	0.000004671804552941176	2.108742	62	0.01117721	207	0.006223555124637682	1.97553	24	43	0.004524034	
Mouse Phenotype	spontaneous skin ulceration	286	0.000002363899	0.00007902530887762238	2.2977	40	0.007211105	381	0.02608755237007874	1.858233	21	40	0.00395853	
Mouse Phenotype	abnormal kidney interlobular artery morphology	314	0.000004588045	0.00013970158676751592	4.016952	16	0.002884442	439	0.03915138028018223	3.539491	5	5	0.0009425071	
Mouse Phenotype	increased transitional stage B cell number	357	0.00001154809	0.00030927531789915966	2.077919	43	0.007751938	294	0.01707490209489796	1.966384	20	36	0.003770028	
Mouse Phenotype	increased trabecular bone mass	393	0.00001922489	0.00046770782007633587	2.251265	34	0.006129439	480	0.04776422631875	2.091517	13	22	0.002450518	
Mouse Phenotype	abnormal lymph node germinal center morphology	447	0.00003776508	0.0008077671809395974	2.203812	33	0.005949162	346	0.022505007868786127	1.990964	18	32	0.003393025	
Mouse Phenotype	increased follicular B cell number	457	0.00004213517	0.0008815193881181619	2.061378	38	0.00685055	346	0.022505007868786127	1.990964	18	32	0.003393025	
Mouse Phenotype	ectopic Paneth cells	749	0.001030061	0.013148749293724967	2.053796	24	0.004326663	379	0.025800547701846966	2.831593	8	10	0.001508011