# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 89 1.628033e-31 2.407110814269663e-29 2.190405 279 0.01512523 780 0.008971942851153847 1.267397 82 113 0.007627197 GO Biological Process regulation of DNA-templated transcription in response to stress 101 9.838035e-27 1.2817693323267327e-24 2.005813 289 0.01566735 772 0.00837300522318653 1.262202 86 119 0.007999256 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 119 1.516988e-23 1.6774827808403361e-21 2.14299 215 0.01165564 558 0.001567765146594982 1.302501 88 118 0.008185285 GO Biological Process translational elongation 143 1.413238e-20 1.3004754434965035e-18 2.056301 205 0.01111352 722 0.006033406967728532 1.278713 82 112 0.007627197 GO Biological Process mitochondrial translation 177 7.049645e-18 5.241032686723163e-16 2.01883 184 0.009975062 793 0.009506106403656999 1.273175 78 107 0.007255139 GO Biological Process mitochondrial translational elongation 194 2.500583e-17 1.6961428709793813e-15 2.180228 148 0.00802342 1125 0.047334525473777776 1.253396 61 85 0.005673891 GO Biological Process adherens junction assembly 197 3.966806e-17 2.649705591573604e-15 2.174348 147 0.007969207 967 0.02477823370320579 1.438323 28 34 0.002604409 GO Biological Process axonal transport 284 6.849568e-14 3.173713567323944e-12 2.193397 114 0.006180202 1076 0.03767158764591078 1.388272 31 39 0.002883453 GO Biological Process termination of RNA polymerase II transcription 347 1.747809e-12 6.628074533429395e-11 2.066248 116 0.006288626 489 0.0006237944565439673 1.417478 56 69 0.005208818 GO Biological Process gene silencing by miRNA 361 3.359936e-12 1.2247478621606648e-10 2.030116 118 0.006397051 946 0.022692945882663847 1.389289 35 44 0.003255511 GO Biological Process mitochondrion transport along microtubule 618 1.62142e-8 3.4524701909385113e-7 2.227979 62 0.003361162 805 0.010273690639006211 1.649505 17 18 0.001581248 GO Biological Process intra-S DNA damage checkpoint 634 2.466495e-8 5.119338754731861e-7 3.067673 34 0.001843218 951 0.02381103753732913 1.637377 15 16 0.001395219 GO Biological Process establishment of mitochondrion localization 668 5.271586e-8 0.0000010384550924251496 2.109824 65 0.003523799 957 0.023908266718913274 1.571882 18 20 0.001674263 GO Biological Process negative regulation of muscle adaptation 683 6.614831e-8 0.0000012744445260468521 2.169722 60 0.003252738 991 0.028724224730575176 1.746535 11 11 0.001023161 GO Biological Process positive regulation of transcription from RNA polymerase I promoter 745 1.481636e-7 0.0000026170265938255034 2.299051 50 0.002710615 1106 0.04381369955244123 1.508371 19 22 0.001767277 GO Biological Process RNA surveillance 927 0.000001930236 0.000027400189346278316 2.564133 33 0.001789006 951 0.02381103753732913 1.637377 15 16 0.001395219 GO Biological Process ubiquinone biosynthetic process 1632 0.0002909784 0.002346191645588235 2.045118 30 0.001626369 951 0.02381103753732913 1.637377 15 16 0.001395219 GO Cellular Component catalytic step 2 spliceosome 52 3.879504e-21 1.2891890215384614e-19 2.056623 211 0.01143879 70 0.00035034854400000005 1.364481 75 96 0.006976095 GO Cellular Component U5 snRNP 185 8.939336e-7 0.000008349823031351351 2.339706 42 0.002276916 167 0.03810390035928144 1.508371 19 22 0.001767277 GO Cellular Component exosome (RNase complex) 216 0.000004966322 0.000039730576 2.114666 45 0.002439553 162 0.025593546666666668 1.518726 20 23 0.001860292 GO Cellular Component precatalytic spliceosome 221 0.000006583116 0.000051473413791855205 2.110366 44 0.002385341 138 0.016383931826086957 1.49703 24 28 0.00223235 GO Molecular Function snRNA binding 53 7.681618e-13 6.119205886037736e-11 2.687604 70 0.003794861 140 0.04219047615714286 1.424805 31 38 0.002883453 Mouse Phenotype Single KO abnormal liver sinusoid morphology 13 4.753744e-26 3.3484641390769235e-23 2.207881 224 0.01214355 482 0.010257373132572613 1.349595 51 66 0.004743745 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 16 1.181006e-22 6.75904496375e-20 2.454736 155 0.008402906 489 0.010708587172801636 1.463313 31 37 0.002883453 Mouse Phenotype Single KO abnormal cellular replicative senescence 21 3.09655e-21 1.3502432547619046e-18 2.32508 161 0.00872818 269 0.0005299700554275093 1.455446 50 60 0.00465073 Mouse Phenotype Single KO early cellular replicative senescence 31 3.394998e-18 1.0028386027741935e-15 2.292777 140 0.007589721 351 0.0023452303150997148 1.44425 43 52 0.003999628 Mouse Phenotype Single KO increased hemangiosarcoma incidence 57 8.335774e-15 1.3391347810175438e-12 2.539827 91 0.004933319 612 0.02326657541993464 1.528218 21 24 0.001953307 Mouse Phenotype Single KO increased skin papilloma incidence 65 2.521361e-14 3.5520157964615387e-12 2.692782 79 0.004282771 504 0.012410098741468253 1.587759 20 22 0.001860292 Mouse Phenotype Single KO increased squamous cell carcinoma incidence 88 5.441061e-13 5.661794951931818e-11 2.434672 85 0.004608045 501 0.011765560621556887 1.545012 23 26 0.002139336 Mouse Phenotype Single KO absent hypoglossal nerve 133 5.506978e-11 3.791533650075188e-9 2.995764 49 0.002656402 691 0.03754999460926194 1.6301 14 15 0.001302204 Mouse Phenotype Single KO lymphoid hyperplasia 153 2.595646e-10 1.5534856484967318e-8 2.038299 96 0.00520438 388 0.003921921859536083 1.565859 26 29 0.00241838 Mouse Phenotype Single KO subcutaneous edema 155 2.664115e-10 1.5738903906451612e-8 2.091841 90 0.004879107 486 0.010617643244444445 1.513664 26 30 0.00241838 Mouse Phenotype Single KO small superior cervical ganglion 178 1.479217e-9 7.609657342134832e-8 2.054348 86 0.004662257 316 0.0012049412317088608 1.582798 29 32 0.002697423 Mouse Phenotype Single KO absent segment of posterior cerebral artery 308 6.999151e-8 0.000002080883951525974 2.135272 62 0.003361162 504 0.012410098741468253 1.587759 20 22 0.001860292 Mouse Phenotype Single KO absent stapedial artery 314 8.69418e-8 0.0000025354333203821657 2.256729 54 0.002927464 370 0.003285793935675676 1.746535 16 16 0.001488234 Mouse Phenotype Single KO abnormal stapedial artery morphology 315 8.782366e-8 0.000002553019855936508 2.236863 55 0.002981676 342 0.0020340521747076023 1.746535 17 17 0.001581248 Mouse Phenotype Single KO abnormal internal carotid artery morphology 345 2.264031e-7 0.000006009197642608696 2.244657 51 0.002764827 579 0.019579706160621758 1.746535 12 12 0.001116175 Mouse Phenotype Single KO reduced sympathetic cervical ganglion size 364 3.408584e-7 0.000008574836178021978 2.564725 38 0.002060067 515 0.01259774719514563 1.746535 13 13 0.00120919 Mouse Phenotype Single KO thin hypoglossal nerve 509 0.000003788833 0.00006816177560117877 2.15908 44 0.002385341 414 0.005131903516183575 1.746535 15 15 0.001395219 Mouse Phenotype Single KO abnormal ductus venosus valve topology 751 0.00006530882 0.0007963153991211717 2.171368 32 0.001734793 747 0.0463320786519411 1.746535 10 10 0.000930146 Mouse Phenotype Single KO abnormal infrahyoid muscle morphology 858 0.0001643663 0.001754198378904429 2.182838 28 0.001517944 747 0.0463320786519411 1.746535 10 10 0.000930146 Mouse Phenotype Single KO abnormal pharyngeal muscle morphology 881 0.0001963707 0.002041051645743473 2.125592 29 0.001572157 651 0.03042785297081413 1.746535 11 11 0.001023161 Mouse Phenotype enlarged liver sinusoidal spaces 21 5.114333e-28 2.328482753e-25 2.499983 188 0.01019191 562 0.0019510700583629892 1.490945 35 41 0.003255511 Mouse Phenotype abnormal liver sinusoid morphology 22 1.920295e-27 8.345427497727271e-25 2.057236 279 0.01512523 528 0.001527578896875 1.36588 61 78 0.005673891 Mouse Phenotype early cellular replicative senescence 26 2.369568e-25 8.713630633846153e-23 2.249078 209 0.01133037 422 0.0004061399518009479 1.411583 59 73 0.005487862 Mouse Phenotype abnormal cellular replicative senescence 30 3.187121e-25 1.0157354627e-22 2.161328 227 0.01230619 455 0.0006962049129890111 1.372278 66 84 0.006138964 Mouse Phenotype abnormal third pharyngeal arch morphology 76 1.352327e-16 1.7012629535526318e-14 2.122743 150 0.008131844 1172 0.04131521835665529 1.434654 23 28 0.002139336 Mouse Phenotype pale placenta 86 1.45715e-15 1.6199780406976745e-13 3.107967 69 0.003740648 1026 0.026405273464912282 1.6301 14 15 0.001302204 Mouse Phenotype lymphoid hyperplasia 168 2.366124e-11 1.3465780692857144e-9 2.041861 107 0.005800716 474 0.0008387348925316455 1.582798 29 32 0.002697423 Mouse Phenotype absent hypoglossal nerve 181 5.506978e-11 2.9089622462983425e-9 2.995764 49 0.002656402 1026 0.026405273464912282 1.6301 14 15 0.001302204 Mouse Phenotype subcutaneous edema 201 2.664115e-10 1.2672439559701493e-8 2.091841 90 0.004879107 762 0.007070653105511812 1.513664 26 30 0.00241838 Mouse Phenotype decreased B cell apoptosis 249 1.768235e-9 6.789596319277108e-8 2.036713 87 0.00471647 1186 0.04529673694856661 1.49703 18 21 0.001674263 Mouse Phenotype increased embryonic neuroepithelium apoptosis 291 6.197754e-9 2.036313608041237e-7 2.102304 75 0.004065922 594 0.002632434636868687 1.606812 23 25 0.002139336 Mouse Phenotype tachypnea 314 1.342233e-8 4.0869712461783435e-7 2.372644 55 0.002981676 1129 0.03680316830912312 1.552476 16 18 0.001488234 Mouse Phenotype abnormal internal carotid artery morphology 320 1.450916e-8 4.3350649612500006e-7 2.366969 55 0.002981676 797 0.00849947108092848 1.746535 13 13 0.00120919 Mouse Phenotype increased kidney tumor incidence 329 1.61128e-8 4.6825070151975686e-7 2.531721 48 0.00260219 932 0.017653196504291847 1.637377 15 16 0.001395219 Mouse Phenotype sacral vertebral transformation 376 5.630575e-8 0.0000014317533929521276 2.679742 40 0.002168492 1186 0.04529673694856661 1.49703 18 21 0.001674263 Mouse Phenotype absent segment of posterior cerebral artery 384 6.999151e-8 0.0000017426792372656253 2.135272 62 0.003361162 791 0.008256184584197218 1.587759 20 22 0.001860292 Mouse Phenotype reduced sympathetic cervical ganglion size 467 3.408584e-7 0.000006978473581156317 2.564725 38 0.002060067 797 0.00849947108092848 1.746535 13 13 0.00120919 Mouse Phenotype thin hypoglossal nerve 610 0.000003788833 0.00005938529887377049 2.15908 44 0.002385341 641 0.0034607553449297972 1.746535 15 15 0.001395219 Mouse Phenotype abnormal ductus venosus valve topology 875 0.00006530882 0.0007136201463085715 2.171368 32 0.001734793 1098 0.03291168749453552 1.746535 10 10 0.000930146 Mouse Phenotype abnormal infrahyoid muscle morphology 993 0.0001643663 0.0015825842842900305 2.182838 28 0.001517944 1098 0.03291168749453552 1.746535 10 10 0.000930146