# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 213 1.461975e-29 9.031985457746479e-28 2.789368 164 0.009950249 712 0.01698839097949438 1.431711 39 54 0.004117399 GO Biological Process regulation of antigen receptor-mediated signaling pathway 225 6.065312e-28 3.547264027022223e-26 2.422344 199 0.01207378 526 0.004214312347528517 1.496128 40 53 0.004222973 GO Biological Process interferon-gamma-mediated signaling pathway 243 2.832808e-26 1.534029649053498e-24 2.480878 178 0.01079966 605 0.00850290426661157 1.424828 46 64 0.004856419 GO Biological Process cellular response to mechanical stimulus 256 4.054473e-25 2.0840941487109374e-23 2.009121 269 0.01632083 563 0.005762083020781528 1.397824 55 78 0.005806588 GO Biological Process tumor necrosis factor-mediated signaling pathway 259 6.547288e-25 3.326477327876448e-23 2.079195 245 0.0148647 762 0.021726959598425195 1.269955 82 128 0.008657095 GO Biological Process Fc receptor mediated stimulatory signaling pathway 271 9.636654e-24 4.679288929372693e-22 2.078151 233 0.01413663 422 0.0010500894472985783 1.46641 54 73 0.005701014 GO Biological Process activation of MAPKK activity 278 2.082619e-23 9.857979647841725e-22 2.167483 208 0.01261983 595 0.007378052256302521 1.468422 40 54 0.004222973 GO Biological Process hepatocyte apoptotic process 280 3.455093e-23 1.6237703138214285e-21 4.228082 72 0.004368402 569 0.006257428271528998 1.982369 12 12 0.001266892 GO Biological Process T cell costimulation 297 1.808386e-22 8.01230685993266e-21 2.234684 186 0.01128504 478 0.002346070484330544 1.457624 50 68 0.005278716 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 299 2.227129e-22 9.801602177591972e-21 3.167517 100 0.006067225 868 0.035198141940092166 1.734573 14 16 0.001478041 GO Biological Process lymphocyte costimulation 309 1.120259e-21 4.7707081491909386e-20 2.185104 188 0.01140638 464 0.002089068956163793 1.451876 52 71 0.005489865 GO Biological Process Fc-gamma receptor signaling pathway 316 3.240104e-21 1.3492572321518987e-19 2.021134 221 0.01340857 504 0.00302252308531746 1.427306 54 75 0.005701014 GO Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis 320 4.318649e-21 1.7759094434687498e-19 2.023309 219 0.01328722 464 0.002089068956163793 1.451876 52 71 0.005489865 GO Biological Process positive regulation of mRNA catabolic process 333 1.67924e-20 6.635771519519519e-19 2.76983 112 0.006795292 634 0.01093981974763407 1.66519 21 25 0.002217061 GO Biological Process negative regulation of antigen receptor-mediated signaling pathway 343 3.794223e-20 1.455632083294461e-18 2.994675 97 0.005885208 878 0.036804059390660594 1.621938 18 22 0.001900338 GO Biological Process nucleotide-binding oligomerization domain containing signaling pathway 354 1.945717e-19 7.23268079180791e-18 2.574521 120 0.00728067 769 0.022972140297789337 1.572224 23 29 0.002428209 GO Biological Process nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 368 5.333581e-19 1.9071900102989132e-17 2.528256 121 0.007341342 697 0.015782770555667142 1.585895 24 30 0.002533784 GO Biological Process response to epidermal growth factor 391 3.265495e-18 1.0989935730179027e-16 2.128954 165 0.01001092 805 0.028086095549068324 1.463177 31 42 0.003272804 GO Biological Process regulation of toll-like receptor 3 signaling pathway 426 5.00718e-17 1.5467014464788734e-15 4.689187 46 0.002790923 843 0.03295461599169632 1.982369 9 9 0.0009501689 GO Biological Process cellular senescence 471 1.309013e-15 3.6571766596602975e-14 2.22413 126 0.007644703 756 0.021394149366402118 1.548726 25 32 0.002639358 GO Cellular Component uropod 102 4.356948e-11 7.381182494117648e-10 3.357678 42 0.002548234 104 0.031246975384615384 1.829879 12 13 0.001266892 GO Molecular Function cytokine receptor activity 10 1.831927e-29 7.734395793999999e-27 2.181395 262 0.01589613 84 0.0031690161109523807 1.400587 65 92 0.006862331 GO Molecular Function phosphatidic acid binding 85 6.584058e-12 3.270340338352941e-10 2.401186 79 0.004793108 110 0.02842461116181818 1.762106 16 18 0.001689189 Mouse Phenotype Single KO abnormal T cell physiology 12 5.410915e-168 4.1289790545833336e-165 2.131741 1585 0.09616551 26 6.737090175769231e-17 1.378219 365 525 0.03853463 Mouse Phenotype Single KO abnormal immunoglobulin level 33 2.0054e-116 5.564681151515151e-114 2.023351 1255 0.07614367 110 9.505815103636362e-9 1.292276 294 451 0.03103885 Mouse Phenotype Single KO abnormal T cell activation 36 1.504126e-111 3.825911606111111e-109 2.260554 941 0.05709259 98 9.924076283673468e-10 1.385601 202 289 0.02132601 Mouse Phenotype Single KO abnormal T cell proliferation 41 1.064176e-103 2.3767462517073168e-101 2.268907 869 0.05272418 99 1.0444696187878789e-9 1.405128 185 261 0.01953125 Mouse Phenotype Single KO autoimmune response 45 2.182692e-95 4.441535698666667e-93 2.167371 882 0.05351292 245 0.00011566169324489796 1.245718 208 331 0.02195946 Mouse Phenotype Single KO abnormal immune tolerance 46 1.109117e-94 2.2078661671739134e-92 2.144866 896 0.05436233 244 0.0001133651986762295 1.243379 212 338 0.02238176 Mouse Phenotype Single KO abnormal self tolerance 47 1.071782e-92 2.088150590212766e-90 2.136632 885 0.05369494 247 0.00012292701577732793 1.24419 209 333 0.02206503 Mouse Phenotype Single KO decreased immunoglobulin level 50 1.308022e-91 2.3955114908000003e-89 2.199094 821 0.04981192 217 0.00004058438523548386 1.28146 181 280 0.01910895 Mouse Phenotype Single KO abnormal IgG level 55 8.029672e-87 1.3368673909818182e-84 2.000019 969 0.05879141 107 5.543154006635513e-9 1.336683 236 350 0.02491554 Mouse Phenotype Single KO abnormal mature B cell number 56 7.047574e-85 1.1524041985357142e-82 2.010058 936 0.05678922 104 2.522552750384615e-9 1.386222 193 276 0.02037584 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 63 2.922356e-77 4.247621252698413e-75 2.177364 708 0.04295595 591 0.014656607433164128 1.19246 157 261 0.01657517 Mouse Phenotype Single KO abnormal IgM level 65 1.502097e-73 2.1161080352307693e-71 2.268834 617 0.03743478 188 0.000010499625642021277 1.363534 130 189 0.01372466 Mouse Phenotype Single KO abnormal tumor necrosis factor secretion 68 2.062631e-71 2.777575303970588e-69 2.266943 600 0.03640335 494 0.007343072445748987 1.236527 126 202 0.01330236 Mouse Phenotype Single KO decreased IgG level 69 7.395243e-71 9.81423770304348e-69 2.16562 657 0.03986167 226 0.000058475426986725665 1.30978 148 224 0.015625 Mouse Phenotype Single KO decreased mature B cell number 72 5.398237e-68 6.865507806805554e-66 2.053092 713 0.04325931 208 0.000029109984135096155 1.334473 138 205 0.01456926 Mouse Phenotype Single KO abnormal B cell activation 73 5.210788e-66 6.536326810410959e-64 2.342837 518 0.03142822 162 0.0000015101978761111111 1.434609 110 152 0.01161318 Mouse Phenotype Single KO increased immunoglobulin level 74 9.136212e-66 1.1305445038378377e-63 2.026136 712 0.04319864 249 0.00012455752248594377 1.279955 164 254 0.01731419 Mouse Phenotype Single KO abnormal lymph node size 76 8.458935e-65 1.0191903657236842e-62 2.133515 621 0.03767747 241 0.0001124730372614108 1.332412 123 183 0.01298564 Mouse Phenotype Single KO decreased apoptosis 80 3.512672e-62 4.020692188e-60 2.062008 645 0.0391336 238 0.00009104497301680673 1.344365 118 174 0.01245777 Mouse Phenotype Single KO enlarged lymph nodes 82 9.084047e-62 1.0144221753536584e-59 2.375669 471 0.02857663 255 0.00013339903236078433 1.386168 93 133 0.009818412 Mouse Phenotype abnormal T cell activation 38 6.024474e-132 1.515789366157895e-129 2.117222 1276 0.07741779 105 1.2315232717142858e-12 1.366817 282 409 0.02977196 Mouse Phenotype abnormal lymph node morphology 47 1.981711e-120 4.031306142765957e-118 2.041934 1269 0.07699308 258 0.0000010857608715116277 1.264615 259 406 0.02734375 Mouse Phenotype abnormal lymph node size 52 1.486025e-112 2.7322855817307694e-110 2.202144 1003 0.06085427 235 2.344711567276596e-7 1.333213 191 284 0.0201647 Mouse Phenotype decreased immunoglobulin level 53 1.641771e-111 2.9616929303773585e-109 2.151794 1045 0.0634025 237 2.906097013164557e-7 1.298794 228 348 0.02407095 Mouse Phenotype abnormal immune tolerance 55 4.599124e-109 7.994949920727272e-107 2.0247 1176 0.07135056 260 0.0000014134669828846154 1.253222 275 435 0.02903294 Mouse Phenotype autoimmune response 56 8.306852e-109 1.418246642357143e-106 2.035874 1158 0.07025846 267 0.0000016484471028089888 1.254723 269 425 0.02839949 Mouse Phenotype abnormal T cell proliferation 58 4.455685e-108 7.344966256034483e-106 2.07678 1098 0.06661813 123 1.7957477973170733e-11 1.368266 254 368 0.02681588 Mouse Phenotype abnormal self tolerance 61 2.0126e-106 3.154503049180328e-104 2.015429 1161 0.07044048 269 0.0000017617258542379182 1.253489 270 427 0.02850507 Mouse Phenotype enlarged lymph nodes 64 3.640877e-96 5.43912890578125e-94 2.296032 787 0.04774906 229 1.7294425287772927e-7 1.381379 154 221 0.01625845 Mouse Phenotype decreased IgG level 65 1.210658e-95 1.7807847904615385e-93 2.225793 835 0.05066133 250 5.8794681108e-7 1.331333 182 271 0.01921453 Mouse Phenotype altered susceptibility to autoimmune disorder 68 8.737529e-92 1.2285222760147058e-89 2.115794 896 0.05436233 782 0.005637619197314577 1.179982 200 336 0.02111486 Mouse Phenotype abnormal B cell activation 69 1.030748e-90 1.4282582069565216e-88 2.336264 717 0.043502 182 7.821050345604395e-9 1.431174 148 205 0.015625 Mouse Phenotype decreased mature B cell number 71 1.471155e-89 1.9810863316901409e-87 2.008295 989 0.06000485 172 5.025321078313953e-9 1.367151 200 290 0.02111486 Mouse Phenotype abnormal IgM level 72 3.293576e-89 4.373594463333333e-87 2.199898 799 0.04847713 257 9.109400859922179e-7 1.340082 169 250 0.01784206 Mouse Phenotype abnormal B cell proliferation 75 2.057646e-84 2.6230871208e-82 2.328025 672 0.04077175 196 2.2067524587244898e-8 1.436955 137 189 0.01446368 Mouse Phenotype abnormal IgG1 level 80 3.484541e-78 4.164462062625e-76 2.153734 734 0.04453343 150 4.8693044802e-10 1.426642 172 239 0.01815878 Mouse Phenotype abnormal marginal zone B cell morphology 88 7.120845e-72 7.736636255113636e-70 2.590455 467 0.02833394 294 0.000005954389173469387 1.426165 100 139 0.01055743 Mouse Phenotype abnormal tumor necrosis factor secretion 91 3.209558e-68 3.372152092087912e-66 2.104334 675 0.04095377 1186 0.03366550635581787 1.166099 150 255 0.01583615 Mouse Phenotype abnormal follicular B cell morphology 97 1.779279e-64 1.7537821153608249e-62 2.672603 396 0.02402621 243 4.4035172456790124e-7 1.539704 80 103 0.008445946 Mouse Phenotype abnormal single-positive T cell number 98 1.50729e-63 1.470530580612245e-61 2.362898 490 0.0297294 379 0.00005432913376781003 1.404828 90 127 0.009501689