# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of T cell differentiation 193 1.754195e-13 1.196033782642487e-11 2.091882 122 0.01917033 304 0.0014116421136842105 1.735622 40 73 0.006747638 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell differentiation 214 5.750945e-13 3.536293703504673e-11 2.968237 60 0.009428033 365 0.0031974607054520545 2.192892 18 26 0.003036437 GO Biological Process vascular smooth muscle cell differentiation 221 7.873877e-13 4.688341513257918e-11 3.614945 45 0.007071025 697 0.048274593878048784 2.262507 10 14 0.00168691 GO Biological Process regulation of nitric oxide biosynthetic process 241 7.056481e-12 3.8529557460165974e-10 2.474707 74 0.01162791 506 0.015645530881422925 1.70107 29 54 0.004892038 GO Biological Process regulation of reactive oxygen species biosynthetic process 242 7.306069e-12 3.972750494669421e-10 2.244025 90 0.01414205 360 0.0031474361460555552 1.692231 39 73 0.006578947 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell activation 243 7.345703e-12 3.97786443526749e-10 2.567689 69 0.01084224 354 0.003046262778050847 2.111673 20 30 0.003373819 GO Biological Process regulation of CD4-positive, alpha-beta T cell activation 366 3.822803e-9 1.3744334611202183e-7 2.088202 78 0.01225644 550 0.022962567449636363 1.715735 26 48 0.004385965 GO Biological Process positive regulation of alpha-beta T cell activation 372 4.475633e-9 1.583195017392473e-7 2.028053 83 0.01304211 371 0.0035538202719676555 1.837156 29 50 0.004892038 GO Biological Process positive regulation of blood vessel endothelial cell migration 378 5.530711e-9 1.9253604774867724e-7 2.226395 66 0.01037084 627 0.03722748259170654 1.823718 19 33 0.003205128 GO Biological Process positive regulation of alpha-beta T cell differentiation 401 9.578091e-9 3.1430947498503744e-7 2.111514 72 0.01131364 246 0.00037434814136178864 2.111673 26 39 0.004385965 GO Biological Process positive regulation of T-helper cell differentiation 408 1.21616e-8 3.922414078431373e-7 2.755262 42 0.006599623 355 0.0030616656090140843 2.375633 15 20 0.002530364 GO Biological Process regulation of transforming growth factor beta production 474 4.091946e-8 0.0000011359898188607595 2.423184 49 0.00769956 601 0.030217596301164724 1.923131 17 28 0.002867746 GO Biological Process lymphocyte costimulation 511 7.456521e-8 0.000001920163597632094 2.04693 68 0.0106851 599 0.029935648554257094 1.561449 35 71 0.005904184 GO Biological Process negative regulation of potassium ion transport 540 1.389936e-7 0.000003387068115555556 2.300871 50 0.007856694 315 0.0016414265065079366 2.228989 19 27 0.003205128 GO Biological Process positive regulation of CREB transcription factor activity 642 8.891781e-7 0.000018225381024766354 2.426397 39 0.006128221 567 0.025152604611992948 2.322841 11 15 0.001855601 GO Biological Process megakaryocyte development 813 0.000007226295 0.00011696287319188191 2.524211 30 0.004714016 690 0.04725488440869566 2.177663 11 16 0.001855601 GO Biological Process response to laminar fluid shear stress 845 0.000009419418 0.0001466865342745562 2.445854 31 0.00487115 697 0.048274593878048784 2.262507 10 14 0.00168691 GO Biological Process bone cell development 903 0.00001747299 0.0002546257756478405 2.150895 38 0.005971087 481 0.012438619983367982 2.159666 15 22 0.002530364 GO Biological Process hematopoietic stem cell differentiation 913 0.0000190185 0.0002741122031763417 3.268316 18 0.00282841 695 0.04769828878848921 2.375633 9 12 0.001518219 GO Biological Process negative regulation of protein autophosphorylation 923 0.00002260988 0.00032234389048754064 2.999315 20 0.003142678 542 0.021282349326752766 2.591599 9 11 0.001518219 GO Molecular Function RNA polymerase II activating transcription factor binding 17 4.123386e-12 1.0240550407058823e-9 2.346181 84 0.01319925 55 0.02852618096727273 1.868019 23 39 0.003879892 GO Molecular Function bHLH transcription factor binding 56 3.829198e-8 0.000002886941777857143 2.169757 62 0.0097423 44 0.008252367258181818 2.149382 19 28 0.003205128 Mouse Phenotype Single KO abnormal T cell activation 28 6.519765e-41 2.13219600375e-38 2.202461 354 0.05562539 160 0.000059004274125 1.424832 130 289 0.02192982 Mouse Phenotype Single KO abnormal T cell proliferation 33 2.222983e-36 6.16844100939394e-34 2.177372 322 0.05059711 232 0.0005373588100862068 1.395646 115 261 0.01939946 Mouse Phenotype Single KO decreased T cell proliferation 35 6.045723e-36 1.5817338717428567e-33 2.553507 232 0.03645506 267 0.0012868589319101125 1.499288 71 150 0.01197706 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 46 3.002195e-31 5.97632600326087e-29 2.182369 274 0.04305468 363 0.007701443136914601 1.32283 109 261 0.01838731 Mouse Phenotype Single KO abnormal erythropoiesis 47 7.674608e-31 1.4952422437446808e-28 2.55254 198 0.03111251 48 3.097958085833333e-9 1.986893 69 110 0.01163968 Mouse Phenotype Single KO decreased erythroid progenitor cell number 59 2.890226e-27 4.485728725762712e-25 3.048367 130 0.0204274 274 0.0017685776328467153 1.863241 30 51 0.005060729 Mouse Phenotype Single KO abnormal platelet activation 60 9.373014e-26 1.4304781533e-23 2.901163 132 0.02074167 175 0.00009167841888000001 1.788712 48 85 0.008097166 Mouse Phenotype Single KO abnormal platelet aggregation 63 2.20641e-24 3.206999423809524e-22 2.87956 126 0.01979887 173 0.00008699155293063584 1.82741 45 78 0.007591093 Mouse Phenotype Single KO decreased erythrocyte cell number 72 2.998533e-22 3.813550927916667e-20 2.008408 233 0.03661219 238 0.0006046917289495798 1.484205 82 175 0.01383266 Mouse Phenotype Single KO decreased susceptibility to autoimmune disorder 74 3.934593e-22 4.868792986621622e-20 2.289809 172 0.02702703 657 0.04537428694672754 1.329572 68 162 0.01147099 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 84 2.578613e-21 2.810995147738095e-19 2.122497 195 0.03064111 176 0.0000970086336590909 1.538505 85 175 0.01433873 Mouse Phenotype Single KO decreased platelet aggregation 87 9.484714e-21 9.982934034252872e-19 3.114575 94 0.01477058 272 0.0016862137450735296 1.794922 34 60 0.005735493 Mouse Phenotype Single KO abnormal platelet physiology 89 1.222981e-20 1.258296294044944e-18 2.360438 150 0.02357008 154 0.000028693358416233763 1.727733 60 110 0.01012146 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 91 1.754431e-20 1.765420293076923e-18 2.277901 160 0.02514142 157 0.00003460529452229299 1.825976 49 85 0.008265857 Mouse Phenotype Single KO enlarged lymph nodes 119 1.656718e-17 1.2748375399999999e-15 2.103152 161 0.02529855 384 0.0089120359421875 1.452768 61 133 0.01029015 Mouse Phenotype Single KO decreased interleukin-2 secretion 130 5.302766e-16 3.735186789384616e-14 2.550012 98 0.01539912 504 0.02355801767857143 1.640318 29 56 0.004892038 Mouse Phenotype Single KO abnormal splenic cell ratio 140 5.871884e-15 3.8406315562857146e-13 2.902414 73 0.01147077 491 0.021297428928716906 1.786801 22 39 0.003711201 Mouse Phenotype Single KO spleen hyperplasia 141 6.059121e-15 3.934990850851064e-13 2.386394 103 0.01618479 492 0.021396893890243903 1.543146 38 78 0.006410256 Mouse Phenotype Single KO extramedullary hematopoiesis 145 7.172079e-15 4.529291545034483e-13 2.194938 122 0.01917033 284 0.002178458683169014 1.55597 56 114 0.009446694 Mouse Phenotype Single KO abnormal cell chemotaxis 148 1.228172e-14 7.598899327027027e-13 2.139222 127 0.019956 412 0.011732083976941745 1.483879 52 111 0.00877193 Mouse Phenotype abnormal erythropoiesis 42 1.30767e-34 2.9768173500000003e-32 2.465036 238 0.03739786 51 6.904641124117647e-10 1.870744 88 149 0.0148448 Mouse Phenotype decreased T cell proliferation 50 3.505103e-31 6.7024579566e-29 2.12866 289 0.04541169 285 0.0002204146644631579 1.457352 98 213 0.01653171 Mouse Phenotype abnormal platelet activation 57 1.671101e-28 2.803052045789474e-26 2.939379 144 0.02262728 323 0.0005009931439318886 1.647105 52 100 0.00877193 Mouse Phenotype abnormal platelet aggregation 62 7.54711e-28 1.163837398548387e-25 2.93276 141 0.02215588 304 0.0003406845340460526 1.684846 50 94 0.008434548 Mouse Phenotype extramedullary hematopoiesis 64 2.265219e-27 3.3840248217187497e-25 2.262001 221 0.03472659 152 0.0000021537536328947365 1.629005 90 175 0.01518219 Mouse Phenotype decreased erythroid progenitor cell number 67 1.243844e-26 1.7749839528358208e-24 2.697919 154 0.02419862 279 0.00019149606959139787 1.792144 43 76 0.007253711 Mouse Phenotype abnormal platelet physiology 74 5.26427e-25 6.801579117567568e-23 2.422664 175 0.02749843 212 0.00002690000879716981 1.655744 69 132 0.01163968 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 88 9.548424e-23 1.0374145666363636e-20 2.080383 219 0.03441232 424 0.002302266250471698 1.42538 81 180 0.01366397 Mouse Phenotype decreased susceptibility to autoimmune disorder 98 8.976446e-22 8.757530633265306e-20 2.148617 194 0.03048397 885 0.03842514043728814 1.288742 83 204 0.01400135 Mouse Phenotype abnormal erythroid progenitor cell morphology 99 9.790973e-22 9.455706348787878e-20 2.182399 187 0.02938404 201 0.000019092142091044774 1.703535 64 119 0.01079622 Mouse Phenotype spleen hyperplasia 108 3.656855e-21 3.237332468055556e-19 2.331374 158 0.02482715 281 0.00019525433370106763 1.639325 59 114 0.009952767 Mouse Phenotype decreased platelet aggregation 110 5.215432e-21 4.533158668363636e-19 2.995185 101 0.01587052 535 0.00648085683364486 1.627748 37 72 0.006241565 Mouse Phenotype abnormal mean corpuscular hemoglobin 113 1.133545e-20 9.59099446460177e-19 2.049322 205 0.03221245 192 0.000014814276510937501 1.56654 91 184 0.01535088 Mouse Phenotype abnormal splenic cell ratio 138 4.140108e-18 2.8683748252173914e-16 2.677811 103 0.01618479 405 0.0018648173365185185 1.765497 34 61 0.005735493 Mouse Phenotype increased spleen white pulp amount 151 6.767854e-17 4.28526172807947e-15 3.627599 61 0.009585167 658 0.013546187540425532 1.863241 20 34 0.003373819 Mouse Phenotype joint inflammation 165 1.472254e-15 8.531042723636364e-14 2.046166 151 0.02372722 758 0.023507005072559366 1.354658 68 159 0.01147099 Mouse Phenotype abnormal megakaryocyte progenitor cell morphology 174 5.747719e-15 3.158272491896551e-13 2.000446 153 0.02404148 724 0.019407416979281767 1.416366 55 123 0.009278003 Mouse Phenotype lymph node hyperplasia 179 3.17608e-14 1.6964525631284918e-12 2.779256 74 0.01162791 706 0.01773963649291785 1.727733 24 44 0.004048583 Mouse Phenotype decreased circulating alanine transaminase level 188 7.776398e-14 3.954794748829788e-12 2.165205 116 0.01822753 253 0.00010412503415810276 1.767913 48 86 0.008097166 Mouse Phenotype arthritis 189 1.037606e-13 5.248968765079365e-12 2.004507 138 0.02168448 751 0.02289320977629827 1.369734 64 148 0.01079622