# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process ribonucleoprotein complex biogenesis 28 3.953829e-19 1.8581584218214286e-16 2.024155 191 0.05734014 191 0.00216760077356021 1.39425 125 454 0.0337109 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 34 3.551558e-17 1.3745574035882354e-14 3.532558 64 0.01921345 295 0.01971617430677966 1.673667 39 118 0.0105178 GO Biological Process cell aging 94 6.464621e-9 9.049781674361703e-7 2.463922 53 0.01591114 211 0.003972634745876777 2.071602 27 66 0.007281553 GO Biological Process regulation of intrinsic apoptotic signaling pathway 104 3.072979e-8 0.000003888204871249999 2.054918 71 0.02131492 349 0.04040310704297995 1.53551 47 155 0.0126753 GO Biological Process pyruvate metabolic process 151 0.000001898572 0.00016545237713907286 2.518536 34 0.01020715 264 0.0120001855625 1.965102 26 67 0.007011866 GO Biological Process heterochromatin assembly 201 0.00001463272 0.0009579699625870647 4.72058 12 0.003602522 323 0.0323575247126935 3.544741 7 10 0.00188781 GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to stress 313 0.000162986 0.00685218138658147 2.95971 16 0.004803362 330 0.0343438615160606 2.531958 12 24 0.003236246 GO Biological Process negative regulation of axon extension 389 0.0003677606 0.012440518599999999 2.173927 25 0.007505254 195 0.002360885207282051 2.953951 14 24 0.00377562 GO Biological Process positive regulation of protein dephosphorylation 394 0.0003765608 0.012576557277157362 2.036729 29 0.008706094 316 0.027366051886392406 2.250629 16 36 0.004314995 GO Biological Process peptidyl-proline hydroxylation to 4-hydroxy-L-proline 412 0.0004616581 0.014745045965776698 4.09712 9 0.002701891 277 0.014235420451624549 5.063916 5 5 0.001348436 GO Biological Process positive regulation of phosphoprotein phosphatase activity 472 0.0008139653 0.022692731743008475 2.216881 21 0.006304413 373 0.04709560237533512 2.848453 9 16 0.002427184 Human Phenotype Vertigo 28 0.000006767324 0.0016127983232857143 3.154257 21 0.006304413 97 0.030264655406185562 2.978774 10 17 0.002696872 Mouse Phenotype Single KO abnormal transitional stage T2 B cell morphology 11 7.076582e-9 0.000005890932852181818 4.852763 21 0.006304413 247 0.04949058209716599 2.848453 9 16 0.002427184 Mouse Phenotype Single KO increased B cell apoptosis 19 4.742029e-7 0.00022854083975263159 2.96341 29 0.008706094 194 0.024754283303608248 2.642043 12 23 0.003236246 Mouse Phenotype Single KO increased pre-B cell number 40 0.000009439107 0.002160847569975 2.756953 25 0.007505254 171 0.01715654984502924 2.633236 13 25 0.003505933 Mouse Phenotype extramedullary hematopoiesis 4 4.039145e-12 9.65456633625e-9 2.092377 107 0.03212249 354 0.02718024847457627 1.504706 52 175 0.01402373 Mouse Phenotype decreased B cell proliferation 12 1.782379e-9 0.00000142011046825 2.086237 81 0.02431702 215 0.006085887788372094 1.746178 40 116 0.01078749 Mouse Phenotype increased transitional stage T2 B cell number 19 2.250177e-8 0.000011323127524736844 10.13861 11 0.003302312 399 0.036393215646616545 5.063916 4 4 0.001078749 Mouse Phenotype abnormal transitional stage T2 B cell morphology 26 9.897151e-8 0.00003639486950423077 3.203915 29 0.008706094 138 0.0017336698026086956 2.793885 16 29 0.004314995 Mouse Phenotype decreased transitional stage T1 B cell number 33 6.410163e-7 0.0001857199043727273 4.427055 17 0.005103573 465 0.04815149886451613 2.680897 9 17 0.002427184 Mouse Phenotype abnormal transitional stage B cell morphology 34 6.459247e-7 0.0001816378251970588 2.103996 54 0.01621135 227 0.006773134544933921 1.86259 32 87 0.008629989 Mouse Phenotype increased B cell apoptosis 54 0.000003672215 0.0006501860669444444 2.155799 44 0.01320925 214 0.0058334073588785056 2.215463 21 48 0.00566343 Mouse Phenotype decreased transitional stage B cell number 59 0.000005044038 0.0008173906325084746 2.220682 40 0.01200841 197 0.004823642920507615 2.057216 26 64 0.007011866 Mouse Phenotype abnormal cortical plate morphology 69 0.000007464361 0.0010343008046521738 2.019767 48 0.01441009 90 0.00027115856489999995 2.531958 24 48 0.006472492 Mouse Phenotype delayed hair appearance 75 0.00001195993 0.0015246518763999998 2.546679 28 0.008405884 337 0.023579542470623147 2.438182 13 27 0.003505933 Mouse Phenotype decreased CD5-positive Ly6C-positive T cell number 99 0.0000313542 0.0030280556181818182 6.820602 8 0.002401681 399 0.036393215646616545 5.063916 4 4 0.001078749 Mouse Phenotype abnormal mesenchymal cell proliferation involved in lung development 129 0.00006125386 0.004539908181860465 2.452382 25 0.007505254 287 0.014655740420905923 2.978774 10 17 0.002696872 Mouse Phenotype abnormal cardiac thrombosis 137 0.00006930279 0.0048365253663503645 3.194 16 0.004803362 455 0.04605657677802198 2.893666 8 14 0.002157497 Mouse Phenotype abnormal transitional stage T1 B cell morphology 172 0.0001313533 0.0073015633796511634 2.555868 21 0.006304413 337 0.023579542470623147 2.438182 13 27 0.003505933 Mouse Phenotype decreased transitional stage T2 B cell number 205 0.0002428825 0.011327802841463413 2.50392 20 0.006004203 304 0.016524210253618422 2.531958 13 26 0.003505933 Mouse Phenotype abnormal stomach glandular epithelium morphology 228 0.0003405383 0.014280204764473683 2.272218 23 0.006904833 339 0.024290910689380527 2.531958 12 24 0.003236246 Mouse Phenotype decreased interscapular fat pad weight 263 0.000537478 0.019539266760456274 2.874394 14 0.004202942 455 0.04605657677802198 2.893666 8 14 0.002157497 Mouse Phenotype increased Purkinje cell number 264 0.0005390801 0.01952327589431818 4.008029 9 0.002701891 399 0.036393215646616545 5.063916 4 4 0.001078749 Mouse Phenotype abnormal vascular endothelial cell apoptosis 304 0.0009245152 0.02907661127368421 3.410711 10 0.003002101 393 0.03655068121374046 4.21993 5 6 0.001348436 Mouse Phenotype increased circulating erythropoietin level 326 0.00110304 0.032350200736196315 2.559719 15 0.004503152 465 0.04815149886451613 2.680897 9 17 0.002427184