# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process	16	4.32172e-33	3.5543445925e-30	2.346176	252	0.02560455	130	7.005993312307692e-10	1.625488	123	198	0.01714047	
GO Biological Process	mRNA catabolic process	19	2.065225e-31	1.4303313565789475e-28	2.231024	265	0.02692542	131	1.0710371270992367e-9	1.59701	130	213	0.01811594	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	20	8.19466e-30	5.3916765470000006e-27	2.64857	180	0.01828897	333	0.0009338788185585586	1.505146	65	113	0.009057971	
GO Biological Process	RNA catabolic process	31	2.904822e-26	1.2330500870322581e-23	2.012028	279	0.0283479	164	4.7656690566463416e-8	1.509182	139	241	0.01937012	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	34	7.160372e-26	2.771274563176471e-23	2.194196	224	0.0227596	515	0.011609983843495144	1.350523	80	155	0.01114827	
GO Biological Process	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	36	1.263814e-25	4.619591229444444e-23	3.754949	92	0.009347694	366	0.001827244358579235	1.941377	23	31	0.003205128	
GO Biological Process	regulation of DNA-templated transcription in response to stress	39	4.098188e-25	1.3827706638974361e-22	2.380469	183	0.01859378	328	0.0008379755509146341	1.495222	68	119	0.009476031	
GO Biological Process	endoplasmic reticulum unfolded protein response	42	1.247996e-24	3.9100903247619043e-22	2.509127	162	0.01646007	300	0.00028997470670666663	1.537849	67	114	0.009336678	
GO Biological Process	rRNA processing	44	1.893099e-24	5.661656759318182e-22	2.017131	257	0.02611258	196	9.963793386734692e-7	1.453688	140	252	0.01950948	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	45	2.395659e-24	7.005439284666666e-22	2.671386	143	0.01452957	199	0.0000013514808779899495	1.663118	75	118	0.01045151	
GO Biological Process	cellular response to topologically incorrect protein	51	1.652402e-23	4.263521160392157e-21	2.293117	184	0.01869539	245	0.000027888276897551022	1.543629	82	139	0.01142698	
GO Biological Process	response to topologically incorrect protein	53	4.796301e-23	1.1908400916792452e-20	2.083458	223	0.022658	202	0.0000020882740193564356	1.526373	105	180	0.01463211	
GO Biological Process	multi-organism metabolic process	54	7.954435e-23	1.9383779660185186e-20	2.294838	178	0.01808575	158	1.7736049996202533e-8	1.673225	94	147	0.01309922	
GO Biological Process	cellular response to unfolded protein	55	2.043393e-22	4.888910634e-20	2.331204	169	0.01717131	249	0.00003426134315180723	1.578633	73	121	0.0101728	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	56	3.046367e-22	7.158418455892857e-20	2.569566	139	0.01412315	333	0.0009338788185585586	1.505146	65	113	0.009057971	
GO Biological Process	response to unfolded protein	59	9.48046e-22	2.1144639515254236e-19	2.094354	207	0.02103231	208	0.000002745743654471154	1.553629	95	160	0.01323857	
GO Biological Process	liver regeneration	61	1.475937e-21	3.1839106529508196e-19	3.259915	92	0.009347694	735	0.048350444912925165	1.644744	22	35	0.003065775	
GO Biological Process	protein targeting to ER	63	5.514479e-21	1.1518258596984128e-18	2.644648	124	0.01259907	274	0.00009303461025547445	1.606254	62	101	0.008639911	
GO Biological Process	viral gene expression	64	5.853554e-21	1.20354557946875e-18	2.436303	144	0.01463117	195	8.556123512307692e-7	1.648276	80	127	0.01114827	
GO Biological Process	cotranslational protein targeting to membrane	75	1.055368e-19	1.8516783349333334e-17	2.629049	117	0.01188783	284	0.0001478679146725352	1.602024	60	98	0.008361204	
GO Cellular Component	ribosomal subunit	34	2.043692e-20	1.0386764047058823e-18	2.139321	184	0.01869539	70	0.00020127055268571428	1.414399	100	185	0.01393534	
GO Cellular Component	methyltransferase complex	37	1.439886e-19	6.724656778378378e-18	2.405534	137	0.01391993	69	0.0001346068424347826	1.610239	56	91	0.00780379	
GO Cellular Component	large ribosomal subunit	43	1.090606e-14	4.382714344186047e-13	2.236064	116	0.01178622	114	0.006635926231578947	1.41071	62	115	0.008639911	
GO Cellular Component	endopeptidase complex	44	1.388725e-14	5.453901818181818e-13	2.528462	90	0.009144483	99	0.004933977599999999	1.554814	41	69	0.005713489	
GO Cellular Component	proteasome complex	48	8.73465e-14	3.1444739999999997e-12	2.473671	88	0.008941272	115	0.006718080834782608	1.539199	40	68	0.005574136	
GO Cellular Component	histone methyltransferase complex	49	1.157673e-13	4.0825692734693875e-12	2.225622	108	0.01097338	86	0.002251577972093023	1.592737	42	69	0.005852843	
GO Cellular Component	catalytic step 2 spliceosome	50	1.542062e-12	5.3293662719999995e-11	2.082552	114	0.01158301	135	0.0135744256	1.417346	52	96	0.007246377	
GO Cellular Component	spliceosomal snRNP complex	53	3.550177e-12	1.1574916709433962e-10	2.57307	71	0.007213981	157	0.029414654369426755	1.477135	35	62	0.004877369	
GO Cellular Component	peptidase complex	54	6.208135e-12	1.9866032000000002e-10	2.122247	103	0.01046535	103	0.005012743456310679	1.486727	50	88	0.00696767	
GO Cellular Component	small nuclear ribonucleoprotein complex	57	2.109655e-11	6.395585684210526e-10	2.354356	78	0.007925218	140	0.018756353828571427	1.47897	39	69	0.005434783	
GO Cellular Component	U5 snRNP	66	1.947676e-10	5.099369890909091e-9	3.654255	35	0.003556188	176	0.041619802909090904	1.784072	15	22	0.002090301	
GO Cellular Component	proton-transporting ATP synthase complex	67	2.140069e-10	5.519461540298507e-9	3.72631	34	0.003454582	137	0.015279959824817517	1.853452	17	24	0.002369008	
GO Cellular Component	mitochondrial proton-transporting ATP synthase complex	71	3.648823e-10	8.880515695774647e-9	3.736428	33	0.003352977	151	0.026141470092715228	1.82027	16	23	0.002229654	
GO Cellular Component	DNA-directed RNA polymerase III complex	87	1.310703e-8	2.6033273379310343e-7	4.299198	23	0.002336923	145	0.02185626835862069	1.92805	14	19	0.001950948	
GO Cellular Component	Bcl-2 family protein complex	93	2.564822e-8	4.765604748387097e-7	4.309834	22	0.002235318	136	0.015101246117647057	2.616639	7	7	0.0009754738	
GO Cellular Component	proton-transporting two-sector ATPase complex	96	3.195702e-8	5.7522636e-7	2.232854	59	0.005994717	128	0.01180519245	1.579857	32	53	0.004459309	
GO Cellular Component	cytosolic small ribosomal subunit	101	6.601176e-8	0.0000011293893196039604	2.275318	54	0.00548669	142	0.018838132732394368	1.605665	27	44	0.003762542	
GO Cellular Component	proteasome accessory complex	113	5.146034e-7	0.000007869333408849557	2.834144	31	0.003149766	177	0.043250727050847454	1.744426	16	24	0.002229654	
GO Cellular Component	endoplasmic reticulum chaperone complex	145	0.00001194062	0.00014229925075862068	3.920394	15	0.00152408	174	0.04090068744827586	2.140886	9	11	0.001254181	
GO Cellular Component	exon-exon junction complex	168	0.00006555966	0.0006743279314285715	2.395908	26	0.002641739	148	0.02432199697297297	1.869028	15	21	0.002090301	
GO Molecular Function	structural constituent of ribosome	10	6.508669e-18	2.7479600518e-15	2.103262	166	0.01686649	58	0.00038228222748275866	1.453688	90	162	0.01254181	
GO Molecular Function	unfolded protein binding	14	3.418455e-15	1.0309083578571428e-12	2.324543	111	0.0112782	105	0.03194169781714285	1.40706	57	106	0.007943144	
GO Molecular Function	thyroid hormone receptor binding	24	1.011816e-9	1.7799529800000002e-7	2.770498	48	0.004877058	96	0.016388018445833333	1.869028	20	28	0.002787068	
Human Phenotype	Increased serum lactate	4	1.070677e-18	1.7861569052500003e-15	2.428081	128	0.01300549	51	0.00041224079954901957	1.59615	61	100	0.008500557	
Human Phenotype	Abnormal CSF metabolite level	14	1.688108e-12	8.046246202857143e-10	2.557071	74	0.007518797	101	0.007687474387128713	1.619824	39	63	0.005434783	
Human Phenotype	Increased CSF lactate	16	2.617893e-12	1.0918249993125e-9	2.632803	69	0.00701077	107	0.012189244804672896	1.624121	36	58	0.005016722	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	73	0.000001784676	0.0001631389444931507	2.969653	26	0.002641739	68	0.0013328905344117646	2.442196	14	15	0.001950948	
Human Phenotype	Basal cell carcinoma	90	0.000006721129	0.0004983343757444445	2.374361	34	0.003454582	158	0.04548781375949367	1.90301	16	22	0.002229654	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	99	0.00001168036	0.0007873034573737373	2.663409	26	0.002641739	92	0.005080389905652174	2.289559	14	16	0.001950948	
Mouse Phenotype Single KO	extramedullary hematopoiesis	5	4.638294e-34	8.4945716316e-31	2.559364	220	0.02235318	116	0.01244922568275862	1.446037	63	114	0.008779264	
Mouse Phenotype Single KO	spleen atrophy	62	1.041977e-10	1.5389328046774193e-8	2.60073	60	0.006096322	146	0.028579868796575345	1.99363	16	21	0.002229654	
Mouse Phenotype Single KO	abnormal stapedial artery morphology	247	0.00001815272	0.0006729735102834009	2.362965	31	0.003149766	130	0.01804712980076923	2.154879	14	17	0.001950948	
Mouse Phenotype Single KO	absent stapedial artery	255	0.00002707661	0.0009723157559607844	2.349772	30	0.003048161	161	0.03171659470559006	2.126019	13	16	0.001811594	
Mouse Phenotype	spleen atrophy	75	1.800477e-10	2.2952480796e-8	2.517701	62	0.006299533	271	0.046678566022140225	1.811519	18	26	0.002508361	
Mouse Phenotype	abnormal stapedial artery morphology	178	9.66432e-7	0.000051910428943820224	2.35894	41	0.00416582	112	0.0019972280217857145	2.224143	17	20	0.002369008	
Mouse Phenotype	absent stapedial artery	186	0.000001435492	0.00007378891941935485	2.348966	40	0.004064215	130	0.0038555217904615384	2.203485	16	19	0.002229654	
Mouse Phenotype	absent Langerhans cell	330	0.0001038832	0.0030097796218181818	3.084809	16	0.001625686	262	0.04337205329770993	2.616639	7	7	0.0009754738