# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	17	2.006744e-48	1.553337899764706e-45	2.648301	300	0.01828711	466	0.0013440721200429183	1.337304	82	113	0.008047895	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	18	6.367905e-45	4.6552923275e-42	2.244904	382	0.02328558	187	3.8049487754545455e-9	1.462406	123	155	0.01207184	
GO Biological Process	regulation of DNA-templated transcription in response to stress	19	6.556007e-45	4.540552427e-42	2.466072	316	0.01926242	428	0.0005401852512383177	1.347308	87	119	0.00853862	
GO Biological Process	mRNA catabolic process	28	6.036098e-41	2.8367504850714284e-38	2.080955	412	0.02511429	175	8.275770294285714e-10	1.410271	163	213	0.01599764	
GO Biological Process	nuclear-transcribed mRNA catabolic process	36	2.785409e-38	1.0181443619722222e-35	2.100173	376	0.02291984	182	2.566533529065934e-9	1.414728	152	198	0.01491805	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	50	3.746592e-34	9.860280825600001e-32	2.532889	226	0.01377629	201	9.588138407462685e-9	1.514901	97	118	0.009520071	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	51	6.238473e-34	1.6096483570000001e-31	2.517549	227	0.01383724	641	0.009730887528705148	1.288378	79	113	0.00775346	
GO Biological Process	endoplasmic reticulum unfolded protein response	55	3.730589e-33	8.925603754727273e-31	2.350906	253	0.01542213	764	0.024190444612565445	1.260911	78	114	0.007655315	
GO Biological Process	multi-organism metabolic process	63	1.468598e-30	3.0675049336507935e-28	2.15796	279	0.01700701	148	5.746591314662162e-11	1.51692	121	147	0.01187555	
GO Biological Process	viral gene expression	66	2.945926e-30	5.8735515506060605e-28	2.344703	231	0.01408107	149	6.105202832818792e-11	1.552654	107	127	0.01050152	
GO Biological Process	cellular response to topologically incorrect protein	70	1.134759e-29	2.1331848115714288e-27	2.115933	283	0.01725084	698	0.0166826352004298	1.246257	94	139	0.009225635	
GO Biological Process	regulation of hematopoietic stem cell differentiation	72	1.657906e-29	3.0300534797222225e-27	2.496488	199	0.01213045	690	0.01591500188898551	1.28822	72	103	0.007066444	
GO Biological Process	cotranslational protein targeting to membrane	75	3.974105e-29	6.972699692666666e-27	2.547896	189	0.01152088	166	4.818093335180723e-10	1.598407	85	98	0.00834233	
GO Biological Process	cellular response to unfolded protein	79	9.557833e-29	1.5920446132531645e-26	2.159938	261	0.01590978	700	0.016716499932714287	1.264117	83	121	0.00814604	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	80	1.360086e-28	2.23717145925e-26	2.237527	240	0.01462969	294	0.000009158395448979592	1.470375	75	94	0.007360879	
GO Biological Process	mitochondrial membrane organization	84	3.073881e-28	4.8153809617857137e-26	2.013367	303	0.01846998	292	0.000008869607637671232	1.411876	95	124	0.009323781	
GO Biological Process	protein targeting to ER	88	1.014366e-27	1.5168229765909092e-25	2.456713	192	0.01170375	172	6.029862341046512e-10	1.587422	87	101	0.00853862	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	89	1.144759e-27	1.6925712001123596e-25	2.454132	192	0.01170375	559	0.0047411947620751346	1.370339	58	78	0.005692413	
GO Biological Process	viral transcription	93	1.191041e-26	1.6852589805376344e-24	2.300317	210	0.01280098	140	1.3746229774285717e-11	1.598241	98	113	0.009618216	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	95	3.712263e-26	5.142070401789474e-24	2.504586	174	0.01060652	159	2.7229811110691825e-10	1.622527	81	92	0.00794975	
GO Cellular Component	ribosomal subunit	39	1.362935e-30	6.038850461538462e-29	2.092602	300	0.01828711	38	1.729749827368421e-13	1.50418	151	185	0.0148199	
GO Cellular Component	large ribosomal subunit	48	3.827018e-22	1.37772648e-20	2.197288	190	0.01158183	43	1.2769964204651162e-9	1.538396	96	115	0.009421926	
GO Cellular Component	mitochondrial ribosome	49	5.279617e-22	1.8618730971428572e-20	2.599119	135	0.008229198	74	0.000048318966486486485	1.452615	67	85	0.006575719	
GO Cellular Component	endopeptidase complex	50	9.397411e-21	3.2477452415999996e-19	2.427077	144	0.008777812	80	0.0001984156344	1.468954	55	69	0.005397978	
GO Cellular Component	proteasome complex	53	2.195832e-20	7.159240935849055e-19	2.411584	143	0.008716855	83	0.0002833707643373494	1.463455	54	68	0.005299833	
GO Cellular Component	peptidase complex	56	7.113171e-20	2.194921337142857e-18	2.163236	175	0.01066748	66	0.0000049339008	1.486861	71	88	0.006968299	
GO Cellular Component	PcG protein complex	58	1.675282e-19	4.991184993103448e-18	2.27137	154	0.009387382	134	0.008273871617910449	1.442246	36	46	0.003533222	
GO Cellular Component	catalytic step 2 spliceosome	60	8.68972e-19	2.50263936e-17	2.049462	187	0.01139896	106	0.00212692999245283	1.343759	70	96	0.006870154	
GO Cellular Component	mitochondrial large ribosomal subunit	69	2.253482e-15	5.6435027478260874e-14	2.720903	84	0.00512039	100	0.0015495440831999998	1.481523	41	51	0.004023947	
GO Cellular Component	mitochondrial nucleoid	103	9.870197e-11	1.655893244271845e-9	2.250437	80	0.004876562	69	0.000011056878469565217	1.667358	38	42	0.003729512	
GO Cellular Component	sex chromosome	151	3.066747e-8	3.5094959046357615e-7	2.219865	60	0.003657422	187	0.042938397433155084	1.488472	21	26	0.002061046	
GO Cellular Component	nuclear origin of replication recognition complex	198	0.00000364941	0.00003184939636363636	3.550361	19	0.001158183	179	0.03931305224581006	1.84287	9	9	0.0008833055	
GO Cellular Component	proteasome accessory complex	241	0.00003437054	0.00024644105029045644	2.084255	38	0.002316367	173	0.028671335583815027	1.535725	20	24	0.001962901	
GO Cellular Component	mitochondrial inner membrane presequence translocase complex	248	0.00005347523	0.0003726016025806452	3.014057	18	0.001097226	144	0.014376972	1.84287	11	11	0.001079596	
GO Molecular Function	unfolded protein binding	10	1.587264e-24	6.701428608e-22	2.336871	186	0.01133801	61	0.00034952726770491805	1.390845	80	106	0.007851605	
GO Molecular Function	protein channel activity	20	2.506256e-17	5.290706416e-15	4.679262	47	0.00286498	115	0.023855981457391307	1.84287	12	12	0.001177741	
GO Molecular Function	protein phosphatase 2A binding	23	3.462979e-16	6.356824929565217e-14	2.422077	110	0.006705273	117	0.02645718104273504	1.569852	23	27	0.002257336	
GO Molecular Function	mRNA 5'-UTR binding	67	4.447082e-10	2.8023254035820898e-8	2.573567	57	0.00347455	140	0.04785787785714286	1.591569	19	22	0.001864756	
Human Phenotype	Increased serum lactate	6	3.783253e-23	4.2076078781666667e-20	2.219192	195	0.01188662	48	0.00027422832520833336	1.41901	77	100	0.007557169	
Human Phenotype	Abnormal CSF metabolite level	19	3.730484e-17	1.3101852490526315e-14	2.425515	117	0.007131972	154	0.030541471709090908	1.374839	47	63	0.004612818	
Human Phenotype	Increased CSF lactate	26	6.20312e-15	1.592054606153846e-12	2.380728	104	0.006339531	145	0.02583884084275862	1.398039	44	58	0.004318383	
Human Phenotype	Abnormality of mitochondrial metabolism	32	6.279631e-14	1.30949930196875e-11	2.019683	139	0.008473027	124	0.012960284455645161	1.388829	52	69	0.005103543	
Human Phenotype	Exercise intolerance	33	7.759176e-14	1.568999437818182e-11	2.171761	116	0.007071015	141	0.020992917251063826	1.368989	52	70	0.005103543	
Human Phenotype	Abnormality of the mitochondrion	34	7.928197e-14	1.556025252382353e-11	2.001825	141	0.008594941	133	0.015982381884962406	1.375663	53	71	0.005201688	
Human Phenotype	Leukodystrophy	64	7.294726e-11	7.6058916559375e-9	2.046655	101	0.00615666	107	0.008366900513084113	1.474296	40	50	0.003925802	
Human Phenotype	External ophthalmoplegia	103	9.392385e-9	6.08498884514563e-7	2.047148	78	0.004754648	136	0.016625789313235294	1.554921	27	32	0.002649917	
Human Phenotype	Hand muscle atrophy	157	1.15414e-7	0.000004905462560509554	3.555561	25	0.001523926	174	0.04594709490229885	1.84287	11	11	0.001079596	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	208	0.000001265429	0.000040597152485576924	2.712598	31	0.001889668	129	0.013844504137209303	1.740488	17	18	0.001668466	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	155	1.621935e-12	9.581973416129032e-11	2.013537	124	0.007558671	144	0.01755453495347222	1.412867	46	60	0.004514673	
Mouse Phenotype	abnormal cellular replicative senescence	65	5.133051e-20	7.550323170923076e-18	2.076933	194	0.01182566	126	0.0006979734878571428	1.42603	65	84	0.006379429	
Mouse Phenotype	early cellular replicative senescence	66	5.292234e-20	7.666522617272728e-18	2.153794	178	0.01085035	120	0.000505184516375	1.464198	58	73	0.005692413	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	175	8.330204e-13	4.551147453942857e-11	2.598984	74	0.00451082	215	0.007924979490697674	1.597154	26	30	0.002551772	
Mouse Phenotype	increased sensitivity to skin irradiation	523	0.000001499328	0.000027409321239005734	3.491693	21	0.001280098	326	0.03513758417484662	1.84287	11	11	0.001079596