# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	11	5.359487e-60	6.411408130272728e-57	2.943797	314	0.02032757	226	2.0300476638495576e-7	1.525433	88	113	0.009180054	
GO Biological Process	regulation of DNA-templated transcription in response to stress	16	1.398389e-52	1.1500875531875e-49	2.668742	322	0.02084547	222	1.7985549303153155e-7	1.514362	92	119	0.009597329	
GO Biological Process	endoplasmic reticulum unfolded protein response	17	8.79364e-52	6.806794632941177e-49	2.832232	287	0.01857966	201	4.180929199452736e-8	1.546416	90	114	0.009388692	
GO Biological Process	IRE1-mediated unfolded protein response	20	1.983381e-47	1.30496552895e-44	3.846659	171	0.01107011	344	0.00008019259087499999	1.587299	47	58	0.004902984	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	21	9.588369e-47	6.008254651000001e-44	5.02609	126	0.008156924	447	0.000795414742818792	1.795561	22	24	0.002295014	
GO Biological Process	cellular response to unfolded protein	22	5.689943e-46	3.4033618153181817e-43	2.592716	295	0.01909756	196	2.509031901020408e-8	1.537896	95	121	0.009910286	
GO Biological Process	cellular response to topologically incorrect protein	23	1.438167e-45	8.22819111e-43	2.493316	314	0.02032757	219	1.4749556570776257e-7	1.479665	105	139	0.01095347	
GO Biological Process	liver regeneration	25	2.107243e-42	1.10916842548e-39	3.657402	162	0.01048747	428	0.0005727319470560748	1.678966	30	35	0.003129564	
GO Biological Process	response to topologically incorrect protein	27	1.573877e-41	7.670610164074074e-39	2.196572	369	0.02388813	215	1.1501755540000001e-7	1.425567	131	180	0.01366576	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	29	1.195604e-39	5.425156219310344e-37	9.040286	66	0.004272674	674	0.011952700412908013	1.958794	11	11	0.001147507	
GO Biological Process	response to unfolded protein	30	1.344577e-39	5.897762914333333e-37	2.21757	344	0.0222697	198	2.6371759167171715e-8	1.469096	120	160	0.01251826	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	38	2.047961e-36	7.091873368157896e-34	2.782804	205	0.01327119	489	0.0015567309589161556	1.431426	57	78	0.005946172	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	52	1.095607e-31	2.772517790961538e-29	2.047106	328	0.0212339	392	0.00028018804106887753	1.339562	106	155	0.01105779	
GO Biological Process	regulation of cellular amino acid metabolic process	68	1.021318e-27	1.9764005238235294e-25	3.16368	126	0.008156924	715	0.01684904493958042	1.403802	43	60	0.004485708	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	71	3.39996e-27	6.301418822535211e-25	2.380509	200	0.0129475	348	0.00009731318723275863	1.410996	85	118	0.008867098	
GO Biological Process	cellular response to epidermal growth factor stimulus	77	2.173046e-26	3.71365094987013e-24	2.540563	171	0.01107011	522	0.002398023810708812	1.597964	31	38	0.003233883	
GO Biological Process	protein targeting to ER	79	2.719435e-26	4.529752552531646e-24	2.459597	181	0.01171749	207	7.18398123236715e-8	1.570914	81	101	0.008449823	
GO Biological Process	response to epidermal growth factor	83	1.030581e-25	1.6339054673493974e-23	2.450575	178	0.01152327	411	0.0004273969560827251	1.632328	35	42	0.003651158	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	87	3.618242e-25	5.472694997471263e-23	2.308555	196	0.01268855	619	0.0072855366849757675	1.317419	76	113	0.007928229	
GO Biological Process	antigen processing and presentation of peptide antigen via MHC class I	93	4.200791e-24	5.943893416021505e-22	2.466791	164	0.01061695	762	0.02194527466141732	1.320535	60	89	0.006259128	
GO Cellular Component	ribosomal subunit	41	1.639889e-26	6.9115321756097565e-25	2.037183	275	0.01780281	44	3.1146351709090914e-8	1.42939	135	185	0.01408304	
GO Cellular Component	catalytic step 2 spliceosome	43	1.079829e-25	4.3394058418604654e-24	2.316239	199	0.01288276	103	0.0010276432776699029	1.387479	68	96	0.007093678	
GO Cellular Component	mitochondrial ribosome	47	2.350117e-23	8.640430161702127e-22	2.719419	133	0.008610086	60	0.0000031874169600000003	1.543991	67	85	0.006989359	
GO Cellular Component	large ribosomal subunit	48	4.826648e-22	1.73759328e-20	2.235305	182	0.01178222	72	0.000027369456	1.430771	84	115	0.008762779	
GO Cellular Component	mitochondrial large ribosomal subunit	50	1.0015e-21	3.461184e-20	3.233655	94	0.006085324	62	0.000003541207122580645	1.68994	44	51	0.004590027	
GO Cellular Component	peptidase complex	51	5.473797e-21	1.8546512188235292e-19	2.244885	171	0.01107011	73	0.00002717743956164384	1.491355	67	88	0.006989359	
GO Cellular Component	endopeptidase complex	55	8.356733e-20	2.625533568e-18	2.434401	136	0.008804299	91	0.0005657663789010989	1.476193	52	69	0.005424578	
GO Cellular Component	proteasome complex	56	1.163163e-18	3.5891886857142853e-17	2.382046	133	0.008610086	97	0.0007917302301030928	1.469096	51	68	0.005320259	
GO Cellular Component	PcG protein complex	59	2.414448e-16	7.071468040677966e-15	2.177279	139	0.008998511	132	0.005765592436363636	1.490387	35	46	0.003651158	
GO Cellular Component	spliceosomal snRNP complex	62	1.479119e-15	4.122447793548387e-14	2.424497	105	0.006797436	148	0.013040048432432432	1.390112	44	62	0.004590027	
GO Cellular Component	high-density lipoprotein particle	63	1.845711e-15	5.0625216000000004e-14	3.501343	58	0.003754774	173	0.040661068578034684	1.523507	21	27	0.002190695	
GO Cellular Component	small nuclear ribonucleoprotein complex	75	1.58186e-12	3.6446054400000004e-11	2.115482	110	0.007121124	152	0.015479844631578947	1.362639	48	69	0.005007302	
GO Cellular Component	very-low-density lipoprotein particle	84	3.086374e-11	6.349112228571428e-10	2.968831	51	0.003301612	89	0.0005620978193258426	1.860854	19	20	0.001982057	
GO Cellular Component	proteasome accessory complex	134	1.648689e-8	2.126070591044776e-7	2.621271	45	0.002913187	174	0.04416236689655172	1.550712	19	24	0.001982057	
GO Cellular Component	mitochondrial nucleoid	140	2.326289e-8	2.87130528e-7	2.091255	70	0.004531624	86	0.0002682227720930233	1.632328	35	42	0.003651158	
GO Cellular Component	pronucleus	168	2.583528e-7	0.0000026573430857142862	2.633681	37	0.002395287	178	0.0451768028764045	1.697622	13	15	0.001356144	
GO Cellular Component	zonula adherens	265	0.00002622214	0.00017098814309433964	2.653947	24	0.0015537	177	0.044982026847457626	1.958794	8	8	0.0008345504	
GO Cellular Component	DNA-directed RNA polymerase I complex	274	0.00003150795	0.0001987070715328467	2.563136	25	0.001618437	150	0.013526887680000002	1.81888	13	14	0.001356144	
GO Molecular Function	unfolded protein binding	9	1.570893e-31	7.369233606666667e-29	2.61523	196	0.01268855	75	0.0015615821330666668	1.385939	75	106	0.00782391	
GO Molecular Function	structural constituent of ribosome	12	2.065986e-23	7.268827410000001e-21	2.010129	249	0.01611963	27	6.393127534814814e-7	1.438867	119	162	0.01241394	
GO Molecular Function	NF-kappaB binding	14	2.402239e-22	7.24446647e-20	3.356535	92	0.005955849	120	0.023340306683333333	1.609009	23	28	0.002399332	
GO Molecular Function	rRNA binding	16	9.141332e-21	2.4121689815e-18	3.103118	95	0.006150062	65	0.0007852289947692308	1.534389	47	60	0.004902984	
GO Molecular Function	ribonuclease activity	18	4.205206e-19	9.863544295555556e-17	2.087708	182	0.01178222	115	0.02118213011652174	1.325649	67	99	0.006989359	
GO Molecular Function	peroxisome proliferator activated receptor binding	22	5.607081e-17	1.0760498173636363e-14	3.856206	57	0.003690037	133	0.038087328631578946	1.958794	10	10	0.001043188	
GO Molecular Function	endoribonuclease activity	43	4.312032e-12	4.2338137451162793e-10	2.138305	103	0.006667961	117	0.02121227343931624	1.434117	41	56	0.004277071	
GO Molecular Function	sequence-specific single stranded DNA binding	127	7.298492e-8	0.0000024263175766929134	2.732889	38	0.002460025	132	0.037556896954545456	1.81888	13	14	0.001356144	
GO Molecular Function	fatty-acyl-CoA binding	304	0.00007420604	0.001030585200263158	2.127053	33	0.002136337	139	0.04679777184172662	1.728348	15	17	0.001564782	
Human Phenotype	Abnormal CSF metabolite level	15	5.624388e-17	2.5021027415999997e-14	2.465859	112	0.007250599	71	0.0034571459602816905	1.492415	48	63	0.005007302	
Human Phenotype	Increased serum lactate	16	1.062959e-16	4.433203379375e-14	2.030494	168	0.0108759	17	0.000009325466471176472	1.527859	78	100	0.008136866	
Human Phenotype	Increased CSF lactate	19	9.297087e-16	3.265234818473684e-13	2.479754	102	0.006603224	69	0.0027918236282608692	1.519754	45	58	0.004694346	
Human Phenotype	Progressive external ophthalmoplegia	22	1.000509e-14	3.034725707727273e-12	3.832787	49	0.003172137	135	0.03158123789851852	1.828208	14	15	0.001460463	
Human Phenotype	Abnormality of reticulocytes	35	4.170669e-11	7.951678353428571e-9	2.4507	70	0.004531624	104	0.016050169086538463	1.60265	27	33	0.002816608	
Human Phenotype	Abnormality of glycolysis	78	1.209681e-8	0.000001034897604230769	3.161589	34	0.002201075	133	0.030716556542105266	1.958794	11	11	0.001147507	
Mouse Phenotype Single KO	pale liver	54	4.903336e-20	8.31478662074074e-18	2.095626	190	0.01230012	198	0.02017385607121212	1.371156	56	80	0.005841853	
Mouse Phenotype Single KO	ruffled hair	388	5.785237e-7	0.000013653457528092784	2.071195	57	0.003690037	217	0.027358934355299538	1.645387	21	25	0.002190695	
Mouse Phenotype Single KO	abnormal inferior vena cava valve morphology	598	0.00005933831	0.000908630275367893	2.125287	34	0.002201075	215	0.026074608608837212	1.958794	11	11	0.001147507	
Mouse Phenotype	ruffled hair	306	1.004997e-8	3.1401229794117644e-7	2.022971	80	0.005178999	206	0.004351099709708738	1.623001	29	35	0.003025245	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	308	1.007001e-8	3.125953428896104e-7	2.275274	61	0.003948987	254	0.009247222283858268	1.632328	25	30	0.00260797	
Mouse Phenotype	abnormal lipoprotein lipase activity	491	0.000001619204	0.00003152995813441955	2.543391	34	0.002201075	361	0.03177679128531856	1.958794	10	10	0.001043188	
Mouse Phenotype	abnormal inferior vena cava valve morphology	712	0.00005933831	0.0007968168285252809	2.125287	34	0.002201075	308	0.019004464888636365	1.958794	11	11	0.001147507	
Mouse Phenotype	decreased macrophage nitric oxide production	856	0.0002744711	0.0030656754522196267	2.112648	28	0.00181265	361	0.03177679128531856	1.958794	10	10	0.001043188