# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 17 2.166322e-16 1.6768606587058824e-13 2.747991 87 0.04208999 124 0.0009648814464596775 1.786754 56 248 0.02359882 GO Biological Process nucleosome assembly 22 1.817181e-15 1.086922035409091e-12 3.343211 61 0.02951137 95 0.00021866324151578945 2.173225 39 142 0.01643489 GO Biological Process nucleosome organization 26 1.072952e-14 5.430375141538461e-12 3.037913 66 0.03193033 132 0.001398092908409091 1.943487 42 171 0.01769912 GO Biological Process DNA replication-dependent nucleosome assembly 29 1.909714e-14 8.665491905517243e-12 18.16482 15 0.007256894 355 0.04816245894647888 2.720014 11 32 0.004635483 GO Biological Process blood coagulation 30 2.648642e-14 1.1617826692666668e-11 2.178938 116 0.05611998 248 0.017270057311693548 1.551523 60 306 0.02528445 GO Biological Process coagulation 32 2.831892e-14 1.164527088375e-11 2.176703 116 0.05611998 261 0.01958260366321839 1.541448 60 308 0.02528445 GO Biological Process hemostasis 33 4.496325e-14 1.7929436568181817e-11 2.161271 116 0.05611998 274 0.024177727070437954 1.526579 60 311 0.02528445 GO Biological Process chromatin assembly 36 7.1328e-14 2.6072365333333335e-11 3.034656 62 0.02999516 126 0.0010789252085714285 2.003233 40 158 0.0168563 GO Biological Process negative regulation of gene expression, epigenetic 37 7.574424e-14 2.6938336598918916e-11 3.931015 44 0.02128689 206 0.009427867755825242 2.012897 29 114 0.01222082 GO Biological Process chromatin assembly or disassembly 39 1.710646e-13 5.771895054871795e-11 2.854817 66 0.03193033 157 0.0032712670529936308 1.867058 42 178 0.01769912 GO Biological Process gene silencing 47 1.025413e-12 2.870938227021277e-10 2.907314 60 0.02902758 97 0.00023895183912371132 2.022152 46 180 0.01938475 GO Biological Process chromatin silencing 68 1.576919e-11 3.0515701648529408e-9 4.336599 32 0.01548137 250 0.017416383906 2.039373 25 97 0.01053519 GO Biological Process protein-DNA complex subunit organization 73 2.192109e-11 3.9515016891780825e-9 2.262511 83 0.04015481 145 0.0021732333529655176 1.740809 55 250 0.02317741 GO Biological Process regulation of megakaryocyte differentiation 89 9.108657e-11 1.346750758011236e-8 3.508126 38 0.01838413 199 0.008100316709045227 2.290538 22 76 0.009270965 GO Biological Process innate immune response in mucosa 92 1.062626e-10 1.519901688478261e-8 9.784927 15 0.007256894 315 0.03576037204 3.237042 9 22 0.003792668 GO Biological Process negative regulation of catabolic process 93 1.123821e-10 1.590146294516129e-8 2.323641 73 0.03531688 285 0.027219516164210526 1.752828 35 158 0.01474926 GO Biological Process protein-DNA complex assembly 97 1.451543e-10 1.969160240927835e-8 2.29444 74 0.03580068 142 0.0018174830857042253 1.806568 50 219 0.02107038 GO Biological Process DNA packaging 101 2.045008e-10 2.6643822051485147e-8 2.449749 64 0.03096275 277 0.0249037590400722 1.670032 42 199 0.01769912 GO Biological Process platelet activation 123 2.18042e-9 2.3326948601626016e-7 2.302621 64 0.03096275 292 0.028805546715753427 1.795806 32 141 0.01348504 GO Biological Process phagocytosis 138 6.602461e-9 6.295781470942029e-7 2.131606 71 0.0343493 114 0.0006748266483596491 1.956454 45 182 0.01896334 GO Cellular Component nucleosome 23 2.050046e-17 1.5402084730434783e-15 5.522856 40 0.01935172 14 0.00004421870537142857 2.48687 33 105 0.01390645 GO Cellular Component DNA packaging complex 26 1.720162e-14 1.1432461292307693e-12 4.484058 40 0.01935172 20 0.0001579174272 2.331441 33 112 0.01390645 GO Cellular Component cell cortex part 37 1.3088e-10 6.112449729729729e-9 2.499005 63 0.03047896 41 0.011915474575609755 1.875619 32 135 0.01348504 GO Cellular Component myelin sheath 43 2.915257e-9 1.1715265339534883e-7 2.33934 61 0.02951137 67 0.04817687211940298 1.660705 34 162 0.01432786 GO Cellular Component cortical cytoskeleton 52 1.966872e-8 6.536066953846154e-7 2.658742 43 0.0208031 42 0.013038566400000002 2.116206 23 86 0.009692373 GO Cellular Component protein-DNA complex 65 1.573364e-7 0.000004182727679999999 2.181423 55 0.02660861 38 0.004213249162105263 1.762745 45 202 0.01896334 GO Cellular Component sex chromosome 85 0.000002994124 0.00006086877967058824 4.404557 15 0.007256894 56 0.02437593942857143 3.043373 10 26 0.004214075 GO Cellular Component Barr body 104 0.00002845934 0.00047286288 8.31083 7 0.003386551 63 0.03138207085714286 6.330215 4 5 0.00168563 GO Molecular Function nucleosome binding 11 1.078023e-12 4.137648278181818e-10 4.100368 38 0.01838413 21 0.00757473443047619 2.517699 21 66 0.008849558 GO Molecular Function cadherin binding 15 1.009199e-11 2.840558785333333e-9 2.010206 112 0.05418481 8 0.0003802407085 1.79599 69 304 0.02907712 GO Molecular Function nucleosomal DNA binding 16 1.195481e-11 3.15457548875e-9 4.998331 28 0.0135462 27 0.014812066055555557 2.752267 16 46 0.00674252 GO Molecular Function chromatin DNA binding 26 1.0263e-7 0.000016665533076923075 2.533918 42 0.0203193 34 0.021263444864705883 2.054276 27 104 0.011378 Mouse Phenotype Single KO abnormal platelet aggregation 9 2.074716e-20 2.1109082680000002e-17 4.292153 61 0.02951137 115 0.005034663519478261 2.333252 23 78 0.009692373 Mouse Phenotype Single KO abnormal platelet activation 12 1.306664e-19 9.970935206666668e-17 4.127791 61 0.02951137 166 0.014518666215662649 2.141102 23 85 0.009692373 Mouse Phenotype Single KO decreased platelet aggregation 18 7.547136e-18 3.839395797333333e-15 4.794667 47 0.02273827 227 0.03685344372643172 2.241951 17 60 0.007163928 Mouse Phenotype Single KO abnormal platelet physiology 23 2.639112e-17 1.0507108080000001e-14 3.343029 69 0.03338171 100 0.0025734237595 2.158028 30 110 0.01264223 Mouse Phenotype Single KO decreased granulocyte number 25 1.510902e-16 5.5341318456e-14 2.562631 99 0.0478955 68 0.00041740231904411766 1.896147 52 217 0.02191319 Mouse Phenotype Single KO abnormal granulocyte number 27 3.64903e-16 1.237561767037037e-13 2.026952 156 0.0754717 53 0.00012770832510566036 1.651518 91 436 0.03834808 Mouse Phenotype Single KO abnormal neutrophil cell number 31 8.11313e-16 2.396513916451613e-13 2.428342 104 0.05031447 205 0.02546916812926829 1.564839 53 268 0.0223346 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 37 4.110486e-15 1.017289737891892e-12 2.427741 99 0.0478955 95 0.002075191148526316 1.728076 57 261 0.02402023 Mouse Phenotype Single KO abnormal T cell activation 39 7.310509e-15 1.7164700234102567e-12 2.222044 116 0.05611998 102 0.002996955029215686 1.670169 61 289 0.02570586 Mouse Phenotype Single KO abnormal neutrophil morphology 40 8.277591e-15 1.894947519675e-12 2.295813 108 0.05224964 169 0.016366701639053252 1.582554 56 280 0.02359882 Mouse Phenotype Single KO decreased T cell proliferation 47 1.491844e-13 2.9065564910638294e-11 2.609333 77 0.03725206 125 0.00682446156448 1.899064 36 150 0.01517067 Mouse Phenotype Single KO abnormal self tolerance 57 1.573234e-12 2.5273866207017543e-10 2.098372 109 0.05273343 155 0.012696771274193549 1.544534 65 333 0.02739149 Mouse Phenotype Single KO abnormal immune tolerance 58 2.602185e-12 4.108311731896552e-10 2.080598 109 0.05273343 180 0.01681629634166667 1.521686 65 338 0.02739149 Mouse Phenotype Single KO autoimmune response 59 2.655342e-12 4.12118079559322e-10 2.096611 107 0.05176584 171 0.016803973215204677 1.529961 64 331 0.02697008 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 61 6.812934e-12 1.0227219120983605e-9 2.717667 62 0.02999516 215 0.029397999079999997 2.048011 22 85 0.009270965 Mouse Phenotype Single KO abnormal T cell proliferation 64 2.032733e-11 2.9083962626562497e-9 2.081931 100 0.04837929 141 0.010259574237588652 1.637125 54 261 0.02275601 Mouse Phenotype Single KO abnormal blood coagulation 71 5.708359e-11 7.362175121549297e-9 2.116386 92 0.04450895 139 0.009911958417266187 1.705964 47 218 0.01980615 Mouse Phenotype Single KO abnormal hemostasis 73 6.914505e-11 8.673441408904109e-9 2.108339 92 0.04450895 150 0.011507467597333334 1.690455 47 220 0.01980615 Mouse Phenotype Single KO abnormal NK cell morphology 84 1.360064e-10 1.4826316723809522e-8 2.416168 67 0.03241413 237 0.040834578978902955 1.746266 32 145 0.01348504 Mouse Phenotype Single KO abnormal macrophage cell number 86 1.807e-10 1.9240347674418605e-8 2.05866 93 0.04499274 198 0.02401105992323232 1.659751 43 205 0.01812052 Mouse Phenotype abnormal embryonic erythropoiesis 13 1.977399e-20 1.4543009106923077e-17 6.20645 43 0.0208031 337 0.027273016349554893 2.807757 11 31 0.004635483 Mouse Phenotype abnormal platelet physiology 15 8.708196e-20 5.5506041304e-17 3.367224 79 0.03821964 129 0.000915544313255814 2.098083 35 132 0.01474926 Mouse Phenotype abnormal embryonic erythrocyte morphology 17 1.283027e-19 7.215894792352941e-17 5.597006 45 0.02177068 305 0.021196711921967214 2.63759 13 39 0.005478298 Mouse Phenotype abnormal platelet aggregation 19 4.145852e-19 2.0862363669473684e-16 3.970441 62 0.02999516 276 0.01733765759021739 2.020281 24 94 0.01011378 Mouse Phenotype abnormal platelet activation 21 1.001457e-18 4.559490655714286e-16 3.896499 62 0.02999516 363 0.033881418421487605 1.899064 24 100 0.01011378 Mouse Phenotype abnormal T cell activation 35 1.681646e-15 4.593776401714285e-13 2.011077 152 0.07353653 105 0.000346238867 1.625116 84 409 0.03539823 Mouse Phenotype decreased T cell proliferation 36 2.037148e-15 5.410325563333333e-13 2.381154 105 0.05079826 95 0.0001731527292631579 1.931756 52 213 0.02191319 Mouse Phenotype increased myeloid cell number 37 3.729862e-15 9.638165022162162e-13 2.175249 124 0.05999032 132 0.0009933560299999998 1.709379 62 287 0.02612727 Mouse Phenotype altered susceptibility to autoimmune disorder 38 4.27808e-15 1.0763874442105263e-12 2.221861 118 0.05708757 160 0.0029780178530625 1.601394 68 336 0.02865571 Mouse Phenotype decreased granulocyte number 40 9.31959e-15 2.2276149997499997e-12 2.281145 109 0.05273343 118 0.0005935589527881356 1.778839 58 258 0.02444164 Mouse Phenotype abnormal neutrophil cell number 54 6.503878e-13 1.1515477325555556e-10 2.021925 123 0.05950653 261 0.014479068503448276 1.501857 67 353 0.0282343 Mouse Phenotype abnormal embryonic hematopoiesis 55 6.85022e-13 1.1908173349090908e-10 3.238197 52 0.02515723 352 0.03041144953125 2.205198 17 61 0.007163928 Mouse Phenotype decreased susceptibility to autoimmune disorder 61 2.098248e-12 3.288745758688524e-10 2.523357 74 0.03580068 391 0.04024733515856777 1.590311 41 204 0.01727771 Mouse Phenotype decreased NK cell number 69 5.158734e-12 7.148210981739131e-10 2.736516 62 0.02999516 223 0.008709818040807175 2.034712 27 105 0.011378 Mouse Phenotype decreased erythrocyte cell number 74 8.108671e-12 1.047662208527027e-9 2.108142 101 0.04886309 210 0.007601363781428571 1.678466 49 231 0.02064897 Mouse Phenotype abnormal NK cell number 76 9.085884e-12 1.1430281174210527e-9 2.393077 77 0.03725206 211 0.00769134871563981 1.829828 37 160 0.01559208 Mouse Phenotype abnormal erythroid progenitor cell morphology 78 2.451446e-11 3.004907077692308e-9 2.479313 69 0.03338171 316 0.022553818078481013 1.861828 28 119 0.01179941 Mouse Phenotype decreased inflammatory response 80 2.848095e-11 3.403829536875e-9 2.145616 92 0.04450895 229 0.009453169455458516 1.572073 60 302 0.02528445 Mouse Phenotype abnormal mean corpuscular hemoglobin 82 3.473115e-11 4.049567379878048e-9 2.339159 76 0.03676826 138 0.0012608062986956521 1.892184 44 184 0.01854193 Mouse Phenotype abnormal NK cell morphology 83 4.380254e-11 5.04573596313253e-9 2.297421 78 0.03773585 219 0.008680309658904109 1.80051 38 167 0.01601349