# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	3	5.319013e-49	2.3330964022333335e-45	2.962425	252	0.02045621	248	0.000009265649853629032	1.526606	79	113	0.009187115	
GO Biological Process	regulation of DNA-templated transcription in response to stress	9	7.542133e-43	1.1027436460777777e-39	2.681261	258	0.02094326	261	0.000013928554453639845	1.504683	82	119	0.009535993	
GO Biological Process	positive regulation of nuclease activity	14	8.450754e-39	7.943105134714286e-36	6.741264	80	0.006494034	642	0.027676902464174456	1.892476	13	15	0.001511804	
GO Biological Process	rRNA metabolic process	24	3.103285e-34	1.7015053047916668e-31	2.077395	342	0.02776199	95	1.3063293900421052e-13	1.53444	182	259	0.02116525	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	26	6.643343e-34	3.3622980975769227e-31	2.238212	286	0.02321617	332	0.00034836625301506026	1.380615	98	155	0.01139667	
GO Biological Process	rRNA processing	28	9.201102e-34	4.3241893292142854e-31	2.088109	333	0.02703141	93	1.2338723122903226e-13	1.542402	178	252	0.02070008	
GO Biological Process	regulation of cellular amino acid metabolic process	29	4.022476e-33	1.8252331615172415e-30	3.778087	120	0.00974105	433	0.003864290781986143	1.528538	42	60	0.004884289	
GO Biological Process	liver regeneration	31	5.985365e-33	2.5406909043548386e-30	3.595258	127	0.01030928	383	0.0012391555438381202	1.746901	28	35	0.003256193	
GO Biological Process	mRNA catabolic process	32	4.437857e-32	1.82493000821875e-29	2.098557	312	0.02532673	106	3.6021719711320757e-13	1.578772	154	213	0.01790906	
GO Biological Process	endoplasmic reticulum unfolded protein response	35	2.784801e-31	1.047005610257143e-28	2.536702	205	0.01664096	692	0.0378344259234104	1.302514	68	114	0.007907896	
GO Biological Process	nuclear-transcribed mRNA catabolic process	37	4.189582e-31	1.4900191767027027e-28	2.142202	288	0.02337852	120	3.5895493038333333e-12	1.577063	143	198	0.01662984	
GO Biological Process	cotranslational protein targeting to membrane	41	1.002387e-30	3.217173300731707e-28	2.890325	161	0.01306924	164	2.3363812523780484e-9	1.715706	77	98	0.00895453	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	46	4.225844e-30	1.2088669825217391e-27	2.808545	165	0.01339394	331	0.0003360356184833837	1.539736	55	78	0.006396093	
GO Biological Process	cellular response to topologically incorrect protein	47	5.809167e-30	1.6264431607021277e-27	2.319916	233	0.01891387	559	0.015311741779248659	1.303892	83	139	0.009652285	
GO Biological Process	regulation of mRNA stability	48	7.363857e-30	2.0187707138125e-27	2.09674	290	0.02354087	182	7.239315396703297e-8	1.532877	106	151	0.01232701	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	49	1.365193e-29	3.6662397320408166e-27	2.656614	178	0.01444922	160	1.0586917186875e-9	1.665477	90	118	0.01046633	
GO Biological Process	protein targeting to ER	51	8.535956e-29	2.2024440196862746e-26	2.760381	162	0.01315042	153	4.773258677189542e-10	1.729605	80	101	0.009303407	
GO Biological Process	regulation of hematopoietic stem cell differentiation	52	8.675946e-29	2.195514873346154e-26	2.739814	164	0.01331277	548	0.01449466731532847	1.356816	64	103	0.007442726	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	54	3.108267e-28	7.574386195e-26	2.599355	176	0.01428687	573	0.017525300880104712	1.333365	69	113	0.008024189	
GO Biological Process	cellular response to unfolded protein	56	8.888806e-28	2.0887106813214285e-25	2.336347	212	0.01720919	525	0.01176394297542857	1.335441	74	121	0.008605652	
GO Cellular Component	ribosomal subunit	33	4.730136e-27	2.4768712145454546e-25	2.19219	236	0.0191574	32	2.44306692e-12	1.593457	135	185	0.0156995	
GO Cellular Component	proteasome complex	35	1.213026e-23	5.988882651428571e-22	2.829683	126	0.0102281	72	0.000074309376	1.605607	50	68	0.00581463	
GO Cellular Component	endopeptidase complex	36	1.270741e-23	6.0995568e-22	2.828085	126	0.0102281	77	0.00014013617703896103	1.582338	50	69	0.00581463	
GO Cellular Component	peptidase complex	37	1.827084e-23	8.532976086486487e-22	2.518594	153	0.01241984	66	0.000021171194181818185	1.563278	63	88	0.007326433	
GO Cellular Component	mitochondrial ribosome	40	1.322992e-22	5.71532544e-21	2.922793	114	0.009253998	61	0.000009466071816393443	1.592762	62	85	0.007210141	
GO Cellular Component	large ribosomal subunit	46	5.780666e-19	2.1715197495652175e-17	2.27927	148	0.01201396	40	2.609766e-9	1.651961	87	115	0.01011746	
GO Cellular Component	PcG protein complex	52	7.598125e-18	2.5249153846153847e-16	2.415867	123	0.009984577	69	0.00003797590539130434	1.756395	37	46	0.004302826	
GO Cellular Component	methyltransferase complex	55	5.346914e-16	1.6799031621818182e-14	2.090187	149	0.01209514	76	0.00011572959410526316	1.511741	63	91	0.007326433	
GO Cellular Component	catalytic step 2 spliceosome	56	1.068523e-15	3.297156685714285e-14	2.101655	144	0.01168926	107	0.005499873555140187	1.387512	61	96	0.007093848	
GO Cellular Component	mitochondrial large ribosomal subunit	59	3.234633e-14	9.47363698983051e-13	2.933212	68	0.005519929	78	0.0001728108996923077	1.669832	39	51	0.004535411	
GO Cellular Component	spliceosomal snRNP complex	62	1.204377e-13	3.3567152516129036e-12	2.490001	86	0.006981086	98	0.002618191542857143	1.51445	43	62	0.005000581	
GO Cellular Component	mitochondrial nucleoid	76	1.545938e-11	3.514974821052632e-10	2.547338	68	0.005519929	64	0.0000156108708	1.819688	35	42	0.004070241	
GO Cellular Component	small nuclear ribonucleoprotein complex	77	1.930364e-11	4.332037651948052e-10	2.194456	91	0.007386963	108	0.0059606624	1.455751	46	69	0.005349459	
GO Cellular Component	proteasome accessory complex	86	1.926078e-10	3.870073004651162e-9	3.140773	43	0.003490543	120	0.01277684496	1.728704	19	24	0.002209559	
GO Cellular Component	small ribosomal subunit	90	5.518144e-10	1.0594836480000001e-8	2.058841	90	0.007305788	95	0.0020206522610526317	1.486079	49	72	0.005698337	
GO Cellular Component	pronucleus	96	3.054855e-9	5.498739e-8	3.213162	36	0.002922315	130	0.017948576492307692	1.892476	13	15	0.001511804	
GO Cellular Component	mitochondrial outer membrane translocase complex	114	4.135152e-8	6.26801987368421e-7	3.886856	24	0.00194821	142	0.03162291109859155	1.985115	10	11	0.001162926	
GO Cellular Component	cytosolic small ribosomal subunit	137	6.564961e-7	0.000008280476356204379	2.019796	60	0.004870525	136	0.02859399105882353	1.488836	30	44	0.003488778	
GO Cellular Component	U2 snRNP	150	0.000001719674	0.00001981064448	2.839089	28	0.002272912	147	0.03988185208163265	1.723915	15	19	0.001744389	
GO Cellular Component	chylomicron	223	0.0001351731	0.0010474399856502243	2.489769	22	0.001785859	141	0.031624887829787236	1.871679	12	14	0.001395511	
GO Molecular Function	structural constituent of ribosome	11	2.154994e-21	8.271258789090909e-19	2.085261	206	0.01672214	17	1.722419786e-9	1.577063	117	162	0.01360623	
GO Molecular Function	ribonucleoprotein complex binding	12	7.552096e-21	2.6570791093333332e-18	2.212052	175	0.0142057	55	0.00004252160432727272	1.500056	79	115	0.009187115	
GO Molecular Function	rRNA binding	25	1.352236e-14	2.2836561568e-12	2.908049	71	0.005763455	114	0.032734362233333335	1.455751	40	60	0.004651704	
GO Molecular Function	oxidoreductase activity, acting on the CH-NH group of donors	67	2.73889e-9	1.7259094895522387e-7	2.464895	56	0.004545824	91	0.00726469332967033	1.779251	22	27	0.002558437	
GO Molecular Function	tRNA-specific ribonuclease activity	71	9.411592e-9	5.596583299154931e-7	3.016161	37	0.003003491	111	0.026649404733333333	1.910673	14	16	0.001628096	
Human Phenotype	Progressive external ophthalmoplegia	13	3.789415e-19	1.9451358688461538e-16	4.904078	50	0.004058771	95	0.010710748009473683	2.038051	14	15	0.001628096	
Human Phenotype	Colon cancer	683	0.004037918	0.03945099094289897	2.163376	16	0.001298807	150	0.039322356339333335	2.183626	9	9	0.001046633	
Mouse Phenotype Single KO	embryo tumor	55	3.952067e-15	6.579832276181819e-13	5.113025	37	0.003003491	176	0.04598860277329546	2.183626	9	9	0.001046633	
Mouse Phenotype Single KO	increased blood uric acid level	69	1.938238e-13	2.5722384588405797e-11	3.053303	60	0.004870525	167	0.03841749164610778	1.910673	14	16	0.001628096	
Mouse Phenotype	embryo tumor	58	3.952067e-15	6.51477803224138e-13	5.113025	37	0.003003491	295	0.02864777986881356	2.183626	9	9	0.001046633	
Mouse Phenotype	thin hypoglossal nerve	160	1.613925e-9	9.644210578125001e-8	3.012497	41	0.003328192	327	0.039480731431192656	1.892476	13	15	0.001511804	
Mouse Phenotype	abnormal heart iron level	573	0.0003913297	0.006529674104188482	2.732863	16	0.001298807	295	0.02864777986881356	2.183626	9	9	0.001046633