# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	2	5.344691e-20	3.51653944345e-16	2.768873	107	0.04240983	62	0.000012234109072903226	1.906158	68	248	0.02517586	
GO Biological Process	negative regulation of gene expression, epigenetic	3	3.17082e-19	1.390827346e-15	4.24525	58	0.02298851	91	0.0003266033433076923	2.195327	36	114	0.0133284	
GO Biological Process	protein folding	4	2.065282e-18	6.7942614595e-15	2.749995	99	0.039239	64	0.000018672113144843748	1.937911	63	226	0.02332469	
GO Biological Process	chromatin silencing	6	4.545887e-17	9.969887838833332e-14	4.885119	44	0.01743956	134	0.00236546184	2.150063	30	97	0.011107	
GO Biological Process	positive regulation of gene expression, epigenetic	7	2.675111e-16	5.028826521285714e-13	4.644847	44	0.01743956	246	0.03544632341138211	1.998663	23	80	0.008515365	
GO Biological Process	regulation of cellular response to heat	15	1.92108e-13	1.685299448e-10	3.405935	51	0.02021403	88	0.0002688445008977273	2.495543	28	78	0.01036653	
GO Biological Process	gene silencing	17	3.449446e-13	2.6700741125882355e-10	2.739132	69	0.02734839	155	0.004495942992516129	1.776589	46	180	0.01703073	
GO Biological Process	regulation of megakaryocyte differentiation	22	1.402896e-12	8.391231119999999e-10	3.479146	46	0.01823226	77	0.000045492987187012987	2.652687	29	76	0.01073676	
GO Biological Process	nucleosome organization	25	3.333628e-12	1.75468843408e-9	2.601978	69	0.02734839	61	0.0000123118818247541	2.114019	52	171	0.01925213	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	27	6.772498e-12	3.3007148585925923e-9	3.317179	46	0.01823226	293	0.04961809787372014	1.784108	29	113	0.01073676	
GO Biological Process	regulation of gene silencing	32	2.766966e-11	1.1378282998125e-8	2.791612	56	0.0221958	183	0.01121722056830601	1.85737	35	131	0.01295816	
GO Biological Process	viral gene expression	35	3.674012e-11	1.3813235402285715e-8	3.101936	47	0.01862862	217	0.024954048425806452	1.806391	33	127	0.0122177	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	37	4.145547e-11	1.4743581884594595e-8	2.927354	51	0.02021403	143	0.0033071327629370633	2.030192	33	113	0.0122177	
GO Biological Process	macromolecular complex disassembly	39	7.800447e-11	2.631950822384615e-8	2.380915	71	0.0281411	176	0.008912074807386363	1.71067	47	191	0.01740096	
GO Biological Process	DNA conformation change	44	2.392761e-10	7.155986817954547e-8	2.016175	97	0.03844629	137	0.002733793776131387	1.632823	66	281	0.02443539	
GO Biological Process	regulation of DNA-templated transcription in response to stress	46	3.348669e-10	9.579377254565218e-8	2.689388	53	0.02100674	150	0.0039697255342	1.986248	34	119	0.01258793	
GO Biological Process	viral transcription	48	3.562522e-10	9.766505624583334e-8	3.062639	43	0.0170432	191	0.014925798991099476	1.90715	31	113	0.01147723	
GO Biological Process	chaperone-mediated protein folding	49	5.05699e-10	1.3580598246938776e-7	3.674362	33	0.01307967	189	0.013596031973544972	2.245989	21	65	0.007774898	
GO Biological Process	chromatin assembly or disassembly	51	7.161624e-10	1.8478394160000002e-7	2.338845	66	0.02615933	87	0.00022025549325287356	1.952772	50	178	0.01851166	
GO Biological Process	nucleosome assembly	64	2.983169e-9	6.13367513609375e-7	2.469562	55	0.02179945	92	0.0003323640146304348	2.056187	42	142	0.0155498	
GO Cellular Component	nucleosome	19	2.346282e-17	2.1338817347368423e-15	4.977138	44	0.01743956	20	2.202473376e-9	2.846956	43	105	0.01592003	
GO Cellular Component	DNA packaging complex	20	3.943809e-16	3.407450976e-14	4.316506	47	0.01862862	24	5.597375039999999e-9	2.731092	44	112	0.01629026	
GO Cellular Component	nuclear nucleosome	21	3.227648e-15	2.6558932114285715e-13	9.363815	23	0.009116132	58	0.027156142675862072	2.433154	14	40	0.005183265	
GO Cellular Component	protein-DNA complex	25	8.087656e-12	5.590187827200001e-10	2.437034	75	0.02972652	18	1.01810688e-9	2.305818	67	202	0.02480563	
GO Cellular Component	ribosome	27	2.731302e-10	1.74803328e-8	2.295065	72	0.02853746	40	0.00045214545600000006	1.737967	59	236	0.02184376	
GO Cellular Component	ribosomal subunit	32	8.165398e-10	4.40931492e-8	2.539875	56	0.0221958	47	0.0039572928	1.728573	46	185	0.01703073	
GO Cellular Component	chromosome, telomeric region	36	7.374222e-9	3.5396265600000003e-7	2.475125	52	0.02061038	54	0.021035456	1.665118	40	167	0.01480933	
GO Cellular Component	nuclear chromosome, telomeric region	37	9.070222e-9	4.236038815135135e-7	2.69981	44	0.01743956	66	0.04594249309090909	1.685302	32	132	0.01184746	
GO Cellular Component	spliceosomal complex	43	1.923874e-7	0.000007731289004651163	2.060535	62	0.02457392	59	0.026992639891525422	1.607153	43	186	0.01592003	
GO Cellular Component	small ribosomal subunit	63	0.000007549853	0.00020708168228571427	2.792405	25	0.009908839	57	0.027557595284210527	2.027629	21	72	0.007774898	
GO Cellular Component	cytosolic ribosome	64	0.000008146754	0.000219962358	2.223431	38	0.01506143	50	0.014672786688	1.862108	30	112	0.011107	
GO Cellular Component	Holliday junction resolvase complex	75	0.00001814688	0.00041810411519999996	26.86381	4	0.001585414	67	0.048773418985074625	5.561496	4	5	0.001480933	
GO Molecular Function	unfolded protein binding	7	1.492875e-12	9.004168928571428e-10	3.594458	44	0.01743956	32	0.007826428269375	2.033094	31	106	0.01147723	
GO Molecular Function	mismatched DNA binding	15	7.184205e-8	0.000020221142339999998	7.9464	12	0.004756243	45	0.04824348048888889	4.055257	7	12	0.002591633	
GO Molecular Function	double-stranded RNA binding	19	3.758276e-7	0.0000835128488	2.62287	36	0.01426873	33	0.010524697554545456	2.31729	22	66	0.008145131	
Mouse Phenotype Single KO	increased integument system tumor incidence	14	1.109072e-7	0.00007254123074285715	2.81206	35	0.01387237	52	0.018571399748076922	2.195327	24	76	0.008885598	
Mouse Phenotype Single KO	increased skin tumor incidence	15	1.492847e-7	0.00009113333319333334	3.49594	25	0.009908839	32	0.00452867447375	2.843947	18	44	0.006664198	
Mouse Phenotype Single KO	abnormal cell nucleus morphology	16	1.619078e-7	0.0000926618577875	2.071258	62	0.02457392	65	0.03963093249230769	1.773925	37	145	0.01369863	
Mouse Phenotype Single KO	increased lung tumor incidence	20	8.568367e-7	0.000392302683095	2.234546	46	0.01823226	48	0.014421466131666666	2.093036	28	93	0.01036653	
Mouse Phenotype Single KO	increased circulating tumor necrosis factor level	37	0.00002878434	0.007123735172432432	2.516583	26	0.01030519	66	0.03903985668030303	2.242539	20	62	0.007404665	
Mouse Phenotype Single KO	abnormal circulating tumor necrosis factor level	38	0.00003659217	0.008817750018157896	2.119634	36	0.01426873	67	0.04113865619701492	1.92004	29	105	0.01073676	
Mouse Phenotype Single KO	increased liver tumor incidence	47	0.00006867825	0.013380568835106382	2.029973	37	0.01466508	63	0.0348527483984127	1.996814	27	94	0.009996298	
Mouse Phenotype Single KO	decreased sensitivity to induced cell death	54	0.0001344283	0.022795554501851847	2.027745	34	0.01347602	56	0.02708668398035714	2.139037	24	78	0.008885598	
Mouse Phenotype	decreased pre-B cell number	2	1.620238e-16	7.745547759e-13	2.78861	86	0.03408641	71	0.03393656750704225	1.938502	29	104	0.01073676	
Mouse Phenotype	abnormal pre-B cell morphology	3	3.87696e-14	1.235587152e-10	2.433586	92	0.03646453	67	0.030668919591044775	1.829439	35	133	0.01295816	
Mouse Phenotype	increased skin tumor incidence	63	0.00007020235	0.010654042354761905	2.100392	34	0.01347602	69	0.0319608295	2.030883	26	89	0.009626064	
Mouse Phenotype	decreased cellular sensitivity to ultraviolet irradiation	64	0.0001133458	0.016932799903125	4.473968	10	0.003963535	45	0.012136514559333334	4.171122	9	15	0.003332099