# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA metabolic process	16	6.33804e-43	5.2126417725000004e-40	2.282358	350	0.03050109	67	5.727680613432836e-16	1.638008	177	259	0.02259382	
GO Biological Process	rRNA processing	18	3.092294e-41	2.2606387081111112e-38	2.275351	338	0.02945534	68	6.647321098970588e-16	1.645463	173	252	0.02208323	
GO Biological Process	mRNA catabolic process	24	3.18769e-39	1.7477838629166667e-36	2.289013	317	0.02762527	99	2.1560184109090908e-12	1.620412	144	213	0.01838141	
GO Biological Process	nuclear-transcribed mRNA catabolic process	27	5.826423e-38	2.8396259354444444e-35	2.33969	293	0.02553377	102	4.975310821862745e-12	1.634223	135	198	0.01723258	
GO Biological Process	protein targeting to ER	31	5.234079e-35	2.221782114870968e-32	3.073167	168	0.01464052	116	3.945946222931034e-11	1.85104	78	101	0.009956599	
GO Biological Process	RNA catabolic process	33	1.026957e-34	4.0950688372727274e-32	2.096815	339	0.02954248	108	1.7299162559259257e-11	1.56144	157	241	0.02004085	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	38	1.183123e-33	4.097030409736842e-31	2.625022	208	0.01812636	516	0.012620781598837208	1.378725	65	113	0.008297166	
GO Biological Process	mitochondrial transport	41	2.333782e-32	7.490301789756098e-30	2.001153	353	0.03076253	220	0.000011538385410909091	1.39399	139	239	0.01774317	
GO Biological Process	translational elongation	42	4.476034e-32	1.4023840810952382e-29	2.821761	175	0.01525054	169	1.3359312682840237e-8	1.712043	80	112	0.0102119	
GO Biological Process	cotranslational protein targeting to membrane	43	1.285972e-31	3.935373383255814e-29	3.006548	156	0.01359477	133	2.2146557424060148e-10	1.834332	75	98	0.009573653	
GO Biological Process	regulation of DNA-templated transcription in response to stress	45	1.433129e-31	4.190787669111111e-29	2.45451	220	0.01917211	396	0.004016724936363637	1.409918	70	119	0.00893541	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	47	2.616488e-31	7.32560970042553e-29	2.787921	174	0.0151634	151	1.953406491324503e-9	1.726552	85	118	0.01085014	
GO Biological Process	protein localization to endoplasmic reticulum	49	4.006625e-31	1.075983232142857e-28	2.59915	195	0.01699346	113	2.1984275494690264e-11	1.778315	92	124	0.01174368	
GO Biological Process	cellular response to topologically incorrect protein	52	6.550059e-30	1.6575428150192306e-27	2.372969	222	0.01934641	701	0.04382487626533524	1.29327	75	139	0.009573653	
GO Biological Process	mitochondrial translational termination	53	7.007897e-30	1.7399418230754717e-27	3.168017	136	0.01185185	201	0.0000014505761455721393	1.708107	62	87	0.00791422	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	54	1.490052e-29	3.6310359755555555e-27	2.725726	170	0.01481481	123	6.742920872113822e-11	1.826179	80	105	0.0102119	
GO Biological Process	macromolecular complex disassembly	55	1.523511e-29	3.645069318e-27	2.101334	285	0.0248366	172	1.4216065530232557e-8	1.543528	123	191	0.01570079	
GO Biological Process	mitochondrial translation	56	1.815387e-29	4.265835273749999e-27	2.821964	160	0.01394336	187	1.790719645080214e-7	1.680042	75	107	0.009573653	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	59	3.501483e-29	7.80949403338983e-27	2.983859	145	0.01263617	127	8.969998132677166e-11	1.875803	72	92	0.009190707	
GO Biological Process	cellular response to unfolded protein	60	6.905562e-29	1.5145048393000003e-26	2.425371	205	0.01786492	644	0.033588633565217386	1.327187	67	121	0.008552464	
GO Cellular Component	ribosomal subunit	25	1.13735e-41	7.8613632e-40	2.612704	262	0.02283224	31	1.6448491974193547e-13	1.68428	130	185	0.01659433	
GO Cellular Component	ribosome	26	6.887325e-41	4.5774221538461535e-39	2.298798	328	0.02858388	30	6.524248319999999e-14	1.614834	159	236	0.02029615	
GO Cellular Component	large ribosomal subunit	38	1.79694e-31	8.171348210526316e-30	2.827177	171	0.01490196	48	4.2223140000000005e-9	1.709065	82	115	0.01046719	
GO Cellular Component	mitochondrial ribosome	39	9.565348e-31	4.23818496e-29	3.440535	125	0.01089325	64	0.0000058680018	1.663703	59	85	0.007531274	
GO Cellular Component	mitochondrial large ribosomal subunit	42	2.644929e-23	1.0881993599999999e-21	3.797267	82	0.007145969	81	0.00060392064	1.691901	36	51	0.004595354	
GO Cellular Component	proteasome core complex	44	6.707412e-22	2.6341836218181817e-20	5.859651	49	0.004270153	124	0.013628266374193548	1.797645	18	24	0.002297677	
GO Cellular Component	nuclear chromosome, telomeric region	56	2.821e-16	8.704799999999999e-15	2.077619	154	0.01342048	91	0.0015917124501098902	1.398168	77	132	0.009828951	
GO Cellular Component	methyltransferase complex	70	8.413036e-14	2.0768180297142858e-12	2.033085	135	0.01176471	85	0.0009092699407058824	1.50133	57	91	0.007275977	
GO Cellular Component	catalytic step 2 spliceosome	73	4.333115e-13	1.0257017424657534e-11	2.02121	129	0.01124183	96	0.0029739852	1.448103	58	96	0.007403625	
GO Cellular Component	MLL1 complex	79	1.413841e-12	3.0925534784810125e-11	3.154713	53	0.004618736	100	0.003421833984	1.818307	22	29	0.002808272	
GO Cellular Component	small ribosomal subunit	80	1.432612e-12	3.0944419200000004e-11	2.283946	93	0.008104575	74	0.0001298714361081081	1.631196	49	72	0.006254787	
GO Cellular Component	proteasome complex	81	1.655016e-12	3.5307008000000004e-11	2.266302	94	0.008191721	134	0.019568013850746267	1.445165	41	68	0.005233597	
GO Cellular Component	endopeptidase complex	82	1.705751e-12	3.594558204878049e-11	2.265022	94	0.008191721	144	0.026930124	1.424221	41	69	0.005233597	
GO Cellular Component	cytosolic large ribosomal subunit	83	1.764501e-12	3.6735635277108434e-11	2.323402	89	0.007755991	68	0.00003636522635294117	1.728883	44	61	0.005616543	
GO Cellular Component	peptidase complex	84	2.664381e-12	5.481012342857143e-11	2.04997	116	0.01010893	109	0.005499055618348624	1.443563	53	88	0.006765382	
GO Cellular Component	preribosome	94	2.29826e-10	4.224886468085106e-9	2.059197	94	0.008191721	69	0.000056343493565217396	1.639957	52	76	0.006637733	
GO Cellular Component	Fanconi anaemia nuclear complex	96	3.35141e-10	6.032538e-9	3.0824	43	0.003747277	141	0.024294711829787236	2.028112	11	13	0.001404136	
GO Cellular Component	BLOC complex	108	5.253751e-9	8.4060016e-8	2.886182	41	0.003572985	139	0.022187035165467626	1.771592	17	23	0.002170028	
GO Cellular Component	spliceosomal snRNP complex	118	2.431404e-8	3.560564501694915e-7	2.113648	68	0.005925926	132	0.01905610909090909	1.469043	38	62	0.004850651	
GO Cellular Component	cytosolic small ribosomal subunit	119	2.965776e-8	4.3066058218487395e-7	2.204493	61	0.005315904	92	0.0020267618086956523	1.688697	31	44	0.00395711	
GO Molecular Function	structural constituent of ribosome	5	6.491409e-37	5.4813457596000005e-34	2.575517	237	0.02065359	10	1.2260240468e-12	1.731065	117	162	0.0149349	
GO Molecular Function	unfolded protein binding	10	1.233715e-23	5.20874473e-21	2.604434	145	0.01263617	98	0.03080837343265306	1.379325	61	106	0.007786571	
GO Molecular Function	rRNA binding	11	4.373777e-23	1.6787351358181815e-20	3.693562	84	0.007320261	51	0.000714340958862745	1.677802	42	60	0.005361246	
GO Molecular Function	ribonucleoprotein complex binding	16	1.630111e-15	4.30145540125e-13	2.049071	151	0.01315904	84	0.01243051795	1.396431	67	115	0.008552464	
GO Molecular Function	nucleosomal DNA binding	41	1.336434e-9	1.3762010604878047e-7	2.250882	70	0.006100218	90	0.018030867253333333	1.615275	31	46	0.00395711	
Human Phenotype	Elevated hepatic transaminases	6	4.424555e-16	4.920842585833333e-13	2.009393	165	0.01437908	10	0.0000014681921254	1.689216	74	105	0.009446005	
Human Phenotype	Increased serum lactate	7	6.974492e-16	6.648683588e-13	2.180162	134	0.01167756	48	0.000774057156375	1.53399	64	100	0.008169517	
Human Phenotype	Exercise intolerance	17	4.81201e-13	1.8888554547058823e-10	2.382142	89	0.007755991	109	0.01755617936055046	1.506598	44	70	0.005616543	
Human Phenotype	Abnormal CSF metabolite level	22	8.618541e-12	2.6141601860454544e-9	2.371001	80	0.006971678	147	0.04372957623129251	1.48377	39	63	0.0049783	
Human Phenotype	Abnormality of the mitochondrion	33	2.762042e-10	5.5851837169696963e-8	2.009397	99	0.008627451	82	0.005887053246219512	1.552895	46	71	0.005871841	
Human Phenotype	Abnormality of mitochondrial metabolism	35	3.608912e-10	6.880648507428572e-8	2.014947	97	0.008453159	96	0.012381668087499999	1.528432	44	69	0.005616543	
Human Phenotype	Abnormality of glycolysis	55	2.795702e-8	0.0000033919489901818183	3.504903	28	0.002440087	155	0.046837227329032255	2.178963	10	11	0.001276487	
Human Phenotype	Generalized aminoaciduria	132	0.000008133211	0.0004111584621439394	3.835226	16	0.001394336	142	0.043051334128873235	2.39686	8	8	0.00102119	
Human Phenotype	Glutaric aciduria	201	0.0000729186	0.0024208249641791044	2.538835	23	0.002004357	142	0.043051334128873235	2.39686	8	8	0.00102119	
Mouse Phenotype	absent segment of posterior cerebral artery	155	6.799324e-8	0.00000419408624283871	2.491285	45	0.003921569	177	0.04117267474406779	1.852119	17	22	0.002170028	
Mouse Phenotype	decreased level of surface class I molecules	216	0.00000101362	0.00004486676305555556	4.533889	16	0.001394336	155	0.030366988182580646	2.197122	11	12	0.001404136	
Mouse Phenotype	abnormal cerebral artery morphology	281	0.000007644294	0.000260096423252669	2.058053	46	0.004008715	194	0.04819701578505154	1.797645	18	24	0.002297677	
Mouse Phenotype	abnormal level of surface class I molecules	330	0.00002810329	0.0008142289566363636	3.303943	17	0.001481481	191	0.04783334260837697	2.054451	12	14	0.001531785