# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	17	1.277512e-73	9.888694357647058e-71	2.247971	634	0.02712996	193	2.8667951947150262e-9	1.340466	174	213	0.0152058	
GO Biological Process	nuclear-transcribed mRNA catabolic process	19	6.510308e-71	4.508902261684211e-68	2.293819	585	0.02503316	196	3.4909135128571427e-9	1.350855	163	198	0.01424452	
GO Biological Process	mitochondrial transport	21	2.986641e-69	1.8714861390000003e-66	2.048783	736	0.03149472	283	0.0000018127550110954066	1.270165	185	239	0.01616709	
GO Biological Process	RNA catabolic process	24	1.543348e-68	8.462048471666666e-66	2.095666	690	0.0295263	185	1.1127236174054054e-9	1.327712	195	241	0.01704099	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	31	1.668524e-62	7.082615263225807e-60	2.565562	414	0.01771578	571	0.00492520859474606	1.26336	87	113	0.007602901	
GO Biological Process	regulation of DNA-templated transcription in response to stress	37	1.858179e-56	6.608588502972973e-54	2.372153	433	0.01852882	581	0.005370953432185886	1.254818	91	119	0.00795246	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	46	5.052352e-52	1.4453021732173912e-49	2.612052	332	0.01420686	184	6.951434844021739e-10	1.460137	105	118	0.009175915	
GO Biological Process	cellular response to topologically incorrect protein	47	1.850455e-51	5.1808802861702125e-49	2.267438	432	0.01848603	329	0.000019897471919148937	1.322177	112	139	0.009787643	
GO Biological Process	endoplasmic reticulum unfolded protein response	53	1.770383e-50	4.3955603579245283e-48	2.420053	371	0.01587573	366	0.00005822012591530055	1.338642	93	114	0.008127239	
GO Biological Process	mitochondrial membrane organization	58	1.319471e-48	2.993606705e-46	2.145726	460	0.0196842	338	0.000026151242767159763	1.336552	101	124	0.008826357	
GO Biological Process	IRE1-mediated unfolded protein response	60	1.045147e-47	2.292181562166667e-45	3.226646	217	0.009285806	596	0.0063622727293624155	1.357999	48	58	0.004194704	
GO Biological Process	regulation of mitochondrial membrane permeability	67	2.624057e-45	5.153726278059701e-43	2.474	318	0.01360777	417	0.0002194587333764988	1.393655	62	73	0.00541816	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	68	6.299612e-45	1.2190675633529413e-42	2.593168	289	0.01236681	553	0.003295484754068716	1.325355	63	78	0.005505549	
GO Biological Process	cellular response to unfolded protein	71	1.124187e-43	2.083546018732394e-41	2.219219	382	0.01634644	367	0.000058440660790190736	1.329006	98	121	0.008564188	
GO Biological Process	regulation of membrane permeability	81	2.084809e-40	3.386913781604939e-38	2.278335	333	0.01424965	409	0.0001890442852836186	1.377559	68	81	0.005942498	
GO Biological Process	protein targeting to ER	82	4.352065e-40	6.984002845731709e-38	2.488108	277	0.01185331	156	1.2204069927564102e-11	1.527189	94	101	0.008214629	
GO Biological Process	cotranslational protein targeting to membrane	84	8.743349e-40	1.369687255845238e-37	2.526779	267	0.01142539	139	5.585376364316547e-13	1.557196	93	98	0.008127239	
GO Biological Process	RNA phosphodiester bond hydrolysis	93	3.205883e-37	4.536152085698925e-35	2.11921	359	0.01536223	445	0.0004828631472808989	1.283122	104	133	0.009088526	
GO Biological Process	cellular response to epidermal growth factor stimulus	98	2.88538e-36	3.874358716326531e-34	2.474791	252	0.01078352	648	0.009338627539969136	1.425006	33	38	0.002883859	
GO Biological Process	translational elongation	107	3.162808e-35	3.88966266093458e-33	2.280275	288	0.01232402	302	0.000004364461216225165	1.377197	94	112	0.008214629	
GO Cellular Component	ribosomal subunit	38	1.227128e-43	5.5802031157894736e-42	2.105571	430	0.01840045	36	3.5257968e-14	1.43691	162	185	0.01415713	
GO Cellular Component	mitochondrial ribosome	42	8.396833e-39	3.454697005714286e-37	2.851747	211	0.009029056	80	0.00000898204464	1.409257	73	85	0.006379446	
GO Cellular Component	large ribosomal subunit	43	1.021455e-33	4.104823813953489e-32	2.265028	279	0.01193889	54	4.705072e-9	1.441152	101	115	0.008826357	
GO Cellular Component	catalytic step 2 spliceosome	45	8.485251e-31	3.258336384e-29	2.161925	281	0.01202448	81	0.000010370363733333333	1.384523	81	96	0.007078563	
GO Cellular Component	mitochondrial large ribosomal subunit	57	2.192934e-26	6.648052547368421e-25	2.978799	131	0.005605717	140	0.0032358021942857145	1.383517	43	51	0.003757756	
GO Cellular Component	PcG protein complex	62	4.568607e-24	1.2733149832258065e-22	2.184669	211	0.009029056	144	0.0048475068	1.391211	39	46	0.003408197	
GO Cellular Component	proteasome core complex	68	6.355955e-22	1.615160329411765e-20	4.110421	70	0.002995421	194	0.04045877740206186	1.435801	21	24	0.001835183	
GO Cellular Component	nuclear ubiquitin ligase complex	73	1.619425e-20	3.8333786301369863e-19	2.68901	118	0.005049424	158	0.009591747402531645	1.394778	34	40	0.002971249	
GO Cellular Component	spliceosomal snRNP complex	86	8.043662e-17	1.6162148762790697e-15	2.182591	143	0.006119218	109	0.0003521354862385321	1.402718	53	62	0.004631653	
GO Cellular Component	endopeptidase complex	88	1.737349e-16	3.4115216727272728e-15	2.011435	170	0.007274595	110	0.0004178801978181818	1.379321	58	69	0.005068601	
GO Cellular Component	DNA-directed RNA polymerase III complex	100	2.022379e-15	3.4946709120000004e-14	3.936161	50	0.002139587	162	0.011463402666666667	1.554552	18	19	0.001573014	
GO Cellular Component	endoribonuclease complex	106	1.262349e-14	2.057867049056604e-13	2.521777	91	0.003894048	153	0.0074497197176470594	1.471166	26	29	0.002272131	
GO Cellular Component	proteasome core complex, beta-subunit complex	118	2.228643e-13	3.2636399186440677e-12	4.842656	34	0.001454919	191	0.03888170085863874	1.640916	11	11	0.0009612864	
GO Cellular Component	MLL1 complex	129	2.991931e-12	4.007795944186047e-11	2.396682	82	0.003508922	177	0.028961192135593217	1.414583	25	29	0.002184742	
GO Cellular Component	U1 snRNP	172	3.163845e-9	3.178560558139535e-8	2.371147	60	0.002567504	126	0.0011168537142857142	1.640916	19	19	0.001660404	
GO Cellular Component	spliceosomal tri-snRNP complex	200	1.164209e-8	1.0058765760000001e-7	2.186421	66	0.002824254	153	0.0074497197176470594	1.471166	26	29	0.002272131	
GO Cellular Component	mRNA cleavage factor complex	203	1.779192e-8	1.5145043231527093e-7	2.274223	59	0.002524712	156	0.007603237661538462	1.55887	19	20	0.001660404	
GO Cellular Component	U12-type spliceosomal complex	224	6.200283e-8	4.783075457142857e-7	2.174345	60	0.002567504	170	0.0216005184	1.451579	23	26	0.002009962	
GO Cellular Component	platelet dense tubular network	233	1.098979e-7	8.150367862660944e-7	2.395465	47	0.002011211	191	0.03888170085863874	1.640916	11	11	0.0009612864	
GO Cellular Component	prespliceosome	235	1.199737e-7	8.821895897872341e-7	2.294229	51	0.002182378	146	0.005177438334246575	1.562777	20	21	0.001747793	
GO Molecular Function	structural constituent of ribosome	11	4.570021e-37	1.7540571510909092e-34	2.054421	385	0.01647482	33	3.635909636363636e-10	1.407946	139	162	0.01214716	
GO Molecular Function	unfolded protein binding	12	1.517168e-34	5.337902746666666e-32	2.346062	266	0.0113826	88	0.0008037853195454546	1.315829	85	106	0.007428122	
GO Molecular Function	ribonuclease activity	15	1.658683e-30	4.668639750666666e-28	2.145798	283	0.01211006	116	0.00998644946551724	1.276268	77	99	0.006729005	
GO Molecular Function	snRNA binding	25	1.53809e-21	2.597526392e-19	3.060911	101	0.004321965	129	0.015050942342635659	1.425006	33	38	0.002883859	
GO Molecular Function	endoribonuclease activity	27	1.510317e-19	2.3616882866666665e-17	2.223062	162	0.006932261	97	0.0020548822206185565	1.406499	48	56	0.004194704	
GO Molecular Function	rRNA binding	30	2.212752e-18	3.114079648e-16	2.526181	117	0.005006633	159	0.034294668716981135	1.312733	48	60	0.004194704	
GO Molecular Function	NF-kappaB binding	62	3.205784e-13	2.1830354916129032e-11	2.315147	96	0.004108006	152	0.02715978435131579	1.465103	25	28	0.002184742	
GO Molecular Function	mRNA 5'-UTR binding	85	5.791958e-12	2.8768996089411766e-10	2.440549	77	0.003294963	118	0.009954874901694914	1.566329	21	22	0.001835183	
GO Molecular Function	5'-3' RNA polymerase activity	96	1.39836e-11	6.14987075e-10	2.148846	97	0.004150798	131	0.01828100216793893	1.385662	38	45	0.003320807	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	104	2.699131e-11	1.0957433732692307e-9	2.151029	94	0.004022423	156	0.029941449692307696	1.37379	36	43	0.003146028	
GO Molecular Function	C-acyltransferase activity	146	3.197162e-9	9.245491756164384e-8	2.090759	79	0.003380547	136	0.021308787902941176	1.55887	19	20	0.001660404	
GO Molecular Function	tRNA-specific ribonuclease activity	186	3.668138e-8	8.32627883655914e-7	2.320502	54	0.002310754	124	0.012272567482258065	1.640916	16	16	0.001398235	
Human Phenotype	Progressive external ophthalmoplegia	27	4.887127e-19	1.2078443878148147e-16	3.619268	70	0.002995421	232	0.01702083835775862	1.640916	15	15	0.001310845	
Human Phenotype	Abnormality of iron homeostasis	28	5.208016e-19	1.2411818131428572e-16	3.331916	78	0.003337755	247	0.0239953920708502	1.504173	22	24	0.001922573	
Human Phenotype	Hemolytic anemia	30	6.846092e-18	1.5227990638666666e-15	2.003492	188	0.008044846	319	0.04956472204702194	1.271132	55	71	0.004806432	
Human Phenotype	External ophthalmoplegia	55	4.631016e-14	5.618685412363637e-12	2.174067	118	0.005049424	129	0.0015080886888372094	1.538359	30	32	0.00262169	
Human Phenotype	Nevus	58	7.135384e-14	8.209382315862069e-12	2.151609	119	0.005092216	284	0.03393533003169014	1.458592	24	27	0.002097352	
Mouse Phenotype	decreased circulating free fatty acid level	14	1.667792e-45	1.138982808e-42	2.037582	486	0.02079678	457	0.04036892701969365	1.21345	88	119	0.007690291	
Mouse Phenotype	absent segment of posterior cerebral artery	322	3.176014e-12	9.430394364596272e-11	2.337879	86	0.003680089	459	0.04227730472549019	1.491742	20	22	0.001747793	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	338	6.558232e-12	1.855125921656805e-10	2.24362	91	0.003894048	253	0.0026242205187747038	1.531521	28	30	0.002446911