# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of catenin import into nucleus 15 1.146095e-76 1.0054309403333334e-73 16.96483 90 0.04103967 298 0.03786222290067114 4.488168 6 11 0.002629273 GO Biological Process negative regulation of fibroblast growth factor receptor signaling pathway 23 5.7127e-66 3.2684095347826087e-63 10.74158 99 0.04514364 208 0.011135746812019232 4.799847 7 12 0.003067485 GO Biological Process regulation of fibroblast growth factor receptor signaling pathway 34 8.62645e-51 3.338689869117647e-48 6.779043 104 0.04742362 190 0.007760450992105263 3.481207 11 26 0.004820333 GO Biological Process positive regulation of cell-substrate adhesion 35 6.255605e-50 2.351928748428572e-47 4.572881 145 0.06611947 302 0.03853000515761589 1.922502 25 107 0.0109553 GO Biological Process chordate embryonic development 41 1.773869e-46 5.69325418804878e-44 2.29058 348 0.1586867 98 0.000502586923744898 1.541881 104 555 0.04557406 GO Biological Process embryo development ending in birth or egg hatching 42 2.288512e-46 7.170126049523809e-44 2.28431 349 0.1591427 97 0.000443945183 1.542808 105 560 0.04601227 GO Biological Process positive regulation of hydrolase activity 47 3.048808e-44 8.53601371744681e-42 2.193265 361 0.1646147 185 0.00696653748708108 1.386538 122 724 0.05346188 GO Biological Process positive regulation of cell death 53 1.264863e-43 3.1404400409433965e-41 2.285816 329 0.1500228 139 0.001739402061151079 1.458829 114 643 0.04995618 GO Biological Process positive regulation of cell morphogenesis involved in differentiation 60 6.116729e-42 1.3415006151833335e-39 3.576367 160 0.07295942 307 0.03886033154039088 1.801819 30 137 0.01314636 GO Biological Process regulation of cell-substrate adhesion 62 2.765251e-41 5.8690222433870966e-39 3.251768 178 0.08116735 248 0.02044985537701613 1.734616 39 185 0.01709027 GO Biological Process regulation of supramolecular fiber organization 65 5.677805e-40 1.1494497845384615e-37 3.019462 191 0.0870953 291 0.03665414126838488 1.537469 54 289 0.02366345 GO Biological Process positive regulation of apoptotic process 72 1.747651e-39 3.1940749318055557e-37 2.273979 302 0.1377109 183 0.006596775681693989 1.434037 103 591 0.04513585 GO Biological Process regulation of cell adhesion 73 2.24038e-39 4.038515126027397e-37 2.100851 353 0.1609667 130 0.0014374749887692308 1.46169 116 653 0.0508326 GO Biological Process actin cytoskeleton organization 76 3.268953e-39 5.6600200693421055e-37 2.549862 244 0.1112631 210 0.011429813407142858 1.499644 76 417 0.03330412 GO Biological Process positive regulation of programmed cell death 80 1.048172e-38 1.7241119185e-36 2.251482 302 0.1377109 198 0.009061792492929294 1.419624 103 597 0.04513585 GO Biological Process regulation of cellular component size 88 5.098546e-37 7.624064410681819e-35 2.713463 208 0.09484724 149 0.0023135615075838925 1.655852 65 323 0.02848379 GO Biological Process positive regulation of cell adhesion 95 8.167478e-36 1.1313246631789475e-33 2.439697 241 0.1098951 194 0.008489922263402061 1.541451 71 379 0.03111306 GO Biological Process actin filament-based process 108 7.683176e-35 9.361380831851851e-33 2.284766 265 0.120839 186 0.007141714737634408 1.477737 88 490 0.03856266 GO Biological Process positive regulation of cellular component movement 109 1.17927e-34 1.4236710027522934e-32 2.261106 269 0.122663 160 0.0029678389156874998 1.535951 84 450 0.03680982 GO Biological Process regulation of epithelial cell proliferation 113 8.975578e-34 1.0452179725840708e-31 2.45402 225 0.1025992 74 0.00013865688090810812 1.831644 65 292 0.02848379 GO Molecular Function enzyme activator activity 7 1.405248e-31 8.475652937142857e-29 2.184902 263 0.119927 9 0.0040047035113333325 1.542808 96 512 0.04206836 GO Molecular Function transcription factor binding 9 5.048679e-31 2.3683914153333333e-28 2.110306 278 0.126767 18 0.02409668971111111 1.456612 94 531 0.04119194 GO Molecular Function azole transmembrane transporter activity 86 0.000002157373 0.00010591196286046513 12.43607 7 0.003191974 20 0.03007003395 6.856924 5 6 0.00219106 GO Molecular Function thiamine transmembrane transporter activity 100 0.000008915257 0.00037640215053999997 13.0223 6 0.002735978 23 0.03995254736521739 8.228309 4 4 0.001752848 Mouse Phenotype Single KO decreased embryo size 16 3.610167e-50 2.0661437011875e-47 2.501706 320 0.1459188 41 0.00015057029306341464 1.619488 99 503 0.043383 Mouse Phenotype Single KO abnormal embryo size 18 3.006353e-48 1.5293985789444444e-45 2.346074 345 0.1573187 35 0.00008527027179142857 1.573059 117 612 0.05127082 Mouse Phenotype Single KO abnormal prenatal body size 26 4.762994e-43 1.6774898483846156e-40 2.113677 379 0.1728226 26 0.00002345995576807692 1.546259 140 745 0.06134969 Mouse Phenotype Single KO small kidney 49 1.539474e-33 2.8769313097959187e-31 2.993435 162 0.07387141 157 0.017854003645859873 1.753574 39 183 0.01709027 Mouse Phenotype Single KO decreased litter size 69 6.852357e-30 9.093772905652174e-28 2.504142 192 0.0875513 166 0.01941256970301205 1.568607 57 299 0.02497809 Mouse Phenotype Single KO abnormal litter size 74 8.899513e-29 1.1012546019054054e-26 2.443908 193 0.0880073 191 0.0246415253539267 1.53949 58 310 0.0254163 Mouse Phenotype Single KO abnormal kidney size 85 8.494491e-27 9.151065186705881e-25 2.462754 177 0.08071135 229 0.03970327648340611 1.552511 50 265 0.0219106 Mouse Phenotype Single KO abnormal cell migration 112 2.083423e-23 1.7033843224107145e-21 2.03397 228 0.1039672 248 0.04671617089919354 1.424902 71 410 0.03111306 Mouse Phenotype Single KO abnormal gastrulation 143 3.95558e-19 2.53295426993007e-17 2.106645 171 0.07797538 196 0.026095641959693876 1.53454 58 311 0.0254163 Mouse Phenotype Single KO pale yolk sac 245 6.434853e-13 2.4050591396326532e-11 2.770864 66 0.03009576 222 0.03637915646261261 2.057077 21 84 0.009202454 Mouse Phenotype Single KO abnormal branching of the mammary ductal tree 251 1.051903e-12 3.83756006812749e-11 3.697794 43 0.01960784 82 0.0019787015120731706 3.248017 15 38 0.006573181 Mouse Phenotype Single KO abnormal vibrissa morphology 283 2.215603e-11 7.169002357243817e-10 2.506422 68 0.03100775 78 0.0018192998462820513 2.338572 27 95 0.01183173 Mouse Phenotype Single KO abnormal osteoclast differentiation 304 1.055501e-10 3.1793495582236845e-9 2.607879 59 0.02690378 144 0.015838233356250002 2.244084 21 77 0.009202454 Mouse Phenotype Single KO abnormal artery development 315 2.514867e-10 7.3106784504761915e-9 2.115839 86 0.03921569 42 0.00016099826498809525 2.391132 34 117 0.01489921 Mouse Phenotype Single KO distended pericardium 334 7.476953e-10 2.0498939706886225e-8 2.652833 52 0.02371181 190 0.02339792302473684 2.438017 16 54 0.007011394 Mouse Phenotype Single KO abnormal mammary gland duct morphology 363 3.064785e-9 7.73119455785124e-8 2.763218 45 0.02051984 123 0.008312158801626017 2.639269 17 53 0.007449606 Mouse Phenotype Single KO abnormal rectum morphology 366 3.637272e-9 9.10013653114754e-8 3.007744 39 0.01778386 119 0.006356216895126051 3.031482 14 38 0.006134969 Mouse Phenotype Single KO abnormal mammary gland development 396 1.43355e-8 3.314903371212121e-7 2.066044 73 0.03328773 38 0.00011408267727894736 2.432717 34 115 0.01489921 Mouse Phenotype Single KO dermal-epidermal separation 415 2.767394e-8 6.106271532048193e-7 8.686113 12 0.005471956 181 0.022681064364088396 5.877363 5 7 0.00219106 Mouse Phenotype Single KO abnormal mammary gland epithelium morphology 422 3.079925e-8 6.683145313981042e-7 2.490752 47 0.02143183 131 0.010120260479389314 2.442779 19 64 0.00832603 Mouse Phenotype decreased chondrocyte number 17 3.69069e-64 2.075687475882353e-61 9.210469 106 0.04833561 203 0.012785642708866996 3.702739 9 20 0.003943909 Mouse Phenotype decreased embryo size 24 3.921125e-55 1.5620781718750002e-52 2.398424 376 0.1714546 30 0.000007283770581 1.627141 123 622 0.05390009 Mouse Phenotype abnormal embryo size 27 3.031718e-53 1.0735650295555555e-50 2.275414 400 0.1823985 28 0.0000062458666649999995 1.578032 140 730 0.06134969 Mouse Phenotype abnormal prenatal body size 30 3.312646e-50 1.0557402802e-47 2.101072 442 0.2015504 22 0.0000020834570665909088 1.541647 166 886 0.07274321 Mouse Phenotype increased cell proliferation 73 6.248683e-35 8.184062762054795e-33 2.944248 173 0.07888737 225 0.017831052533333332 1.619225 49 249 0.02147239 Mouse Phenotype lethality, incomplete penetrance 88 2.002725e-32 2.1759151960227273e-30 2.500128 209 0.09530324 101 0.0009601922973267327 1.736771 61 289 0.02673094 Mouse Phenotype embryonic lethality during organogenesis, incomplete penetrance 106 1.368175e-29 1.2340680353773586e-27 2.335675 216 0.09849521 250 0.0226480700292 1.519072 60 325 0.02629273 Mouse Phenotype prenatal lethality, incomplete penetrance 121 1.662656e-27 1.3137730591735534e-25 2.117641 245 0.1117191 276 0.03256594726847826 1.421253 76 440 0.03330412 Mouse Phenotype small kidney 128 5.696195e-27 4.254790655859375e-25 2.441547 181 0.08253534 201 0.01250771922686567 1.632855 51 257 0.02234882 Mouse Phenotype decreased litter size 137 2.593366e-26 1.809866593138686e-24 2.231267 210 0.09575923 137 0.002437035392627737 1.608887 70 358 0.03067485 Mouse Phenotype neonatal lethality, incomplete penetrance 144 1.713845e-25 1.1379216697916667e-23 2.024836 251 0.1144551 238 0.02085370599579832 1.466431 72 404 0.03155127 Mouse Phenotype abnormal litter size 146 2.056062e-25 1.346438957671233e-23 2.188437 211 0.09621523 153 0.003296937752156863 1.583225 71 369 0.03111306 Mouse Phenotype reduced female fertility 188 4.64406e-22 2.361800939361702e-20 2.158469 188 0.08572731 227 0.01852566737312775 1.561984 56 295 0.02453988 Mouse Phenotype abnormal long bone epiphyseal plate morphology 194 8.945111e-22 4.408464240773196e-20 2.349678 156 0.07113543 313 0.0423692202172524 1.606479 41 210 0.0179667 Mouse Phenotype abnormal hair follicle outer root sheath morphology 196 9.956872e-22 4.857023122040816e-20 6.368389 45 0.02051984 291 0.0372751848556701 2.938682 10 28 0.004382121 Mouse Phenotype abnormal kidney size 200 3.075921e-21 1.4704440340500002e-19 2.05341 202 0.09211126 222 0.01749596675945946 1.502171 67 367 0.02936021 Mouse Phenotype decreased survivor rate 230 5.959109e-19 2.4771757021304348e-17 2.180668 157 0.07159143 141 0.0026163201840425534 1.755832 51 239 0.02234882 Mouse Phenotype abnormal placenta morphology 240 4.719815e-18 1.880256300625e-16 2.02141 177 0.08071135 269 0.030052575930111524 1.467752 66 370 0.028922 Mouse Phenotype abnormal cartilage development 268 2.080769e-16 7.423221048134329e-15 2.04305 156 0.07113543 308 0.0412035330487013 1.599949 42 216 0.01840491 Mouse Phenotype abnormal placenta labyrinth morphology 284 8.16312e-16 2.7481545887323942e-14 2.360299 110 0.0501596 315 0.04328246488571429 1.637046 38 191 0.01665206