# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of adaptive immune response 149 1.270639e-43 1.1221703759060403e-41 2.120918 421 0.02408191 486 0.0009034054226748972 1.367375 86 131 0.009539656 GO Biological Process regulation of antigen receptor-mediated signaling pathway 191 5.490002e-39 3.782352686806283e-37 2.685452 234 0.0133852 445 0.0003464125971011236 1.611271 41 53 0.004547976 GO Biological Process regulation of type I interferon production 211 3.494265e-36 2.1791958831753554e-34 2.256819 302 0.01727491 511 0.001218245284148728 1.371641 81 123 0.008985025 GO Biological Process tumor necrosis factor-mediated signaling pathway 222 1.351119e-34 8.008727441891891e-33 2.272303 284 0.01624528 1047 0.04703477801623687 1.252972 77 128 0.00854132 GO Biological Process Fc receptor mediated stimulatory signaling pathway 240 3.423018e-32 1.87681224425e-30 2.253589 268 0.01533005 247 3.91355692340081e-7 1.683409 59 73 0.006544648 GO Biological Process Fc-gamma receptor signaling pathway 245 1.160583e-31 6.233514978367346e-30 2.259035 262 0.01498684 279 0.000002260962872293907 1.638518 59 75 0.006544648 GO Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis 247 1.363151e-31 7.262228343724695e-30 2.264698 260 0.01487244 234 2.5635795826068376e-7 1.701493 58 71 0.006433722 GO Biological Process B cell receptor signaling pathway 258 2.507477e-30 1.2789104590310077e-28 2.657597 183 0.01046791 854 0.021894896455503514 1.547269 26 35 0.002884082 GO Biological Process T cell activation involved in immune response 268 5.814568e-30 2.8549962802985075e-28 2.498705 202 0.01155474 903 0.02760973873532669 1.399956 41 61 0.004547976 GO Biological Process lymphocyte activation involved in immune response 269 7.085136e-30 3.4659221049814127e-28 2.033273 314 0.01796133 801 0.016088400395505617 1.327314 65 102 0.007210205 GO Biological Process regulation of alpha-beta T cell activation 287 4.706048e-28 2.1577312066898953e-26 2.005799 304 0.01738931 413 0.0001446898641549637 1.53474 56 76 0.006211869 GO Biological Process telomere organization 307 8.752187e-27 3.751466733973941e-25 2.202055 232 0.01327079 614 0.0033618351734527687 1.35297 76 117 0.008430394 GO Biological Process regulation of B cell proliferation 323 8.806535e-26 3.587776906037152e-24 2.119435 243 0.01390001 351 0.000021438177923646723 1.659229 47 59 0.005213533 GO Biological Process regulation of cell killing 332 2.972346e-25 1.1781054522289156e-23 2.239397 210 0.01201236 513 0.001214359974483431 1.52082 46 63 0.005102607 GO Biological Process leukocyte homeostasis 337 8.757318e-25 3.4195117970919876e-23 2.151543 225 0.01287038 550 0.001741250558981818 1.4922 48 67 0.005324459 GO Biological Process peptidyl-tyrosine autophosphorylation 341 1.30231e-24 5.025541727272727e-23 2.277754 197 0.01126873 740 0.010882901995945944 1.506751 34 47 0.003771492 GO Biological Process lymphocyte homeostasis 344 3.034944e-24 1.160954305116279e-22 2.367463 179 0.0102391 445 0.0003464125971011236 1.611271 41 53 0.004547976 GO Biological Process positive regulation of leukocyte chemotaxis 351 1.207553e-23 4.527119637321937e-22 2.022822 248 0.01418602 619 0.003514983610662359 1.404177 60 89 0.006655574 GO Biological Process regulation of toll-like receptor signaling pathway 357 1.739585e-23 6.41210056442577e-22 2.38817 170 0.009724288 753 0.011862833257370519 1.447413 41 59 0.004547976 GO Biological Process regulation of T cell receptor signaling pathway 369 4.537485e-23 1.6181237158536585e-21 2.800649 125 0.007150212 981 0.03735141237716615 1.504289 26 36 0.002884082 GO Cellular Component extrinsic component of cytoplasmic side of plasma membrane 36 1.066264e-33 5.118067199999999e-32 2.040986 353 0.0201922 75 0.002430337536 1.375835 72 109 0.007986689 GO Cellular Component uropod 44 9.152281e-26 3.594350356363637e-24 5.049907 67 0.003832513 95 0.01968521229473684 1.922642 12 13 0.001331115 GO Cellular Component death-inducing signaling complex 252 0.00003388956 0.00023238555428571427 2.610329 24 0.001372841 102 0.022913805176470587 2.082862 9 9 0.0009983361 GO Molecular Function cytokine receptor activity 23 8.32497e-28 1.5281749278260871e-25 2.103713 268 0.01533005 72 0.0005067753385555557 1.471587 65 92 0.007210205 GO Molecular Function non-membrane spanning protein tyrosine kinase activity 26 4.806656e-27 7.805269858461538e-25 2.323603 209 0.01195515 121 0.011233573099173555 1.511096 37 51 0.004104271 GO Molecular Function protein phosphorylated amino acid binding 40 5.395171e-22 5.6946029905e-20 2.180307 192 0.01098273 49 0.0000014461194399999998 1.846173 39 44 0.004326123 GO Molecular Function phosphotyrosine binding 44 8.205307e-21 7.873365034999999e-19 2.267294 166 0.009495481 54 0.000004854086565925926 1.904331 32 35 0.003549639 GO Molecular Function tumor necrosis factor receptor superfamily binding 68 9.216393e-16 5.722295771470588e-14 2.260603 123 0.007035808 145 0.04945793474482759 1.462435 33 47 0.003660566 GO Molecular Function 14-3-3 protein binding 84 5.995036e-14 3.0132192847619045e-12 2.140847 121 0.006921405 136 0.03324558020588236 1.66629 20 25 0.002218525 GO Molecular Function NAD+ ADP-ribosyltransferase activity 207 1.236746e-7 0.000002522483870531401 2.05854 65 0.00371811 122 0.013693049949180329 1.78531 18 21 0.001996672 Mouse Phenotype Single KO abnormal lymphocyte physiology 1 0 0 2.173769 2848 0.1629104 5 1.0567615704599999e-32 1.4288 592 863 0.06566833 Mouse Phenotype Single KO abnormal immune serum protein physiology 10 1.253049e-267 1.1474169693e-264 2.028513 2740 0.1567326 19 5.561928063684211e-22 1.335677 606 945 0.0672213 Mouse Phenotype Single KO abnormal T cell physiology 11 8.128769e-249 6.766830703000001e-246 2.36865 1868 0.1068528 13 1.6150496741538464e-25 1.487758 375 525 0.04159734 Mouse Phenotype Single KO abnormal cytokine secretion 20 1.194632e-198 5.469622612e-196 2.209789 1729 0.09890173 43 2.0952414928139536e-16 1.3752 377 571 0.04181919 Mouse Phenotype Single KO abnormal B cell physiology 24 4.402098e-180 1.67958380775e-177 2.114943 1729 0.09890173 38 3.116724714736842e-17 1.394979 363 542 0.04026622 Mouse Phenotype Single KO abnormal immunoglobulin level 31 9.708865e-157 2.8678734453225808e-154 2.172094 1429 0.08174122 61 5.834032782622951e-13 1.376259 298 451 0.03305602 Mouse Phenotype Single KO abnormal humoral immune response 33 1.860608e-155 5.16290528969697e-153 2.104591 1519 0.08688937 62 9.505695606129032e-13 1.357466 320 491 0.03549639 Mouse Phenotype Single KO abnormal T cell activation 37 1.059204e-146 2.6213867643243245e-144 2.427945 1072 0.06132022 64 1.4915751453125e-12 1.463048 203 289 0.02251803 Mouse Phenotype Single KO abnormal interleukin secretion 41 5.821933e-139 1.3002790361219512e-136 2.151167 1299 0.074305 63 1.4144990865555554e-12 1.385253 278 418 0.03083749 Mouse Phenotype Single KO abnormal T cell proliferation 43 1.22643e-136 2.6117254674418606e-134 2.439436 991 0.05668688 77 3.312975247922078e-11 1.460397 183 261 0.0202995 Mouse Phenotype Single KO autoimmune response 49 8.554141e-129 1.5985769211632652e-126 2.342257 1011 0.05783091 162 4.936862586481482e-7 1.321453 210 331 0.02329451 Mouse Phenotype Single KO abnormal immune tolerance 50 1.309291e-126 2.3978355374e-124 2.308802 1023 0.05851733 150 2.5783621296e-7 1.324897 215 338 0.02384914 Mouse Phenotype Single KO abnormal self tolerance 51 2.166188e-125 3.889369316862745e-123 2.308039 1014 0.05800252 164 5.245146908963414e-7 1.319771 211 333 0.02340544 Mouse Phenotype Single KO abnormal IgG level 55 9.467404e-113 1.576236698690909e-110 2.123019 1091 0.06240705 87 1.2824431126436783e-10 1.386591 233 350 0.02584581 Mouse Phenotype Single KO abnormal B cell activation 58 4.67082e-110 7.374258403448276e-108 2.754632 646 0.03695229 104 7.812497941057692e-10 1.562146 114 152 0.01264559 Mouse Phenotype Single KO decreased immunoglobulin level 60 1.259365e-107 1.9220008841666665e-105 2.272804 900 0.05148152 119 2.2647146264705884e-8 1.383615 186 280 0.02063228 Mouse Phenotype Single KO abnormal mature B cell number 62 5.14409e-104 7.597489053225806e-102 2.097545 1036 0.05926095 57 1.0903578869649122e-13 1.494227 198 276 0.02196339 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 64 1.077523e-102 1.54169970484375e-100 2.342761 808 0.04621897 337 0.0004535000174183977 1.26887 159 261 0.01763727 Mouse Phenotype Single KO abnormal B cell proliferation 67 4.958996e-93 6.777541249552239e-91 2.644037 585 0.03346299 116 1.1423886395689655e-8 1.5546 103 138 0.0114254 Mouse Phenotype Single KO increased immunoglobulin level 68 1.186655e-89 1.5979705639705884e-87 2.186578 815 0.04661938 171 8.293650194152047e-7 1.36124 166 254 0.01841375 Mouse Phenotype abnormal lymphocyte physiology 1 0 0 2.047168 3406 0.194829 6 4.6710297369999996e-39 1.412757 740 1091 0.08208541 Mouse Phenotype abnormal T cell physiology 17 5.972288e-262 3.3588850334117647e-259 2.174016 2318 0.1325935 19 7.67938010368421e-30 1.454412 486 696 0.05391015 Mouse Phenotype abnormal cytokine secretion 23 4.287953e-231 1.782483418826087e-228 2.133816 2145 0.1226976 57 6.0820020278947366e-18 1.347053 465 719 0.0515807 Mouse Phenotype abnormal B cell physiology 28 1.845847e-217 6.302908273928572e-215 2.088808 2122 0.121382 45 9.724280633333335e-23 1.402996 454 674 0.05036051 Mouse Phenotype abnormal humoral immune response 39 5.890896e-185 1.4441758116923075e-182 2.06599 1868 0.1068528 70 5.487027851142857e-16 1.359598 391 599 0.04337216 Mouse Phenotype abnormal immunoglobulin level 40 8.186273e-184 1.9567239038250003e-181 2.122108 1750 0.100103 65 6.780925966153846e-17 1.38605 366 550 0.040599 Mouse Phenotype abnormal T cell activation 44 5.678244e-174 1.233856611e-171 2.265182 1448 0.08282805 61 1.5859018785245903e-17 1.456476 286 409 0.0317249 Mouse Phenotype abnormal interleukin secretion 47 2.411444e-166 4.905492783829787e-164 2.089408 1647 0.09421119 99 2.0541963021212121e-13 1.347279 348 538 0.03860233 Mouse Phenotype abnormal T cell proliferation 50 2.537032e-153 4.851312590399999e-151 2.271832 1274 0.07287496 73 1.2709284062054795e-15 1.454607 257 368 0.02850804 Mouse Phenotype abnormal IgG level 52 5.795402e-150 1.065573817730769e-147 2.152802 1396 0.07985356 83 7.678545077349398e-15 1.409565 291 430 0.03227953 Mouse Phenotype abnormal lymph node morphology 53 2.427582e-149 4.3792663211320755e-147 2.139036 1410 0.08065439 91 9.798107546703296e-14 1.405675 274 406 0.03039379 Mouse Phenotype autoimmune response 55 5.957798e-140 1.0356819396000001e-137 2.156445 1301 0.0744194 151 1.1408888028476823e-10 1.347734 275 425 0.03050471 Mouse Phenotype abnormal immune tolerance 56 1.413232e-137 2.4128412771428573e-135 2.131262 1313 0.07510582 156 1.699464685576923e-10 1.340693 280 435 0.03105935 Mouse Phenotype abnormal self tolerance 57 4.968511e-137 8.334023451052633e-135 2.134183 1304 0.07459101 153 1.2294758607843137e-10 1.346299 276 427 0.03061564 Mouse Phenotype abnormal mature B cell number 61 2.407757e-131 3.773863061803279e-129 2.066553 1346 0.07699348 63 4.167879683809524e-17 1.466727 269 382 0.02983916 Mouse Phenotype decreased immunoglobulin level 62 4.254251e-130 6.560466743709678e-128 2.217019 1142 0.06532433 109 6.381477169816514e-13 1.424486 238 348 0.02640044 Mouse Phenotype abnormal spleen white pulp morphology 63 6.758598e-128 1.0256977059999999e-125 2.163929 1183 0.0676696 92 1.0320778375108696e-13 1.42874 249 363 0.02762063 Mouse Phenotype abnormal B cell activation 65 1.152856e-122 1.695762494769231e-120 2.540546 827 0.0473058 78 4.726808856153846e-15 1.595167 157 205 0.01741542 Mouse Phenotype abnormal lymph node size 67 9.6346e-121 1.3748718e-118 2.210725 1068 0.06109141 123 5.632089719512195e-12 1.452136 198 284 0.02196339 Mouse Phenotype altered susceptibility to autoimmune disorder 69 4.294539e-116 5.950737301304347e-114 2.235208 1004 0.0574305 322 0.000004994025040993789 1.289391 208 336 0.02307266