# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of CD4-positive, alpha-beta T cell activation 54 7.617357e-41 1.8562370511666665e-38 4.246478 130 0.01793103 659 0.022829686880121394 1.986242 17 30 0.003173418 GO Biological Process regulation of T cell differentiation 64 7.29924e-40 1.5007921743749999e-37 2.504916 268 0.03696552 328 0.0008544531865243903 1.613474 58 126 0.01082696 GO Biological Process regulation of leukocyte differentiation 67 1.297693e-39 2.548707789104478e-37 2.030493 414 0.05710345 207 0.000054899316214975846 1.500197 107 250 0.01997387 GO Biological Process positive regulation of leukocyte differentiation 76 7.160924e-39 1.2398763015263158e-36 2.396044 284 0.03917241 232 0.00012334554618103447 1.672905 63 132 0.01176031 GO Biological Process regulation of lymphocyte differentiation 82 1.95982e-38 3.1450330951219514e-36 2.352504 291 0.04013793 287 0.00040719489286062717 1.580746 69 153 0.01288034 GO Biological Process positive regulation of T cell activation 101 9.573452e-37 1.2472975729504952e-34 2.188307 323 0.04455172 428 0.0036279332254672897 1.429955 82 201 0.01530707 GO Biological Process positive regulation of leukocyte cell-cell adhesion 108 2.522224e-36 3.0731431125925925e-34 2.127073 340 0.04689655 327 0.0008380077760856268 1.468818 88 210 0.0164271 GO Biological Process regulation of CD4-positive, alpha-beta T cell activation 111 3.574682e-36 4.237769408828828e-34 3.454517 147 0.02027586 552 0.011711939097826089 1.82559 25 48 0.004666791 GO Biological Process positive regulation of T cell differentiation 118 4.064304e-35 4.532387825084746e-33 2.844667 189 0.02606897 377 0.0018302340003713527 1.776574 37 73 0.006906851 GO Biological Process myeloid cell differentiation 120 4.152681e-35 4.5537607732499996e-33 2.240454 293 0.04041379 179 0.000027943952505027936 1.596579 87 191 0.01624043 GO Biological Process platelet activation 125 6.404761e-34 6.74241999992e-32 2.441304 238 0.03282759 164 0.000017858287518292683 1.715278 69 141 0.01288034 GO Biological Process positive regulation of hemopoiesis 133 9.190715e-33 9.093279600375941e-31 2.135574 303 0.0417931 260 0.00027735502663461543 1.571999 74 165 0.0138137 GO Biological Process positive regulation of angiogenesis 139 2.358492e-32 2.232762318561151e-30 2.308498 253 0.03489655 782 0.04457333598465473 1.402053 54 135 0.01008027 GO Biological Process coronary artery morphogenesis 141 2.822421e-32 2.6340594282978723e-30 6.151404 71 0.009793103 828 0.04953543446376812 2.726215 7 9 0.001306702 GO Biological Process positive regulation of lymphocyte differentiation 146 1.293351e-31 1.1656990280136987e-29 2.607728 196 0.02703448 455 0.004542316166813187 1.669111 40 84 0.007466866 GO Biological Process platelet aggregation 155 3.309582e-30 2.8097283572903223e-28 4.277665 94 0.01296552 714 0.03307109190616246 1.795312 21 41 0.003920105 GO Biological Process coronary vasculature morphogenesis 165 1.628975e-29 1.2991322439393937e-27 4.699493 83 0.01144828 763 0.04151495485321101 2.336756 10 15 0.001866716 GO Biological Process regulation of alpha-beta T cell activation 171 2.568429e-29 1.976488725789474e-27 2.70468 170 0.02344828 611 0.01839891595368249 1.614206 35 76 0.006533508 GO Biological Process positive regulation of vasculature development 189 5.718608e-28 3.981542998518518e-26 2.100515 267 0.03682759 676 0.02597757900591716 1.406665 61 152 0.01138697 GO Biological Process positive regulation of alpha-beta T cell differentiation 196 3.050612e-27 2.0481124136734695e-25 3.166349 123 0.01696552 748 0.0395551271644385 1.797504 20 39 0.003733433 GO Cellular Component RISC complex 235 0.00003024736 0.00022241463012765957 3.037769 19 0.00262069 69 0.02751233947826087 2.804107 8 10 0.001493373 GO Molecular Function type II transforming growth factor beta receptor binding 166 2.822376e-7 0.000007178356308433734 3.488337 24 0.003310345 52 0.01245562261153846 3.505133 7 7 0.001306702 GO Molecular Function protein phosphatase activator activity 239 0.00001955439 0.0003454336174895397 3.031359 20 0.002758621 79 0.04923114939746835 3.066992 7 8 0.001306702 Mouse Phenotype Single KO abnormal hemopoiesis 4 4.374513e-121 1.001435388525e-117 2.113308 1115 0.1537931 7 8.289386023285714e-16 1.526045 320 735 0.05973493 Mouse Phenotype Single KO abnormal definitive hematopoiesis 5 1.726174e-112 3.1613150636e-109 2.095109 1061 0.1463448 9 1.0554327676666666e-15 1.534116 309 706 0.05768154 Mouse Phenotype Single KO abnormal T cell physiology 14 2.677664e-94 1.7513835177142856e-91 2.290124 749 0.1033103 30 1.7132515022666666e-11 1.528906 229 525 0.04274781 Mouse Phenotype Single KO abnormal erythropoiesis 26 2.130095e-80 7.502030736538462e-78 3.587226 317 0.04372414 74 1.0706755428648647e-7 1.975621 62 110 0.01157364 Mouse Phenotype Single KO abnormal cytokine secretion 27 1.352069e-79 4.585516975185185e-77 2.175773 706 0.09737931 48 1.12125404675e-9 1.460984 238 571 0.04442785 Mouse Phenotype Single KO abnormal T cell activation 28 1.011981e-78 3.3095392917857143e-76 2.643276 484 0.06675862 109 0.0000022422485471559633 1.52819 126 289 0.02352063 Mouse Phenotype Single KO abnormal bone marrow cell morphology/development 34 8.376263e-72 2.2559247144411765e-69 2.073416 710 0.09793103 47 8.957059827446809e-10 1.524307 197 453 0.03677431 Mouse Phenotype Single KO abnormal T cell proliferation 38 1.857626e-67 4.476389811052631e-65 2.576075 434 0.05986207 174 0.00004180408897758621 1.490689 111 261 0.02072055 Mouse Phenotype Single KO abnormal platelet physiology 39 2.693149e-67 6.323375741794872e-65 3.619052 262 0.03613793 91 2.825610709230769e-7 1.943756 61 110 0.01138697 Mouse Phenotype Single KO abnormal platelet aggregation 40 4.108203e-67 9.404703717750001e-65 4.293007 214 0.02951724 125 0.000004908896280960001 2.022192 45 78 0.008400224 Mouse Phenotype Single KO abnormal platelet activation 41 7.57454e-67 1.6917088482926826e-64 4.205783 218 0.03006897 141 0.000013143003134042553 1.938133 47 85 0.008773567 Mouse Phenotype Single KO decreased T cell proliferation 49 5.526805e-63 1.032835783367347e-60 3.024027 313 0.04317241 219 0.00015976171905936074 1.612361 69 150 0.01288034 Mouse Phenotype Single KO abnormal interleukin secretion 54 2.289803e-60 3.88291223537037e-58 2.168293 543 0.07489655 89 2.607846723033708e-7 1.46746 175 418 0.03266754 Mouse Phenotype Single KO abnormal granulocyte number 57 1.010784e-57 1.6238156294736842e-55 2.089299 564 0.0777931 92 2.932307292282609e-7 1.455113 181 436 0.03378757 Mouse Phenotype Single KO decreased erythroid progenitor cell number 58 6.715644e-57 1.0602612432413793e-54 4.013753 195 0.02689655 389 0.004901782117737789 1.855659 27 51 0.005040134 Mouse Phenotype Single KO abnormal granulocyte morphology 61 1.553336e-55 2.3317865167213116e-53 2.026216 583 0.08041379 83 1.7740231206024097e-7 1.449092 191 462 0.03565428 Mouse Phenotype Single KO decreased myeloid cell number 66 3.745996e-52 5.197285662424242e-50 2.144772 481 0.06634483 236 0.00021159739514406783 1.413546 123 305 0.02296061 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 68 5.496743e-52 7.402011125147059e-50 3.827427 188 0.02593103 288 0.0005445467590625 1.984038 30 53 0.005600149 Mouse Phenotype Single KO enlarged spleen 70 2.845599e-51 3.722450006142857e-49 2.094018 499 0.06882759 178 0.00005017342022865169 1.396577 153 384 0.02856076 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 71 8.493619e-50 1.0954375941267607e-47 2.90564 262 0.03613793 161 0.00003114392388819876 1.670231 71 149 0.01325369 Mouse Phenotype abnormal hemopoiesis 1 1.479455e-140 1.4145069255e-136 2.036607 1380 0.1903448 9 2.5144240186666666e-17 1.4628 419 1004 0.07821542 Mouse Phenotype abnormal definitive hematopoiesis 2 5.277855e-134 2.52307858275e-130 2.027631 1335 0.1841379 8 1.510020120375e-17 1.473016 411 978 0.07672205 Mouse Phenotype abnormal T cell physiology 23 7.212504e-92 2.9982065540869568e-89 2.060254 911 0.1256552 52 2.7923415323076923e-12 1.465508 291 696 0.05432145 Mouse Phenotype abnormal lymphopoiesis 31 8.267952e-87 2.549996421677419e-84 2.00192 922 0.1271724 88 1.543088903181818e-9 1.421437 264 651 0.04928131 Mouse Phenotype abnormal T cell activation 33 7.195797e-83 2.0848186399090913e-80 2.357586 625 0.0862069 142 8.360374058450704e-8 1.482611 173 409 0.03229419 Mouse Phenotype abnormal cytokine secretion 37 1.352809e-81 3.495731580810811e-79 2.026933 845 0.1165517 85 9.735337523647057e-10 1.404003 288 719 0.05376143 Mouse Phenotype abnormal bone marrow cell morphology/development 38 1.045867e-80 2.631456417631579e-78 2.002624 860 0.1186207 57 7.587170129473684e-12 1.497971 253 592 0.04722793 Mouse Phenotype abnormal erythropoiesis 39 2.230278e-79 5.467612296923077e-77 3.245687 357 0.04924138 114 2.1839001368421052e-8 1.858426 79 149 0.01474706 Mouse Phenotype abnormal platelet physiology 44 7.59689e-71 1.650769665681818e-68 3.499773 288 0.03972414 165 4.3657391843636355e-7 1.832229 69 132 0.01288034 Mouse Phenotype abnormal T cell proliferation 47 1.740516e-68 3.54065393106383e-66 2.313355 538 0.0742069 271 0.000027247696329520295 1.409673 148 368 0.0276274 Mouse Phenotype abnormal platelet aggregation 50 3.383526e-67 6.4699784172e-65 4.108015 225 0.03103448 281 0.000040903387046263344 1.827144 49 94 0.009146911 Mouse Phenotype abnormal platelet activation 51 2.040794e-66 3.825888516470588e-64 4.049429 226 0.03117241 328 0.0001326657834054878 1.752567 50 100 0.009333582 Mouse Phenotype abnormal thymus size 54 9.877648e-64 1.7488924542222222e-61 2.010984 679 0.09365517 446 0.0008741545126008969 1.299052 169 456 0.03154751 Mouse Phenotype decreased T cell proliferation 57 1.357254e-62 2.2766149989473685e-60 2.586191 400 0.05517241 209 0.000003878410500717703 1.596234 97 213 0.01810715 Mouse Phenotype decreased erythroid progenitor cell number 67 1.188009e-58 1.695306574477612e-56 3.5677 232 0.032 395 0.0005580830735696202 1.798687 39 76 0.007280194 Mouse Phenotype thymus hypoplasia 69 1.637019e-57 2.2683389360869563e-55 2.394565 423 0.05834483 515 0.001972920704271845 1.414916 88 218 0.0164271 Mouse Phenotype decreased inflammatory response 71 1.163161e-56 1.5663355381690143e-54 2.520031 379 0.05227586 354 0.0002522914006610169 1.404375 121 302 0.02258727 Mouse Phenotype decreased myeloid cell number 74 7.526959e-55 9.725034459324325e-53 2.050472 560 0.07724138 233 0.000008021408173390557 1.418107 159 393 0.02968079 Mouse Phenotype small thymus 78 2.971403e-54 3.6422543696153845e-52 2.021376 573 0.07903448 288 0.000051551252104166666 1.402053 144 360 0.02688072 Mouse Phenotype anemia 79 8.298685e-54 1.0043509782911392e-51 2.074222 535 0.0737931 141 8.370980980851064e-8 1.507584 160 372 0.02986746