# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 1 2.430752e-23 3.1986265568e-19 4.785729 63 0.02591526 82 0.0002854400532560976 2.217494 36 114 0.01346298 GO Biological Process regulation of gene expression, epigenetic 3 3.265945e-20 1.4325523418333333e-16 2.819946 105 0.0431921 54 0.000050212794518518515 1.868775 66 248 0.02468212 GO Biological Process chromatin assembly or disassembly 5 1.038176e-19 2.7322715968e-16 3.162921 86 0.03537639 35 0.000009302322682857143 2.130289 54 178 0.02019447 GO Biological Process nucleosome organization 7 3.205562e-19 6.02599862257143e-16 3.209229 82 0.03373097 45 0.000032067137857777775 2.0943 51 171 0.01907255 GO Biological Process chromatin assembly 8 3.738802e-19 6.149861939749999e-16 3.287762 79 0.03249691 31 0.000007499216468709677 2.222172 50 158 0.01869858 GO Biological Process nucleosome assembly 10 1.403576e-18 1.8469656584e-15 3.401828 73 0.03002879 42 0.000026827904983809522 2.225302 45 142 0.01682872 GO Biological Process DNA conformation change 12 6.213586e-18 6.8137148478333335e-15 2.48077 115 0.04730564 78 0.00022106529532051283 1.749269 70 281 0.02617801 GO Biological Process chromatin silencing 13 1.203813e-17 1.218536559e-14 5.069994 44 0.01809955 119 0.006004255973697479 2.09938 29 97 0.01084518 GO Biological Process DNA replication-dependent nucleosome assembly 14 3.479838e-17 3.270799160142857e-14 18.53395 18 0.00740436 146 0.0211234577109589 2.852714 13 32 0.004861631 GO Biological Process protein-DNA complex subunit organization 15 9.102376e-17 7.985211052266667e-14 2.480001 107 0.04401481 55 0.00006786500640181818 1.853825 66 250 0.02468212 GO Biological Process protein-DNA complex assembly 18 3.983134e-16 2.9118922392222224e-13 2.557245 97 0.03990128 68 0.00011099974502205882 1.891789 59 219 0.02206432 GO Biological Process DNA packaging 19 1.053579e-15 7.296866347894737e-13 2.733861 84 0.03455368 66 0.00011300103833939393 1.940772 55 199 0.02056844 GO Biological Process gene silencing 24 6.329355e-14 3.470332601875e-11 2.842793 69 0.02838338 129 0.008921187913333333 1.755516 45 180 0.01682872 GO Biological Process protein folding 41 2.861965e-10 9.185511569512195e-8 2.21983 77 0.03167421 166 0.037391353989759034 1.584625 51 226 0.01907255 GO Biological Process mitochondrial transport 42 2.948439e-10 9.237740190714284e-8 2.167496 81 0.03331962 154 0.027092005544155848 1.586575 54 239 0.02019447 GO Biological Process platelet aggregation 60 1.222969e-9 2.682174845166667e-7 3.935772 29 0.01192925 104 0.002433405299807692 2.911588 17 41 0.006357517 GO Biological Process regulation of gene silencing 74 9.46254e-9 0.0000016826697818918922 2.535102 49 0.02015631 150 0.025199309546666663 1.822521 34 131 0.01271503 GO Biological Process macromolecular complex disassembly 98 8.889569e-8 0.000011936514129693877 2.122989 61 0.02509255 159 0.03067202343647799 1.654413 45 191 0.01682872 GO Biological Process regulation of posttranscriptional gene silencing 100 1.17515e-7 0.00001546379885 2.556773 41 0.01686549 169 0.038999772124260354 1.868256 29 109 0.01084518 GO Biological Process regulation of gene silencing by RNA 100 1.17515e-7 0.00001546379885 2.556773 41 0.01686549 169 0.038999772124260354 1.868256 29 109 0.01084518 GO Cellular Component nucleosome 12 1.162383e-25 1.6738315200000002e-23 6.339471 54 0.02221308 16 1.30643604e-7 2.675072 40 105 0.01495886 GO Cellular Component DNA packaging complex 16 2.510788e-22 2.7116510400000003e-20 5.242392 55 0.02262443 19 2.7546238989473683e-7 2.570577 41 112 0.01533283 GO Cellular Component protein-DNA complex 24 2.430937e-11 1.75027464e-9 2.428092 72 0.02961744 24 0.00006849452159999999 1.911948 55 202 0.02056844 GO Cellular Component melanosome 41 5.07256e-7 0.000021378984585365855 2.233256 48 0.01974496 46 0.02240016542608696 1.87255 28 105 0.0104712 GO Cellular Component platelet dense tubular network membrane 84 0.0001331313 0.0027387010285714287 4.864815 9 0.00370218 45 0.01815457152 4.681376 6 9 0.002243829 GO Cellular Component cytoplasmic stress granule 88 0.0001634789 0.0032101311272727277 2.581463 20 0.008227067 36 0.00193225296 2.776165 17 43 0.006357517 GO Molecular Function nucleosome binding 16 4.622836e-9 0.0000012198508495 3.211166 35 0.01439737 27 0.03365773708888889 2.234293 21 66 0.007853403 Mouse Phenotype Single KO abnormal platelet morphology 20 1.516665e-13 6.944050702499999e-11 2.079458 122 0.05018511 29 0.0004566134892413793 1.768715 67 266 0.0250561 Mouse Phenotype Single KO abnormal T cell activation 25 1.370126e-12 5.018497512800001e-10 2.003343 123 0.05059646 71 0.0036017240997183097 1.627953 67 289 0.0250561 Mouse Phenotype Single KO abnormal platelet activation 36 1.236651e-11 3.1455592241666666e-9 2.991897 52 0.02139037 111 0.018935430318018014 2.065313 25 85 0.009349289 Mouse Phenotype Single KO abnormal platelet cell number 37 1.961411e-11 4.85422716945946e-9 2.078455 101 0.04154669 83 0.006436278779518073 1.706296 52 214 0.01944652 Mouse Phenotype Single KO abnormal platelet physiology 44 8.325438e-11 1.7326371765e-8 2.554102 62 0.02550391 116 0.020083756023275865 1.915108 30 110 0.01121915 Mouse Phenotype Single KO decreased granulocyte number 59 1.151592e-9 1.787309821016949e-7 2.002847 91 0.03743316 121 0.024154516226446283 1.617987 50 217 0.01869858 Mouse Phenotype Single KO increased interleukin-1 beta secretion 69 3.936193e-9 5.223727434927537e-7 4.092268 26 0.01069519 86 0.008204132162906977 2.979058 14 33 0.005235602 Mouse Phenotype Single KO decreased erythroid progenitor cell number 108 1.758559e-7 0.00001491030070648148 2.516825 41 0.01686549 76 0.004635672211447369 2.616063 19 51 0.00710546 Mouse Phenotype Single KO abnormal interleukin-1 beta secretion 134 0.000002887706 0.0001973337600149254 2.505988 33 0.01357466 133 0.03631280642105263 2.106619 21 70 0.007853403 Mouse Phenotype Single KO extramedullary hematopoiesis 142 0.000004246269 0.0002738245438943662 2.119436 45 0.0185109 91 0.008975038334835164 1.971106 32 114 0.01196709 Mouse Phenotype Single KO abnormal NK cell physiology 144 0.000004802269 0.0003053776196736111 2.018403 50 0.02056767 132 0.03509218379772727 1.915108 27 99 0.01009723 Mouse Phenotype Single KO increased mean platelet volume 145 0.000005231984 0.00033040881026206895 2.785464 26 0.01069519 32 0.0005691164208437501 3.102773 19 43 0.00710546 Mouse Phenotype Single KO abnormal platelet volume 148 0.000006044869 0.0003740058475202703 2.591218 29 0.01192925 44 0.0010218595983636364 2.71027 22 57 0.008227375 Mouse Phenotype Single KO abnormal vascular endothelial cell morphology 155 0.000008480289 0.0005009935895032258 2.246777 37 0.01522007 148 0.04665343626824324 2.25236 17 53 0.006357517 Mouse Phenotype Single KO increased skin tumor incidence 166 0.00001108621 0.0006115447287349397 3.047723 21 0.00863842 145 0.04703206341172413 2.393886 15 44 0.005609574 Mouse Phenotype Single KO increased integument system tumor incidence 189 0.00002109942 0.0010222613171428571 2.41817 29 0.01192925 142 0.04362375454225352 2.032703 22 76 0.008227375 Mouse Phenotype Single KO abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number 274 0.0002264977 0.007569487003284671 2.071443 30 0.0123406 124 0.025876552144354838 2.387502 17 50 0.006357517 Mouse Phenotype Single KO abnormal cellular hemoglobin content 381 0.001510398 0.03630108788976378 4.276552 7 0.002879473 110 0.019093693576363636 4.468586 7 11 0.002617801 Mouse Phenotype Single KO decreased spleen iron level 430 0.002273654 0.04841825506511628 3.01167 10 0.004113534 144 0.04695065430486111 3.511032 8 16 0.002991773 Mouse Phenotype abnormal erythropoiesis 87 3.720267e-8 0.000004088445147931034 2.006426 74 0.03044015 20 0.000025010538631499997 2.215014 47 149 0.01757666 Mouse Phenotype decreased erythroid progenitor cell number 106 1.385114e-7 0.000012493466937735851 2.293102 50 0.02056767 86 0.0033368757160465116 2.30989 25 76 0.009349289 Mouse Phenotype abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number 171 0.00001937679 0.0010834005215789473 2.215556 35 0.01439737 74 0.001752953792837838 2.633274 21 56 0.007853403 Mouse Phenotype abnormal choroid plexus morphology 172 0.00001986251 0.0011041015006395347 2.044066 42 0.01727684 174 0.04883306026206896 2.117765 19 63 0.00710546 Mouse Phenotype increased mean platelet volume 177 0.00002765143 0.0014936458883050847 2.522501 26 0.01069519 77 0.002470634417922078 2.722841 19 49 0.00710546 Mouse Phenotype abnormal platelet volume 189 0.00004406567 0.002229163337936508 2.318399 29 0.01192925 101 0.0051397067699999995 2.376699 22 65 0.008227375 Mouse Phenotype abnormal cellular hemoglobin content 392 0.001510398 0.0368390695867347 4.276552 7 0.002879473 123 0.01782902632682927 4.468586 7 11 0.002617801